PGS Publication: PGP000844

Publication Information (EuropePMC)
Title Helicobacter pylori Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer.
PubMed ID 38809553(Europe PMC)
doi 10.1001/jamanetworkopen.2024.13708
Publication Date May 1, 2024
Journal JAMA Netw Open
Author(s) Xu HM, Han Y, Liu ZC, Yin ZY, Wang MY, Yu C, Ma JL, Sun D, Liu WD, Zhang Y, Zhou T, Zhang JY, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Chen Z, You WC, Li L, Pan KF, Lv J, Li WQ.
Released in PGS Catalog: Aug. 26, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019954
(PRS12_GC)
 PGP000844 |
Xu HM et al. JAMA Netw Open (2024)
 Gastric Cancer gastric cancer 12
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019954/ScoringFiles/PGS019954.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038148 PGS019954
(PRS12_GC)
 PSS013840|
East Asian Ancestry|
50,316 individuals
 PGP000844 |
Xu HM et al. JAMA Netw Open (2024)
 Reported Trait: Gastric cancer HR: 1.13 [1.03, 1.24] — — age, sex, regions, PC —
PPM038149 PGS019954
(PRS12_GC)
 PSS013841|
East Asian Ancestry|
1,394 individuals
 PGP000844 |
Xu HM et al. JAMA Netw Open (2024)
 Reported Trait: Gastric cancer HR: 1.14 [1.02, 1.28] — — age, sex, PC —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013840 — — 50,316 individuals,
42.79 % Male samples
 — East Asian — CKB —
PSS013841 — — 1,394 individuals,
62.2 % Male samples
 — East Asian — NR —