Trait: gastric cancer

Trait Information
Identifier MONDO_0001056
Description A primary or metastatic malignant neoplasm involving the stomach. [NCIT: C9331]
Trait category
Other trait
Synonyms 28 synonyms
  • Ca body - stomach
  • Ca lesser curvature - stomach
  • GC
  • ca greater curvature of stomach
  • cancer of stomach
  • gastric cancer
  • gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
  • gastric neoplasm
  • malignant gastric neoplasm
  • malignant gastric tumor
  • malignant gastric tumour
  • malignant neoplasm of body of stomach
  • malignant neoplasm of lesser curve of stomach
  • malignant neoplasm of stomach
  • malignant neoplasm of the stomach
  • malignant stomach neoplasm
  • malignant tumor of body of stomach
  • malignant tumor of greater curve of stomach
  • malignant tumor of lesser curve of stomach
  • malignant tumor of stomach
  • malignant tumor of the stomach
  • malignant tumour of body of stomach
  • malignant tumour of greater curve of stomach
  • malignant tumour of lesser curve of stomach
  • malignant tumour of stomach
  • malignant tumour of the stomach
  • stomach cancer
Mapped terms 11 mapped terms
  • DOID:10534
  • ICD10CM:C16
  • ICD9:151
  • ICD9:151.4
  • ICD9:151.5
  • ICD9:151.6
  • ICD9:151.9
  • MEDGEN:44264
  • NCIT:C9331
  • OMIM:613659
  • UMLS:C0024623

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002299
(PRS3_gastric)
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Gastric cancer gastric cancer 3
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002299/ScoringFiles/PGS002299.txt.gz
PGS005161
(PRS-GC)
 PGP000711 |
Zhu M et al. PLoS Med (2025)
 Stomach cancer gastric cancer 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005161/ScoringFiles/PGS005161.txt.gz
PGS018480
(TPMI_151_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cancer of stomach gastric cancer 2
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018480/ScoringFiles/PGS018480.txt.gz
PGS018481
(TPMI_151_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cancer of stomach gastric cancer 130,571
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018481/ScoringFiles/PGS018481.txt.gz
PGS018482
(TPMI_151_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cancer of stomach gastric cancer 488,012
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018482/ScoringFiles/PGS018482.txt.gz
PGS018483
(TPMI_151_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cancer of stomach gastric cancer 983,814
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018483/ScoringFiles/PGS018483.txt.gz
PGS018484
(TPMI_151_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cancer of stomach gastric cancer 991,822
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018484/ScoringFiles/PGS018484.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013028 PGS002299
(PRS3_gastric)
 PSS009662|
European Ancestry|
272 individuals
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Reported Trait: Gastric cancer — AUROC: 0.56 [0.54, 0.58] — — —
PPM013036 PGS002299
(PRS3_gastric)
 PSS009662|
European Ancestry|
272 individuals
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Reported Trait: Gastric cancer — — Hazard ratio (HR top 5% vs average): 1.27 [0.75, 2.15] Age, birth cohort, genotyping array, top 10 PCs for ancestry and sex (for nonsex specific cancer only) —
PPM022398 PGS005161
(PRS-GC)
 PSS011938|
East Asian Ancestry|
100,219 individuals
 PGP000711 |
Zhu M et al. PLoS Med (2025)
 Reported Trait: Stomach Cancer HR: 1.27 [1.18, 1.38]
β: 0.239		 C-index: 0.572 — Age,Sex (if applicable),Region,Top 10 genetic ancestry principal components The HR and C-index values were derived from Cox proportional hazards regression models.
PPM036662 PGS018480
(TPMI_151_Lassosum2)
 PSS012383|
East Asian Ancestry|
15,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of stomach — AUROC: 0.61614 R²: 0.00612 sex, age, array, PCs 1-10 —
PPM036663 PGS018481
(TPMI_151_LDpred2)
 PSS012382|
East Asian Ancestry|
15,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of stomach — AUROC: 0.61559 R²: 0.00612 sex, age, array, PCs 1-10 —
PPM036664 PGS018482
(TPMI_151_MegaPRS)
 PSS012384|
East Asian Ancestry|
15,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of stomach — AUROC: 0.61564 R²: 0.00613 sex, age, array, PCs 1-10 —
PPM036665 PGS018483
(TPMI_151_PRS-CS)
 PSS012385|
East Asian Ancestry|
15,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of stomach — AUROC: 0.61565 R²: 0.00612 sex, age, array, PCs 1-10 —
PPM036666 PGS018484
(TPMI_151_SBayesR)
 PSS012386|
East Asian Ancestry|
15,552 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of stomach — AUROC: 0.61721 R²: 0.00624 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012382 151, 209.23, 230.2, V10.04,C16, C7A.0, D00.2, Z85.02 —
[
  • 230 cases
  • , 15,322 controls
]
,
43.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS011938 ICD-10: C16 Median = 11.33 years
Range = [10.18, 12.26] years
[
  • 745 cases
  • , 99,474 controls
]
,
42.8 % Male samples
 Mean = 53.69 years
Sd = 11.01 years		 East Asian
(Chinese)		 — CKB —
PSS012383 151, 209.23, 230.2, V10.04,C16, C7A.0, D00.2, Z85.02 —
[
  • 230 cases
  • , 15,322 controls
]
,
43.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012384 151, 209.23, 230.2, V10.04,C16, C7A.0, D00.2, Z85.02 —
[
  • 230 cases
  • , 15,322 controls
]
,
43.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012385 151, 209.23, 230.2, V10.04,C16, C7A.0, D00.2, Z85.02 —
[
  • 230 cases
  • , 15,322 controls
]
,
43.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012386 151, 209.23, 230.2, V10.04,C16, C7A.0, D00.2, Z85.02 —
[
  • 230 cases
  • , 15,322 controls
]
,
43.27 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS009662 gastric cancer (ICD- 9 = 151 or ICD-10 = C16) — 272 individuals — European — UKB —