PGS Catalog - post-traumatic stress disorder [EFO:0001358] (Polygenic Trait)

Trait: post-traumatic stress disorder

Experimental Factor Ontology (EFO) Information
Identifier	EFO_0001358
Description	An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term. [NCIT: P378]
Trait category	Neurological disorder
Synonyms	39 synonyms ACUTE POST TRAUMATIC STRESS DIS Acute Post Traumatic Stress Disorder Acute Post-Traumatic Stress Disorder CHRONIC POST TRAUMATIC STRESS DIS Chronic Post Traumatic Stress Disorder Chronic Post-Traumatic Stress Disorder DELAYED ONSET POST TRAUMATIC STRESS DIS Delayed Onset Post Traumatic Stress Disorder Delayed Onset Post-Traumatic Stress Disorder Neuroses, Post Traumatic Neuroses, Post-Traumatic Neuroses, Posttraumatic POST TRAUMATIC STRESS DIS POSTTRAUMATIC STRESS DIS POSTTRAUMATIC STRESS DISORDERS PTSD PTSD - Post-traumatic stress disorder Post Traumatic Stress Disorders Post-Traumatic Neuroses Post-Traumatic Neurosis Post-Traumatic Stress Disorders Post-traumatic stress syndrome Posttraumatic Neuroses Posttraumatic stress disorder Posttraumatic stress disorder (disorder) Posttraumatic stress disorder, NOS STRESS DIS POST TRAUMATIC STRESS DIS POSTTRAUMATIC Stress Disorder, Post Traumatic Stress Disorder, Post-Traumatic Stress Disorder, Posttraumatic Stress Disorders, Post Traumatic Stress Disorders, Post-Traumatic Stress Disorders, Posttraumatic combat neurosis disorder, post-traumatic stress post-traumatic stress disease post-traumatic stress disorder traumatic neurosis

Associated Polygenic Score(s)

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS005393 (PGS_SEXUAL_ASSAULT_PTSD)	PGP000778 \| Bugiga AVG et al. Braz J Psychiatry (2024)	Post-traumatic stress disorder	post-traumatic stress disorder	53,705	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005393/ScoringFiles/PGS005393.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM023435	PGS005393 (PGS_SEXUAL_ASSAULT_PTSD)	PSS012181\| Hispanic or Latin American Ancestry\| 117 individuals	PGP000778 \| Bugiga AVG et al. Braz J Psychiatry (2024)	Reported Trait: PTSD diagnosis	—	—	R²: 0.087	PC1-PC10	best p-value threshold of 0.333
PPM023436	PGS005393 (PGS_SEXUAL_ASSAULT_PTSD)	PSS012181\| Hispanic or Latin American Ancestry\| 117 individuals	PGP000778 \| Bugiga AVG et al. Braz J Psychiatry (2024)	Reported Trait: PTSD diagnosis	OR: 0.035	—	—	Trauma history, genetic ancestry (10 PCs), age, education, income.	best p-value threshold of 0.333

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS012181	—	—	117 individuals [ 57 cases , 60 controls ]	—	Hispanic or Latin American (Brazilian)	—	NR	—