Experimental Factor Ontology (EFO) Information | |
Identifier | EFO_0003761 |
Description | An episode of depression lasting two or more weeks without an intervening episode of mania. [NCIT: P378] | Trait category |
Neurological disorder
|
Synonyms |
58 synonyms
|
Mapped terms |
22 mapped terms
|
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000767 (GRS14) |
PGP000174 | Guffanti G et al. Transl Psychiatry (2019) |
Depression | unipolar depression, depressive symptom measurement |
14 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000767/ScoringFiles/PGS000767.txt.gz |
PGS002759 (Depression_prscs) |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Depression | unipolar depression | 1,091,613 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002759/ScoringFiles/PGS002759.txt.gz |
PGS004591 (PRS17_MDD) |
PGP000570 | Li D et al. BMC Med (2023) |
Major depressive disorder | unipolar depression | 17 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004591/ScoringFiles/PGS004591.txt.gz |
PGS004759 (depression_PRSmix_eur) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Depression | unipolar depression | 1,538,576 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004759/ScoringFiles/PGS004759.txt.gz |
PGS004760 (depression_PRSmixPlus_eur) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Depression | unipolar depression | 2,141,267 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004760/ScoringFiles/PGS004760.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001972 | PGS000767 (GRS14) |
PSS000984| Multi-ancestry (including European)| 62 individuals |
PGP000174 | Guffanti G et al. Transl Psychiatry (2019) |
Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change | — | — | R²: 0.065 | PCs(1-2) | — |
PPM001973 | PGS000767 (GRS14) |
PSS000985| Multi-ancestry (including European)| 63 individuals |
PGP000174 | Guffanti G et al. Transl Psychiatry (2019) |
Reported Trait: Bilateral putamen stress induced reward prediciton error change | — | — | R²: 0.074 | PCs(1-2) | — |
PPM001974 | PGS000767 (GRS14) |
PSS000986| Multi-ancestry (including European)| 73 individuals |
PGP000174 | Guffanti G et al. Transl Psychiatry (2019) |
Reported Trait: Bilateral nucleus acumbens volume | — | — | R²: 0.064 | PCs(1-2) | — |
PPM001975 | PGS000767 (GRS14) |
PSS000986| Multi-ancestry (including European)| 73 individuals |
PGP000174 | Guffanti G et al. Transl Psychiatry (2019) |
Reported Trait: Bilateral putamen volume | — | — | R²: 0.095 | PCs(1-2) | — |
PPM014959 | PGS002759 (Depression_prscs) |
PSS009939| European Ancestry| 39,444 individuals |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Reported Trait: Depression | OR: 1.26 [1.22, 1.3] | — | — | age, sex, 10 PCs, technical covariates | — |
PPM020721 | PGS004591 (PRS17_MDD) |
PSS011382| Multi-ancestry (including European)| 354,897 individuals |
PGP000570 | Li D et al. BMC Med (2023) |
Reported Trait: Major depressive disorder with PM2.5 air pollution | — | — | Hazard ratio (HR, PRS in top tertile and high PM2.5 exposure vs PRS in bottom tertile and low PM2.5 exposure): 1.34 [1.23, 1.46] | Age, gender, ethnicity, education level, employment status, household income, and Townsend deprivation index | — |
PPM020720 | PGS004591 (PRS17_MDD) |
PSS011382| Multi-ancestry (including European)| 354,897 individuals |
PGP000570 | Li D et al. BMC Med (2023) |
Reported Trait: Major depressive disorder | — | — | Hazard ratio (HR, per IQR change in PRS): 1.1 [1.07, 1.12] | Age, gender, ethnicity, education level, employment status, household income, Townsend deprivation index, genotyping batch, and first 10 PCs | — |
PPM020984 | PGS004759 (depression_PRSmix_eur) |
PSS011465| European Ancestry| 9,462 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Depression | — | — | Incremental R2 (Full model versus model with only covariates): 0.016 [0.011, 0.021] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
PPM020985 | PGS004760 (depression_PRSmixPlus_eur) |
PSS011465| European Ancestry| 9,462 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Depression | — | — | Incremental R2 (Full model versus model with only covariates): 0.024 [0.018, 0.03] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011382 | — | — | [
|
— | European | — | UKB | — |
PSS000984 | — | — | 62 individuals, 0.0 % Male samples |
— | European, Hispanic or Latin American, African unspecified, Asian unspecified, NR | — | NR | — |
PSS000985 | — | — | 63 individuals, 0.0 % Male samples |
— | European, Hispanic or Latin American, African unspecified, Asian unspecified, NR | — | NR | — |
PSS000986 | — | — | 73 individuals, 0.0 % Male samples |
— | European, Hispanic or Latin American, African unspecified, Asian unspecified, NR | — | NR | — |
PSS011382 | — | — | [
|
— | Asian unspecified | — | UKB | — |
PSS011382 | — | — | [
|
— | African unspecified | — | UKB | — |
PSS011382 | — | — | [
|
— | East Asian (Chinese) |
— | UKB | — |
PSS011382 | — | — | [
|
— | Not reported | — | UKB | — |
PSS011465 | — | — | 9,462 individuals | — | European | — | AllofUs | — |
PSS009939 | — | — | 39,444 individuals | — | European (Finnish) |
— | FinnGen | — |