Trait: unipolar depression

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003761
Description An episode of depression lasting two or more weeks without an intervening episode of mania. [NCIT: P378]
Trait category
Neurological disorder
Synonyms 58 synonyms
  • DEPRESSIVE DIS
  • DEPRESSIVE DIS MAJOR
  • Depression
  • Depression, Emotional
  • Depression, Endogenous
  • Depression, Involutional
  • Depression, Neurotic
  • Depression, Unipolar
  • Depressions
  • Depressions, Emotional
  • Depressions, Endogenous
  • Depressions, Neurotic
  • Depressions, Unipolar
  • Depressive Disorder
  • Depressive Disorder, Major
  • Depressive Disorders
  • Depressive Disorders, Major
  • Depressive Neuroses
  • Depressive Neurosis
  • Depressive Symptom
  • Depressive Symptoms
  • Depressive Syndrome
  • Depressive Syndromes
  • Disorder, Depressive
  • Disorder, Major Depressive
  • Disorders, Depressive
  • Disorders, Major Depressive
  • Emotional Depression
  • Emotional Depressions
  • Endogenous Depression
  • Endogenous Depressions
  • Involutional Depression
  • Involutional Psychoses
  • Involutional Psychosis
  • MAJOR DEPRESSIVE DIS
  • Major Depressive Disorders
  • Neuroses, Depressive
  • Neurosis, Depressive
  • Neurotic Depression
  • Neurotic Depressions
  • Paraphrenia, Involutional
  • Psychoses, Involutional
  • Psychosis, Involutional
  • Symptom, Depressive
  • Symptoms, Depressive
  • Syndrome, Depressive
  • Syndromes, Depressive
  • Unipolar Depressions
  • major depression
  • major depressive disorder
  • major depressive disorder 1
  • major depressive disorder 2
  • major depressive disorder and accelerated response to antidepressant drug treatment
  • major depressive disorder, response to citalopram therapy in
  • recurrent major depression
  • single major depressive episode
  • unipolar depression
  • unipolar depression, susceptibility to
Mapped terms 22 mapped terms
  • DOID:1470
  • DOID:1595
  • DOID:2848
  • ICD10:F32
  • ICD10:F33
  • ICD9:296.2
  • ICD9:296.20
  • ICD9:296.3
  • ICD9:296.30
  • MESH:D003865
  • MFOMD:0000143
  • MONDO:0002009
  • MeSH:D003865
  • MedDRA:10045543
  • NCIT:C35094
  • NCIt:C35094
  • OMIM:608516
  • SCTID:300706003
  • SCTID:370143000
  • SNOMEDCT:300706003
  • SNOMEDCT:321717001
  • SNOMEDCT:370143000

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000767
(GRS14)
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Depression unipolar depression,
depressive symptom measurement
14
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000767/ScoringFiles/PGS000767.txt.gz
PGS002759
(Depression_prscs)
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Depression unipolar depression 1,091,613
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002759/ScoringFiles/PGS002759.txt.gz
PGS004591
(PRS17_MDD)
PGP000570 |
Li D et al. BMC Med (2023)
Major depressive disorder unipolar depression 17
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004591/ScoringFiles/PGS004591.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001972 PGS000767
(GRS14)
PSS000984|
Multi-ancestry (including European)|
62 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change : 0.065 PCs(1-2)
PPM001973 PGS000767
(GRS14)
PSS000985|
Multi-ancestry (including European)|
63 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral putamen stress induced reward prediciton error change : 0.074 PCs(1-2)
PPM001974 PGS000767
(GRS14)
PSS000986|
Multi-ancestry (including European)|
73 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral nucleus acumbens volume : 0.064 PCs(1-2)
PPM001975 PGS000767
(GRS14)
PSS000986|
Multi-ancestry (including European)|
73 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral putamen volume : 0.095 PCs(1-2)
PPM014959 PGS002759
(Depression_prscs)
PSS009939|
European Ancestry|
39,444 individuals
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Reported Trait: Depression OR: 1.26 [1.22, 1.3] age, sex, 10 PCs, technical covariates
PPM020721 PGS004591
(PRS17_MDD)
PSS011382|
Multi-ancestry (including European)|
354,897 individuals
PGP000570 |
Li D et al. BMC Med (2023)
Reported Trait: Major depressive disorder with PM2.5 air pollution Hazard ratio (HR, PRS in top tertile and high PM2.5 exposure vs PRS in bottom tertile and low PM2.5 exposure): 1.34 [1.23, 1.46] Age, gender, ethnicity, education level, employment status, household income, and Townsend deprivation index
PPM020720 PGS004591
(PRS17_MDD)
PSS011382|
Multi-ancestry (including European)|
354,897 individuals
PGP000570 |
Li D et al. BMC Med (2023)
Reported Trait: Major depressive disorder Hazard ratio (HR, per IQR change in PRS): 1.1 [1.07, 1.12] Age, gender, ethnicity, education level, employment status, household income, Townsend deprivation index, genotyping batch, and first 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011382
[
  • 14,172 cases
  • , 326,236 controls
]
European UKB
PSS000984 62 individuals,
0.0 % Male samples
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR NR
PSS000985 63 individuals,
0.0 % Male samples
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR NR
PSS000986 73 individuals,
0.0 % Male samples
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR NR
PSS011382
[
  • 165 cases
  • , 4,966 controls
]
Asian unspecified UKB
PSS011382
[
  • 91 cases
  • , 3,014 controls
]
African unspecified UKB
PSS011382
[
  • 8 cases
  • , 775 controls
]
East Asian
(Chinese)
UKB
PSS011382
[
  • 274 cases
  • , 5,196 controls
]
Not reported UKB
PSS009939 39,444 individuals European
(Finnish)
FinnGen