Trait: unipolar depression

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003761
Description A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.
Trait category
Neurological disorder
Synonyms 49 synonyms
  • DEPRESSIVE DIS
  • DEPRESSIVE DIS MAJOR
  • Depression
  • Depression, Emotional
  • Depression, Endogenous
  • Depression, Involutional
  • Depression, Neurotic
  • Depression, Unipolar
  • Depressions
  • Depressions, Emotional
  • Depressions, Endogenous
  • Depressions, Neurotic
  • Depressions, Unipolar
  • Depressive Disorder
  • Depressive Disorder, Major
  • Depressive Disorders
  • Depressive Disorders, Major
  • Depressive Neuroses
  • Depressive Neurosis
  • Depressive Symptom
  • Depressive Symptoms
  • Depressive Syndrome
  • Depressive Syndromes
  • Disorder, Depressive
  • Disorder, Major Depressive
  • Disorders, Depressive
  • Disorders, Major Depressive
  • Emotional Depression
  • Emotional Depressions
  • Endogenous Depression
  • Endogenous Depressions
  • Involutional Depression
  • Involutional Psychoses
  • Involutional Psychosis
  • MAJOR DEPRESSIVE DIS
  • Major Depressive Disorders
  • Neuroses, Depressive
  • Neurosis, Depressive
  • Neurotic Depression
  • Neurotic Depressions
  • Paraphrenia, Involutional
  • Psychoses, Involutional
  • Psychosis, Involutional
  • Symptom, Depressive
  • Symptoms, Depressive
  • Syndrome, Depressive
  • Syndromes, Depressive
  • Unipolar Depressions
  • major depressive disorder
Mapped terms 12 mapped terms
  • DOID:1470
  • DOID:1595
  • DOID:2848
  • ICD10:F32
  • ICD10:F33
  • MeSH:D003865
  • MedDRA:10045543
  • NCIt:C35094
  • OMIM:608516
  • SNOMEDCT:300706003
  • SNOMEDCT:321717001
  • SNOMEDCT:370143000

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000767
(GRS14)
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Depression unipolar depression,
depressive symptom measurement		 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000767/ScoringFiles/PGS000767.txt.gz
PGS002759
(Depression_prscs)
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Depression unipolar depression 1,091,613
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002759/ScoringFiles/PGS002759.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001972 PGS000767
(GRS14)
 PSS000984|
Multi-ancestry (including European)|
62 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change — — R²: 0.065 PCs(1-2) —
PPM001973 PGS000767
(GRS14)
 PSS000985|
Multi-ancestry (including European)|
63 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen stress induced reward prediciton error change — — R²: 0.074 PCs(1-2) —
PPM001974 PGS000767
(GRS14)
 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral nucleus acumbens volume — — R²: 0.064 PCs(1-2) —
PPM001975 PGS000767
(GRS14)
 PSS000986|
Multi-ancestry (including European)|
73 individuals
 PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
 Reported Trait: Bilateral putamen volume — — R²: 0.095 PCs(1-2) —
PPM014959 PGS002759
(Depression_prscs)
 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Depression OR: 1.26 [1.22, 1.3] — — age, sex, 10 PCs, technical covariates —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000986 — — 73 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —
PSS000984 — — 62 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —
PSS000985 — — 63 individuals,
0.0 % Male samples
 — European, Hispanic or Latin American, African unspecified, Asian unspecified, NR — NR —