Trait: testosterone measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004908
Description
  • is a quantification of testosterone, typically in serum. Testosterone is a steroid hormone.Testosterone measurement is used in the diagnosis of precocious or delayed puberty, infertility (in men and women), ovarian tumours, adrenal tumours and pituitary disorders.
Trait category
Other measurement
Synonyms 2 synonyms
  • testosterone level
  • testosterone levels
Mapped term(s) 2 mapped terms
  • NCIt:C75378
  • SNOMEDCT:104957004

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000321
(snpnet_Testosterone_combined)
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels testosterone measurement 7,319
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000321/ScoringFiles/PGS000321.txt.gz
PGS000322
(snpnet_Testosterone_female-specific)
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels in females testosterone measurement,
female
7,168
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000322/ScoringFiles/PGS000322.txt.gz
PGS000323
(snpnet_Testosterone_male-specific)
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels in males testosterone measurement,
male
8,235
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000323/ScoringFiles/PGS000323.txt.gz
PGS000696
(snpnet.Testosterone)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Testosterone [nmol/L] testosterone measurement 8,223
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000696/ScoringFiles/PGS000696.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001424 PGS000696
(snpnet.Testosterone)
PSS000757|
African Ancestry|
5,453 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Testosterone [nmol/L] : 0.89659
Spearman's ρ: 0.091
Age, sex, PCs(1-40)
PPM000866 PGS000323
(snpnet_Testosterone_male-specific)
PSS000421|
European Ancestry|
28,640 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in females : 0.023 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000865 PGS000321
(snpnet_Testosterone_combined)
PSS000421|
European Ancestry|
28,640 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in females : 0.13 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000864 PGS000322
(snpnet_Testosterone_female-specific)
PSS000421|
European Ancestry|
28,640 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in females : 0.18 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000863 PGS000322
(snpnet_Testosterone_female-specific)
PSS000422|
European Ancestry|
28,601 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in males : 0.02 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000862 PGS000321
(snpnet_Testosterone_combined)
PSS000422|
European Ancestry|
28,601 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in males : 0.21 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000861 PGS000323
(snpnet_Testosterone_male-specific)
PSS000422|
European Ancestry|
28,601 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in males : 0.31 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM001459 PGS000696
(snpnet.Testosterone)
PSS000758|
East Asian Ancestry|
1,008 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Testosterone [nmol/L] : 0.91376
Spearman's ρ: 0.115
Age, sex, PCs(1-40)
PPM001494 PGS000696
(snpnet.Testosterone)
PSS000759|
European Ancestry|
21,344 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Testosterone [nmol/L] : 0.90433
Spearman's ρ: 0.169
Age, sex, PCs(1-40)
PPM001529 PGS000696
(snpnet.Testosterone)
PSS000760|
South Asian Ancestry|
6,680 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Testosterone [nmol/L] : 0.89983
Spearman's ρ: 0.149
Age, sex, PCs(1-40)
PPM001564 PGS000696
(snpnet.Testosterone)
PSS000761|
European Ancestry|
57,774 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Testosterone [nmol/L] : 0.9055
Spearman's ρ: 0.175
Age, sex, PCs(1-40)
PPM001572 PGS000696
(snpnet.Testosterone)
PSS000831|
European Ancestry|
2,129 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Testosterone [nmol/L] Spearman's ρ: 0.104 Age, sex

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000421 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,640 individuals,
0.0 % Male samples
European UKB
PSS000422 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,601 individuals,
100.0 % Male samples
European UKB
PSS000757 5,453 individuals African unspecified UKB
PSS000758 1,008 individuals East Asian UKB
PSS000759 21,344 individuals European Non-British White UKB
PSS000760 6,680 individuals South Asian UKB
PSS000761 57,774 individuals European
(British)
UKB
PSS000831 2,129 individuals European Participants self-identifying as white MESA