Trait: Hepatitis

Trait Information
Identifier HP_0012115
Description Inflammation of the liver.
Trait category
Other trait
Synonym Liver inflammation
Child trait(s) chronic hepatitis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "Hepatitis" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018430
(TPMI_070.4_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 305
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018430/ScoringFiles/PGS018430.txt.gz
PGS018431
(TPMI_070.4_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 939,883
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018431/ScoringFiles/PGS018431.txt.gz
PGS018432
(TPMI_070.4_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 35,057
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018432/ScoringFiles/PGS018432.txt.gz
PGS018433
(TPMI_070.4_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 983,814
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018433/ScoringFiles/PGS018433.txt.gz
PGS018434
(TPMI_070.4_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 947,767
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018434/ScoringFiles/PGS018434.txt.gz
PGS018435
(TPMI_070.9_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hepatitis NOS Hepatitis 60
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018435/ScoringFiles/PGS018435.txt.gz
PGS018436
(TPMI_070.9_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hepatitis NOS Hepatitis 182,889
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018436/ScoringFiles/PGS018436.txt.gz
PGS018437
(TPMI_070.9_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hepatitis NOS Hepatitis 27,412
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018437/ScoringFiles/PGS018437.txt.gz
PGS018438
(TPMI_070.9_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hepatitis NOS Hepatitis 983,808
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018438/ScoringFiles/PGS018438.txt.gz
PGS018439
(TPMI_070.9_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hepatitis NOS Hepatitis 998,827
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018439/ScoringFiles/PGS018439.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036612 PGS018430
(TPMI_070.4_Lassosum2)
 PSS012328|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.65199 R²: 0.07014 sex, age, array, PCs 1-10 —
PPM036613 PGS018431
(TPMI_070.4_LDpred2)
 PSS012327|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.65308 R²: 0.07119 sex, age, array, PCs 1-10 —
PPM036614 PGS018432
(TPMI_070.4_MegaPRS)
 PSS012329|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.64771 R²: 0.06696 sex, age, array, PCs 1-10 —
PPM036615 PGS018433
(TPMI_070.4_PRS-CS)
 PSS012330|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.65273 R²: 0.07088 sex, age, array, PCs 1-10 —
PPM036616 PGS018434
(TPMI_070.4_SBayesR)
 PSS012331|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.64746 R²: 0.06666 sex, age, array, PCs 1-10 —
PPM036617 PGS018435
(TPMI_070.9_Lassosum2)
 PSS012333|
East Asian Ancestry|
15,446 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hepatitis NOS — AUROC: 0.67275 R²: 0.05813 sex, age, array, PCs 1-10 —
PPM036618 PGS018436
(TPMI_070.9_LDpred2)
 PSS012332|
East Asian Ancestry|
15,446 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hepatitis NOS — AUROC: 0.67078 R²: 0.05725 sex, age, array, PCs 1-10 —
PPM036619 PGS018437
(TPMI_070.9_MegaPRS)
 PSS012334|
East Asian Ancestry|
15,446 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hepatitis NOS — AUROC: 0.66492 R²: 0.05559 sex, age, array, PCs 1-10 —
PPM036620 PGS018438
(TPMI_070.9_PRS-CS)
 PSS012335|
East Asian Ancestry|
15,446 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hepatitis NOS — AUROC: 0.67089 R²: 0.05827 sex, age, array, PCs 1-10 —
PPM036621 PGS018439
(TPMI_070.9_SBayesR)
 PSS012336|
East Asian Ancestry|
15,446 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hepatitis NOS — AUROC: 0.67099 R²: 0.05755 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012327 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012328 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012329 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012330 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012331 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012332 573.3,K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.50, K71.51, K71.6, K71.7, K71.8, K71.9, K75.2, K75.3, K75.89, K75.9, K76.4 —
[
  • 535 cases
  • , 14,911 controls
]
,
44.92 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012333 573.3,K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.50, K71.51, K71.6, K71.7, K71.8, K71.9, K75.2, K75.3, K75.89, K75.9, K76.4 —
[
  • 535 cases
  • , 14,911 controls
]
,
44.92 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012334 573.3,K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.50, K71.51, K71.6, K71.7, K71.8, K71.9, K75.2, K75.3, K75.89, K75.9, K76.4 —
[
  • 535 cases
  • , 14,911 controls
]
,
44.92 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012335 573.3,K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.50, K71.51, K71.6, K71.7, K71.8, K71.9, K75.2, K75.3, K75.89, K75.9, K76.4 —
[
  • 535 cases
  • , 14,911 controls
]
,
44.92 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012336 573.3,K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.50, K71.51, K71.6, K71.7, K71.8, K71.9, K75.2, K75.3, K75.89, K75.9, K76.4 —
[
  • 535 cases
  • , 14,911 controls
]
,
44.92 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —