Trait: specific developmental disorder

Trait Information
Identifier MONDO_0000592
Description A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. [DOID: 0060038]
Trait category
Other trait
Child trait(s) attention deficit-hyperactivity disorder

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "specific developmental disorder" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002746
(PRS_ADHD)
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Attention-deficit hyperactivity disorder attention deficit-hyperactivity disorder 513,659
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002746/ScoringFiles/PGS002746.txt.gz
PGS003753
(PRS35445_ADHD)
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Attention deficit hyperactivity disorder attention deficit-hyperactivity disorder 35,445
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003753/ScoringFiles/PGS003753.txt.gz
PGS018951
(TPMI_315_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Develomental delays and disorders specific developmental disorder 21
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018951/ScoringFiles/PGS018951.txt.gz
PGS018952
(TPMI_315_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Develomental delays and disorders specific developmental disorder 178,694
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018952/ScoringFiles/PGS018952.txt.gz
PGS018953
(TPMI_315_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Develomental delays and disorders specific developmental disorder 28,656
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018953/ScoringFiles/PGS018953.txt.gz
PGS018954
(TPMI_315_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Develomental delays and disorders specific developmental disorder 983,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018954/ScoringFiles/PGS018954.txt.gz
PGS018955
(TPMI_315_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Develomental delays and disorders specific developmental disorder 1,013,967
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018955/ScoringFiles/PGS018955.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014920 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Specific internalizing (at baseline) β: -0.06 (0.02) — — — —
PPM014921 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Specific conduct problem (1-year follow-up) β: 0.09 (0.02) — — — —
PPM014922 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Specific ADHD (1-year follow-up) β: 0.11 (0.03) — — — —
PPM014924 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: UPPS Impulsive Behavior Scale (Positive urgency) β: 0.046 (0.016) — — Age, sex, and the first 10 principal components of population structure —
PPM014925 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Latent executive functioning β: -0.042 — — Age, sex, and the first 10 principal components of population structure —
PPM014919 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: General factor of psychological problems (1-year follow-up) β: 0.07 (0.02) — — — —
PPM014923 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: UPPS Impulsive Behavior Scale (Low perseverance) β: 0.043 (0.017) — — Age, sex, and the first 10 principal components of population structure —
PPM018515 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: ADHD scores from DAWBA questionnaire β: 1.35e-06 — — — —
PPM018516 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (cingulo-opercular network) β: -3e-05 (1.28e-05) — — — —
PPM018517 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (default mode) β: 2e-05 (1.05e-05) — — — —
PPM037133 PGS018951
(TPMI_315_Lassosum2)
 PSS012854|
East Asian Ancestry|
19,934 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Develomental delays and disorders — AUROC: 0.66544 R²: 0.00499 sex, age, array, PCs 1-10 —
PPM037134 PGS018952
(TPMI_315_LDpred2)
 PSS012853|
East Asian Ancestry|
19,934 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Develomental delays and disorders — AUROC: 0.66519 R²: 0.00497 sex, age, array, PCs 1-10 —
PPM037135 PGS018953
(TPMI_315_MegaPRS)
 PSS012855|
East Asian Ancestry|
19,934 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Develomental delays and disorders — AUROC: 0.66353 R²: 0.00494 sex, age, array, PCs 1-10 —
PPM037136 PGS018954
(TPMI_315_PRS-CS)
 PSS012856|
East Asian Ancestry|
19,934 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Develomental delays and disorders — AUROC: 0.66181 R²: 0.00498 sex, age, array, PCs 1-10 —
PPM037137 PGS018955
(TPMI_315_SBayesR)
 PSS012857|
East Asian Ancestry|
19,934 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Develomental delays and disorders — AUROC: 0.66238 R²: 0.00511 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011004 — — 237 individuals,
51.0 % Male samples
 — Hispanic or Latin American
(Brazilian)		 — NR BHRCS
PSS009931 — 4,483 individuals,
53.2 % Male samples
 Mean = 118.94 months
Sd = 7.48 months		 European — NR ABCD
PSS012853 307.9, 315, 317, 318, 319, V40,F63.3, F70, F71, F72, F73, F78, F79, F80, F81.0, F81.2, F81.8, F81.9, F82, F88, F89, H93.25, R45.1, R45.81, R45.82 —
[
  • 103 cases
  • , 19,831 controls
]
,
45.98 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012854 307.9, 315, 317, 318, 319, V40,F63.3, F70, F71, F72, F73, F78, F79, F80, F81.0, F81.2, F81.8, F81.9, F82, F88, F89, H93.25, R45.1, R45.81, R45.82 —
[
  • 103 cases
  • , 19,831 controls
]
,
45.98 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012855 307.9, 315, 317, 318, 319, V40,F63.3, F70, F71, F72, F73, F78, F79, F80, F81.0, F81.2, F81.8, F81.9, F82, F88, F89, H93.25, R45.1, R45.81, R45.82 —
[
  • 103 cases
  • , 19,831 controls
]
,
45.98 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012856 307.9, 315, 317, 318, 319, V40,F63.3, F70, F71, F72, F73, F78, F79, F80, F81.0, F81.2, F81.8, F81.9, F82, F88, F89, H93.25, R45.1, R45.81, R45.82 —
[
  • 103 cases
  • , 19,831 controls
]
,
45.98 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012857 307.9, 315, 317, 318, 319, V40,F63.3, F70, F71, F72, F73, F78, F79, F80, F81.0, F81.2, F81.8, F81.9, F82, F88, F89, H93.25, R45.1, R45.81, R45.82 —
[
  • 103 cases
  • , 19,831 controls
]
,
45.98 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —