Trait: auditory system disorder

Trait Information
Identifier MONDO_0002409
Description A disease involving the auditory system.
Trait category
Other trait
Synonyms 6 synonyms
  • auditory disease
  • auditory system disease
  • auditory system disease or disorder
  • disease of auditory system
  • disease or disorder of auditory system
  • disorder of auditory system
Child trait(s) 10 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "auditory system disorder" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000762
(PRS_HD)
 PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
 Hearing difficulty presbycusis 100,325
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000762/ScoringFiles/PGS000762.txt.gz
PGS000763
(PRS_HAID)
 PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
 Hearing aid use presbycusis 4,270
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000763/ScoringFiles/PGS000763.txt.gz
PGS001252
(GBE_BIN_FC3002247)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Hearing difficulty and deafness deafness,
hearing loss disorder		 3,731
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001252/ScoringFiles/PGS001252.txt.gz
PGS001253
(GBE_BIN_FC1002247)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Hearing difficulty hearing loss disorder 3,098
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001253/ScoringFiles/PGS001253.txt.gz
PGS001255
(GBE_HC914)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Otosclerosis (time-to-event) otosclerosis 213
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001255/ScoringFiles/PGS001255.txt.gz
PGS001891
(portability-PLR_bad_hearing)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Hearing difficulty/problems hearing disorder 19,960
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001891/ScoringFiles/PGS001891.txt.gz
PGS002046
(portability-ldpred2_383)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Otosclerosis otosclerosis 570,308
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002046/ScoringFiles/PGS002046.txt.gz
PGS002104
(portability-ldpred2_bad_hearing)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Hearing difficulty/problems hearing disorder 869,179
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002104/ScoringFiles/PGS002104.txt.gz
PGS018414
(pgshl)
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Hearing loss (HL) hearing loss disorder 2,370,365
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018414/ScoringFiles/PGS018414.txt.gz
PGS019076
(TPMI_381.11_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 46,921
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019076/ScoringFiles/PGS019076.txt.gz
PGS019077
(TPMI_381.11_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 939,893
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019077/ScoringFiles/PGS019077.txt.gz
PGS019078
(TPMI_381.11_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 486,781
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019078/ScoringFiles/PGS019078.txt.gz
PGS019079
(TPMI_381.11_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019079/ScoringFiles/PGS019079.txt.gz
PGS019080
(TPMI_381.11_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Suppurative and unspecified otitis media otitis media 999,521
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019080/ScoringFiles/PGS019080.txt.gz
PGS019081
(TPMI_386_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Vertiginous syndromes and other disorders of vestibular system vestibular disorder 125,242
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019081/ScoringFiles/PGS019081.txt.gz
PGS019082
(TPMI_386_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Vertiginous syndromes and other disorders of vestibular system vestibular disorder 939,898
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019082/ScoringFiles/PGS019082.txt.gz
PGS019083
(TPMI_386_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Vertiginous syndromes and other disorders of vestibular system vestibular disorder 22,265
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019083/ScoringFiles/PGS019083.txt.gz
PGS019084
(TPMI_386_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Vertiginous syndromes and other disorders of vestibular system vestibular disorder 983,829
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019084/ScoringFiles/PGS019084.txt.gz
PGS019085
(TPMI_386_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Vertiginous syndromes and other disorders of vestibular system vestibular disorder 914,097
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019085/ScoringFiles/PGS019085.txt.gz
PGS019086
(TPMI_386.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 802,789
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019086/ScoringFiles/PGS019086.txt.gz
PGS019087
(TPMI_386.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 939,888
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019087/ScoringFiles/PGS019087.txt.gz
PGS019088
(TPMI_386.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 23,220
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019088/ScoringFiles/PGS019088.txt.gz
PGS019089
(TPMI_386.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 983,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019089/ScoringFiles/PGS019089.txt.gz
PGS019090
(TPMI_386.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 987,552
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019090/ScoringFiles/PGS019090.txt.gz
PGS019096
(TPMI_386.3_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 245
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019096/ScoringFiles/PGS019096.txt.gz
PGS019097
(TPMI_386.3_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 939,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019097/ScoringFiles/PGS019097.txt.gz
PGS019098
(TPMI_386.3_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 14,820
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019098/ScoringFiles/PGS019098.txt.gz
PGS019099
(TPMI_386.3_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019099/ScoringFiles/PGS019099.txt.gz
PGS019100
(TPMI_386.3_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 957,643
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019100/ScoringFiles/PGS019100.txt.gz
PGS019111
(TPMI_389_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hearing loss hearing loss disorder 409,744
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019111/ScoringFiles/PGS019111.txt.gz
PGS019112
(TPMI_389_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hearing loss hearing loss disorder 939,885
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019112/ScoringFiles/PGS019112.txt.gz
PGS019113
(TPMI_389_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hearing loss hearing loss disorder 531,934
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019113/ScoringFiles/PGS019113.txt.gz
PGS019114
(TPMI_389_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hearing loss hearing loss disorder 983,822
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019114/ScoringFiles/PGS019114.txt.gz
PGS019115
(TPMI_389_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hearing loss hearing loss disorder 928,045
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019115/ScoringFiles/PGS019115.txt.gz
PGS019116
(TPMI_389.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sensorineural hearing loss sensorineural hearing loss disorder 697,131
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019116/ScoringFiles/PGS019116.txt.gz
PGS019117
(TPMI_389.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sensorineural hearing loss sensorineural hearing loss disorder 939,879
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019117/ScoringFiles/PGS019117.txt.gz
PGS019118
(TPMI_389.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sensorineural hearing loss sensorineural hearing loss disorder 23,594
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019118/ScoringFiles/PGS019118.txt.gz
PGS019119
(TPMI_389.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sensorineural hearing loss sensorineural hearing loss disorder 983,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019119/ScoringFiles/PGS019119.txt.gz
PGS019120
(TPMI_389.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sensorineural hearing loss sensorineural hearing loss disorder 976,192
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019120/ScoringFiles/PGS019120.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001938 PGS000762
(PRS_HD)
 PSS000972|
European Ancestry|
3,636 individuals
 PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
 Reported Trait: Hearing difficulties — — R²: 0.0911 Age, sex —
PPM001937 PGS000763
(PRS_HAID)
 PSS000971|
European Ancestry|
2,912 individuals
 PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
 Reported Trait: Hearing aid use — — R²: 0.1923 Age, sex —
PPM008769 PGS001252
(GBE_BIN_FC3002247)
 PSS003899|
African Ancestry|
6,123 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty and Deafness — AUROC: 0.58635 [0.56411, 0.60859] R²: 0.01752
Incremental AUROC (full-covars): -0.00041
PGS R2 (no covariates): 0.00138
PGS AUROC (no covariates): 0.52307 [0.50054, 0.54561]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008770 PGS001252
(GBE_BIN_FC3002247)
 PSS003900|
East Asian Ancestry|
1,568 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty and Deafness — AUROC: 0.62777 [0.58865, 0.66688] R²: 0.04973
Incremental AUROC (full-covars): 0.00284
PGS R2 (no covariates): 0.00305
PGS AUROC (no covariates): 0.53516 [0.49316, 0.57716]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008771 PGS001252
(GBE_BIN_FC3002247)
 PSS003901|
European Ancestry|
23,697 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty and Deafness — AUROC: 0.62252 [0.61446, 0.63058] R²: 0.05132
Incremental AUROC (full-covars): 0.00531
PGS R2 (no covariates): 0.00527
PGS AUROC (no covariates): 0.53867 [0.53034, 0.54699]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008772 PGS001252
(GBE_BIN_FC3002247)
 PSS003902|
South Asian Ancestry|
7,266 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty and Deafness — AUROC: 0.61586 [0.5994, 0.63232] R²: 0.04282
Incremental AUROC (full-covars): 0.00304
PGS R2 (no covariates): 0.00345
PGS AUROC (no covariates): 0.53204 [0.5154, 0.54867]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008773 PGS001252
(GBE_BIN_FC3002247)
 PSS003903|
European Ancestry|
65,065 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty and Deafness — AUROC: 0.62548 [0.62074, 0.63023] R²: 0.05558
Incremental AUROC (full-covars): 0.00728
PGS R2 (no covariates): 0.00646
PGS AUROC (no covariates): 0.54216 [0.53723, 0.54709]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008774 PGS001253
(GBE_BIN_FC1002247)
 PSS003755|
African Ancestry|
6,121 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty — AUROC: 0.58714 [0.56491, 0.60938] R²: 0.01786
Incremental AUROC (full-covars): 0.00082
PGS R2 (no covariates): 0.00162
PGS AUROC (no covariates): 0.52504 [0.50255, 0.54753]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008775 PGS001253
(GBE_BIN_FC1002247)
 PSS003756|
East Asian Ancestry|
1,568 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty — AUROC: 0.62831 [0.58912, 0.6675] R²: 0.04992
Incremental AUROC (full-covars): 0.00338
PGS R2 (no covariates): 0.003
PGS AUROC (no covariates): 0.53605 [0.49383, 0.57827]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008776 PGS001253
(GBE_BIN_FC1002247)
 PSS003757|
European Ancestry|
23,689 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty — AUROC: 0.62276 [0.6147, 0.63082] R²: 0.0516
Incremental AUROC (full-covars): 0.00532
PGS R2 (no covariates): 0.00515
PGS AUROC (no covariates): 0.53825 [0.52992, 0.54658]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008777 PGS001253
(GBE_BIN_FC1002247)
 PSS003758|
South Asian Ancestry|
7,257 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty — AUROC: 0.61668 [0.60019, 0.63317] R²: 0.04334
Incremental AUROC (full-covars): 0.00291
PGS R2 (no covariates): 0.00324
PGS AUROC (no covariates): 0.53126 [0.51459, 0.54793]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008778 PGS001253
(GBE_BIN_FC1002247)
 PSS003759|
European Ancestry|
65,054 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hearing difficulty — AUROC: 0.62552 [0.62077, 0.63026] R²: 0.05561
Incremental AUROC (full-covars): 0.00726
PGS R2 (no covariates): 0.00632
PGS AUROC (no covariates): 0.54175 [0.53682, 0.54668]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008781 PGS001255
(GBE_HC914)
 PSS004702|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE otosclerosis — AUROC: 0.91156 [0.77281, 1.0] R²: 0.29139
Incremental AUROC (full-covars): 0.03981
PGS R2 (no covariates): 0.06779
PGS AUROC (no covariates): 0.7376 [0.46621, 1.0]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008782 PGS001255
(GBE_HC914)
 PSS004703|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE otosclerosis — AUROC: 0.66807 [0.58985, 0.74629] R²: 0.03365
Incremental AUROC (full-covars): 0.05467
PGS R2 (no covariates): 0.01522
PGS AUROC (no covariates): 0.62631 [0.54794, 0.70468]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008783 PGS001255
(GBE_HC914)
 PSS004704|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE otosclerosis — AUROC: 0.71231 [0.61511, 0.80951] R²: 0.04349
Incremental AUROC (full-covars): 0.03275
PGS R2 (no covariates): 0.00824
PGS AUROC (no covariates): 0.59763 [0.48884, 0.70642]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008784 PGS001255
(GBE_HC914)
 PSS004705|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE otosclerosis — AUROC: 0.6532 [0.60975, 0.69665] R²: 0.02085
Incremental AUROC (full-covars): 0.05946
PGS R2 (no covariates): 0.01341
PGS AUROC (no covariates): 0.6319 [0.58724, 0.67656]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM010013 PGS001891
(portability-PLR_bad_hearing)
 PSS009161|
European Ancestry|
3,907 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0758 [0.0445, 0.107] sex, age, birth date, deprivation index, 16 PCs —
PPM010014 PGS001891
(portability-PLR_bad_hearing)
 PSS008715|
European Ancestry|
6,265 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0537 [0.0289, 0.0784] sex, age, birth date, deprivation index, 16 PCs —
PPM010015 PGS001891
(portability-PLR_bad_hearing)
 PSS008489|
Greater Middle Eastern Ancestry|
1,089 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0251 [-0.0349, 0.0849] sex, age, birth date, deprivation index, 16 PCs —
PPM010016 PGS001891
(portability-PLR_bad_hearing)
 PSS008267|
South Asian Ancestry|
5,858 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0738 [0.0482, 0.0993] sex, age, birth date, deprivation index, 16 PCs —
PPM010017 PGS001891
(portability-PLR_bad_hearing)
 PSS008045|
East Asian Ancestry|
1,684 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0734 [0.0254, 0.121] sex, age, birth date, deprivation index, 16 PCs —
PPM010018 PGS001891
(portability-PLR_bad_hearing)
 PSS007831|
African Ancestry|
2,325 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0133 [-0.0275, 0.0541] sex, age, birth date, deprivation index, 16 PCs —
PPM010019 PGS001891
(portability-PLR_bad_hearing)
 PSS008935|
African Ancestry|
3,691 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.011 [-0.0213, 0.0434] sex, age, birth date, deprivation index, 16 PCs —
PPM010012 PGS001891
(portability-PLR_bad_hearing)
 PSS009387|
European Ancestry|
19,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0921 [0.0781, 0.1062] sex, age, birth date, deprivation index, 16 PCs —
PPM011232 PGS002046
(portability-ldpred2_383)
 PSS009309|
European Ancestry|
19,770 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Otosclerosis — — Partial Correlation (partial-r): 0.0182 [0.0043, 0.0321] sex, age, birth date, deprivation index, 16 PCs —
PPM011233 PGS002046
(portability-ldpred2_383)
 PSS009083|
European Ancestry|
4,097 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Otosclerosis — — Partial Correlation (partial-r): 0.0328 [0.0021, 0.0634] sex, age, birth date, deprivation index, 16 PCs —
PPM011234 PGS002046
(portability-ldpred2_383)
 PSS008637|
European Ancestry|
6,611 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Otosclerosis — — Partial Correlation (partial-r): -0.0025 [-0.0266, 0.0217] sex, age, birth date, deprivation index, 16 PCs —
PPM011235 PGS002046
(portability-ldpred2_383)
 PSS008411|
Greater Middle Eastern Ancestry|
1,182 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Otosclerosis — — Partial Correlation (partial-r): 0.0315 [-0.026, 0.0889] sex, age, birth date, deprivation index, 16 PCs —
PPM011236 PGS002046
(portability-ldpred2_383)
 PSS008191|
South Asian Ancestry|
6,238 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Otosclerosis — — Partial Correlation (partial-r): 0.0251 sex, age, birth date, deprivation index, 16 PCs —
PPM011237 PGS002046
(portability-ldpred2_383)
 PSS007756|
African Ancestry|
2,469 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Otosclerosis — — Partial Correlation (partial-r): 0.0104 [-0.0293, 0.0499] sex, age, birth date, deprivation index, 16 PCs —
PPM011688 PGS002104
(portability-ldpred2_bad_hearing)
 PSS009387|
European Ancestry|
19,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.1065 [0.0925, 0.1205] sex, age, birth date, deprivation index, 16 PCs —
PPM011689 PGS002104
(portability-ldpred2_bad_hearing)
 PSS009161|
European Ancestry|
3,907 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0785 [0.0471, 0.1096] sex, age, birth date, deprivation index, 16 PCs —
PPM011690 PGS002104
(portability-ldpred2_bad_hearing)
 PSS008715|
European Ancestry|
6,265 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0784 [0.0537, 0.103] sex, age, birth date, deprivation index, 16 PCs —
PPM011691 PGS002104
(portability-ldpred2_bad_hearing)
 PSS008489|
Greater Middle Eastern Ancestry|
1,089 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0425 [-0.0175, 0.1022] sex, age, birth date, deprivation index, 16 PCs —
PPM011692 PGS002104
(portability-ldpred2_bad_hearing)
 PSS008267|
South Asian Ancestry|
5,858 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0702 [0.0446, 0.0956] sex, age, birth date, deprivation index, 16 PCs —
PPM011693 PGS002104
(portability-ldpred2_bad_hearing)
 PSS008045|
East Asian Ancestry|
1,684 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0612 [0.0132, 0.1089] sex, age, birth date, deprivation index, 16 PCs —
PPM011695 PGS002104
(portability-ldpred2_bad_hearing)
 PSS008935|
African Ancestry|
3,691 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0136 [-0.0187, 0.046] sex, age, birth date, deprivation index, 16 PCs —
PPM011694 PGS002104
(portability-ldpred2_bad_hearing)
 PSS007831|
African Ancestry|
2,325 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): -0.0054 [-0.0462, 0.0354] sex, age, birth date, deprivation index, 16 PCs —
PPM036591 PGS018414
(pgshl)
 PSS012317|
Multi-ancestry (including European)|
390 individuals
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Reported Trait: cisplatin-induced ototoxicity — — R²: 0.023
p-value: 0.00293		 — —
PPM036593 PGS018414
(pgshl)
 PSS012318|
Ancestry Not Reported|
238 individuals
 PGP000832 |
Miao DNR et al. Hum Genomics (2024)
 Reported Trait: cisplatin-induced ototoxicity — — R²: 0.006
p-value: 0.52		 age at diagnosis , protocol (SJMB96 or SJMB03) , 10 principal components , craniospinal irradiation dose (CSI dose)*score —
PPM037258 PGS019076
(TPMI_381.11_Lassosum2)
 PSS012979|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63418 R²: 0.01229 sex, age, array, PCs 1-10 —
PPM037259 PGS019077
(TPMI_381.11_LDpred2)
 PSS012978|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63992 R²: 0.01294 sex, age, array, PCs 1-10 —
PPM037260 PGS019078
(TPMI_381.11_MegaPRS)
 PSS012980|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63614 R²: 0.01221 sex, age, array, PCs 1-10 —
PPM037261 PGS019079
(TPMI_381.11_PRS-CS)
 PSS012981|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63258 R²: 0.01178 sex, age, array, PCs 1-10 —
PPM037262 PGS019080
(TPMI_381.11_SBayesR)
 PSS012982|
East Asian Ancestry|
19,521 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Suppurative and unspecified otitis media — AUROC: 0.63187 R²: 0.0115 sex, age, array, PCs 1-10 —
PPM037263 PGS019081
(TPMI_386_Lassosum2)
 PSS013009|
East Asian Ancestry|
19,232 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Vertiginous syndromes and other disorders of vestibular system — AUROC: 0.59319 R²: 0.03898 sex, age, array, PCs 1-10 —
PPM037264 PGS019082
(TPMI_386_LDpred2)
 PSS013008|
East Asian Ancestry|
19,232 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Vertiginous syndromes and other disorders of vestibular system — AUROC: 0.59425 R²: 0.04012 sex, age, array, PCs 1-10 —
PPM037265 PGS019083
(TPMI_386_MegaPRS)
 PSS013010|
East Asian Ancestry|
19,232 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Vertiginous syndromes and other disorders of vestibular system — AUROC: 0.59217 R²: 0.03816 sex, age, array, PCs 1-10 —
PPM037266 PGS019084
(TPMI_386_PRS-CS)
 PSS013011|
East Asian Ancestry|
19,232 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Vertiginous syndromes and other disorders of vestibular system — AUROC: 0.5934 R²: 0.0392 sex, age, array, PCs 1-10 —
PPM037267 PGS019085
(TPMI_386_SBayesR)
 PSS013012|
East Asian Ancestry|
19,232 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Vertiginous syndromes and other disorders of vestibular system — AUROC: 0.59204 R²: 0.03809 sex, age, array, PCs 1-10 —
PPM037268 PGS019086
(TPMI_386.1_Lassosum2)
 PSS012984|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61707 R²: 0.01248 sex, age, array, PCs 1-10 —
PPM037269 PGS019087
(TPMI_386.1_LDpred2)
 PSS012983|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61731 R²: 0.01262 sex, age, array, PCs 1-10 —
PPM037270 PGS019088
(TPMI_386.1_MegaPRS)
 PSS012985|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61749 R²: 0.01255 sex, age, array, PCs 1-10 —
PPM037271 PGS019089
(TPMI_386.1_PRS-CS)
 PSS012986|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61682 R²: 0.01254 sex, age, array, PCs 1-10 —
PPM037272 PGS019090
(TPMI_386.1_SBayesR)
 PSS012987|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61747 R²: 0.01243 sex, age, array, PCs 1-10 —
PPM037278 PGS019096
(TPMI_386.3_Lassosum2)
 PSS012999|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.57817 R²: 0.00841 sex, age, array, PCs 1-10 —
PPM037279 PGS019097
(TPMI_386.3_LDpred2)
 PSS012998|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.58246 R²: 0.00937 sex, age, array, PCs 1-10 —
PPM037280 PGS019098
(TPMI_386.3_MegaPRS)
 PSS013000|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.58134 R²: 0.0089 sex, age, array, PCs 1-10 —
PPM037281 PGS019099
(TPMI_386.3_PRS-CS)
 PSS013001|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.58388 R²: 0.00948 sex, age, array, PCs 1-10 —
PPM037282 PGS019100
(TPMI_386.3_SBayesR)
 PSS013002|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.57912 R²: 0.0088 sex, age, array, PCs 1-10 —
PPM037293 PGS019111
(TPMI_389_Lassosum2)
 PSS013024|
East Asian Ancestry|
19,259 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hearing loss — AUROC: 0.5933 R²: 0.02351 sex, age, array, PCs 1-10 —
PPM037294 PGS019112
(TPMI_389_LDpred2)
 PSS013023|
East Asian Ancestry|
19,259 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hearing loss — AUROC: 0.59236 R²: 0.02335 sex, age, array, PCs 1-10 —
PPM037295 PGS019113
(TPMI_389_MegaPRS)
 PSS013025|
East Asian Ancestry|
19,259 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hearing loss — AUROC: 0.58885 R²: 0.0216 sex, age, array, PCs 1-10 —
PPM037296 PGS019114
(TPMI_389_PRS-CS)
 PSS013026|
East Asian Ancestry|
19,259 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hearing loss — AUROC: 0.59015 R²: 0.02245 sex, age, array, PCs 1-10 —
PPM037297 PGS019115
(TPMI_389_SBayesR)
 PSS013027|
East Asian Ancestry|
19,259 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hearing loss — AUROC: 0.58585 R²: 0.02066 sex, age, array, PCs 1-10 —
PPM037298 PGS019116
(TPMI_389.1_Lassosum2)
 PSS013014|
East Asian Ancestry|
18,218 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sensorineural hearing loss — AUROC: 0.60128 R²: 0.00481 sex, age, array, PCs 1-10 —
PPM037299 PGS019117
(TPMI_389.1_LDpred2)
 PSS013013|
East Asian Ancestry|
18,218 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sensorineural hearing loss — AUROC: 0.60384 R²: 0.00487 sex, age, array, PCs 1-10 —
PPM037300 PGS019118
(TPMI_389.1_MegaPRS)
 PSS013015|
East Asian Ancestry|
18,218 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sensorineural hearing loss — AUROC: 0.60145 R²: 0.00461 sex, age, array, PCs 1-10 —
PPM037301 PGS019119
(TPMI_389.1_PRS-CS)
 PSS013016|
East Asian Ancestry|
18,218 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sensorineural hearing loss — AUROC: 0.59978 R²: 0.0048 sex, age, array, PCs 1-10 —
PPM037302 PGS019120
(TPMI_389.1_SBayesR)
 PSS013017|
East Asian Ancestry|
18,218 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sensorineural hearing loss — AUROC: 0.59804 R²: 0.00448 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003900 — —
[
  • 214 cases
  • , 1,354 controls
]
 — East Asian — UKB —
PSS003901 — —
[
  • 6,214 cases
  • , 17,483 controls
]
 — European non-white British ancestry UKB —
PSS003902 — —
[
  • 1,425 cases
  • , 5,841 controls
]
 — South Asian — UKB —
PSS003903 — —
[
  • 18,231 cases
  • , 46,834 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS009161 — — 3,907 individuals — European Poland (NE Europe) UKB —
PSS008267 — — 5,858 individuals — South Asian India (South Asia) UKB —
PSS007756 — — 2,469 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008411 — — 1,182 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009309 — — 19,770 individuals — European UK (+ Ireland) UKB —
PSS004702 — —
[
  • 4 cases
  • , 6,493 controls
]
 — African unspecified — UKB —
PSS004703 — —
[
  • 53 cases
  • , 24,852 controls
]
 — European non-white British ancestry UKB —
PSS004704 — —
[
  • 20 cases
  • , 7,811 controls
]
 — South Asian — UKB —
PSS004705 — —
[
  • 156 cases
  • , 67,269 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008935 — — 3,691 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008045 — — 1,684 individuals — East Asian China (East Asia) UKB —
PSS012978 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012979 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS009083 — — 4,097 individuals — European Poland (NE Europe) UKB —
PSS012980 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012981 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012982 382,H66, H67 —
[
  • 175 cases
  • , 19,346 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008191 — — 6,238 individuals — South Asian India (South Asia) UKB —
PSS012984 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012983 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012985 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012986 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012987 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS000971 Hearing aid use cases responded ‘Yes’ to either ‘Do you wear a hearing aid?’ or ‘Wearing a hearing aid’ while controls responded ‘No’. —
[
  • 216 cases
  • , 2,696 controls
]
,
8.0 % Male samples
 Mean = 59.32 years
Sd = 9.69 years		 European
(British)		 — TwinsUK —
PSS000972 Hearing difficulty cases were defined as responding either ‘Yes, diagnosed by doctor or health professional’ or ‘Yes, not diagnosed by health professional’ to ‘Do you suffer from hearing loss?’ while participants that responded ‘No’ were assigned as controls. —
[
  • 970 cases
  • , 2,666 controls
]
,
8.5 % Male samples
 Mean = 60.34 years
Sd = 10.18 years		 European
(British)		 — TwinsUK —
PSS008715 — — 6,265 individuals — European Italy (South Europe) UKB —
PSS012999 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012998 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013000 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013001 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013002 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007831 — — 2,325 individuals — African American or Afro-Caribbean Carribean UKB —
PSS013009 386, 780.4,H81, H82, H83.0, H83.1, H83.2, H83.9, R42 —
[
  • 2,051 cases
  • , 17,181 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013008 386, 780.4,H81, H82, H83.0, H83.1, H83.2, H83.9, R42 —
[
  • 2,051 cases
  • , 17,181 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013010 386, 780.4,H81, H82, H83.0, H83.1, H83.2, H83.9, R42 —
[
  • 2,051 cases
  • , 17,181 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013011 386, 780.4,H81, H82, H83.0, H83.1, H83.2, H83.9, R42 —
[
  • 2,051 cases
  • , 17,181 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013012 386, 780.4,H81, H82, H83.0, H83.1, H83.2, H83.9, R42 —
[
  • 2,051 cases
  • , 17,181 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013014 389.1,H90.3, H90.4, H90.5, H90.A2, H90.A21, H90.A22 —
[
  • 267 cases
  • , 17,951 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013013 389.1,H90.3, H90.4, H90.5, H90.A2, H90.A21, H90.A22 —
[
  • 267 cases
  • , 17,951 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012317 — —
[
  • 168 cases
  • , 222 controls
]
,
46.0 % Male samples
 — African American or Afro-Caribbean, European, Hispanic or Latin American 92% European and 8% non-European ancestry (African-American/African-Caribbean and Latin American) PCL —
PSS012318 — —
[
  • 93 cases
  • , 145 controls
]
,
62.0 % Male samples
 — Not reported — NR —
PSS013015 389.1,H90.3, H90.4, H90.5, H90.A2, H90.A21, H90.A22 —
[
  • 267 cases
  • , 17,951 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013016 389.1,H90.3, H90.4, H90.5, H90.A2, H90.A21, H90.A22 —
[
  • 267 cases
  • , 17,951 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013017 389.1,H90.3, H90.4, H90.5, H90.A2, H90.A21, H90.A22 —
[
  • 267 cases
  • , 17,951 controls
]
,
46.26 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013023 388.0, 388.1, 388.2, 388.3, 388.4, 388.5, 389, 794.15, V41.2, V49.85, V53.2,H83.3, H90, H91, H93.0, H93.1, H93.2, H93.3, H93.A, H93.A1, H93.A2, H93.A3, H93.A9, H94.0, R94.120, Z96.2, Z97.4 —
[
  • 1,308 cases
  • , 17,951 controls
]
,
46.08 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013024 388.0, 388.1, 388.2, 388.3, 388.4, 388.5, 389, 794.15, V41.2, V49.85, V53.2,H83.3, H90, H91, H93.0, H93.1, H93.2, H93.3, H93.A, H93.A1, H93.A2, H93.A3, H93.A9, H94.0, R94.120, Z96.2, Z97.4 —
[
  • 1,308 cases
  • , 17,951 controls
]
,
46.08 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013025 388.0, 388.1, 388.2, 388.3, 388.4, 388.5, 389, 794.15, V41.2, V49.85, V53.2,H83.3, H90, H91, H93.0, H93.1, H93.2, H93.3, H93.A, H93.A1, H93.A2, H93.A3, H93.A9, H94.0, R94.120, Z96.2, Z97.4 —
[
  • 1,308 cases
  • , 17,951 controls
]
,
46.08 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008489 — — 1,089 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS013026 388.0, 388.1, 388.2, 388.3, 388.4, 388.5, 389, 794.15, V41.2, V49.85, V53.2,H83.3, H90, H91, H93.0, H93.1, H93.2, H93.3, H93.A, H93.A1, H93.A2, H93.A3, H93.A9, H94.0, R94.120, Z96.2, Z97.4 —
[
  • 1,308 cases
  • , 17,951 controls
]
,
46.08 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS009387 — — 19,161 individuals — European UK (+ Ireland) UKB —
PSS013027 388.0, 388.1, 388.2, 388.3, 388.4, 388.5, 389, 794.15, V41.2, V49.85, V53.2,H83.3, H90, H91, H93.0, H93.1, H93.2, H93.3, H93.A, H93.A1, H93.A2, H93.A3, H93.A9, H94.0, R94.120, Z96.2, Z97.4 —
[
  • 1,308 cases
  • , 17,951 controls
]
,
46.08 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS003755 — —
[
  • 697 cases
  • , 5,424 controls
]
 — African unspecified — UKB —
PSS003756 — —
[
  • 214 cases
  • , 1,354 controls
]
 — East Asian — UKB —
PSS003757 — —
[
  • 6,205 cases
  • , 17,484 controls
]
 — European non-white British ancestry UKB —
PSS003758 — —
[
  • 1,416 cases
  • , 5,841 controls
]
 — South Asian — UKB —
PSS003759 — —
[
  • 18,220 cases
  • , 46,834 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008637 — — 6,611 individuals — European Italy (South Europe) UKB —
PSS003899 — —
[
  • 699 cases
  • , 5,424 controls
]
 — African unspecified — UKB —