Trait: male

Trait Information
Identifier PATO_0000384
Description
  • A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes.
Trait category
Sex-specific PGS
Mapped term(s) 6 mapped terms
  • CARO:0000027
  • MO:652
  • MeSH:D008297
  • NCIt:C20197
  • PATO:0000384
  • SNOMEDCT:248153007

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000319
(cPRS_M)
PGP000095 |
Meisner A et al. Am J Hum Genet (2020)
All-cause mortality (male) age at death,
male
4,092
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000319/ScoringFiles/PGS000319.txt.gz
PGS000323
(snpnet_Testosterone_male-specific)
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Serum testosterone levels in males testosterone measurement,
male
8,235
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000323/ScoringFiles/PGS000323.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000857 PGS000319
(cPRS_M)
PSS000410|
European Ancestry|
52,074 individuals
PGP000095 |
Meisner A et al. Am J Hum Genet (2020)
Reported Trait: Years of life lost (males) β: 0.92 [0.43, 1.4] 10 genetic PCs, risk factors measured at baseline (BMI, smoking status, alcohol consumption, SBP, DBP, eGFR, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood glucose, and sleep duration)
PPM000855 PGS000319
(cPRS_M)
PSS000410|
European Ancestry|
52,074 individuals
PGP000095 |
Meisner A et al. Am J Hum Genet (2020)
Reported Trait: All-cause mortality (age at death in males) HR: 1.1 [1.04, 1.15] 10 genetic PCs, risk factors measured at baseline (BMI, smoking status, alcohol consumption, SBP, DBP, eGFR, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood glucose, and sleep duration)
PPM000853 PGS000319
(cPRS_M)
PSS000410|
European Ancestry|
52,074 individuals
PGP000095 |
Meisner A et al. Am J Hum Genet (2020)
Reported Trait: Years of life lost (males) β: 1.36 [0.98, 1.73] 10 genetic PCs
PPM000851 PGS000319
(cPRS_M)
PSS000410|
European Ancestry|
52,074 individuals
PGP000095 |
Meisner A et al. Am J Hum Genet (2020)
Reported Trait: All-cause mortality (age at death in males) HR: 1.15 [1.1, 1.19] 10 genetic PCs
PPM000861 PGS000323
(snpnet_Testosterone_male-specific)
PSS000422|
European Ancestry|
28,601 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in males : 0.31 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000866 PGS000323
(snpnet_Testosterone_male-specific)
PSS000421|
European Ancestry|
28,640 individuals
PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
Reported Trait: Serum testosterone levels in females : 0.023 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000410 The death registry data were available through November 30, 2016, for the centers in Scotland and January 31, 2018, for the centers in England and Wales. We determined whether an individual died of a particular disease by considering the ICD-10 code listed as the primary cause of death Mean = 8.7 years
Sd = 1.3 years
[
  • 2,784 cases
  • , 49,290 controls
]
,
100.0 % Male samples
Mean (Baseline) = 57.6 years
Sd = 8.1 years
European UKB
PSS000421 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,640 individuals,
0.0 % Male samples
European UKB
PSS000422 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,601 individuals,
100.0 % Male samples
European UKB