Trait: Sleep Disorder

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008568
Description A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep. [NCIT: C3376]
Trait category
Neurological disorder
Synonyms 9 synonyms
  • Disturbances, Sleep
  • Sleep Disorders
  • Sleep Disturbance
  • Sleep Disturbances
  • disturbances, sleep
  • parasomnia
  • sleep disorder
  • sleep disturbance
  • sleep disturbances
Mapped terms 4 mapped terms
  • ICD10:G47
  • MedDRA:10040984
  • NCIT:C3376
  • NCIt:C3376
Child trait(s) 3 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "Sleep Disorder" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000756
(GRS3_Nar)
PGP000162 |
Ouyang H et al. Ann Transl Med (2020)
Narcolepsy narcolepsy with cataplexy 32
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000756/ScoringFiles/PGS000756.txt.gz
PGS000757
(GRS4_Nar)
PGP000162 |
Ouyang H et al. Ann Transl Med (2020)
Narcolepsy narcolepsy with cataplexy 5
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000757/ScoringFiles/PGS000757.txt.gz
PGS000908
(PRS_Insomnia)
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Insomnia insomnia 2,746,982
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000908/ScoringFiles/PGS000908.txt.gz
PGS000926
(GBE_QT_FC1001220)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Daytime dozing / sleeping (narcolepsy) narcolepsy 4,194
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000926/ScoringFiles/PGS000926.txt.gz
PGS001932
(portability-PLR_insomnia)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Sleeplessness / insomnia insomnia 37,712
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001932/ScoringFiles/PGS001932.txt.gz
PGS001995
(portability-PLR_narcolepsy)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Daytime dozing / sleeping (narcolepsy) narcolepsy 27,143
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001995/ScoringFiles/PGS001995.txt.gz
PGS002144
(portability-ldpred2_hard_falling_asleep)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Trouble falling asleep Sleep Disorder 539,784
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002144/ScoringFiles/PGS002144.txt.gz
PGS002149
(portability-ldpred2_insomnia)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Sleeplessness / insomnia insomnia 926,585
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002149/ScoringFiles/PGS002149.txt.gz
PGS002212
(portability-ldpred2_narcolepsy)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Daytime dozing / sleeping (narcolepsy) narcolepsy 893,802
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002212/ScoringFiles/PGS002212.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001925 PGS000756
(GRS3_Nar)
PSS000966|
East Asian Ancestry|
2,884 individuals
PGP000162 |
Ouyang H et al. Ann Transl Med (2020)
Reported Trait: Incident narcolepsy OR: 1.149 [1.119, 1.181] Odds Ratio (OR, high vs low risk): 2.586 [2.109, 3.173] Individuals with a high polygenic risk had a score ≥28. Individuals with a low polygenic risk had a score <25.
PPM001926 PGS000756
(GRS3_Nar)
PSS000966|
East Asian Ancestry|
2,884 individuals
PGP000162 |
Ouyang H et al. Ann Transl Med (2020)
Reported Trait: Incident narcolepsy OR: 1.152 [1.12, 1.185] AUROC: 0.723 Odds Ratio (OR, high vs low risk): 2.602 [2.097, 3.232] Gender Individuals with a high polygenic risk had a score ≥28. Individuals with a low polygenic risk had a score <25.
PPM001927 PGS000757
(GRS4_Nar)
PSS000966|
East Asian Ancestry|
2,884 individuals
PGP000162 |
Ouyang H et al. Ann Transl Med (2020)
Reported Trait: Incident narcolepsy OR: 1.449 [1.367, 1.536] Odds Ratio (OR, high vs low risk): 4.298 [3.378, 5.481] Individuals with a high polygenic risk had a score ≥8. Individuals with a low polygenic risk had a score <6.
PPM001928 PGS000757
(GRS4_Nar)
PSS000966|
East Asian Ancestry|
2,884 individuals
PGP000162 |
Ouyang H et al. Ann Transl Med (2020)
Reported Trait: Incident narcolepsy OR: 1.442 [1.357, 1.534] AUROC: 0.736 Odds Ratio (OR, high vs low risk): 4.157 [3.224, 5.371] Gender Individuals with a high polygenic risk had a score ≥8. Individuals with a low polygenic risk had a score <6.
PPM002950 PGS000908
(PRS_Insomnia)
PSS001293|
European Ancestry|
5,713 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Sertraline takers OR: 1.06 [0.99, 1.14] Variance explained (Nagelkerke's R2*100): 0.09 sex, age at study enrollment, genetic PCs 1-20
PPM002951 PGS000908
(PRS_Insomnia)
PSS001289|
European Ancestry|
4,362 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Escitalopram takers OR: 1.12 [1.03, 1.21] Variance explained (Nagelkerke's R2*100): 0.27 sex, age at study enrollment, genetic PCs 1-20
PPM002952 PGS000908
(PRS_Insomnia)
PSS001294|
European Ancestry|
3,964 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Venlafaxine takers OR: 1.03 [0.95, 1.11] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002953 PGS000908
(PRS_Insomnia)
PSS001285|
European Ancestry|
1,655 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Amitriptyline takers OR: 1.28 [1.07, 1.52] Variance explained (Nagelkerke's R2*100): 1.03 sex, age at study enrollment, genetic PCs 1-20
PPM002954 PGS000908
(PRS_Insomnia)
PSS001291|
European Ancestry|
1,986 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Mirtazapine takers OR: 1.03 [0.88, 1.2] Variance explained (Nagelkerke's R2*100): 0.01 sex, age at study enrollment, genetic PCs 1-20
PPM002955 PGS000908
(PRS_Insomnia)
PSS001287|
European Ancestry|
2,523 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Desvenlafaxine takers OR: 1.13 [1.03, 1.25] Variance explained (Nagelkerke's R2*100): 0.38 sex, age at study enrollment, genetic PCs 1-20
PPM002956 PGS000908
(PRS_Insomnia)
PSS001286|
European Ancestry|
2,585 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Citalopram takers OR: 1.08 [0.96, 1.21] Variance explained (Nagelkerke's R2*100): 0.12 sex, age at study enrollment, genetic PCs 1-20
PPM002957 PGS000908
(PRS_Insomnia)
PSS001290|
European Ancestry|
3,665 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Fluoxetine takers OR: 1.03 [0.94, 1.13] Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20
PPM002958 PGS000908
(PRS_Insomnia)
PSS001288|
European Ancestry|
1,994 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Duloxetine takers OR: 1.14 [1.02, 1.28] Variance explained (Nagelkerke's R2*100): 0.4 sex, age at study enrollment, genetic PCs 1-20
PPM002959 PGS000908
(PRS_Insomnia)
PSS001292|
European Ancestry|
1,577 individuals
PGP000238 |
Campos AI et al. medRxiv (2021)
|Pre
Reported Trait: Insomnia in Paroxetine takers OR: 1.16 [1.01, 1.33] Variance explained (Nagelkerke's R2*100): 0.47 sex, age at study enrollment, genetic PCs 1-20
PPM007457 PGS000926
(GBE_QT_FC1001220)
PSS007536|
African Ancestry|
6,254 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Daytime dozing / sleeping (narcolepsy) : 0.02468 [0.01723, 0.03213]
Incremental R2 (full-covars): -0.00089
PGS R2 (no covariates): 0.00034 [-0.00056, 0.00125]
age, sex, UKB array type, Genotype PCs
PPM007458 PGS000926
(GBE_QT_FC1001220)
PSS007537|
East Asian Ancestry|
1,629 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Daytime dozing / sleeping (narcolepsy) : 0.03667 [0.01919, 0.05415]
Incremental R2 (full-covars): 0.00183
PGS R2 (no covariates): 0.00244 [-0.00223, 0.0071]
age, sex, UKB array type, Genotype PCs
PPM007459 PGS000926
(GBE_QT_FC1001220)
PSS007538|
European Ancestry|
24,713 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Daytime dozing / sleeping (narcolepsy) : 0.02067 [0.01717, 0.02417]
Incremental R2 (full-covars): 0.00439
PGS R2 (no covariates): 0.00422 [0.00261, 0.00583]
age, sex, UKB array type, Genotype PCs
PPM007460 PGS000926
(GBE_QT_FC1001220)
PSS007539|
South Asian Ancestry|
7,410 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Daytime dozing / sleeping (narcolepsy) : 0.0158 [0.01032, 0.02128]
Incremental R2 (full-covars): 0.00236
PGS R2 (no covariates): 0.00251 [0.0003, 0.00473]
age, sex, UKB array type, Genotype PCs
PPM007461 PGS000926
(GBE_QT_FC1001220)
PSS007540|
European Ancestry|
67,196 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Daytime dozing / sleeping (narcolepsy) : 0.02284 [0.02061, 0.02507]
Incremental R2 (full-covars): 0.00532
PGS R2 (no covariates): 0.00542 [0.00431, 0.00652]
age, sex, UKB array type, Genotype PCs
PPM010331 PGS001932
(portability-PLR_insomnia)
PSS009419|
European Ancestry|
19,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1248 [0.1111, 0.1384] sex, age, birth date, deprivation index, 16 PCs
PPM010332 PGS001932
(portability-PLR_insomnia)
PSS009193|
European Ancestry|
4,116 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1003 [0.0699, 0.1305] sex, age, birth date, deprivation index, 16 PCs
PPM010333 PGS001932
(portability-PLR_insomnia)
PSS008747|
European Ancestry|
6,626 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1093 [0.0854, 0.133] sex, age, birth date, deprivation index, 16 PCs
PPM010334 PGS001932
(portability-PLR_insomnia)
PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0776 [0.0195, 0.1353] sex, age, birth date, deprivation index, 16 PCs
PPM010335 PGS001932
(portability-PLR_insomnia)
PSS008299|
South Asian Ancestry|
6,199 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0768 [0.052, 0.1015] sex, age, birth date, deprivation index, 16 PCs
PPM010337 PGS001932
(portability-PLR_insomnia)
PSS007863|
African Ancestry|
2,460 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0475 [0.0078, 0.087] sex, age, birth date, deprivation index, 16 PCs
PPM010338 PGS001932
(portability-PLR_insomnia)
PSS008967|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.033 [0.0013, 0.0645] sex, age, birth date, deprivation index, 16 PCs
PPM010336 PGS001932
(portability-PLR_insomnia)
PSS008076|
East Asian Ancestry|
1,788 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0473 sex, age, birth date, deprivation index, 16 PCs
PPM010835 PGS001995
(portability-PLR_narcolepsy)
PSS009478|
European Ancestry|
19,922 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0959 [0.0822, 0.1097] sex, age, birth date, deprivation index, 16 PCs
PPM010836 PGS001995
(portability-PLR_narcolepsy)
PSS009252|
European Ancestry|
4,057 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0898 [0.0591, 0.1203] sex, age, birth date, deprivation index, 16 PCs
PPM010837 PGS001995
(portability-PLR_narcolepsy)
PSS008806|
European Ancestry|
6,571 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0631 [0.039, 0.0872] sex, age, birth date, deprivation index, 16 PCs
PPM010838 PGS001995
(portability-PLR_narcolepsy)
PSS008580|
Greater Middle Eastern Ancestry|
1,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0622 [0.002, 0.1221] sex, age, birth date, deprivation index, 16 PCs
PPM010839 PGS001995
(portability-PLR_narcolepsy)
PSS008358|
South Asian Ancestry|
6,001 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0739 [0.0487, 0.0991] sex, age, birth date, deprivation index, 16 PCs
PPM010840 PGS001995
(portability-PLR_narcolepsy)
PSS008135|
East Asian Ancestry|
1,752 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0367 [-0.0104, 0.0837] sex, age, birth date, deprivation index, 16 PCs
PPM010841 PGS001995
(portability-PLR_narcolepsy)
PSS007922|
African Ancestry|
2,395 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0267 [-0.0135, 0.0668] sex, age, birth date, deprivation index, 16 PCs
PPM010842 PGS001995
(portability-PLR_narcolepsy)
PSS009026|
African Ancestry|
3,750 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0356 [0.0036, 0.0677] sex, age, birth date, deprivation index, 16 PCs
PPM011999 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS009414|
European Ancestry|
2,491 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): 0.0646 [0.0253, 0.1038] sex, age, birth date, deprivation index, 16 PCs
PPM012000 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS009188|
European Ancestry|
490 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): 0.0519 [-0.0387, 0.1417] sex, age, birth date, deprivation index, 16 PCs
PPM012001 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS008742|
European Ancestry|
898 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): -0.0252 [-0.0912, 0.041] sex, age, birth date, deprivation index, 16 PCs
PPM012002 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS008516|
Greater Middle Eastern Ancestry|
75 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): 0.0283 [-0.2388, 0.2914] sex, age, birth date, deprivation index, 16 PCs
PPM012003 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS008294|
South Asian Ancestry|
311 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): 0.062 [-0.0534, 0.1757] sex, age, birth date, deprivation index, 16 PCs
PPM012004 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS008071|
East Asian Ancestry|
147 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): 0.0992 [-0.0763, 0.2688] sex, age, birth date, deprivation index, 16 PCs
PPM012005 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS007858|
African Ancestry|
149 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): -0.0892 [-0.258, 0.085] sex, age, birth date, deprivation index, 16 PCs
PPM012006 PGS002144
(portability-ldpred2_hard_falling_asleep)
PSS008962|
African Ancestry|
151 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Trouble falling asleep Partial Correlation (partial-r): -0.0423 [-0.2123, 0.1301] sex, age, birth date, deprivation index, 16 PCs
PPM012040 PGS002149
(portability-ldpred2_insomnia)
PSS009193|
European Ancestry|
4,116 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1208 [0.0905, 0.1508] sex, age, birth date, deprivation index, 16 PCs
PPM012039 PGS002149
(portability-ldpred2_insomnia)
PSS009419|
European Ancestry|
19,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1411 [0.1275, 0.1547] sex, age, birth date, deprivation index, 16 PCs
PPM012041 PGS002149
(portability-ldpred2_insomnia)
PSS008747|
European Ancestry|
6,626 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.1253 [0.1015, 0.149] sex, age, birth date, deprivation index, 16 PCs
PPM012042 PGS002149
(portability-ldpred2_insomnia)
PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0852 [0.0271, 0.1427] sex, age, birth date, deprivation index, 16 PCs
PPM012043 PGS002149
(portability-ldpred2_insomnia)
PSS008299|
South Asian Ancestry|
6,199 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0985 [0.0737, 0.1231] sex, age, birth date, deprivation index, 16 PCs
PPM012044 PGS002149
(portability-ldpred2_insomnia)
PSS008076|
East Asian Ancestry|
1,788 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0345 [-0.0122, 0.081] sex, age, birth date, deprivation index, 16 PCs
PPM012045 PGS002149
(portability-ldpred2_insomnia)
PSS007863|
African Ancestry|
2,460 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0283 [-0.0114, 0.0679] sex, age, birth date, deprivation index, 16 PCs
PPM012046 PGS002149
(portability-ldpred2_insomnia)
PSS008967|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia Partial Correlation (partial-r): 0.0314 sex, age, birth date, deprivation index, 16 PCs
PPM012543 PGS002212
(portability-ldpred2_narcolepsy)
PSS009478|
European Ancestry|
19,922 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.1104 [0.0966, 0.1241] sex, age, birth date, deprivation index, 16 PCs
PPM012544 PGS002212
(portability-ldpred2_narcolepsy)
PSS009252|
European Ancestry|
4,057 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0922 [0.0616, 0.1227] sex, age, birth date, deprivation index, 16 PCs
PPM012545 PGS002212
(portability-ldpred2_narcolepsy)
PSS008806|
European Ancestry|
6,571 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0802 [0.0561, 0.1042] sex, age, birth date, deprivation index, 16 PCs
PPM012546 PGS002212
(portability-ldpred2_narcolepsy)
PSS008580|
Greater Middle Eastern Ancestry|
1,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0377 [-0.0227, 0.0977] sex, age, birth date, deprivation index, 16 PCs
PPM012547 PGS002212
(portability-ldpred2_narcolepsy)
PSS008358|
South Asian Ancestry|
6,001 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0784 [0.0531, 0.1035] sex, age, birth date, deprivation index, 16 PCs
PPM012548 PGS002212
(portability-ldpred2_narcolepsy)
PSS008135|
East Asian Ancestry|
1,752 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0407 [-0.0064, 0.0876] sex, age, birth date, deprivation index, 16 PCs
PPM012549 PGS002212
(portability-ldpred2_narcolepsy)
PSS007922|
African Ancestry|
2,395 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.05 [0.0098, 0.0901] sex, age, birth date, deprivation index, 16 PCs
PPM012550 PGS002212
(portability-ldpred2_narcolepsy)
PSS009026|
African Ancestry|
3,750 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Daytime dozing / sleeping (narcolepsy) Partial Correlation (partial-r): 0.0511 [0.019, 0.0831] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008516 75 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009414 2,491 individuals European UK (+ Ireland) UKB
PSS008135 1,752 individuals East Asian China (East Asia) UKB
PSS008521 1,153 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009419 19,978 individuals European UK (+ Ireland) UKB
PSS009188 490 individuals European Poland (NE Europe) UKB
PSS008806 6,571 individuals European Italy (South Europe) UKB
PSS008294 311 individuals South Asian India (South Asia) UKB
PSS009193 4,116 individuals European Poland (NE Europe) UKB
PSS008299 6,199 individuals South Asian India (South Asia) UKB
PSS007922 2,395 individuals African American or Afro-Caribbean Carribean UKB
PSS007536 6,254 individuals African unspecified UKB
PSS007537 1,629 individuals East Asian UKB
PSS007538 24,713 individuals European non-white British ancestry UKB
PSS007539 7,410 individuals South Asian UKB
PSS007540 67,196 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS000966 The narcolepsy patients had either hypocretin deficiency (CSF hypocretin-1 ≤110 pg/mL) or clear-cut cataplexy and HLA-DQB1*06:02.
[
  • 903 cases
  • , 1,981 controls
]
,
44.94 % Male samples
East Asian
(Han Chinese, Chinese)
NR
PSS008962 151 individuals African unspecified Nigeria (West Africa) UKB
PSS008580 1,078 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009478 19,922 individuals European UK (+ Ireland) UKB
PSS008967 3,863 individuals African unspecified Nigeria (West Africa) UKB
PSS008071 147 individuals East Asian China (East Asia) UKB
PSS008076 1,788 individuals East Asian China (East Asia) UKB
PSS001285
[
  • 140 cases
  • , 1,515 controls
]
European AGDS
PSS001286
[
  • 367 cases
  • , 2,218 controls
]
European AGDS
PSS001287
[
  • 488 cases
  • , 2,035 controls
]
European AGDS
PSS001288
[
  • 382 cases
  • , 1,612 controls
]
European AGDS
PSS001289
[
  • 712 cases
  • , 3,650 controls
]
European AGDS
PSS001290
[
  • 582 cases
  • , 3,083 controls
]
European AGDS
PSS001291
[
  • 186 cases
  • , 1,800 controls
]
European AGDS
PSS001292
[
  • 235 cases
  • , 1,342 controls
]
European AGDS
PSS001293
[
  • 1,018 cases
  • , 4,695 controls
]
European AGDS
PSS001294
[
  • 793 cases
  • , 3,171 controls
]
European AGDS
PSS009252 4,057 individuals European Poland (NE Europe) UKB
PSS008358 6,001 individuals South Asian India (South Asia) UKB
PSS008742 898 individuals European Italy (South Europe) UKB
PSS008747 6,626 individuals European Italy (South Europe) UKB
PSS007858 149 individuals African American or Afro-Caribbean Carribean UKB
PSS007863 2,460 individuals African American or Afro-Caribbean Carribean UKB
PSS009026 3,750 individuals African unspecified Nigeria (West Africa) UKB