| Trait Information | |
| Identifier | MONDO_0002515 |
| Description | A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma. [NCIT: P378] | Trait categories |
Digestive system disorder
Other disease
|
| Synonyms |
9 synonyms
|
| Child trait(s) | 11 child traits |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000655 (NAFLD-10) |
PGP000119 | Namjou B et al. BMC Med (2019) |
Non-alcoholic fatty liver disease | metabolic dysfunction-associated steatotic liver disease | 10 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000655/ScoringFiles/PGS000655.txt.gz |
| PGS000704 (HC171) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Alcoholic cirrhosis | alcoholic liver cirrhosis | 183,271 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000704/ScoringFiles/PGS000704.txt.gz |
| PGS000705 (HC188) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Gallstones | gallstones | 183,458 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000705/ScoringFiles/PGS000705.txt.gz |
| PGS000726 (PGS12_CIR) |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Cirrhosis | cirrhosis of liver | 12 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000726/ScoringFiles/PGS000726.txt.gz | |
| PGS000776 (GRS9_Cirr) |
PGP000180 | Innes H et al. Gastroenterology (2020) |
Cirrhosis | cirrhosis of liver | 9 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000776/ScoringFiles/PGS000776.txt.gz | |
| PGS000872 (PRS-5) |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Non-alcoholic fatty liver disease | metabolic dysfunction-associated steatotic liver disease | 5 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000872/ScoringFiles/PGS000872.txt.gz | |
| PGS001174 (GBE_HC1125) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Cholelithiasis (time-to-event) | cholelithiasis | 970 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001174/ScoringFiles/PGS001174.txt.gz |
| PGS001256 (GBE_HC188) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Gallstones | gallstones | 876 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001256/ScoringFiles/PGS001256.txt.gz |
| PGS001293 (GBE_HC1123) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Other diseases of liver (time-to-event) | liver disorder | 92 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001293/ScoringFiles/PGS001293.txt.gz |
| PGS001777 (3-SNP_cirr) |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Cirrhosis (alcohol related) | alcoholic liver cirrhosis | 3 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001777/ScoringFiles/PGS001777.txt.gz |
| PGS001860 (portability-PLR_571.5) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Other chronic nonalcoholic liver disease | liver disorder | 497 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001860/ScoringFiles/PGS001860.txt.gz |
| PGS001861 (portability-PLR_574) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Cholelithiasis and cholecystitis | Cholecystitis, cholelithiasis |
2,059 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001861/ScoringFiles/PGS001861.txt.gz |
| PGS001862 (portability-PLR_575) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Other biliary tract disease | biliary tract disorder | 151 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001862/ScoringFiles/PGS001862.txt.gz |
| PGS002071 (portability-ldpred2_571.5) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Other chronic nonalcoholic liver disease | liver disorder | 352,506 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002071/ScoringFiles/PGS002071.txt.gz |
| PGS002072 (portability-ldpred2_574) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Cholelithiasis and cholecystitis | Cholecystitis, cholelithiasis |
428,587 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002072/ScoringFiles/PGS002072.txt.gz |
| PGS002073 (portability-ldpred2_575) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Other biliary tract disease | biliary tract disorder | 363,801 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002073/ScoringFiles/PGS002073.txt.gz |
| PGS002282 (GRS68_NAFLD) |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Nonalcoholic fatty liver disease | metabolic dysfunction-associated steatotic liver disease | 68 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002282/ScoringFiles/PGS002282.txt.gz |
| PGS002283 (GRS15_NAFLD) |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Nonalcoholic fatty liver disease | metabolic dysfunction-associated steatotic liver disease | 15 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002283/ScoringFiles/PGS002283.txt.gz |
| PGS004476 (disease.K80.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
K80 (Cholelithiasis) | cholelithiasis | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004476/ScoringFiles/PGS004476.txt.gz |
| PGS004546 (meta.K80.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
K80 (Cholelithiasis) | cholelithiasis | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004546/ScoringFiles/PGS004546.txt.gz |
| PGS004621 (cirrhosis_pgs_eur) |
PGP000594 | Ghouse J et al. Nat Genet (2024) |
Cirrhosis | cirrhosis of liver | 1,089,806 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004621/ScoringFiles/PGS004621.txt.gz |
| PGS004913 (PRSALC) |
PGP000645 | Schwantes-An TH et al. Hepatol Commun (2024) |
Alcohol-associated liver cirrhosis | alcoholic liver cirrhosis | 20 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004913/ScoringFiles/PGS004913.txt.gz | |
| PGS005150 (Cholelithiasis (PRS-CSx; EAS+EUR)) |
PGP000704 | Jung HU et al. Commun Biol (2025) |
Cholelithiasis | cholelithiasis | 908,465 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005150/ScoringFiles/PGS005150.txt.gz |
| PGS012549 (PRS10_NAFLD) |
PGP000792 | Tang L et al. BMC Med (2023) |
Nonalcoholic fatty liver disease | metabolic dysfunction-associated steatotic liver disease | 10 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012549/ScoringFiles/PGS012549.txt.gz |
| PGS012582 (PRS13_cholelithiasis) |
PGP000816 | Mi N et al. Prev Med (2024) |
Cholelithiasis | cholelithiasis | 13 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012582/ScoringFiles/PGS012582.txt.gz |
| PGS018419 (TPMI_070_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis | viral hepatitis | 1,584 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018419/ScoringFiles/PGS018419.txt.gz | |
| PGS018420 (TPMI_070_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis | viral hepatitis | 939,805 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018420/ScoringFiles/PGS018420.txt.gz | |
| PGS018421 (TPMI_070_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis | viral hepatitis | 49,513 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018421/ScoringFiles/PGS018421.txt.gz | |
| PGS018422 (TPMI_070_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis | viral hepatitis | 983,768 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018422/ScoringFiles/PGS018422.txt.gz | |
| PGS018423 (TPMI_070_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis | viral hepatitis | 136,488 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018423/ScoringFiles/PGS018423.txt.gz | |
| PGS018424 (TPMI_070.2_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis B | hepatitis B virus infection | 4,575 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018424/ScoringFiles/PGS018424.txt.gz | |
| PGS018425 (TPMI_070.2_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis B | hepatitis B virus infection | 939,797 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018425/ScoringFiles/PGS018425.txt.gz | |
| PGS018426 (TPMI_070.2_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis B | hepatitis B virus infection | 253,455 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018426/ScoringFiles/PGS018426.txt.gz | |
| PGS018427 (TPMI_070.2_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis B | hepatitis B virus infection | 983,762 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018427/ScoringFiles/PGS018427.txt.gz | |
| PGS018428 (TPMI_070.2_PRSmix+) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis B | hepatitis B virus infection | 1,071,340 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018428/ScoringFiles/PGS018428.txt.gz | |
| PGS018429 (TPMI_070.2_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Viral hepatitis B | hepatitis B virus infection | 73,098 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018429/ScoringFiles/PGS018429.txt.gz | |
| PGS018500 (TPMI_155_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cancer of liver and intrahepatic bile duct | liver cancer | 20 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018500/ScoringFiles/PGS018500.txt.gz | |
| PGS018501 (TPMI_155_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cancer of liver and intrahepatic bile duct | liver cancer | 939,828 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018501/ScoringFiles/PGS018501.txt.gz | |
| PGS018502 (TPMI_155_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cancer of liver and intrahepatic bile duct | liver cancer | 25,084 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018502/ScoringFiles/PGS018502.txt.gz | |
| PGS018503 (TPMI_155_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cancer of liver and intrahepatic bile duct | liver cancer | 983,778 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018503/ScoringFiles/PGS018503.txt.gz | |
| PGS018504 (TPMI_155_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Cancer of liver and intrahepatic bile duct | liver cancer | 977,058 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018504/ScoringFiles/PGS018504.txt.gz | |
| PGS018505 (TPMI_155.1_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Malignant neoplasm of liver primary | liver cancer | 76 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018505/ScoringFiles/PGS018505.txt.gz | |
| PGS018506 (TPMI_155.1_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Malignant neoplasm of liver primary | liver cancer | 939,828 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018506/ScoringFiles/PGS018506.txt.gz | |
| PGS018507 (TPMI_155.1_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Malignant neoplasm of liver primary | liver cancer | 24,458 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018507/ScoringFiles/PGS018507.txt.gz | |
| PGS018508 (TPMI_155.1_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Malignant neoplasm of liver primary | liver cancer | 983,777 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018508/ScoringFiles/PGS018508.txt.gz | |
| PGS018509 (TPMI_155.1_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Malignant neoplasm of liver primary | liver cancer | 973,600 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018509/ScoringFiles/PGS018509.txt.gz | |
| PGS019355 (TPMI_571_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Chronic liver disease and cirrhosis | alcoholic liver cirrhosis | 383 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019355/ScoringFiles/PGS019355.txt.gz | |
| PGS019356 (TPMI_571_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Chronic liver disease and cirrhosis | alcoholic liver cirrhosis | 939,833 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019356/ScoringFiles/PGS019356.txt.gz | |
| PGS019357 (TPMI_571_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Chronic liver disease and cirrhosis | alcoholic liver cirrhosis | 53,187 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019357/ScoringFiles/PGS019357.txt.gz | |
| PGS019358 (TPMI_571_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Chronic liver disease and cirrhosis | alcoholic liver cirrhosis | 983,786 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019358/ScoringFiles/PGS019358.txt.gz | |
| PGS019359 (TPMI_571_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Chronic liver disease and cirrhosis | alcoholic liver cirrhosis | 711,573 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019359/ScoringFiles/PGS019359.txt.gz | |
| PGS019360 (TPMI_571.5_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Other chronic nonalcoholic liver disease | metabolic dysfunction-associated steatotic liver disease | 17 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019360/ScoringFiles/PGS019360.txt.gz | |
| PGS019361 (TPMI_571.5_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Other chronic nonalcoholic liver disease | metabolic dysfunction-associated steatotic liver disease | 939,879 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019361/ScoringFiles/PGS019361.txt.gz | |
| PGS019362 (TPMI_571.5_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Other chronic nonalcoholic liver disease | metabolic dysfunction-associated steatotic liver disease | 40,372 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019362/ScoringFiles/PGS019362.txt.gz | |
| PGS019363 (TPMI_571.5_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Other chronic nonalcoholic liver disease | metabolic dysfunction-associated steatotic liver disease | 983,820 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019363/ScoringFiles/PGS019363.txt.gz | |
| PGS019364 (TPMI_571.5_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Other chronic nonalcoholic liver disease | metabolic dysfunction-associated steatotic liver disease | 513,027 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019364/ScoringFiles/PGS019364.txt.gz | |
| PGS019365 (TPMI_571.51_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cirrhosis of liver without mention of alcohol | cirrhosis of liver | 25 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019365/ScoringFiles/PGS019365.txt.gz | |
| PGS019366 (TPMI_571.51_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cirrhosis of liver without mention of alcohol | cirrhosis of liver | 20,027 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019366/ScoringFiles/PGS019366.txt.gz | |
| PGS019367 (TPMI_571.51_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cirrhosis of liver without mention of alcohol | cirrhosis of liver | 41,074 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019367/ScoringFiles/PGS019367.txt.gz | |
| PGS019368 (TPMI_571.51_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cirrhosis of liver without mention of alcohol | cirrhosis of liver | 983,776 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019368/ScoringFiles/PGS019368.txt.gz | |
| PGS019369 (TPMI_571.51_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Cirrhosis of liver without mention of alcohol | cirrhosis of liver | 1,012,645 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019369/ScoringFiles/PGS019369.txt.gz | |
| PGS019370 (TPMI_573_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Other disorders of liver | liver disorder | 98 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019370/ScoringFiles/PGS019370.txt.gz | |
| PGS019371 (TPMI_573_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Other disorders of liver | liver disorder | 939,877 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019371/ScoringFiles/PGS019371.txt.gz | |
| PGS019372 (TPMI_573_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Other disorders of liver | liver disorder | 37,901 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019372/ScoringFiles/PGS019372.txt.gz | |
| PGS019373 (TPMI_573_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Other disorders of liver | liver disorder | 983,820 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019373/ScoringFiles/PGS019373.txt.gz | |
| PGS019374 (TPMI_573_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Other disorders of liver | liver disorder | 481,850 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019374/ScoringFiles/PGS019374.txt.gz | |
| PGS019380 (TPMI_574_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis and cholecystitis | cholelithiasis | 828 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019380/ScoringFiles/PGS019380.txt.gz | |
| PGS019381 (TPMI_574_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis and cholecystitis | cholelithiasis | 301,092 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019381/ScoringFiles/PGS019381.txt.gz | |
| PGS019382 (TPMI_574_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis and cholecystitis | cholelithiasis | 504,100 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019382/ScoringFiles/PGS019382.txt.gz | |
| PGS019383 (TPMI_574_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis and cholecystitis | cholelithiasis | 983,827 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019383/ScoringFiles/PGS019383.txt.gz | |
| PGS019384 (TPMI_574_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis and cholecystitis | cholelithiasis | 961,215 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019384/ScoringFiles/PGS019384.txt.gz | |
| PGS019385 (TPMI_574.1_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis | cholelithiasis | 822 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019385/ScoringFiles/PGS019385.txt.gz | |
| PGS019386 (TPMI_574.1_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis | cholelithiasis | 299,623 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019386/ScoringFiles/PGS019386.txt.gz | |
| PGS019387 (TPMI_574.1_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis | cholelithiasis | 14,247 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019387/ScoringFiles/PGS019387.txt.gz | |
| PGS019388 (TPMI_574.1_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis | cholelithiasis | 983,827 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019388/ScoringFiles/PGS019388.txt.gz | |
| PGS019389 (TPMI_574.1_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholelithiasis | cholelithiasis | 950,200 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019389/ScoringFiles/PGS019389.txt.gz | |
| PGS019390 (TPMI_575_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Other biliary tract disease | biliary tract disorder | 114 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019390/ScoringFiles/PGS019390.txt.gz | |
| PGS019391 (TPMI_575_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Other biliary tract disease | biliary tract disorder | 939,893 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019391/ScoringFiles/PGS019391.txt.gz | |
| PGS019392 (TPMI_575_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Other biliary tract disease | biliary tract disorder | 521,023 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019392/ScoringFiles/PGS019392.txt.gz | |
| PGS019393 (TPMI_575_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Other biliary tract disease | biliary tract disorder | 983,826 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019393/ScoringFiles/PGS019393.txt.gz | |
| PGS019394 (TPMI_575_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Other biliary tract disease | biliary tract disorder | 964,528 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019394/ScoringFiles/PGS019394.txt.gz | |
| PGS019395 (TPMI_575.6_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholesterolosis of gallbladder | isolated agenesis of gallbladder | 94 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019395/ScoringFiles/PGS019395.txt.gz | |
| PGS019396 (TPMI_575.6_LDpred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholesterolosis of gallbladder | isolated agenesis of gallbladder | 317,692 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019396/ScoringFiles/PGS019396.txt.gz | |
| PGS019397 (TPMI_575.6_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholesterolosis of gallbladder | isolated agenesis of gallbladder | 22,140 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019397/ScoringFiles/PGS019397.txt.gz | |
| PGS019398 (TPMI_575.6_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholesterolosis of gallbladder | isolated agenesis of gallbladder | 983,820 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019398/ScoringFiles/PGS019398.txt.gz | |
| PGS019399 (TPMI_575.6_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Cholesterolosis of gallbladder | isolated agenesis of gallbladder | 1,012,242 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019399/ScoringFiles/PGS019399.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001341 | PGS000655 (NAFLD-10) |
PSS000584| European Ancestry| 235 individuals |
PGP000119 | Namjou B et al. BMC Med (2019) |
Reported Trait: Nonalcoholic fatty liver disease severity (NAFLD activity score above 5) | — | AUROC: 0.724 | Odds Ratio (OR, highest vs. lowest quintile): 8.5 [3.45, 20.96] | sex, age, PCs (1-3), BMI, study site/medical centre | — |
| PPM001340 | PGS000655 (NAFLD-10) |
PSS000583| European Ancestry| 9,677 individuals |
PGP000119 | Namjou B et al. BMC Med (2019) |
Reported Trait: Nonalcoholic fatty liver disease | — | AUROC: 0.596 | Odds Ratio (OR, highest vs. lowest quintile): 2.16 [1.81, 2.58] | sex, age, PCs (1-3), BMI, study site/medical centre | — |
| PPM001596 | PGS000704 (HC171) |
PSS000792| European Ancestry| 87,413 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alcoholic cirrhosis | — | AUROC: 0.55471 | — | Age, sex, PCs(1-10) | — |
| PPM001607 | PGS000704 (HC171) |
PSS000793| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alcoholic cirrhosis | HR: 1.18 [1.11, 1.27] | C-index: 0.711 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM022382 | PGS000704 (HC171) |
PSS011933| Multi-ancestry (including European)| 312,599 individuals |
PGP000708 | Ding C et al. Nat Commun (2023) |Ext. |
Reported Trait: Alcohol-related cirrhosis | HR: 1.67 [1.55, 1.8] | — | — | sex, age, ethnicity, Townsend deprivation index at recruitment, physical activity, smoking, total weekly alcohol intake, beverage type, drinking with/without meal, daily alcohol consumption group, diabetes, BMI, first 10 principal genetic components, and genotyping array | — |
| PPM022383 | PGS000704 (HC171) |
PSS011933| Multi-ancestry (including European)| 312,599 individuals |
PGP000708 | Ding C et al. Nat Commun (2023) |Ext. |
Reported Trait: Alcoholic hepatitis | HR: 1.32 [1.12, 1.57] | — | — | sex, age, ethnicity, Townsend deprivation index at recruitment, physical activity, smoking, total weekly alcohol intake, beverage type, drinking with/without meal, daily alcohol consumption group, diabetes, BMI, first 10 principal genetic components, and genotyping array | — |
| PPM022384 | PGS000704 (HC171) |
PSS011933| Multi-ancestry (including European)| 312,599 individuals |
PGP000708 | Ding C et al. Nat Commun (2023) |Ext. |
Reported Trait: Alcohol-related cirrhosis x alcohol consumption interaction | — | — | Hazard ratio (HR, heavy binge drinking and high PRS vs. below daily limit drinking and low PRS): 12.41 [4.96, 31.05] | total weekly alcohol intake, diabetes, BMI, sex, age, ethnicity, Townsend deprivation index, physical activity, smoke, alcohol type, drinking with/without meals, genotyping array, and first 10 ancestry principal components | — |
| PPM001597 | PGS000705 (HC188) |
PSS000811| European Ancestry| 87,413 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Gallstones | — | AUROC: 0.62164 | — | Age, sex, PCs(1-10) | — |
| PPM001613 | PGS000705 (HC188) |
PSS000812| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Gallstones | HR: 1.34 [1.32, 1.37] | C-index: 0.605 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM001656 | PGS000726 (PGS12_CIR) |
PSS000861| European Ancestry| 30,469 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Cirrhosis | OR: 1.32 | — | Odds Ratio (OR, top 20% vs. bottom 20%): 2.26 [1.87, 2.73] | Age, sex, PCs (1-5) | — |
| PPM001657 | PGS000726 (PGS12_CIR) |
PSS000861| European Ancestry| 30,469 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Biopsy-confirmed cirrhosis | OR: 1.39 | — | Odds Ratio (OR, top 20% vs. bottom 20%): 2.21 [1.59, 3.08] | Age, sex, PCs (1-5) | — |
| PPM001658 | PGS000726 (PGS12_CIR) |
PSS000861| European Ancestry| 30,469 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Esophageal varices | OR: 1.45 | — | Odds Ratio (OR, top 20% vs. bottom 20%): 3.1 [1.97, 4.9] | Age, sex, PCs (1-5) | — |
| PPM001659 | PGS000726 (PGS12_CIR) |
PSS000861| European Ancestry| 30,469 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Hepatocellular carcioma | OR: 1.39 | — | Odds Ratio (OR, top 20% vs. bottom 20%): 2.51 [1.59, 3.97] | Age, sex, PCs (1-5) | — |
| PPM001660 | PGS000726 (PGS12_CIR) |
PSS000861| European Ancestry| 30,469 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Death from liver disease | OR: 1.29 | — | Odds Ratio (OR, top 20% vs. bottom 20%): 2.03 [1.24, 3.32] | Age, sex, PCs (1-5) | — |
| PPM001661 | PGS000726 (PGS12_CIR) |
PSS000866| African Ancestry| 1,442 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Cirrhosis | — | — | Odds Ratio (OR, 20-80% vs. bottom 20%): 3.63 [1.55, 8.5] Odds Ratio (OR, top 20% risk vs. bottom 20%): 2.44 [0.92, 6.48] |
Age, sex, PCs (1-5) | — |
| PPM001662 | PGS000726 (PGS12_CIR) |
PSS000863| Ancestry Not Reported| 13,826 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Cirrhosis | — | — | Odds Ratio (OR, top 1% vs. bottom 20%): 3.16 [2.03, 4.9] | Age, sex, PCs (1-5) | — |
| PPM001663 | PGS000726 (PGS12_CIR) |
PSS000862| Ancestry Not Reported| 13,047 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Biopsy-confirmed cirrhosis | — | — | Odds Ratio (OR, top 1% vs. bottom 20%): 6.12 [3.55, 10.58] | Age, sex, PCs (1-5) | — |
| PPM001664 | PGS000726 (PGS12_CIR) |
PSS000864| European Ancestry| 213 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Cirrhosis in individuals with hepatitis B | — | — | Odds ratio (OR, top 20% vs. bottom 20%): 4.83 [1.12, 20.0] | Age, sex, PCs (1-5) | — |
| PPM001665 | PGS000726 (PGS12_CIR) |
PSS000865| European Ancestry| 661 individuals |
PGP000136 | Emdin CA et al. Gastroenterology (2020) |
Reported Trait: Cirrhosis in individuals with hepatitis C | — | — | Odds ratio (OR, top 20% vs. bottom 20%): 2.2 [1.2, 4.05] | Age, sex, PCs (1-5) | — |
| PPM030744 | PGS000726 (PGS12_CIR) |
PSS012276| European Ancestry| 448,645 individuals |
PGP000819 | Ge X et al. J Clin Transl Hepatol (2024) |Ext. |
Reported Trait: Cirrhosis | — | — | Hazard ratio (HR, high vs low tertile): 1.94 [1.72, 2.19] | age, age2, sex, smoking status, drinking status, the top 10 principal components of ancestry and genotyping batch | — |
| PPM030745 | PGS000726 (PGS12_CIR) |
PSS012276| European Ancestry| 448,645 individuals |
PGP000819 | Ge X et al. J Clin Transl Hepatol (2024) |Ext. |
Reported Trait: Compensated cirrhosis | — | — | Hazard ratio (HR, high vs low tertile): 2.39 [2.06, 2.79] | age, age2, sex, smoking status, drinking status, the top 10 principal components of ancestry and genotyping batch | — |
| PPM030746 | PGS000726 (PGS12_CIR) |
PSS012276| European Ancestry| 448,645 individuals |
PGP000819 | Ge X et al. J Clin Transl Hepatol (2024) |Ext. |
Reported Trait: Decompensated cirrhosis | — | — | Hazard ratio (HR, high vs low tertile): 1.89 [1.63, 2.2] | age, age2, sex, smoking status, drinking status, the top 10 principal components of ancestry and genotyping batch | — |
| PPM030747 | PGS000726 (PGS12_CIR) |
PSS012276| European Ancestry| 448,645 individuals |
PGP000819 | Ge X et al. J Clin Transl Hepatol (2024) |Ext. |
Reported Trait: Cirrhosis x Age-related mosaic chromosomal alterations interaction | — | — | Hazard ratio (HR, with Age-related mosaic chromosomal alterations and high PRS vs. without Age-related mosaic chromosomal alterations and low PRS): 2.53 [1.74, 3.66] | — | — |
| PPM030748 | PGS000726 (PGS12_CIR) |
PSS012276| European Ancestry| 448,645 individuals |
PGP000819 | Ge X et al. J Clin Transl Hepatol (2024) |Ext. |
Reported Trait: Cirrhosis x copy-neutral loss of heterozygosity interaction | — | — | Hazard ratio (HR, with Cell fraction ≥10% and high PRS vs. LOH event - and low PRS): 5.39 [2.41, 12.07] | age, age2, sex, smoking status, drinking status, the top 10 principal components of ancestry and genotyping batch | — |
| PPM002011 | PGS000776 (GRS9_Cirr) |
PSS000996| Ancestry Not Reported| 107,014 individuals |
PGP000180 | Innes H et al. Gastroenterology (2020) |
Reported Trait: Incident liver cirrhosis in individuals at-risk for nonalcoholic fatty liver disease (time to first hospitilisation) | — | C-index: 0.62 [0.59, 0.64] | Hazard Ratio (HR, top 20% vs bottom 20%): 3.12 [2.37, 4.12] | — | — |
| PPM002012 | PGS000776 (GRS9_Cirr) |
PSS000996| Ancestry Not Reported| 107,014 individuals |
PGP000180 | Innes H et al. Gastroenterology (2020) |
Reported Trait: Incident liver cirrhosis in individuals at-risk for nonalcoholic fatty liver disease (time to first hospitilisation) | — | — | Hazard Ratio (HR, top 20% vs bottom 20%): 3.16 [2.38, 4.21] | Age, sex, BMI, diabetes, units of alcohol consumed per week | — |
| PPM002013 | PGS000776 (GRS9_Cirr) |
PSS000996| Ancestry Not Reported| 107,014 individuals |
PGP000180 | Innes H et al. Gastroenterology (2020) |
Reported Trait: Incident liver cirrhosis in individuals at-risk for nonalcoholic fatty liver disease (time to first hospitilisation) | — | C-index: 0.677 [0.653, 0.7] | — | Age, sex | — |
| PPM002418 | PGS000872 (PRS-5) |
PSS001096| European Ancestry| 364,048 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Cirrhosis | OR: 4.4 [3.5, 5.6] | — | — | — | — |
| PPM002420 | PGS000872 (PRS-5) |
PSS001096| European Ancestry| 364,048 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Cirrhosis | OR: 4.5 [3.6, 5.7] | — | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre | — |
| PPM002432 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Severe fibrosis in individuals within stage F3-F4 of fatty liver disease | OR: 9.4 [5.4, 16.2] | — | — | Age, sex, body mass index, type 2 diabetes | — |
| PPM002419 | PGS000872 (PRS-5) |
PSS001096| European Ancestry| 364,048 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 11.9 [6.6, 21.3] | — | — | — | — |
| PPM002421 | PGS000872 (PRS-5) |
PSS001096| European Ancestry| 364,048 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 11.7 [6.54, 21.0] | — | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre | — |
| PPM002422 | PGS000872 (PRS-5) |
PSS001096| European Ancestry| 364,048 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 4.8 [2.6, 8.9] | — | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre, diagnosis of cirrhosis | — |
| PPM002428 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Fatty liver disease | OR: 9.0 [6.0, 13.4] | — | — | — | — |
| PPM002429 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Severe fibrosis in individuals within stage F3-F4 of fatty liver disease | OR: 12.6 [8.2, 19.3] | — | — | — | — |
| PPM002430 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 9.1 [5.2, 16.0] | — | — | — | — |
| PPM002431 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Fatty liver disease | OR: 10.7 [6.6, 17.3] | — | — | Age, sex, body mass index, type 2 diabetes | — |
| PPM002433 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 3.3 [1.6, 6.9] | — | — | Age, sex, body mass index, type 2 diabetes | — |
| PPM002440 | PGS000872 (PRS-5) |
PSS001094| European Ancestry| 2,564 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 2.9 [2.1, 3.8] | AUROC: 0.65 | — | Age, sex, body mass index, type 2 diabetes | Only 2,245 participants were available for this analysis. |
| PPM002443 | PGS000872 (PRS-5) |
PSS001097| European Ancestry| 356,943 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 3.4 [2.5, 4.7] | AUROC: 0.63 | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre | PRS-5 was treated as a binary variable with a cutoff of ≥0.495 |
| PPM002445 | PGS000872 (PRS-5) |
PSS001101| European Ancestry| 355,450 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma in individuals with no cirrhosis | OR: 1.9 [1.1, 3.2] | AUROC: 0.54 | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre | PRS-5 was treated as a binary variable with a cutoff of ≥0.495 |
| PPM002447 | PGS000872 (PRS-5) |
PSS001098| European Ancestry| 85,890 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma in individuals with a body mass index ≥30 | OR: 5.5 [3.6, 8.5] | AUROC: 0.69 | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre | PRS-5 was treated as a binary variable with a cutoff of ≥0.495 |
| PPM002449 | PGS000872 (PRS-5) |
PSS001103| European Ancestry| 25,039 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma in individuals with type 2 diabetes | OR: 4.6 [2.9, 7.3] | AUROC: 0.71 | — | Age, sex, body mass index, type 2 diabetes, PCs(1-10), array batch, assessment centre | PRS-5 was treated as a binary variable with a cutoff of ≥0.495 |
| PPM002451 | PGS000872 (PRS-5) |
PSS001095| Ancestry Not Reported| 429 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 8.61 [3.31, 22.37] | AUROC: 0.65 | — | — | — |
| PPM002453 | PGS000872 (PRS-5) |
PSS001095| Ancestry Not Reported| 429 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 6.36 [1.67, 24.31] | — | — | Age, sex, body mass index, type 2 diabetes | — |
| PPM002455 | PGS000872 (PRS-5) |
PSS001095| Ancestry Not Reported| 429 individuals |
PGP000215 | Bianco C et al. J Hepatol (2020) |
Reported Trait: Hepatocellular carcinoma | OR: 2.4 [1.19, 4.83] | — | — | — | PRS-5 was treated as a binary variable with a cutoff of ≥0.495 |
| PPM019102 | PGS000872 (PRS-5) |
PSS011182| European Ancestry| 381,825 individuals |
PGP000505 | Liu Z et al. Liver Int (2023) |Ext. |
Reported Trait: Non-alcoholic fatty liver disease | — | — | p-value (inferior to): 0.001 | age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR | — |
| PPM019103 | PGS000872 (PRS-5) |
PSS011182| European Ancestry| 381,825 individuals |
PGP000505 | Liu Z et al. Liver Int (2023) |Ext. |
Reported Trait: Severe liver disease | — | — | p-value (inferior to): 0.001 | age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR | — |
| PPM019104 | PGS000872 (PRS-5) |
PSS011182| European Ancestry| 381,825 individuals |
PGP000505 | Liu Z et al. Liver Int (2023) |Ext. |
Reported Trait: Serum uric acid levels x PRS interaction for liver disease | HR: 1.03 [1.01, 1.05] | — | — | age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR | — |
| PPM019105 | PGS000872 (PRS-5) |
PSS011182| European Ancestry| 381,825 individuals |
PGP000505 | Liu Z et al. Liver Int (2023) |Ext. |
Reported Trait: Serum uric acid levels x PRS interaction for severe liver disease | HR: 1.06 [1.03, 1.1] | — | — | age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR | — |
| PPM019101 | PGS000872 (PRS-5) |
PSS011182| European Ancestry| 381,825 individuals |
PGP000505 | Liu Z et al. Liver Int (2023) |Ext. |
Reported Trait: Liver disease | — | — | p-value (inferior to): 0.001 | age, sex, ethnicity, Townsend deprivation index (quintiles), education level, household income, employment status, self-reported smoking status, self-reported frequency of alcohol intake, sedentary behaviour, body mass index, baseline diabetes, baseline hypertension, serum triglyceride level, C-reactive protein level, and eGFR | — |
| PPM021276 | PGS000872 (PRS-5) |
PSS011674| European Ancestry| 5,209 individuals |
PGP000622 | Åberg F et al. Liver Int (2023) |Ext. |
Reported Trait: Liver-related hospitalization, hepatocellular cancer or liver-related death | HR: 5.05 [1.55, 16.5] | — | — | Enhanced liver fibrosis (ELF) test, chronic liver disease (CLivD) score | PGS did not increase predictive performance over ELF test + CLivD score |
| PPM008580 | PGS001174 (GBE_HC1125) |
PSS004139| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE cholelithiasis | — | AUROC: 0.69202 [0.6517, 0.73234] | R²: 0.05473 Incremental AUROC (full-covars): 0.01651 PGS R2 (no covariates): 0.00765 PGS AUROC (no covariates): 0.56963 [0.52438, 0.61487] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008581 | PGS001174 (GBE_HC1125) |
PSS004140| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE cholelithiasis | — | AUROC: 0.69749 [0.6348, 0.76018] | R²: 0.06838 Incremental AUROC (full-covars): 0.01442 PGS R2 (no covariates): 0.00347 PGS AUROC (no covariates): 0.557 [0.48585, 0.62815] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008582 | PGS001174 (GBE_HC1125) |
PSS004141| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE cholelithiasis | — | AUROC: 0.66706 [0.6514, 0.68272] | R²: 0.05295 Incremental AUROC (full-covars): 0.04311 PGS R2 (no covariates): 0.02808 PGS AUROC (no covariates): 0.62342 [0.60688, 0.63996] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008583 | PGS001174 (GBE_HC1125) |
PSS004142| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE cholelithiasis | — | AUROC: 0.68516 [0.65563, 0.7147] | R²: 0.05864 Incremental AUROC (full-covars): 0.01084 PGS R2 (no covariates): 0.00661 PGS AUROC (no covariates): 0.55746 [0.52498, 0.58993] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008584 | PGS001174 (GBE_HC1125) |
PSS004143| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE cholelithiasis | — | AUROC: 0.67421 [0.66558, 0.68284] | R²: 0.05848 Incremental AUROC (full-covars): 0.04052 PGS R2 (no covariates): 0.02571 PGS AUROC (no covariates): 0.61632 [0.60704, 0.62561] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008785 | PGS001256 (GBE_HC188) |
PSS004334| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Gallstones | — | AUROC: 0.68692 [0.64329, 0.73056] | R²: 0.04974 Incremental AUROC (full-covars): 0.02029 PGS R2 (no covariates): 0.00785 PGS AUROC (no covariates): 0.56814 [0.51821, 0.61807] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008786 | PGS001256 (GBE_HC188) |
PSS004335| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Gallstones | — | AUROC: 0.67793 [0.60585, 0.75001] | R²: 0.06195 Incremental AUROC (full-covars): 0.00834 PGS R2 (no covariates): 0.00064 PGS AUROC (no covariates): 0.52583 [0.44852, 0.60314] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008787 | PGS001256 (GBE_HC188) |
PSS004336| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Gallstones | — | AUROC: 0.66809 [0.65163, 0.68454] | R²: 0.05165 Incremental AUROC (full-covars): 0.04397 PGS R2 (no covariates): 0.0275 PGS AUROC (no covariates): 0.62496 [0.60759, 0.64234] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008788 | PGS001256 (GBE_HC188) |
PSS004337| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Gallstones | — | AUROC: 0.68743 [0.65645, 0.71841] | R²: 0.0581 Incremental AUROC (full-covars): 0.01295 PGS R2 (no covariates): 0.00775 PGS AUROC (no covariates): 0.56733 [0.53369, 0.60096] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008789 | PGS001256 (GBE_HC188) |
PSS004338| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Gallstones | — | AUROC: 0.67227 [0.66315, 0.68138] | R²: 0.05484 Incremental AUROC (full-covars): 0.04156 PGS R2 (no covariates): 0.02494 PGS AUROC (no covariates): 0.6171 [0.6073, 0.6269] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008963 | PGS001293 (GBE_HC1123) |
PSS004134| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE other diseases of liver | — | AUROC: 0.63246 [0.57311, 0.69181] | R²: 0.03109 Incremental AUROC (full-covars): -0.0062 PGS R2 (no covariates): 0.0 PGS AUROC (no covariates): 0.50545 [0.44895, 0.56196] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008964 | PGS001293 (GBE_HC1123) |
PSS004135| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE other diseases of liver | — | AUROC: 0.69904 [0.62545, 0.77263] | PGS R2 (no covariates): 0.01113 Incremental AUROC (full-covars): 0.02137 R²: 0.05749 PGS AUROC (no covariates): 0.60324 [0.52305, 0.68342] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008965 | PGS001293 (GBE_HC1123) |
PSS004136| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE other diseases of liver | — | AUROC: 0.63842 [0.61377, 0.66307] | R²: 0.02524 Incremental AUROC (full-covars): 0.02435 PGS R2 (no covariates): 0.01187 PGS AUROC (no covariates): 0.59189 [0.56464, 0.61913] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008966 | PGS001293 (GBE_HC1123) |
PSS004137| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE other diseases of liver | — | AUROC: 0.60451 [0.56674, 0.64227] | R²: 0.01731 Incremental AUROC (full-covars): 0.00746 PGS R2 (no covariates): 0.00179 PGS AUROC (no covariates): 0.53523 [0.49417, 0.57629] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008967 | PGS001293 (GBE_HC1123) |
PSS004138| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE other diseases of liver | — | AUROC: 0.58372 [0.56726, 0.60017] | R²: 0.00961 Incremental AUROC (full-covars): 0.01977 PGS R2 (no covariates): 0.00443 PGS AUROC (no covariates): 0.5536 [0.53634, 0.57086] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009254 | PGS001777 (3-SNP_cirr) |
PSS007668| European Ancestry| 1,766 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis (females) | β: 0.897 (0.172) | AUROC: 0.635 (0.025) | Odds Ratio (OR, top 20% vs bottom 20%): 3.81 [2.05, 7.07] | — | — |
| PPM009255 | PGS001777 (3-SNP_cirr) |
PSS007669| European Ancestry| 6,898 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis (males) | β: 0.8 (0.088) | AUROC: 0.635 (0.016) | Odds Ratio (OR, top 20% vs bottom 20%): 3.44 [2.48, 4.77] | — | — |
| PPM009256 | PGS001777 (3-SNP_cirr) |
PSS007669| European Ancestry| 6,898 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis (females) | — | AUROC: 0.554 (0.036) | Odds Ratio (OR, top 20% vs bottom 20%): 2.08 [1.11, 3.89] | — | — |
| PPM009247 | PGS001777 (3-SNP_cirr) |
PSS007667| European Ancestry| 1,390 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis | β: 1.092 (0.099) | AUROC: 0.665 (0.014) | Odds Ratio (OR, top 20% vs bottom 20%): 5.99 [4.18, 8.6] | — | — |
| PPM009248 | PGS001777 (3-SNP_cirr) |
PSS007668| European Ancestry| 1,766 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis | β: 0.669 (0.09) | AUROC: 0.606 (0.014) | Odds Ratio (OR, top 20% vs bottom 20%): 2.81 [2.03, 3.89] | — | — |
| PPM009249 | PGS001777 (3-SNP_cirr) |
PSS007669| European Ancestry| 6,898 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis | β: 0.729 (0.08) | AUROC: 0.619 (0.014) | Odds Ratio (OR, top 20% vs bottom 20%): 3.1 [2.32, 4.14] | — | — |
| PPM009250 | PGS001777 (3-SNP_cirr) |
PSS007669| European Ancestry| 6,898 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis | β: 0.748 (0.073) | AUROC: 0.636 (0.015) | Odds Ratio (OR, top 20% vs bottom 20%): 3.37 [2.38, 4.78] | BMI, coffee | — |
| PPM009251 | PGS001777 (3-SNP_cirr) |
PSS007667| European Ancestry| 1,390 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis (males) | β: 1.132 (0.116) | AUROC: 0.671 (0.016) | Odds Ratio (OR, top 20% vs bottom 20%): 6.18 [4.05, 9.41] | — | — |
| PPM009252 | PGS001777 (3-SNP_cirr) |
PSS007667| European Ancestry| 1,390 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis (females) | β: 0.974 (0.192) | AUROC: 0.65 (0.027) | Odds Ratio (OR, top 20% vs bottom 20%): 5.4 [2.67, 10.92] | — | — |
| PPM009253 | PGS001777 (3-SNP_cirr) |
PSS007668| European Ancestry| 1,766 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis (males) | β: 0.575 (0.107) | AUROC: 0.592 (0.017) | Odds Ratio (OR, top 20% vs bottom 20%): 2.47 [1.68, 3.62] | — | — |
| PPM009257 | PGS001777 (3-SNP_cirr) |
PSS007667| European Ancestry| 1,390 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis in diabetics | — | — | Odds Ratio (OR, high vs. low PRS): 5.32 [2.06, 13.7] | — | PRS Thresholds: Low (<= 0), High( >0.70) |
| PPM009258 | PGS001777 (3-SNP_cirr) |
PSS007667| European Ancestry| 1,390 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis in non-diabetics | — | — | Odds Ratio (OR, high vs. low PRS): 4.77 [3.45, 6.58] | — | PRS Thresholds: Low (<= 0), High( >0.70) |
| PPM009259 | PGS001777 (3-SNP_cirr) |
PSS007669| European Ancestry| 6,898 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis in diabetics | — | — | Odds Ratio (OR, high vs. low PRS): 3.74 [2.16, 6.48] | — | PRS Thresholds: Low (<= 0), High( >0.70) |
| PPM009260 | PGS001777 (3-SNP_cirr) |
PSS007669| European Ancestry| 6,898 individuals |
PGP000258 | Whitfield JB et al. J Hepatol (2021) |
Reported Trait: Cirrhosis in non-diabetics | — | — | Odds Ratio (OR, high vs. low PRS): 2.37 [1.86, 3.03] | — | PRS Thresholds: Low (<= 0), High( >0.70) |
| PPM009769 | PGS001860 (portability-PLR_571.5) |
PSS009335| European Ancestry| 19,586 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0413 [0.0273, 0.0553] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009770 | PGS001860 (portability-PLR_571.5) |
PSS009109| European Ancestry| 4,060 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.034 [0.0032, 0.0648] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009771 | PGS001860 (portability-PLR_571.5) |
PSS008663| European Ancestry| 6,543 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0281 [0.0038, 0.0523] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009772 | PGS001860 (portability-PLR_571.5) |
PSS008437| Greater Middle Eastern Ancestry| 1,185 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0168 [-0.0407, 0.0741] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009773 | PGS001860 (portability-PLR_571.5) |
PSS008217| South Asian Ancestry| 6,209 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0246 | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009774 | PGS001860 (portability-PLR_571.5) |
PSS007998| East Asian Ancestry| 1,783 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0455 [-0.0012, 0.092] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009775 | PGS001860 (portability-PLR_571.5) |
PSS007782| African Ancestry| 2,429 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): -0.013 [-0.0529, 0.0269] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009776 | PGS001860 (portability-PLR_571.5) |
PSS008886| African Ancestry| 3,837 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): -0.0259 [-0.0576, 0.0058] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009777 | PGS001861 (portability-PLR_574) |
PSS009336| European Ancestry| 19,908 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0948 [0.081, 0.1085] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009778 | PGS001861 (portability-PLR_574) |
PSS009110| European Ancestry| 4,121 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0809 [0.0504, 0.1112] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009779 | PGS001861 (portability-PLR_574) |
PSS008664| European Ancestry| 6,631 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0769 [0.0529, 0.1008] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009780 | PGS001861 (portability-PLR_574) |
PSS008438| Greater Middle Eastern Ancestry| 1,197 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0684 [0.0113, 0.1251] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009781 | PGS001861 (portability-PLR_574) |
PSS008218| South Asian Ancestry| 6,310 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0422 [0.0175, 0.0668] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009782 | PGS001861 (portability-PLR_574) |
PSS007999| East Asian Ancestry| 1,806 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.041 [-0.0054, 0.0872] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009783 | PGS001861 (portability-PLR_574) |
PSS007783| African Ancestry| 2,477 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0362 [-0.0033, 0.0757] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009784 | PGS001861 (portability-PLR_574) |
PSS008887| African Ancestry| 3,912 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0251 [-0.0063, 0.0565] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009785 | PGS001862 (portability-PLR_575) |
PSS009337| European Ancestry| 19,288 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0221 [0.008, 0.0362] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009786 | PGS001862 (portability-PLR_575) |
PSS009111| European Ancestry| 3,998 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0485 [0.0174, 0.0795] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009787 | PGS001862 (portability-PLR_575) |
PSS008665| European Ancestry| 6,436 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): -0.0029 [-0.0274, 0.0215] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009788 | PGS001862 (portability-PLR_575) |
PSS008439| Greater Middle Eastern Ancestry| 1,170 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0133 [-0.0445, 0.0711] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009789 | PGS001862 (portability-PLR_575) |
PSS008219| South Asian Ancestry| 6,142 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0217 [-0.0033, 0.0468] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009790 | PGS001862 (portability-PLR_575) |
PSS008000| East Asian Ancestry| 1,775 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.03 [-0.0168, 0.0767] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009792 | PGS001862 (portability-PLR_575) |
PSS008888| African Ancestry| 3,852 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): -0.0004 [-0.0321, 0.0312] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009791 | PGS001862 (portability-PLR_575) |
PSS007784| African Ancestry| 2,432 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0111 [-0.0288, 0.051] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011429 | PGS002071 (portability-ldpred2_571.5) |
PSS009335| European Ancestry| 19,586 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0415 [0.0275, 0.0555] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011430 | PGS002071 (portability-ldpred2_571.5) |
PSS009109| European Ancestry| 4,060 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.029 [-0.0018, 0.0598] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011431 | PGS002071 (portability-ldpred2_571.5) |
PSS008663| European Ancestry| 6,543 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0289 [0.0047, 0.0532] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011432 | PGS002071 (portability-ldpred2_571.5) |
PSS008437| Greater Middle Eastern Ancestry| 1,185 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0227 [-0.0348, 0.08] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011433 | PGS002071 (portability-ldpred2_571.5) |
PSS008217| South Asian Ancestry| 6,209 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.0224 [-0.0025, 0.0473] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011434 | PGS002071 (portability-ldpred2_571.5) |
PSS007998| East Asian Ancestry| 1,783 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): 0.043 [-0.0037, 0.0895] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011435 | PGS002071 (portability-ldpred2_571.5) |
PSS007782| African Ancestry| 2,429 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): -0.0077 [-0.0476, 0.0323] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011436 | PGS002071 (portability-ldpred2_571.5) |
PSS008886| African Ancestry| 3,837 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other chronic nonalcoholic liver disease | — | — | Partial Correlation (partial-r): -0.0167 [-0.0484, 0.015] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011437 | PGS002072 (portability-ldpred2_574) |
PSS009336| European Ancestry| 19,908 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.098 [0.0842, 0.1117] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011439 | PGS002072 (portability-ldpred2_574) |
PSS008664| European Ancestry| 6,631 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0805 [0.0565, 0.1044] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011440 | PGS002072 (portability-ldpred2_574) |
PSS008438| Greater Middle Eastern Ancestry| 1,197 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0663 [0.0092, 0.123] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011441 | PGS002072 (portability-ldpred2_574) |
PSS008218| South Asian Ancestry| 6,310 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0503 [0.0256, 0.0749] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011442 | PGS002072 (portability-ldpred2_574) |
PSS007999| East Asian Ancestry| 1,806 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0441 [-0.0023, 0.0903] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011443 | PGS002072 (portability-ldpred2_574) |
PSS007783| African Ancestry| 2,477 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0336 [-0.0059, 0.0731] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011444 | PGS002072 (portability-ldpred2_574) |
PSS008887| African Ancestry| 3,912 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.033 [0.0016, 0.0643] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011438 | PGS002072 (portability-ldpred2_574) |
PSS009110| European Ancestry| 4,121 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Cholelithiasis and cholecystitis | — | — | Partial Correlation (partial-r): 0.0792 [0.0487, 0.1096] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011445 | PGS002073 (portability-ldpred2_575) |
PSS009337| European Ancestry| 19,288 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0215 [0.0074, 0.0356] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011446 | PGS002073 (portability-ldpred2_575) |
PSS009111| European Ancestry| 3,998 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0453 [0.0142, 0.0762] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011447 | PGS002073 (portability-ldpred2_575) |
PSS008665| European Ancestry| 6,436 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): -0.0067 [-0.0311, 0.0178] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011448 | PGS002073 (portability-ldpred2_575) |
PSS008439| Greater Middle Eastern Ancestry| 1,170 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): -0.0075 [-0.0653, 0.0503] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011449 | PGS002073 (portability-ldpred2_575) |
PSS008219| South Asian Ancestry| 6,142 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.029 [0.004, 0.054] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011450 | PGS002073 (portability-ldpred2_575) |
PSS008000| East Asian Ancestry| 1,775 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.053 [0.0062, 0.0995] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011452 | PGS002073 (portability-ldpred2_575) |
PSS008888| African Ancestry| 3,852 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0035 [-0.0281, 0.0352] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011451 | PGS002073 (portability-ldpred2_575) |
PSS007784| African Ancestry| 2,432 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Other biliary tract disease | — | — | Partial Correlation (partial-r): 0.0039 [-0.036, 0.0438] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012973 | PGS002282 (GRS68_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels | β: 0.13 (0.002) | — | — | — | — |
| PPM012975 | PGS002282 (GRS68_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels x physical activity interaction | β: -0.28 (0.053) | — | — | — | — |
| PPM012976 | PGS002282 (GRS68_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels x grip strength interaction | β: -0.0067 (0.002) | — | — | — | — |
| PPM012977 | PGS002282 (GRS68_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels x BMI interaction | β: 0.037 (0.002) | — | — | — | — |
| PPM012981 | PGS002282 (GRS68_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: Nonalcoholic fatty liver disease in those with normal weight and high level of physical activity | — | — | Odds Ratio (OR, high vs. low GRS): 1.6 | Sex, age, socioeconomic status, assessment center, genotyping array, and the first 10 principal components | — |
| PPM012974 | PGS002283 (GRS15_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels | β: 0.094 (0.002) | — | — | — | — |
| PPM012978 | PGS002283 (GRS15_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels x physical activity interaction | β: -0.3 (0.053) | — | — | — | — |
| PPM012979 | PGS002283 (GRS15_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels x grip strength interaction | β: -0.011 (0.002) | — | — | — | — |
| PPM012980 | PGS002283 (GRS15_NAFLD) |
PSS009638| European Ancestry| 25,716 individuals |
PGP000312 | Schnurr TM et al. Hepatol Commun (2022) |
Reported Trait: ALT levels x BMI interaction | β: 0.039 (0.002) | — | — | — | — |
| PPM020591 | PGS004476 (disease.K80.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: K80 (Cholelithiasis) | OR: 1.21943 | — | — | — | — |
| PPM020661 | PGS004546 (meta.K80.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: K80 (Cholelithiasis) | OR: 1.29862 | — | — | — | — |
| PPM020806 | PGS004621 (cirrhosis_pgs_eur) |
PSS011418| European Ancestry| 1,153,995 individuals |
PGP000594 | Ghouse J et al. Nat Genet (2024) |
Reported Trait: Cirrhosis | OR: 1.42 | AUROC: 0.68 | — | age,sex,10 PCs | — |
| PPM021374 | PGS004913 (PRSALC) |
PSS011711| European Ancestry| 9,448 individuals |
PGP000645 | Schwantes-An TH et al. Hepatol Commun (2024) |
Reported Trait: Alcohol-associated liver cirrhosis | — | — | R²: 0.02 Odds ratio (OR, top vs bottom PRS deciles): 2.75 [1.79, 4.21] |
Age, sex, 10 PCs | — |
| PPM021375 | PGS004913 (PRSALC) |
PSS011709| European Ancestry| 3,360 individuals |
PGP000645 | Schwantes-An TH et al. Hepatol Commun (2024) |
Reported Trait: Alcohol-associated liver cirrhosis | — | — | R²: 0.029 Odds ratio (OR, top vs bottom PRS deciles): 4.4 [1.56, 12.44] |
Age, sex, 10 PCs | — |
| PPM021376 | PGS004913 (PRSALC) |
PSS011710| European Ancestry| 3,709 individuals |
PGP000645 | Schwantes-An TH et al. Hepatol Commun (2024) |
Reported Trait: Metabolic dysfunction-associated steatotic liver disease cirrhosis | — | — | Odds ratio (OR, top vs bottom PRS deciles): 3.94 [2.23, 6.95] | Age, sex, BMI, 10 PCs | — |
| PPM022370 | PGS005150 (Cholelithiasis (PRS-CSx; EAS+EUR)) |
PSS011920| East Asian Ancestry| 58,628 individuals |
PGP000704 | Jung HU et al. Commun Biol (2025) |
Reported Trait: Cholelithiasis | β: 1.19056 | — | — | age, sex | — |
| PPM030658 | PGS012549 (PRS10_NAFLD) |
PSS012225| Multi-ancestry (including European)| 465,032 individuals |
PGP000792 | Tang L et al. BMC Med (2023) |
Reported Trait: Nonalcoholic fatty liver disease x telomere length interaction | — | — | Hazard ratio (HR, high telomere length tertile and high PRS vs. low telomere length tertile and low PRS): 1.99 [1.74, 2.27] | age, gender, ethnicity, Townsend deprivation index, BMI, cholesterol, hypertension, diabetes, lifestyle, air pollution score, the top 10 genetic principal components, and genotyping batch | — |
| PPM030657 | PGS012549 (PRS10_NAFLD) |
PSS012225| Multi-ancestry (including European)| 465,032 individuals |
PGP000792 | Tang L et al. BMC Med (2023) |
Reported Trait: Nonalcoholic fatty liver disease | HR: 1.23 [1.2, 1.27] | — | — | age, gender, ethnicity, Townsend deprivation index, BMI, cholesterol, hypertension, diabetes, lifestyle, air pollution score, the top 10 genetic principal components, and genotyping batch | — |
| PPM030739 | PGS012582 (PRS13_cholelithiasis) |
PSS012273| European Ancestry| 317,640 individuals |
PGP000816 | Mi N et al. Prev Med (2024) |
Reported Trait: cholelithiasis | — | — | Hazard ratio (HR, high vs low tertile): 1.24 [1.16, 1.32] | age, sex, UK Biobank assessment centers, and additionally adjusted for index of multiple deprivation, overall health rating, long-standing illness, obesity, dyslipidemia for triglycerides, dyslipidemia for high-density lipoprotein cholesterol, hypertension, hyperglycemia, multivitamin use, mineral use, aspirin use, non-steroidal anti-inflammatory drugs use, statin use, proton pump inhibitors use, lifestyle factors (diet, smoking, alcohol consumption, coffee consumption, physical activity and body weight) | — |
| PPM030740 | PGS012582 (PRS13_cholelithiasis) |
PSS012273| European Ancestry| 317,640 individuals |
PGP000816 | Mi N et al. Prev Med (2024) |
Reported Trait: cholelithiasis x lifestyle interaction | — | — | Hazard ratio (HR, unfavorable lifestyle and high PRS vs. favorable lifestyle and low PRS): 1.98 [1.67, 2.35] | cerides, dyslipidemia for high-density lipoprotein cholesterol, hypertension, hyperglycemia, multivitamin use, mineral use, aspirin use, non-steroidal anti-inflammatory drugs use, statin use and proton pump inhibitors use | — |
| PPM036601 | PGS018419 (TPMI_070_Lassosum2) |
PSS012338| East Asian Ancestry| 18,392 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis | — | AUROC: 0.66584 | R²: 0.09632 | sex, age, array, PCs 1-10 | — |
| PPM036602 | PGS018420 (TPMI_070_LDpred2) |
PSS012337| East Asian Ancestry| 18,392 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis | — | AUROC: 0.66706 | R²: 0.09753 | sex, age, array, PCs 1-10 | — |
| PPM036603 | PGS018421 (TPMI_070_MegaPRS) |
PSS012339| East Asian Ancestry| 18,392 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis | — | AUROC: 0.65859 | R²: 0.08984 | sex, age, array, PCs 1-10 | — |
| PPM036604 | PGS018422 (TPMI_070_PRS-CS) |
PSS012340| East Asian Ancestry| 18,392 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis | — | AUROC: 0.66524 | R²: 0.09576 | sex, age, array, PCs 1-10 | — |
| PPM036605 | PGS018423 (TPMI_070_SBayesR) |
PSS012341| East Asian Ancestry| 18,392 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis | — | AUROC: 0.66205 | R²: 0.09237 | sex, age, array, PCs 1-10 | — |
| PPM036606 | PGS018424 (TPMI_070.2_Lassosum2) |
PSS012322| East Asian Ancestry| 16,415 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis B | — | AUROC: 0.73149 | R²: 0.12951 | sex, age, array, PCs 1-10 | — |
| PPM036607 | PGS018425 (TPMI_070.2_LDpred2) |
PSS012321| East Asian Ancestry| 16,415 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis B | — | AUROC: 0.73251 | R²: 0.13063 | sex, age, array, PCs 1-10 | — |
| PPM036608 | PGS018426 (TPMI_070.2_MegaPRS) |
PSS012323| East Asian Ancestry| 16,415 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis B | — | AUROC: 0.70874 | R²: 0.10883 | sex, age, array, PCs 1-10 | — |
| PPM036609 | PGS018427 (TPMI_070.2_PRS-CS) |
PSS012324| East Asian Ancestry| 16,415 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis B | — | AUROC: 0.72807 | R²: 0.12453 | sex, age, array, PCs 1-10 | — |
| PPM036610 | PGS018428 (TPMI_070.2_PRSmix+) |
PSS012325| East Asian Ancestry| 16,415 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis B | — | AUROC: 0.73833 | R²: 0.13621 | sex, age, array, PCs 1-10 | — |
| PPM036611 | PGS018429 (TPMI_070.2_SBayesR) |
PSS012326| East Asian Ancestry| 16,415 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Viral hepatitis B | — | AUROC: 0.71321 | R²: 0.11347 | sex, age, array, PCs 1-10 | — |
| PPM036682 | PGS018500 (TPMI_155_Lassosum2) |
PSS012408| East Asian Ancestry| 15,739 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cancer of liver and intrahepatic bile duct | — | AUROC: 0.65034 | R²: 0.0208 | sex, age, array, PCs 1-10 | — |
| PPM036683 | PGS018501 (TPMI_155_LDpred2) |
PSS012407| East Asian Ancestry| 15,739 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cancer of liver and intrahepatic bile duct | — | AUROC: 0.6513 | R²: 0.02088 | sex, age, array, PCs 1-10 | — |
| PPM036684 | PGS018502 (TPMI_155_MegaPRS) |
PSS012409| East Asian Ancestry| 15,739 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cancer of liver and intrahepatic bile duct | — | AUROC: 0.64296 | R²: 0.01875 | sex, age, array, PCs 1-10 | — |
| PPM036685 | PGS018503 (TPMI_155_PRS-CS) |
PSS012410| East Asian Ancestry| 15,739 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cancer of liver and intrahepatic bile duct | — | AUROC: 0.65049 | R²: 0.02078 | sex, age, array, PCs 1-10 | — |
| PPM036686 | PGS018504 (TPMI_155_SBayesR) |
PSS012411| East Asian Ancestry| 15,739 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cancer of liver and intrahepatic bile duct | — | AUROC: 0.64158 | R²: 0.01837 | sex, age, array, PCs 1-10 | — |
| PPM036687 | PGS018505 (TPMI_155.1_Lassosum2) |
PSS012403| East Asian Ancestry| 15,712 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Malignant neoplasm of liver primary | — | AUROC: 0.65226 | R²: 0.01923 | sex, age, array, PCs 1-10 | — |
| PPM036688 | PGS018506 (TPMI_155.1_LDpred2) |
PSS012402| East Asian Ancestry| 15,712 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Malignant neoplasm of liver primary | — | AUROC: 0.65258 | R²: 0.0191 | sex, age, array, PCs 1-10 | — |
| PPM036689 | PGS018507 (TPMI_155.1_MegaPRS) |
PSS012404| East Asian Ancestry| 15,712 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Malignant neoplasm of liver primary | — | AUROC: 0.64163 | R²: 0.01662 | sex, age, array, PCs 1-10 | — |
| PPM036690 | PGS018508 (TPMI_155.1_PRS-CS) |
PSS012405| East Asian Ancestry| 15,712 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Malignant neoplasm of liver primary | — | AUROC: 0.6475 | R²: 0.01834 | sex, age, array, PCs 1-10 | — |
| PPM036691 | PGS018509 (TPMI_155.1_SBayesR) |
PSS012406| East Asian Ancestry| 15,712 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Malignant neoplasm of liver primary | — | AUROC: 0.64158 | R²: 0.01663 | sex, age, array, PCs 1-10 | — |
| PPM037537 | PGS019355 (TPMI_571_Lassosum2) |
PSS013268| East Asian Ancestry| 18,730 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Chronic liver disease and cirrhosis | — | AUROC: 0.64281 | R²: 0.06977 | sex, age, array, PCs 1-10 | — |
| PPM037538 | PGS019356 (TPMI_571_LDpred2) |
PSS013267| East Asian Ancestry| 18,730 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Chronic liver disease and cirrhosis | — | AUROC: 0.64424 | R²: 0.07074 | sex, age, array, PCs 1-10 | — |
| PPM037539 | PGS019357 (TPMI_571_MegaPRS) |
PSS013269| East Asian Ancestry| 18,730 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Chronic liver disease and cirrhosis | — | AUROC: 0.63961 | R²: 0.06771 | sex, age, array, PCs 1-10 | — |
| PPM037540 | PGS019358 (TPMI_571_PRS-CS) |
PSS013270| East Asian Ancestry| 18,730 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Chronic liver disease and cirrhosis | — | AUROC: 0.64417 | R²: 0.07095 | sex, age, array, PCs 1-10 | — |
| PPM037541 | PGS019359 (TPMI_571_SBayesR) |
PSS013271| East Asian Ancestry| 18,730 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Chronic liver disease and cirrhosis | — | AUROC: 0.64095 | R²: 0.0684 | sex, age, array, PCs 1-10 | — |
| PPM037542 | PGS019360 (TPMI_571.5_Lassosum2) |
PSS013263| East Asian Ancestry| 17,248 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other chronic nonalcoholic liver disease | — | AUROC: 0.63741 | R²: 0.04831 | sex, age, array, PCs 1-10 | — |
| PPM037543 | PGS019361 (TPMI_571.5_LDpred2) |
PSS013262| East Asian Ancestry| 17,248 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other chronic nonalcoholic liver disease | — | AUROC: 0.64097 | R²: 0.05021 | sex, age, array, PCs 1-10 | — |
| PPM037544 | PGS019362 (TPMI_571.5_MegaPRS) |
PSS013264| East Asian Ancestry| 17,248 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other chronic nonalcoholic liver disease | — | AUROC: 0.63636 | R²: 0.04788 | sex, age, array, PCs 1-10 | — |
| PPM037545 | PGS019363 (TPMI_571.5_PRS-CS) |
PSS013265| East Asian Ancestry| 17,248 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other chronic nonalcoholic liver disease | — | AUROC: 0.6399 | R²: 0.04984 | sex, age, array, PCs 1-10 | — |
| PPM037546 | PGS019364 (TPMI_571.5_SBayesR) |
PSS013266| East Asian Ancestry| 17,248 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other chronic nonalcoholic liver disease | — | AUROC: 0.63748 | R²: 0.04844 | sex, age, array, PCs 1-10 | — |
| PPM037547 | PGS019365 (TPMI_571.51_Lassosum2) |
PSS013258| East Asian Ancestry| 16,177 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cirrhosis of liver without mention of alcohol | — | AUROC: 0.6726 | R²: 0.04527 | sex, age, array, PCs 1-10 | — |
| PPM037548 | PGS019366 (TPMI_571.51_LDpred2) |
PSS013257| East Asian Ancestry| 16,177 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cirrhosis of liver without mention of alcohol | — | AUROC: 0.67568 | R²: 0.04607 | sex, age, array, PCs 1-10 | — |
| PPM037549 | PGS019367 (TPMI_571.51_MegaPRS) |
PSS013259| East Asian Ancestry| 16,177 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cirrhosis of liver without mention of alcohol | — | AUROC: 0.65832 | R²: 0.0395 | sex, age, array, PCs 1-10 | — |
| PPM037550 | PGS019368 (TPMI_571.51_PRS-CS) |
PSS013260| East Asian Ancestry| 16,177 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cirrhosis of liver without mention of alcohol | — | AUROC: 0.6721 | R²: 0.04481 | sex, age, array, PCs 1-10 | — |
| PPM037551 | PGS019369 (TPMI_571.51_SBayesR) |
PSS013261| East Asian Ancestry| 16,177 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cirrhosis of liver without mention of alcohol | — | AUROC: 0.66588 | R²: 0.04222 | sex, age, array, PCs 1-10 | — |
| PPM037552 | PGS019370 (TPMI_573_Lassosum2) |
PSS013278| East Asian Ancestry| 17,690 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other disorders of liver | — | AUROC: 0.65124 | R²: 0.06577 | sex, age, array, PCs 1-10 | — |
| PPM037553 | PGS019371 (TPMI_573_LDpred2) |
PSS013277| East Asian Ancestry| 17,690 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other disorders of liver | — | AUROC: 0.65109 | R²: 0.06577 | sex, age, array, PCs 1-10 | — |
| PPM037554 | PGS019372 (TPMI_573_MegaPRS) |
PSS013279| East Asian Ancestry| 17,690 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other disorders of liver | — | AUROC: 0.64866 | R²: 0.06493 | sex, age, array, PCs 1-10 | — |
| PPM037555 | PGS019373 (TPMI_573_PRS-CS) |
PSS013280| East Asian Ancestry| 17,690 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other disorders of liver | — | AUROC: 0.6524 | R²: 0.06666 | sex, age, array, PCs 1-10 | — |
| PPM037556 | PGS019374 (TPMI_573_SBayesR) |
PSS013281| East Asian Ancestry| 17,690 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other disorders of liver | — | AUROC: 0.65143 | R²: 0.06603 | sex, age, array, PCs 1-10 | — |
| PPM037562 | PGS019380 (TPMI_574_Lassosum2) |
PSS013288| East Asian Ancestry| 19,486 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis and cholecystitis | — | AUROC: 0.59197 | R²: 0.02302 | sex, age, array, PCs 1-10 | — |
| PPM037563 | PGS019381 (TPMI_574_LDpred2) |
PSS013287| East Asian Ancestry| 19,486 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis and cholecystitis | — | AUROC: 0.59372 | R²: 0.02396 | sex, age, array, PCs 1-10 | — |
| PPM037564 | PGS019382 (TPMI_574_MegaPRS) |
PSS013289| East Asian Ancestry| 19,486 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis and cholecystitis | — | AUROC: 0.58961 | R²: 0.02289 | sex, age, array, PCs 1-10 | — |
| PPM037565 | PGS019383 (TPMI_574_PRS-CS) |
PSS013290| East Asian Ancestry| 19,486 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis and cholecystitis | — | AUROC: 0.59024 | R²: 0.02264 | sex, age, array, PCs 1-10 | — |
| PPM037566 | PGS019384 (TPMI_574_SBayesR) |
PSS013291| East Asian Ancestry| 19,486 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis and cholecystitis | — | AUROC: 0.58855 | R²: 0.02182 | sex, age, array, PCs 1-10 | — |
| PPM037567 | PGS019385 (TPMI_574.1_Lassosum2) |
PSS013283| East Asian Ancestry| 19,438 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis | — | AUROC: 0.58757 | R²: 0.01886 | sex, age, array, PCs 1-10 | — |
| PPM037568 | PGS019386 (TPMI_574.1_LDpred2) |
PSS013282| East Asian Ancestry| 19,438 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis | — | AUROC: 0.59115 | R²: 0.02041 | sex, age, array, PCs 1-10 | — |
| PPM037569 | PGS019387 (TPMI_574.1_MegaPRS) |
PSS013284| East Asian Ancestry| 19,438 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis | — | AUROC: 0.58583 | R²: 0.01848 | sex, age, array, PCs 1-10 | — |
| PPM037570 | PGS019388 (TPMI_574.1_PRS-CS) |
PSS013285| East Asian Ancestry| 19,438 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis | — | AUROC: 0.59133 | R²: 0.02096 | sex, age, array, PCs 1-10 | — |
| PPM037571 | PGS019389 (TPMI_574.1_SBayesR) |
PSS013286| East Asian Ancestry| 19,438 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholelithiasis | — | AUROC: 0.58758 | R²: 0.01896 | sex, age, array, PCs 1-10 | — |
| PPM037572 | PGS019390 (TPMI_575_Lassosum2) |
PSS013298| East Asian Ancestry| 19,086 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other biliary tract disease | — | AUROC: 0.63162 | R²: 0.01929 | sex, age, array, PCs 1-10 | — |
| PPM037573 | PGS019391 (TPMI_575_LDpred2) |
PSS013297| East Asian Ancestry| 19,086 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other biliary tract disease | — | AUROC: 0.63075 | R²: 0.01931 | sex, age, array, PCs 1-10 | — |
| PPM037574 | PGS019392 (TPMI_575_MegaPRS) |
PSS013299| East Asian Ancestry| 19,086 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other biliary tract disease | — | AUROC: 0.62631 | R²: 0.01769 | sex, age, array, PCs 1-10 | — |
| PPM037575 | PGS019393 (TPMI_575_PRS-CS) |
PSS013300| East Asian Ancestry| 19,086 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other biliary tract disease | — | AUROC: 0.62879 | R²: 0.01838 | sex, age, array, PCs 1-10 | — |
| PPM037576 | PGS019394 (TPMI_575_SBayesR) |
PSS013301| East Asian Ancestry| 19,086 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Other biliary tract disease | — | AUROC: 0.62573 | R²: 0.01768 | sex, age, array, PCs 1-10 | — |
| PPM037577 | PGS019395 (TPMI_575.6_Lassosum2) |
PSS013293| East Asian Ancestry| 18,765 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholesterolosis of gallbladder | — | AUROC: 0.7218 | R²: 0.01449 | sex, age, array, PCs 1-10 | — |
| PPM037578 | PGS019396 (TPMI_575.6_LDpred2) |
PSS013292| East Asian Ancestry| 18,765 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholesterolosis of gallbladder | — | AUROC: 0.71101 | R²: 0.01282 | sex, age, array, PCs 1-10 | — |
| PPM037579 | PGS019397 (TPMI_575.6_MegaPRS) |
PSS013294| East Asian Ancestry| 18,765 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholesterolosis of gallbladder | — | AUROC: 0.71115 | R²: 0.01278 | sex, age, array, PCs 1-10 | — |
| PPM037580 | PGS019398 (TPMI_575.6_PRS-CS) |
PSS013295| East Asian Ancestry| 18,765 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholesterolosis of gallbladder | — | AUROC: 0.71248 | R²: 0.01294 | sex, age, array, PCs 1-10 | — |
| PPM037581 | PGS019399 (TPMI_575.6_SBayesR) |
PSS013296| East Asian Ancestry| 18,765 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Cholesterolosis of gallbladder | — | AUROC: 0.71278 | R²: 0.01299 | sex, age, array, PCs 1-10 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS008663 | — | — | 6,543 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS008664 | — | — | 6,631 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS008665 | — | — | 6,436 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS011709 | — | — | [
|
— | European | — | IB-liver | — |
| PSS011710 | — | — | [
|
— | European | — | IB-liver | — |
| PSS011711 | Cirrhosis cases were defined as having ICD10 code K70.3; “alcohol-associated cirrhosis of liver', or ICD-9 code 571.2, “Cirrhosis, liver, alcohol-associated or ICD10 code K70.1; “alcoholic hepatitis without ascites” or ICD-9 code 571.1, “acute alcoholic hepatitis.” Controls were defined as having (1) reported alcohol intake of ≥80 g/d (males) and ≥50 g/d (females) and/or (2) ICD10 diagnosis of F10.2 (mental and behavioral disorders due to alcohol) but with no recorded diagnosis of any liver disease as defined previously | — | [
|
— | European | — | UKB | — |
| PSS008217 | — | — | 6,209 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS008218 | — | — | 6,310 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS008219 | — | — | 6,142 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS000996 | All individuals (cases and controls) met the at-risk criteria for nonalcoholic fatty liver disease (NAFLD) defined as a BMI ≥30 kg/m2 or diagnosis of type 2 diabetes, or both, without evidence of any other cause of liver disease including excess alcohol . Cases were individuals who had been hospitalised with cirrhosis for the first time. A hospital admission for cirrhosis was defined according to the Ratib et al (PMID: 24419483) validated algorithm incorporating appropriate ICD discharge codes and OPCS Classification of Interventions and Procedures version 4 codes. | Mean = 7.9 years | [ ,
43.0 % Male samples |
Median = 59.0 years Range = [52.0, 64.0] years |
Not reported | — | UKB | GRS dataset used to test/ evaluate performance of GRS. The GRS dataset is independent of the discovery analysis datasets containing UKB participants. Possible sample overlap between the GRS dataset and the phase 1 replication/validation analysis and phase 2 replication analysis datasets containing UKB participants. |
| PSS000792 | — | — | 87,413 individuals | — | European | — | UKB | — |
| PSS000793 | ICD-10 K70 | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS011920 | — | — | [
|
— | East Asian (Korean) |
— | HEXA | — |
| PSS012225 | — | — | [
|
— | European | — | UKB | — |
| PSS012225 | — | — | [
|
— | Asian unspecified | — | UKB | — |
| PSS012225 | — | — | [
|
— | African American or Afro-Caribbean (Black) |
— | UKB | — |
| PSS012225 | — | — | [
|
— | East Asian (Chinese) |
— | UKB | — |
| PSS012225 | — | — | [
|
— | Not reported | — | UKB | — |
| PSS000811 | — | — | 87,413 individuals | — | European | — | UKB | — |
| PSS000812 | — | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS011933 | — | — | 294,816 individuals | — | European | — | UKB | — |
| PSS011933 | — | — | 17,783 individuals | — | Not reported | — | UKB | — |
| PSS007782 | — | — | 2,429 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS007783 | — | — | 2,477 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS007784 | — | — | 2,432 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS004334 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004335 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004336 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004337 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004338 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009335 | — | — | 19,586 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS009336 | — | — | 19,908 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS009337 | — | — | 19,288 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS009638 | — | — | 25,716 individuals, 41.5 % Male samples |
Mean = 56.0 years Sd = 7.7 years |
European | — | UKB | — |
| PSS000861 | Cases included individuals with cirrhosis, biopsy confirmed cirrhosis and/or cirrhosis ascertained through ICD codes:Hospitalization or death due to physician diagnosed cirrhosis: K70.2 (alcoholic fibrosis and sclerosis of the liver), K70.3 (alcoholic cirrhosis), K70.4 (alcoholic hepatic failure), K74.0 (hepatic fibrosis), K74.1 (hepatic sclerosis), K74.2 (hepatic fibrosis with hepatic sclerosis), K74.6 (other and unspecific cirrhosis of liver), K76.6 (portal hypertension), or I85 (esophageal varices). | — | [
|
— | European | — | PHB | — |
| PSS000862 | Cases included individuals with cirrhosis, biopsy confirmed cirrhosis and/or cirrhosis ascertained through ICD codes:Hospitalization or death due to physician diagnosed cirrhosis: K70.2 (alcoholic fibrosis and sclerosis of the liver), K70.3 (alcoholic cirrhosis), K70.4 (alcoholic hepatic failure), K74.0 (hepatic fibrosis), K74.1 (hepatic sclerosis), K74.2 (hepatic fibrosis with hepatic sclerosis), K74.6 (other and unspecific cirrhosis of liver), K76.6 (portal hypertension), or I85 (esophageal varices). | — | [
|
— | NR | — | PHB | — |
| PSS000863 | Cases included individuals with cirrhosis, biopsy confirmed cirrhosis and/or cirrhosis ascertained through ICD codes:Hospitalization or death due to physician diagnosed cirrhosis: K70.2 (alcoholic fibrosis and sclerosis of the liver), K70.3 (alcoholic cirrhosis), K70.4 (alcoholic hepatic failure), K74.0 (hepatic fibrosis), K74.1 (hepatic sclerosis), K74.2 (hepatic fibrosis with hepatic sclerosis), K74.6 (other and unspecific cirrhosis of liver), K76.6 (portal hypertension), or I85 (esophageal varices). | — | [
|
— | NR | — | PHB | — |
| PSS000864 | All individuals had hepatitis B. Cases included individuals cirrhosis, biopsy confirmed cirrhosis and/or cirrhosis ascertained through ICD codes:Hospitalization or death due to physician diagnosed cirrhosis: K70.2 (alcoholic fibrosis and sclerosis of the liver), K70.3 (alcoholic cirrhosis), K70.4 (alcoholic hepatic failure), K74.0 (hepatic fibrosis), K74.1 (hepatic sclerosis), K74.2 (hepatic fibrosis with hepatic sclerosis), K74.6 (other and unspecific cirrhosis of liver), K76.6 (portal hypertension), or I85 (esophageal varices). | — | [
|
— | European | — | PHB | — |
| PSS000865 | All individuals had hepatitis B. Cases included individuals cirrhosis, biopsy confirmed cirrhosis and/or cirrhosis ascertained through ICD codes:Hospitalization or death due to physician diagnosed cirrhosis: K70.2 (alcoholic fibrosis and sclerosis of the liver), K70.3 (alcoholic cirrhosis), K70.4 (alcoholic hepatic failure), K74.0 (hepatic fibrosis), K74.1 (hepatic sclerosis), K74.2 (hepatic fibrosis with hepatic sclerosis), K74.6 (other and unspecific cirrhosis of liver), K76.6 (portal hypertension), or I85 (esophageal varices). | — | [
|
— | European | — | PHB | — |
| PSS000866 | Cases included individuals with cirrhosis, biopsy confirmed cirrhosis and/or cirrhosis ascertained through ICD codes:Hospitalization or death due to physician diagnosed cirrhosis: K70.2 (alcoholic fibrosis and sclerosis of the liver), K70.3 (alcoholic cirrhosis), K70.4 (alcoholic hepatic failure), K74.0 (hepatic fibrosis), K74.1 (hepatic sclerosis), K74.2 (hepatic fibrosis with hepatic sclerosis), K74.6 (other and unspecific cirrhosis of liver), K76.6 (portal hypertension), or I85 (esophageal varices). | — | [
|
— | African unspecified | — | PHB | — |
| PSS008886 | — | — | 3,837 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008887 | — | — | 3,912 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008888 | — | — | 3,852 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS012273 | — | Median = 12.7 years | [ ,
48.1 % Male samples |
Mean = 56.7 years Sd = 7.97 years |
European | — | UKB | — |
| PSS000583 | Case inclusion ICD codes: ICD9=571.5, ICD9=571.8, ICD9=571.9, ICD10=K75.81, ICD10=K76.0, ICD10=K76.9 | — | [ ,
42.6 % Male samples |
— | European | — | eMERGE | — |
| PSS000584 | Controls are cases with Nonalcoholic fatty liver disease activity score <5 and cases are those with a score >5. Case inclusion ICD codes: ICD9=571.5, ICD9=571.8, ICD9=571.9, ICD10=K75.81, ICD10=K76.0, ICD10=K76.9 | — | [
|
— | European | — | eMERGE | — |
| PSS012276 | — | — | [ ,
45.6 % Male samples |
Median = 58.0 years Range = [45.0, 71.0] years |
European | — | UKB | — |
| PSS008437 | — | — | 1,185 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS008438 | — | — | 1,197 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS008439 | — | — | 1,170 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS011182 | — | — | 381,825 individuals | — | European | — | UKB | — |
| PSS013257 | 571.5,K74.0, K74.6 | — | [ ,
44.9 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013258 | 571.5,K74.0, K74.6 | — | [ ,
44.9 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013259 | 571.5,K74.0, K74.6 | — | [ ,
44.9 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013260 | 571.5,K74.0, K74.6 | — | [ ,
44.9 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013261 | 571.5,K74.0, K74.6 | — | [ ,
44.9 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013262 | 571.5, 571.8, 571.9,K74.0, K74.1, K74.2, K74.6, K75.81, K76.0, K76.8 | — | [ ,
45.36 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013263 | 571.5, 571.8, 571.9,K74.0, K74.1, K74.2, K74.6, K75.81, K76.0, K76.8 | — | [ ,
45.36 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013264 | 571.5, 571.8, 571.9,K74.0, K74.1, K74.2, K74.6, K75.81, K76.0, K76.8 | — | [ ,
45.36 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013265 | 571.5, 571.8, 571.9,K74.0, K74.1, K74.2, K74.6, K75.81, K76.0, K76.8 | — | [ ,
45.36 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013266 | 571.5, 571.8, 571.9,K74.0, K74.1, K74.2, K74.6, K75.81, K76.0, K76.8 | — | [ ,
45.36 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013267 | 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 | — | [ ,
45.81 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013268 | 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 | — | [ ,
45.81 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013269 | 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 | — | [ ,
45.81 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013270 | 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 | — | [ ,
45.81 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013271 | 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 | — | [ ,
45.81 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS013277 | 570, 573, 782.4, 789.1, 790.4, 790.5, 794.8, 996.82, V42.7,K71.1, K71.5, K72.00, K72.01, K76, K77, R16.0, R16.2, R17, R74, R94.5, T86.4, Z94.4 | — | [ ,
45.14 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013278 | 570, 573, 782.4, 789.1, 790.4, 790.5, 794.8, 996.82, V42.7,K71.1, K71.5, K72.00, K72.01, K76, K77, R16.0, R16.2, R17, R74, R94.5, T86.4, Z94.4 | — | [ ,
45.14 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013279 | 570, 573, 782.4, 789.1, 790.4, 790.5, 794.8, 996.82, V42.7,K71.1, K71.5, K72.00, K72.01, K76, K77, R16.0, R16.2, R17, R74, R94.5, T86.4, Z94.4 | — | [ ,
45.14 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013280 | 570, 573, 782.4, 789.1, 790.4, 790.5, 794.8, 996.82, V42.7,K71.1, K71.5, K72.00, K72.01, K76, K77, R16.0, R16.2, R17, R74, R94.5, T86.4, Z94.4 | — | [ ,
45.14 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013281 | 570, 573, 782.4, 789.1, 790.4, 790.5, 794.8, 996.82, V42.7,K71.1, K71.5, K72.00, K72.01, K76, K77, R16.0, R16.2, R17, R74, R94.5, T86.4, Z94.4 | — | [ ,
45.14 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013282 | 574.0, 574.1, 574.2,K80 | — | [ ,
45.87 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013283 | 574.0, 574.1, 574.2,K80 | — | [ ,
45.87 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013284 | 574.0, 574.1, 574.2,K80 | — | [ ,
45.87 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013285 | 574.0, 574.1, 574.2,K80 | — | [ ,
45.87 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013286 | 574.0, 574.1, 574.2,K80 | — | [ ,
45.87 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013287 | 574, 575.0, 575.1,K80, K81 | — | [ ,
45.91 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013288 | 574, 575.0, 575.1,K80, K81 | — | [ ,
45.91 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013289 | 574, 575.0, 575.1,K80, K81 | — | [ ,
45.91 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013290 | 574, 575.0, 575.1,K80, K81 | — | [ ,
45.91 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013291 | 574, 575.0, 575.1,K80, K81 | — | [ ,
45.91 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013292 | 575.6,K82.4 | — | [ ,
45.93 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013293 | 575.6,K82.4 | — | [ ,
45.93 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013294 | 575.6,K82.4 | — | [ ,
45.93 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013295 | 575.6,K82.4 | — | [ ,
45.93 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013296 | 575.6,K82.4 | — | [ ,
45.93 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013297 | 575, 576, 793.3,K80.30, K80.31, K80.32, K80.33, K80.34, K80.35, K80.36, K80.37, K82, K83, K87, K91.5, R93.2 | — | [ ,
46.06 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013298 | 575, 576, 793.3,K80.30, K80.31, K80.32, K80.33, K80.34, K80.35, K80.36, K80.37, K82, K83, K87, K91.5, R93.2 | — | [ ,
46.06 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013299 | 575, 576, 793.3,K80.30, K80.31, K80.32, K80.33, K80.34, K80.35, K80.36, K80.37, K82, K83, K87, K91.5, R93.2 | — | [ ,
46.06 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013300 | 575, 576, 793.3,K80.30, K80.31, K80.32, K80.33, K80.34, K80.35, K80.36, K80.37, K82, K83, K87, K91.5, R93.2 | — | [ ,
46.06 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013301 | 575, 576, 793.3,K80.30, K80.31, K80.32, K80.33, K80.34, K80.35, K80.36, K80.37, K82, K83, K87, K91.5, R93.2 | — | [ ,
46.06 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS007998 | — | — | 1,783 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS007999 | — | — | 1,806 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS008000 | — | — | 1,775 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS012321 | 070.2, 070.3,B16, B18.0, B18.1, B19.1 | — | [ ,
46.13 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012322 | 070.2, 070.3,B16, B18.0, B18.1, B19.1 | — | [ ,
46.13 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012323 | 070.2, 070.3,B16, B18.0, B18.1, B19.1 | — | [ ,
46.13 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012324 | 070.2, 070.3,B16, B18.0, B18.1, B19.1 | — | [ ,
46.13 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012325 | 070.2, 070.3,B16, B18.0, B18.1, B19.1 | — | [ ,
46.13 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012326 | 070.2, 070.3,B16, B18.0, B18.1, B19.1 | — | [ ,
46.13 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012337 | 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 | — | [ ,
46.26 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012338 | 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 | — | [ ,
46.26 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012339 | 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 | — | [ ,
46.26 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012340 | 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 | — | [ ,
46.26 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012341 | 070, 571.4, 573.1, 573.2, 573.3,B15.0, B15.9, B16, B17.0, B17.1, B17.2, B17.8, B17.9, B18.0, B18.1, B18.2, B18.8, B18.9, B19, B25.1, K71.0, K71.10, K71.11, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K73, K75.2, K75.3, K75.4, K75.89, K75.9, K76.4 | — | [ ,
46.26 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS007667 | — | — | [ ,
72.3 % Male samples |
— | European | — | GenomALC | — |
| PSS007668 | — | — | [ ,
62.06 % Male samples |
— | European | — | GenomALC | — |
| PSS007669 | — | — | [ ,
77.02 % Male samples |
— | European | — | UKB | — |
| PSS009109 | — | — | 4,060 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS009110 | — | — | 4,121 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS009111 | — | — | 3,998 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS001094 | Cases were individuals with liver disease. Of the 1,699 cases, 1,473 had fatty liver disease (FLD) whilst 226 had hepatocellular carcinoma (HCC). Of the 1,473 individuals with FLD, 297 had severe fibrosis and were therefore classified as being within stage 3-4 of FLD. Severe fibrosis was defined in the presence of histological fibrosis F3-F4 (when liver biopsy was available) or in presence of clinical, endoscopic or radiological signs of portal hypertension or cirrhosis, or liver stiffness ≥8.4 kPa evaluated by Fibroscan. Diagnosis of HCC was based on EASL-EORTC Clinical Practice Guidelines. | — | [ ,
57.76 % Male samples |
— | European | — | NR | Cases were obtained from the Nonalcoholic Fatty Liver Disease (NAFLD) Case-Control Cross-Sectional Cohort. |
| PSS001095 | All individuals had liver disease. Of the 158 cases, 72 had cirrhosis whilst 84 had hepatocellular cancer. Diagnosis of HCC was based on EASL-EORTC Clinical Practice Guidelines | — | [ ,
43.59 % Male samples |
— | Not reported | — | NR | — |
| PSS001096 | Cases were individuals with liver disease. Of the 1,628 cases, 1,426 individuals had cirrhosis whilst 202 had hepatocellular cancer (HCC). Cirrhosis was defined as ICD-10 codes I85.0, I85.9, K70.3, K70.4, K72.1, K74.1, K74.2, K74.6, K76.6, K76.7 using hospitalization records (data-field 41270). HCC was defined by combining International Classification of Diseases, Tenth Revision (ICD-10) code C22.0 from both UK cancer registry (data-field 40006), and hospitalization records (data-field 41270). | — | [ ,
46.22 % Male samples |
— | European | — | UKB | — |
| PSS001097 | Cases were individuals with hepatocellular cancer (HCC). HCC was defined by combining International Classification of Diseases, Tenth Revision (ICD-10) code C22.0 from both UK cancer registry (data-field 40006), and hospitalization records (data-field 41270). | — | [
|
— | European | — | UKB | — |
| PSS001098 | All individuals had a body mass index ≥30. Cases were individuals with hepatocellular cancer (HCC). HCC was defined by combining International Classification of Diseases, Tenth Revision (ICD-10) code C22.0 from both UK cancer registry (data-field 40006), and hospitalization records (data-field 41270). | — | [
|
— | European | — | UKB | — |
| PSS001101 | All individuals had no diagnosis of cirrhosis. Cases were individuals with hepatocellular cancer (HCC). HCC was defined by combining International Classification of Diseases, Tenth Revision (ICD-10) code C22.0 from both UK cancer registry (data-field 40006), and hospitalization records (data-field 41270). | — | [
|
— | European | — | UKB | — |
| PSS001103 | All individuals had type 2 diabetes (T2D). Diabetes was defined as individuals having either of following criteria: 1) self-reported type 2 or unspecified diabetes (codes 1220 and 1223 in data-field 20002); 2) ICD10 diagnoses codes E11 and E14 (data-field 41270); 3) insulin treatment or use of oral glucose lowering drugs (data-fields 6153, 6177 and 20003); 4) serum glucose level ≥11.1 mmol/L (200mg/dL); 5) HbA1c ≥ 48 mmol/mol (6.5%). Cases were individuals with hepatocellular cancer (HCC). HCC was defined by combining International Classification of Diseases, Tenth Revision (ICD-10) code C22.0 from both UK cancer registry (data-field 40006), and hospitalization records (data-field 41270). | — | [
|
— | European | — | UKB | — |
| PSS011674 | — | — | [
|
— | European (Finnish) |
— | Health2000 | — |
| PSS011418 | ICD10: K70.2, K70.3, K70.4, K74.0, K74.1, K74.2, K74.6, K76.6, or I85 | — | [
|
— | European | — | 7 cohorts
|
— |
| PSS004134 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004135 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004136 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004137 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004138 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS004139 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004140 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004141 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004142 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004143 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS012402 | 155.0, V10.07,C22.0, C22.2, C22.3, C22.4, C22.7, C22.8, Z85.05 | — | [ ,
43.78 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012403 | 155.0, V10.07,C22.0, C22.2, C22.3, C22.4, C22.7, C22.8, Z85.05 | — | [ ,
43.78 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012404 | 155.0, V10.07,C22.0, C22.2, C22.3, C22.4, C22.7, C22.8, Z85.05 | — | [ ,
43.78 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012405 | 155.0, V10.07,C22.0, C22.2, C22.3, C22.4, C22.7, C22.8, Z85.05 | — | [ ,
43.78 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012406 | 155.0, V10.07,C22.0, C22.2, C22.3, C22.4, C22.7, C22.8, Z85.05 | — | [ ,
43.78 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012407 | 155, 230.8, V10.07,C22, D01.5, Z85.05 | — | [ ,
43.8 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012408 | 155, 230.8, V10.07,C22, D01.5, Z85.05 | — | [ ,
43.8 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012409 | 155, 230.8, V10.07,C22, D01.5, Z85.05 | — | [ ,
43.8 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012410 | 155, 230.8, V10.07,C22, D01.5, Z85.05 | — | [ ,
43.8 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS012411 | 155, 230.8, V10.07,C22, D01.5, Z85.05 | — | [ ,
43.8 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |