Trait: Alzheimer disease

Trait Information
Identifier MONDO_0004975
Description A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language. [NCIT: P378]
Trait category
Neurological disorder
Synonyms 9 synonyms
  • AD
  • Alzheimer dementia
  • Alzheimer disease
  • Alzheimer disease, familial
  • Alzheimer's dementia
  • Alzheimer's disease
  • Alzheimers dementia
  • Alzheimers disease
  • presenile and senile dementia
Mapped terms 11 mapped terms
  • DOID:10652
  • HP:0002511
  • ICD10CM:G30
  • ICD9:290.1
  • ICD9:331.0
  • MESH:D000544
  • NCIT:C2866
  • NIFSTD:birnlex_2092
  • Orphanet:238616
  • SCTID:142811000119104
  • UMLS:C0002395
Child trait(s) late-onset Alzheimer's disease

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "Alzheimer disease" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000025
(GRS)
PGP000015 |
Chouraki V et al. J Alzheimers Dis (2016)
Alzheimer's disease Alzheimer disease 19
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000025/ScoringFiles/PGS000025.txt.gz
PGS000026
(PHS)
PGP000016 |
Desikan RS et al. PLoS Med (2017)
Alzheimer's disease Alzheimer disease 31
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000026/ScoringFiles/PGS000026.txt.gz
PGS000053
(ALZ21_NIA-LOAD)
PGP000039 |
Tosto G et al. Neurology (2017)
Alzheimer's disease (late onset) late-onset Alzheimer's disease 21
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000053/ScoringFiles/PGS000053.txt.gz
PGS000054
(ALZ21_EFIGA)
PGP000039 |
Tosto G et al. Neurology (2017)
Alzheimer's disease (late onset) late-onset Alzheimer's disease 21
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000054/ScoringFiles/PGS000054.txt.gz
PGS000334
(GRSfull_22)
PGP000101 |
Zhang Q et al. Nat Commun (2020)
Late-onset Alzheimer’s disease late-onset Alzheimer's disease 22
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000334/ScoringFiles/PGS000334.txt.gz
PGS000779
(PGS7_AD)
PGP000183 |
Zhou X et al. Alzheimers Dement (Amst) (2020)
Alzheimer's disease Alzheimer disease 7
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000779/ScoringFiles/PGS000779.txt.gz
PGS000811
(AD-PRS_39)
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Alzheimer's disease Alzheimer disease 39
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000811/ScoringFiles/PGS000811.txt.gz
PGS000812
(AD-PRS_57)
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Alzheimer's disease Alzheimer disease 57
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000812/ScoringFiles/PGS000812.txt.gz
PGS000823
(GRS23_AD)
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Alzheimer's disease Alzheimer disease 23
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000823/ScoringFiles/PGS000823.txt.gz
PGS000876
(PRS31_AD)
PGP000222 |
Leonenko G et al. Ann Clin Transl Neurol (2019)
Alzheimer's disease Alzheimer disease 31
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000876/ScoringFiles/PGS000876.txt.gz
PGS000898
(PRS39_AD)
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Alzheimer's disease Alzheimer disease 40
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000898/ScoringFiles/PGS000898.txt.gz
PGS000945
(GBE_HC710)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Dementia in Alzheimer's disease (time-to-event) dementia,
Alzheimer disease
26
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000945/ScoringFiles/PGS000945.txt.gz
PGS001348
(GBE_HC1584)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Alzheimer's disease (algorithmically-defined) Alzheimer disease 15
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001348/ScoringFiles/PGS001348.txt.gz
PGS001349
(GBE_HC807)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Alzheimer's disease (time-to-event) Alzheimer disease 6
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001349/ScoringFiles/PGS001349.txt.gz
PGS001775
(PRS39_AD)
PGP000255 |
Ebenau JL et al. Alzheimers Dement (Amst) (2021)
Alzheimer's disease Alzheimer disease 39
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001775/ScoringFiles/PGS001775.txt.gz
PGS001828
(portability-PLR_290.11)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Alzheimer's disease Alzheimer disease 38
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001828/ScoringFiles/PGS001828.txt.gz
PGS002249
(AD_PRS_0.5)
PGP000276 |
Lourida I et al. JAMA (2019)
Alzheimer's disease Alzheimer disease 249,273
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002249/ScoringFiles/PGS002249.txt.gz
PGS002280
(GRS83_AD)
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Alzheimer's disease Alzheimer disease 83
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002280/ScoringFiles/PGS002280.txt.gz
PGS002289
(GRS23_AD)
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Late-onset Alzheimer's disease late-onset Alzheimer's disease 23
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002289/ScoringFiles/PGS002289.txt.gz
PGS002731
(oA-PRS)
PGP000339 |
Xicota L et al. Neurology (2022)
Alzheimer's disease Alzheimer disease 17
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002731/ScoringFiles/PGS002731.txt.gz
PGS002753
(Alzheimer_s_disease_prscs)
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Alzheimer's disease Alzheimer disease 1,092,011
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002753/ScoringFiles/PGS002753.txt.gz
PGS003440
(GRS11_nonapoeAD)
PGP000444 |
Petrican R et al. Sci Rep (2023)
Alzheimer's disease in non APOE APOE carrier status,
Alzheimer disease
11
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003440/ScoringFiles/PGS003440.txt.gz
PGS003441
(GRS28_AD)
PGP000444 |
Petrican R et al. Sci Rep (2023)
Alzheimer's disease Alzheimer disease 28
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003441/ScoringFiles/PGS003441.txt.gz
PGS003574
(GRS_Dementia21)
PGP000459 |
Mukadam N et al. PLoS One (2022)
Alzheimer's disease (late onset) Alzheimer disease 21
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003574/ScoringFiles/PGS003574.txt.gz
PGS003953
(AD_Bellenguez)
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 1,937
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003953/ScoringFiles/PGS003953.txt.gz
PGS003954
(AD_FINNGEN)
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 81
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003954/ScoringFiles/PGS003954.txt.gz
PGS003955
(AD_Jun)
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 85
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003955/ScoringFiles/PGS003955.txt.gz
PGS003956
(AD_Kunkle_AFR)
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 157
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003956/ScoringFiles/PGS003956.txt.gz
PGS003957
(AD_Kunkle)
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 12,002
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003957/ScoringFiles/PGS003957.txt.gz
PGS003958
(AD_Unweighted_PRSsum)
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 14,109
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003958/ScoringFiles/PGS003958.txt.gz
PGS003992
(dbslmm.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 1,136,212
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003992/ScoringFiles/PGS003992.txt.gz
PGS004008
(lassosum.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 5,663
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004008/ScoringFiles/PGS004008.txt.gz
PGS004034
(ldpred2.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 1,046,908
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004034/ScoringFiles/PGS004034.txt.gz
PGS004062
(megaprs.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 691,136
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004062/ScoringFiles/PGS004062.txt.gz
PGS004092
(prscs.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 1,109,233
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004092/ScoringFiles/PGS004092.txt.gz
PGS004116
(pt_clump.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 58
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004116/ScoringFiles/PGS004116.txt.gz
PGS004146
(sbayesr.auto.GCST90012877.AD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Alzheimer's disease Alzheimer disease 915,771
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004146/ScoringFiles/PGS004146.txt.gz
PGS004227
(ad_apoe_gw_pgs)
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 15
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004227/ScoringFiles/PGS004227.txt.gz
PGS004228
(ad_apoe_0.1_pgs)
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 8,863
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004228/ScoringFiles/PGS004228.txt.gz
PGS004229
(ad_noapoe_0.1_pgs)
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Alzheimer's disease Alzheimer disease 8,858
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004229/ScoringFiles/PGS004229.txt.gz
PGS004285
(GenoBoost_alzheimer_s_disease_0)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Alzheimer's disease Alzheimer disease 20
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004285/ScoringFiles/PGS004285.txt.gz
PGS004286
(GenoBoost_alzheimer_s_disease_1)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Alzheimer's disease Alzheimer disease 10
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004286/ScoringFiles/PGS004286.txt.gz
PGS004287
(GenoBoost_alzheimer_s_disease_2)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Alzheimer's disease Alzheimer disease 30
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004287/ScoringFiles/PGS004287.txt.gz
PGS004288
(GenoBoost_alzheimer_s_disease_3)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Alzheimer's disease Alzheimer disease 200
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004288/ScoringFiles/PGS004288.txt.gz
PGS004289
(GenoBoost_alzheimer_s_disease_4)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Alzheimer's disease Alzheimer disease 40
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004289/ScoringFiles/PGS004289.txt.gz
PGS004588
(PRS39_Eur)
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Alzheimer's disease Alzheimer disease 39
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004588/ScoringFiles/PGS004588.txt.gz
PGS004589
(PRS80_trans)
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Alzheimer's disease Alzheimer disease 80
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004589/ScoringFiles/PGS004589.txt.gz
PGS004590
(PRS363_rand_eff)
PGP000569 |
Lake J et al. Mol Psychiatry (2023)
Alzheimer's disease Alzheimer disease 363
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004590/ScoringFiles/PGS004590.txt.gz
PGS004600
(PRS_AD83)
PGP000578 |
Tomassen J et al. BMC Neurol (2022)
Alzheimer's disease Alzheimer disease 83
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004600/ScoringFiles/PGS004600.txt.gz
PGS004863
(PRS74_AD)
PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
Alzheimer's disease Alzheimer disease 74
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004863/ScoringFiles/PGS004863.txt.gz
PGS004898
(PRS_AD)
PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
Alzheimer's disease Alzheimer disease 44
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004898/ScoringFiles/PGS004898.txt.gz
PGS004918
(PRS8_Synapse)
PGP000649 |
Lawingco T et al. Neurobiol Aging (2020)
Late-onset Alzheimers disease (based on SNPs in genes involved in synaptic function) late-onset Alzheimer's disease 8
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004918/ScoringFiles/PGS004918.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000051 PGS000025
(GRS)
PSS000034|
European Ancestry|
4,353 individuals
PGP000015 |
Chouraki V et al. J Alzheimers Dis (2016)
Reported Trait: Incident Alzheimer's disease in APOE Ɛ4 carriers HR: 1.24 [1.15, 1.34] ΔC-index between models with and without GRS: 0.0112 [0.0015, 0.0208] age at baseline, sex, education level HRs are derived from a meta-analysis of studies (adjusted for study center, and participant relatedness)
PPM000052 PGS000025
(GRS)
PSS000035|
European Ancestry|
15,334 individuals
PGP000015 |
Chouraki V et al. J Alzheimers Dis (2016)
Reported Trait: Incident Alzheimer's disease in APOE Ɛ4 non-carriers HR: 1.13 [1.08, 1.18] ΔC-index between models with and without GRS: 0.0018 [-0.0003, 0.0039] age at baseline, sex, education level HRs are derived from a meta-analysis of studies (adjusted for study center, and participant relatedness)
PPM000050 PGS000025
(GRS)
PSS000033|
European Ancestry|
19,687 individuals
PGP000015 |
Chouraki V et al. J Alzheimers Dis (2016)
Reported Trait: Incident Alzheimer's disease HR: 1.17 [1.13, 1.21] ΔC-index between models with and without GRS: 0.0043 [0.0019, 0.0067] age at baseline, sex, education level, APOE Ɛ4 status HRs are derived from a meta-analysis of studies (adjusted for study center, and participant relatedness)
PPM000053 PGS000026
(PHS)
PSS000036|
European Ancestry|
17,956 individuals
PGP000016 |
Desikan RS et al. PLoS Med (2017)
Reported Trait: Alzheimer disease r (correlation between between binned quantiles of PHS-predicted and empirical age of AD onset): 0.9 APOE risk alleles (e2 and e4), age, sex, genetic PCs 1-5
PPM002504 PGS000026
(PHS)
PSS001127|
European Ancestry|
8,415 individuals
PGP000222 |
Leonenko G et al. Ann Clin Transl Neurol (2019)
|Ext.
Reported Trait: Age at Alzheimer's disease onset β: 0.11 (0.02) Gender, PCs (1-3), APOE(ε2 + ε4) Due to SNP availability issues in the dataset, only 25 out of the 31 variants in Desikan et al's polygenic hazard score (PGS000026) were used. No APOE alleles were included
PPM014811 PGS000026
(PHS)
PSS009898|
Ancestry Not Reported|
780 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in neocortical region β: 19.98 [14.3, 25.7]
PPM014812 PGS000026
(PHS)
PSS009898|
Ancestry Not Reported|
780 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in posterior cingulate region β: 25.54 [18.4, 32.6]
PPM014814 PGS000026
(PHS)
PSS009900|
Ancestry Not Reported|
278 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in neocortical region (in APOE E4 carriers) β: 25.28 [17.4, 33.2]
PPM014815 PGS000026
(PHS)
PSS009900|
Ancestry Not Reported|
278 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in posterior cingulate region (in APOE E4 carriers) β: 33.06 [23.3, 42.8]
PPM014816 PGS000026
(PHS)
PSS009900|
Ancestry Not Reported|
278 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in frontal cortex region (in APOE E4 carriers) β: 26.63 [18.0, 35.3]
PPM014817 PGS000026
(PHS)
PSS009899|
Ancestry Not Reported|
502 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in neocortical region (in APOE E4 non-carriers) β: 12.61 [3.9, 21.3]
PPM014818 PGS000026
(PHS)
PSS009899|
Ancestry Not Reported|
502 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in posterior cingulate region (in APOE E4 non-carriers) β: 14.28 [3.42, 25.1]
PPM014819 PGS000026
(PHS)
PSS009899|
Ancestry Not Reported|
502 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in frontal cortex region (in APOE E4 non-carriers) β: 13.62 [4.24, 23.0]
PPM014813 PGS000026
(PHS)
PSS009898|
Ancestry Not Reported|
780 individuals
PGP000340 |
Vacher M et al. BMC Genomics (2022)
|Ext.
Reported Trait: Aβ-amyloid deposition in frontal cortex region β: 21.19 [15.0, 27.4]
PPM000137 PGS000053
(ALZ21_NIA-LOAD)
PSS000085|
European Ancestry|
4,792 individuals
PGP000039 |
Tosto G et al. Neurology (2017)
Reported Trait: Alzheimer's disease (age-at-onset) β: -0.7 (0.15) years
PPM000133 PGS000053
(ALZ21_NIA-LOAD)
PSS000085|
European Ancestry|
4,792 individuals
PGP000039 |
Tosto G et al. Neurology (2017)
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) OR: 1.29 [1.21, 1.37] Age, sex
PPM000134 PGS000053
(ALZ21_NIA-LOAD)
PSS000085|
European Ancestry|
4,792 individuals
PGP000039 |
Tosto G et al. Neurology (2017)
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) OR: 1.29 [1.21, 1.38] Age, sex, APOE e4
PPM000138 PGS000054
(ALZ21_EFIGA)
PSS000084|
Hispanic or Latin American Ancestry|
3,324 individuals
PGP000039 |
Tosto G et al. Neurology (2017)
Reported Trait: Alzheimer's disease (age-at-onset) β: -0.86 (0.15) years
PPM000135 PGS000054
(ALZ21_EFIGA)
PSS000084|
Hispanic or Latin American Ancestry|
3,324 individuals
PGP000039 |
Tosto G et al. Neurology (2017)
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) OR: 1.73 [1.57, 1.93] Age, sex
PPM000136 PGS000054
(ALZ21_EFIGA)
PSS000084|
Hispanic or Latin American Ancestry|
3,324 individuals
PGP000039 |
Tosto G et al. Neurology (2017)
Reported Trait: Familial late-onset Alzheimer's disease (LOAD) OR: 1.71 [1.55, 1.9] Age, sex, APOE e4
PPM000901 PGS000334
(GRSfull_22)
PSS000449|
European Ancestry|
3,810 individuals
PGP000101 |
Zhang Q et al. Nat Commun (2020)
Reported Trait: Late-onset Alzheimer’s disease : 0.191 [0.131, 0.269] R2 = variance explained on the liability scale
PPM002022 PGS000779
(PGS7_AD)
PSS001005|
East Asian Ancestry|
112 individuals
PGP000183 |
Zhou X et al. Alzheimers Dement (Amst) (2020)
Reported Trait: Alzheimer's disease AUROC: 0.612 Beta (β, top 33.3% vs bottom 33.3%): 1.485 (0.602) Age, sex
PPM002023 PGS000779
(PGS7_AD)
PSS001006|
European Ancestry|
2,696 individuals
PGP000183 |
Zhou X et al. Alzheimers Dement (Amst) (2020)
Reported Trait: Alzheimer's disease AUROC: 0.717 Beta (β, top 33.3% vs bottom 33.3%): 2.283 (1.021) Age, sex, PCs(1-5)
PPM002140 PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriers HR: 1.22 [1.1, 1.35] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002143 PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriers aged between 70 and 94 HR: 1.16 [1.01, 1.34] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002144 PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriers aged 95 years or above HR: 1.28 [1.1, 1.5] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002145 PGS000811
(AD-PRS_39)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 carriers aged 95 years or above HR: 0.62 [0.41, 0.95] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002141 PGS000812
(AD-PRS_57)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia HR: 1.09 [1.01, 1.19] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002142 PGS000812
(AD-PRS_57)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in APOE ɛ4 non-carriers HR: 1.15 [1.05, 1.27] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002146 PGS000812
(AD-PRS_57)
PSS001052|
European Ancestry|
2,052 individuals
PGP000196 |
Najar J et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Incident dementia in individuals aged 95 or above HR: 1.15 [1.01, 1.32] Age at blood sampling, birth year, sex, PCs(1-10)
PPM002216 PGS000823
(GRS23_AD)
PSS001080|
European Ancestry|
12,255 individuals
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Reported Trait: Incident dementia at age 85 in individuals homozygous for APOE ε4 Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.00022 Mortality
PPM002218 PGS000823
(GRS23_AD)
PSS001080|
European Ancestry|
12,255 individuals
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Reported Trait: Incident dementia at age 90 Cumulative risk p-value (top 33.3% vs bottom 33.3%): 5.20e-13 Mortality
PPM002219 PGS000823
(GRS23_AD)
PSS001081|
European Ancestry|
12,978 individuals
PGP000208 |
Riaz M et al. Aging Cell (2021)
|Ext.
Reported Trait: Incident all-cause dementia Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.76] Age at enrolment, sex
PPM002220 PGS000823
(GRS23_AD)
PSS001081|
European Ancestry|
12,978 individuals
PGP000208 |
Riaz M et al. Aging Cell (2021)
|Ext.
Reported Trait: Incident all-cause dementia Hazard Ratio (HR, top 33.3% vs bottom 33.3%): 1.36 [1.04, 1.77] Age at enrolment, sex, competing risk of death
PPM002215 PGS000823
(GRS23_AD)
PSS001080|
European Ancestry|
12,255 individuals
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Reported Trait: Incident Alzheimer's disease at age 80 in individuals homozygous for APOE ε4 Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.0056 Non-Alzheimer's disease dementia, mortality
PPM002217 PGS000823
(GRS23_AD)
PSS001080|
European Ancestry|
12,255 individuals
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Reported Trait: Incident Alzheimer's disease at age 85 Cumulative risk p-value (top 33.3% vs bottom 33.3%): 7.90e-14 Non-Alzheimer's disease dementia, mortality
PPM002214 PGS000823
(GRS23_AD)
PSS001080|
European Ancestry|
12,255 individuals
PGP000207 |
van der Lee SJ et al. Lancet Neurol (2018)
Reported Trait: Incident Alzheimer's disease at age 85 in individuals homozygous for APOE ε4 Cumulative risk p-value (top 33.3% vs bottom 33.3%): 0.0085 Non-Alzheimer's disease dementia, mortality
PPM002505 PGS000876
(PRS31_AD)
PSS001127|
European Ancestry|
8,415 individuals
PGP000222 |
Leonenko G et al. Ann Clin Transl Neurol (2019)
Reported Trait: Age at Alzheimer's disease onset β: 0.13 (0.02) Gender, PCs (1-3), APOE(ε2 + ε4) Due to SNP availability issues in the dataset, only 25 out of the 31 variants used to construct the polygenic risk score were used.
PPM002506 PGS000876
(PRS31_AD)
PSS001125|
European Ancestry|
9,903 individuals
PGP000222 |
Leonenko G et al. Ann Clin Transl Neurol (2019)
Reported Trait: Age at Alzheimer's disease onset β: 0.28 (0.04) Gender, PCs (1-3), APOE ε2, APOE ε4
PPM002507 PGS000876
(PRS31_AD)
PSS001126|
European Ancestry|
4,100 individuals
PGP000222 |
Leonenko G et al. Ann Clin Transl Neurol (2019)
Reported Trait: Age at Alzheimer's disease onset in individuals above the age of 55 β: 0.29 (0.03) Gender, PCs (1-3), APOE ε2, APOE ε4
PPM002634 PGS000898
(PRS39_AD)
PSS001167|
European Ancestry|
2,394 individuals
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Reported Trait: Alzheimer's disease (clinically confirmed) OR: 1.3 [1.18, 1.44] PCs(1-4)
PPM002635 PGS000898
(PRS39_AD)
PSS001167|
European Ancestry|
2,394 individuals
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Reported Trait: Alzheimer's disease (pathologically confirmed) OR: 1.38 [1.21, 1.58] PCs(1-4)
PPM002636 PGS000898
(PRS39_AD)
PSS001167|
European Ancestry|
2,394 individuals
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Reported Trait: Alzheimer's disease (pathologically confirmed, males) OR: 1.33 [1.13, 1.56] PCs(1-4)
PPM002637 PGS000898
(PRS39_AD)
PSS001167|
European Ancestry|
2,394 individuals
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Reported Trait: Alzheimer's disease (pathologically confirmed, females) OR: 1.32 [1.19, 1.47] PCs(1-4)
PPM002638 PGS000898
(PRS39_AD)
PSS001167|
European Ancestry|
2,394 individuals
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Reported Trait: Early-onset Alzheimer's disease (< 65 years) OR: 1.58 [1.22, 2.05] PCs(1-4)
PPM002639 PGS000898
(PRS39_AD)
PSS001167|
European Ancestry|
2,394 individuals
PGP000231 |
de Rojas I et al. Nat Commun (2021)
Reported Trait: Late-onset Alzheimer's disease (> 85 years) OR: 1.29 [1.1, 1.51] PCs(1-4)
PPM007551 PGS000945
(GBE_HC710)
PSS004614|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.98515 [0.97381, 0.9965] : 0.33632
Incremental AUROC (full-covars): 0.00807
PGS R2 (no covariates): 0.02667
PGS AUROC (no covariates): 0.7414 [0.59579, 0.88702]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007552 PGS000945
(GBE_HC710)
PSS004615|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.8807 [0.81377, 0.94763] : 0.16889
Incremental AUROC (full-covars): 0.0235
PGS R2 (no covariates): 0.04331
PGS AUROC (no covariates): 0.66609 [0.55451, 0.77766]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007553 PGS000945
(GBE_HC710)
PSS004616|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.9584 [0.92052, 0.99629] : 0.25982
Incremental AUROC (full-covars): 0.0131
PGS R2 (no covariates): 0.0675
PGS AUROC (no covariates): 0.67849 [0.36185, 0.99513]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007554 PGS000945
(GBE_HC710)
PSS004617|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE dementia in alzheimer's disease AUROC: 0.8916 [0.86249, 0.9207] : 0.16679
Incremental AUROC (full-covars): 0.05458
PGS R2 (no covariates): 0.06543
PGS AUROC (no covariates): 0.75273 [0.69847, 0.80699]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009221 PGS001348
(GBE_HC1584)
PSS004307|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD alzheimer's disease AUROC: 0.96694 [0.94819, 0.98568] : 0.31464
Incremental AUROC (full-covars): 0.01598
PGS R2 (no covariates): 0.04322
PGS AUROC (no covariates): 0.69389 [0.49462, 0.89316]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009222 PGS001348
(GBE_HC1584)
PSS004309|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD alzheimer's disease AUROC: 0.8626 [0.81314, 0.91206] : 0.15552
Incremental AUROC (full-covars): 0.03113
PGS R2 (no covariates): 0.05179
PGS AUROC (no covariates): 0.66389 [0.57085, 0.75693]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009223 PGS001348
(GBE_HC1584)
PSS004310|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD alzheimer's disease AUROC: 0.91522 [0.82612, 1.0] : 0.23563
Incremental AUROC (full-covars): 0.0091
PGS R2 (no covariates): 0.01731
PGS AUROC (no covariates): 0.59348 [0.39906, 0.7879]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009224 PGS001348
(GBE_HC1584)
PSS004311|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD alzheimer's disease AUROC: 0.8686 [0.84242, 0.89478] : 0.1517
Incremental AUROC (full-covars): 0.05292
PGS R2 (no covariates): 0.05685
PGS AUROC (no covariates): 0.72349 [0.67813, 0.76886]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009225 PGS001349
(GBE_HC807)
PSS004632|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE alzheimer's disease AUROC: 0.96248 [0.93046, 0.9945] : 0.31063
Incremental AUROC (full-covars): 0.00757
PGS R2 (no covariates): 0.03204
PGS AUROC (no covariates): 0.63583 [0.42385, 0.84781]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009226 PGS001349
(GBE_HC807)
PSS004634|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE alzheimer's disease AUROC: 0.86841 [0.82079, 0.91602] : 0.16057
Incremental AUROC (full-covars): 0.03323
PGS R2 (no covariates): 0.05188
PGS AUROC (no covariates): 0.67961 [0.58969, 0.76952]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009227 PGS001349
(GBE_HC807)
PSS004635|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE alzheimer's disease AUROC: 0.9136 [0.8364, 0.9908] : 0.24293
Incremental AUROC (full-covars): 0.00891
PGS R2 (no covariates): 0.01019
PGS AUROC (no covariates): 0.53145 [0.34417, 0.71873]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009228 PGS001349
(GBE_HC807)
PSS004636|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE alzheimer's disease AUROC: 0.8666 [0.84246, 0.89075] : 0.15418
Incremental AUROC (full-covars): 0.04665
PGS R2 (no covariates): 0.05271
PGS AUROC (no covariates): 0.71238 [0.66844, 0.75632]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009238 PGS001775
(PRS39_AD)
PSS007663|
European Ancestry|
532 individuals
PGP000255 |
Ebenau JL et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Other dementia (excluding all-type dementia and Alzheimer's disease) HR: 0.5 [0.3, 0.9] Age, sex, population substructure, Mini-Mental State Examination (predictor: APOE ε4 allele or normalized PRS, outcome: clinical progression to dementia)
PPM009237 PGS001775
(PRS39_AD)
PSS007663|
European Ancestry|
532 individuals
PGP000255 |
Ebenau JL et al. Alzheimers Dement (Amst) (2021)
Reported Trait: Alzheimer's disease dementia HR: 1.7 [1.1, 2.8] Age, sex, population substructure, Mini-Mental State Examination (predictor: APOE ε4 allele or normalized PRS, outcome: clinical progression to dementia)
PPM009517 PGS001828
(portability-PLR_290.11)
PSS009298|
European Ancestry|
19,563 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.0482 [0.0342, 0.0622] sex, age, birth date, deprivation index, 16 PCs
PPM009519 PGS001828
(portability-PLR_290.11)
PSS008626|
European Ancestry|
6,544 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.0354 [0.0111, 0.0596] sex, age, birth date, deprivation index, 16 PCs
PPM009520 PGS001828
(portability-PLR_290.11)
PSS008400|
Greater Middle Eastern Ancestry|
1,183 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.0684 [0.011, 0.1254] sex, age, birth date, deprivation index, 16 PCs
PPM009521 PGS001828
(portability-PLR_290.11)
PSS008180|
South Asian Ancestry|
6,205 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.0283 [0.0034, 0.0532] sex, age, birth date, deprivation index, 16 PCs
PPM009522 PGS001828
(portability-PLR_290.11)
PSS007965|
East Asian Ancestry|
1,802 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.045 [-0.0015, 0.0912] sex, age, birth date, deprivation index, 16 PCs
PPM009523 PGS001828
(portability-PLR_290.11)
PSS007746|
African Ancestry|
2,429 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.0414 [0.0015, 0.0812] sex, age, birth date, deprivation index, 16 PCs
PPM009524 PGS001828
(portability-PLR_290.11)
PSS008850|
African Ancestry|
3,836 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): 0.0338 [0.002, 0.0654] sex, age, birth date, deprivation index, 16 PCs
PPM009518 PGS001828
(portability-PLR_290.11)
PSS009072|
European Ancestry|
4,062 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease Partial Correlation (partial-r): -0.0098 [-0.0406, 0.021] sex, age, birth date, deprivation index, 16 PCs
PPM012797 PGS002249
(AD_PRS_0.5)
PSS009559|
European Ancestry|
196,383 individuals
PGP000276 |
Lourida I et al. JAMA (2019)
Reported Trait: Incident dementia Hazard Ratio (HR, high vs. low genetic risk): 1.91 [1.64, 2.23] Age, sex, education, socioeconomic status, relatedness, number of alleles, weighted lifestyle categories
PPM012798 PGS002249
(AD_PRS_0.5)
PSS009559|
European Ancestry|
196,383 individuals
PGP000276 |
Lourida I et al. JAMA (2019)
Reported Trait: Incident dementia in individuals with high genetic risk Incidence (%): 1.23 [1.13, 1.35]
Incidence (%, individuals with unfavourable lifestyle): 1.78 [1.38, 2.28]
Incidence (%, individuals with favourable lifestyle): 1.13 [1.01, 1.26]
PPM020316 PGS002249
(AD_PRS_0.5)
PSS011330|
European Ancestry|
196,368 individuals
PGP000543 |
Klee M et al. Am J Prev Med (2023)
|Ext.
Reported Trait: Incident dementia with area-level socioeconomic deprivation Hazard ratio (HR, high deprivation and PRS in top quintile vs. low-moderate deprivation and PRS in bottom quintile): 2.31 [1.84, 2.91] 20 first PCs, third-degree relatedness, number of alleles used to compute PRS, age, sex, education, marital status, healthy lifestyle, depressive symptoms in the last 2 weeks, individual-level deprivation
PPM020317 PGS002249
(AD_PRS_0.5)
PSS011330|
European Ancestry|
196,368 individuals
PGP000543 |
Klee M et al. Am J Prev Med (2023)
|Ext.
Reported Trait: Incident dementia with individual-level socioeconomic deprivation Hazard ratio (HR, high deprivation and PRS in top quintile vs. low-moderate deprivation and PRS in bottom quintile): 4.06 [2.63, 6.26] 20 first PCs, third-degree relatedness, number of alleles used to compute PRS, age, sex, education, marital status, healthy lifestyle, depressive symptoms in the last 2 weeks, area-level deprivation
PPM020431 PGS002249
(AD_PRS_0.5)
PSS011359|
European Ancestry|
60,298 individuals
PGP000556 |
Shannon OM et al. BMC Med (2023)
|Ext.
Reported Trait: Dementia Hazard ratio (HR, top vs bottom PRS quintile): 1.224 [1.102, 1.36]
PPM020432 PGS002249
(AD_PRS_0.5)
PSS011359|
European Ancestry|
60,298 individuals
PGP000556 |
Shannon OM et al. BMC Med (2023)
|Ext.
Reported Trait: Dementia x MedDiet adherence (MEDAS score) interaction HR: 1.042 [1.003, 1.082]
PPM012966 PGS002280
(GRS83_AD)
PSS009635|
European Ancestry|
17,545 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease HR: 1.076 [1.064, 1.088] Hazard Ratio (HR; highest vs. lowest decile): 1.93 [1.75, 2.13] Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components Fixed-effect meta-analysis
PPM012967 PGS002280
(GRS83_AD)
PSS009634|
European Ancestry|
4,114 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease (in mild cognitive impairment) HR: 1.056 [1.04, 1.072] Hazard Ratio (HR; highest vs. lowest decile): 1.63 [1.42, 1.87] Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components Fixed-effect meta-analysis
PPM012968 PGS002280
(GRS83_AD)
PSS009635|
European Ancestry|
17,545 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease within 5 years NRI (net reclassification improvement): 0.248 [0.159, 0.336]
Delta C-index: 0.002 [0.0004, 0.004]
Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components Fixed-effect meta-analysis
PPM012969 PGS002280
(GRS83_AD)
PSS009635|
European Ancestry|
17,545 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease within 3 years (in mild cognitive impairment) NRI (net reclassification improvement): 0.232 [0.14, 0.325]
Delta C-index: 0.007 [0.001, 0.012]
Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal components Fixed-effect meta-analysis
PPM012991 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 1 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.3
PPM012992 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) no. of incorrect in person round 1 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.4
PPM012993 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) time to complete online round 1 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 3.5
PPM012994 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 2 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.5
PPM012995 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Numeric memory (short-term memory and attention) no. of correct online x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 8.8
PPM012996 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Symbol digit substitution (processing speed) no. of correct in person x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.8
PPM012997 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Symbol digit substitution (processing speed) no. attempted in person x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.7
PPM012998 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Symbol digit substitution (processing speed) time to complete 10 substitutions online x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.5
PPM012999 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Symbol digit substitution (processing speed) no. of correct online x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.4
PPM013000 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Symbol digit substitution (processing speed) no. attempted online x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.0
PPM012988 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) no. of correct online round 1 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 11.5
PPM012989 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 1 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 7.9
PPM012990 PGS002289
(GRS23_AD)
PSS009642|
European Ancestry|
497,087 individuals
PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 2 x age interaction Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 9.4
PPM014809 PGS002731
(oA-PRS)
PSS009897|
Ancestry Not Reported|
228 individuals
PGP000339 |
Xicota L et al. Neurology (2022)
Reported Trait: Amyloid burden OR: 3.38 [1.02, 11.63]
PPM014810 PGS002731
(oA-PRS)
PSS009897|
Ancestry Not Reported|
228 individuals
PGP000339 |
Xicota L et al. Neurology (2022)
Reported Trait: Amyloid burden in E4 carriers OR: 44.94 [3.03, 1277.0]
PPM014953 PGS002753
(Alzheimer_s_disease_prscs)
PSS009939|
European Ancestry|
39,444 individuals
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Reported Trait: Alzheimer's disease OR: 1.64 [1.5, 1.79] age, sex, 10 PCs, technical covariates
PPM017176 PGS003440
(GRS11_nonapoeAD)
PSS010155|
Ancestry Not Reported|
117 individuals
PGP000444 |
Petrican R et al. Sci Rep (2023)
Reported Trait: Fluid cognition via cortical thickness in adoptees β: 0.008 (0.005)
PPM017177 PGS003440
(GRS11_nonapoeAD)
PSS010156|
Ancestry Not Reported|
4,382 individuals
PGP000444 |
Petrican R et al. Sci Rep (2023)
Reported Trait: Fluid cognition via cortical thickness in non-adoptees β: 0.0001 (0.001)
PPM017178 PGS003441
(GRS28_AD)
PSS010155|
Ancestry Not Reported|
117 individuals
PGP000444 |
Petrican R et al. Sci Rep (2023)
Reported Trait: Fluid cognition via cortical thickness in adoptees β: 0.011 (0.006)
PPM017179 PGS003441
(GRS28_AD)
PSS010156|
Ancestry Not Reported|
4,382 individuals
PGP000444 |
Petrican R et al. Sci Rep (2023)
Reported Trait: Fluid cognition via cortical thickness in non-adoptees β: -0.001 (0.001)
PPM018176 PGS003574
(GRS_Dementia21)
PSS010944|
Multi-ancestry (including European)|
378,471 individuals
PGP000459 |
Mukadam N et al. PLoS One (2022)
Reported Trait: Dementia OR: 1.21 [1.18, 1.24] age, sex, ethnic group, PRS*ethnicity Excluding APOE variants
PPM018175 PGS003574
(GRS_Dementia21)
PSS010944|
Multi-ancestry (including European)|
378,471 individuals
PGP000459 |
Mukadam N et al. PLoS One (2022)
Reported Trait: Dementia OR: 1.73 [1.69, 1.77] age, sex, ethnic group, PRS*ethnicity
PPM019088 PGS003953
(AD_Bellenguez)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment OR: 1.06 [0.96, 1.18] age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts
PPM019090 PGS003953
(AD_Bellenguez)
PSS011179|
Multi-ancestry (including European)|
23,157 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment (with Alzheimer's disease) OR: 1.13 (0.04) two SNPs defining the APOE alleles
PPM019084 PGS003954
(AD_FINNGEN)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment OR: 1.19 [1.06, 1.33] age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts
PPM019085 PGS003955
(AD_Jun)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment OR: 1.15 [1.01, 1.31] age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts
PPM019092 PGS003955
(AD_Jun)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Cognititve function (G-Factor change) β: -0.03 [-0.06, -0.01]
PPM019094 PGS003955
(AD_Jun)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Cognititve function (SEVLT recall change) β: -0.09 [-0.17, -0.01]
PPM019087 PGS003956
(AD_Kunkle_AFR)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment OR: 1.14 [1.02, 1.28] age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts
PPM019096 PGS003956
(AD_Kunkle_AFR)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Cognititve function (SEVLT recall change) β: -0.08 [-0.17, 0.0]
PPM019086 PGS003957
(AD_Kunkle)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment OR: 1.34 [1.05, 1.71] age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts
PPM019095 PGS003957
(AD_Kunkle)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Cognititve function (SEVLT recall change) β: -0.2 [-0.4, 0.0]
PPM019089 PGS003958
(AD_Unweighted_PRSsum)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Mild cognitive impairment OR: 1.28 [1.12, 1.46] age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL‑INCA visit, sex, study center, 5 principal components, and APOE‑E4 and APOE‑E2 allele counts
PPM019091 PGS003958
(AD_Unweighted_PRSsum)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Cognititve function (SEVLT recall change) β: -0.13 [-0.24, -0.02] APOE alleles
PPM019093 PGS003958
(AD_Unweighted_PRSsum)
PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
Reported Trait: Cognititve function (G-Factor change) β: -0.04 [-0.06, -0.01]
PPM019922 PGS003992
(dbslmm.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.36764
β: 0.31309
AUROC: 0.59 0 beta = log(or)/sd_pgs
PPM019923 PGS003992
(dbslmm.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.33446
β: 0.28853
AUROC: 0.58 0 beta = log(or)/sd_pgs
PPM019924 PGS003992
(dbslmm.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.59974
β: 0.46984
AUROC: 0.63 0 beta = log(or)/sd_pgs
PPM019937 PGS004008
(lassosum.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.42671
β: 0.35537
AUROC: 0.6 0 beta = log(or)/sd_pgs
PPM019938 PGS004008
(lassosum.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.48397
β: 0.39472
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019939 PGS004008
(lassosum.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.73288
β: 0.54979
AUROC: 0.66 0 beta = log(or)/sd_pgs
PPM019928 PGS004034
(ldpred2.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.45859
β: 0.37747
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019929 PGS004034
(ldpred2.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.5321
β: 0.42664
AUROC: 0.62 0 beta = log(or)/sd_pgs
PPM019930 PGS004034
(ldpred2.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.78882
β: 0.58156
AUROC: 0.67 0 beta = log(or)/sd_pgs
PPM019931 PGS004062
(megaprs.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.46172
β: 0.37961
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019933 PGS004062
(megaprs.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.73895
β: 0.55328
AUROC: 0.66 0 beta = log(or)/sd_pgs
PPM019932 PGS004062
(megaprs.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.48022
β: 0.39219
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019934 PGS004092
(prscs.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.50751
β: 0.41046
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019935 PGS004092
(prscs.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.48977
β: 0.39862
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019936 PGS004092
(prscs.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.77852
β: 0.57578
AUROC: 0.66 0 beta = log(or)/sd_pgs
PPM019919 PGS004116
(pt_clump.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.27295
β: 0.24134
AUROC: 0.57 0 beta = log(or)/sd_pgs
PPM019920 PGS004116
(pt_clump.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.2393
β: 0.21454
AUROC: 0.56 0 beta = log(or)/sd_pgs
PPM019921 PGS004116
(pt_clump.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.44592
β: 0.36875
AUROC: 0.6 0 beta = log(or)/sd_pgs
PPM019927 PGS004146
(sbayesr.auto.GCST90012877.AD)
PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.79245
β: 0.58358
AUROC: 0.67 0 beta = log(or)/sd_pgs
PPM019925 PGS004146
(sbayesr.auto.GCST90012877.AD)
PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.48544
β: 0.39571
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019926 PGS004146
(sbayesr.auto.GCST90012877.AD)
PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: AD OR: 1.52213
β: 0.42011
AUROC: 0.62 0 beta = log(or)/sd_pgs
PPM020218 PGS004227
(ad_apoe_gw_pgs)
PSS011307|
Ancestry Not Reported|
1,638 individuals
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Reported Trait: Alzheimer's disease biomarker (1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1) β: -0.06101 [-0.108607308, -0.013407489]
PPM020220 PGS004227
(ad_apoe_gw_pgs)
PSS011307|
Ancestry Not Reported|
1,638 individuals
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Reported Trait: Alzheimer's disease biomarker (palmitoyl-myristoyl-glycerol (16:0/14:0) [1]) β: -0.0502 [-0.098164771, -0.002232543]
PPM020219 PGS004227
(ad_apoe_gw_pgs)
PSS011307|
Ancestry Not Reported|
1,638 individuals
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Reported Trait: Alzheimer's disease biomarker (palmitoyl-palmitoyl-glycerol (16:0/16:0) [1]) β: -0.0559 [-0.103719741, -0.008088708]
PPM020221 PGS004228
(ad_apoe_0.1_pgs)
PSS011307|
Ancestry Not Reported|
1,638 individuals
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Reported Trait: Alzheimer's disease biomarker (docosapentaenoate (DPA; 22:5n3)) β: -0.05808 [-0.106496039, -0.009669554]
PPM020223 PGS004229
(ad_noapoe_0.1_pgs)
PSS011307|
Ancestry Not Reported|
1,638 individuals
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Reported Trait: Alzheimer's disease biomarker (linolenate (18:3n3 or 3n6)) β: -0.05431 [-0.103025695, -0.005590157]
PPM020222 PGS004229
(ad_noapoe_0.1_pgs)
PSS011307|
Ancestry Not Reported|
1,638 individuals
PGP000527 |
Green RE et al. Alzheimers Res Ther (2023)
Reported Trait: Alzheimer's disease biomarker (docosapentaenoate (DPA; 22:5n3)) β: -0.07733 [-0.125825807, -0.028839878]
PPM020353 PGS004285
(GenoBoost_alzheimer_s_disease_0)
PSS011336|
European Ancestry|
67,428 individuals
PGP000546 |
Ohta R et al. Nat Commun (2024)
Reported Trait: Alzheimer's disease AUROC: 0.8336 Covariate-adjusted pseudo-R2: 0.0421
AUPRC: 0.8336
age, sex, PC1-10
PPM020354 PGS004286
(GenoBoost_alzheimer_s_disease_1)
PSS011336|
European Ancestry|
67,428 individuals
PGP000546 |
Ohta R et al. Nat Commun (2024)
Reported Trait: Alzheimer's disease AUROC: 0.8321 Covariate-adjusted pseudo-R2: 0.04019
AUPRC: 0.8321
age, sex, PC1-10
PPM020355 PGS004287
(GenoBoost_alzheimer_s_disease_2)
PSS011336|
European Ancestry|
67,428 individuals
PGP000546 |
Ohta R et al. Nat Commun (2024)
Reported Trait: Alzheimer's disease AUROC: 0.83179 Covariate-adjusted pseudo-R2: 0.04182
AUPRC: 0.83179
age, sex, PC1-10
PPM020356 PGS004288
(GenoBoost_alzheimer_s_disease_3)
PSS011336|
European Ancestry|
67,428 individuals
PGP000546 |
Ohta R et al. Nat Commun (2024)
Reported Trait: Alzheimer's disease AUROC: 0.83004 Covariate-adjusted pseudo-R2: 0.03836
AUPRC: 0.83004
age, sex, PC1-10
PPM020357 PGS004289
(GenoBoost_alzheimer_s_disease_4)
PSS011336|
European Ancestry|
67,428 individuals
PGP000546 |
Ohta R et al. Nat Commun (2024)
Reported Trait: Alzheimer's disease AUROC: 0.83162 Covariate-adjusted pseudo-R2: 0.04076
AUPRC: 0.83162
age, sex, PC1-10
PPM020711 PGS004588
(PRS39_Eur)
PSS011377|
East Asian Ancestry|
379 individuals
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Reported Trait: Alzheimer's disease dementia OR: 1.85 [1.05, 3.32] Sex, age, education year, 4 PCs, APOE ε4 status
PPM020712 PGS004589
(PRS80_trans)
PSS011377|
East Asian Ancestry|
379 individuals
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Reported Trait: Alzheimer's disease dementia OR: 2.09 [1.09, 4.04] Sex, age, education year, 4 PCs, APOE ε4 status
PPM020719 PGS004590
(PRS363_rand_eff)
PSS011381|
Multi-ancestry (including European)|
368 individuals
PGP000569 |
Lake J et al. Mol Psychiatry (2023)
Reported Trait: Alzheimer's disease AUROC: 0.68 : 0.0044 Age, sex, 5 PCs
PPM020755 PGS004600
(PRS_AD83)
PSS011392|
European Ancestry|
276 individuals
PGP000578 |
Tomassen J et al. BMC Neurol (2022)
Reported Trait: Memory function over time β: -0.04 (0.01) age, sex, center, education
PPM020756 PGS004600
(PRS_AD83)
PSS011392|
European Ancestry|
276 individuals
PGP000578 |
Tomassen J et al. BMC Neurol (2022)
Reported Trait: Positive amyloid-beta status OR: 1.43 [1.02, 2.0] age, sex, center, education
PPM021094 PGS004863
(PRS74_AD)
PSS011524|
East Asian Ancestry|
528 individuals
PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
Reported Trait: Cortical amyloid positivity OR: 1.186 [0.992, 1.418] AUROC: 0.751 [0.705, 0.796] APOE haplotype, age, sex, 3 PCs
PPM021095 PGS004863
(PRS74_AD)
PSS011525|
East Asian Ancestry|
696 individuals
PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
Reported Trait: Clinical Dementia Rating global score ≥ 1 OR: 1.04 [0.871, 1.243] AUROC: 0.637 [0.586, 0.689] APOE haplotype, age, sex, 3 PCs
PPM021096 PGS004863
(PRS74_AD)
PSS011522|
South Asian Ancestry|
718 individuals
PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
Reported Trait: All-cause dementia OR: 1.11 [0.94, 1.33] AUROC: 0.69 [0.62, 0.76] APOE haplotype, age, sex, 3 PCs
PPM021097 PGS004863
(PRS74_AD)
PSS011523|
East Asian Ancestry|
2,000 individuals
PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
Reported Trait: Alzheimer's disease or mild cognitive impairment OR: 1.12 AUROC: 0.625 [0.601, 0.65] APOE haplotype, age, sex, 3 PCs
PPM021098 PGS004863
(PRS74_AD)
PSS011526|
European Ancestry|
229,265 individuals
PGP000609 |
Sleiman PM et al. Alzheimers Dement (2023)
Reported Trait: Alzheimer's disease or dementia OR: 1.003 [0.99, 1.007] AUROC: 0.746 [0.738, 0.754] APOE haplotype, age, sex, 3 PCs
PPM021281 PGS004898
(PRS_AD)
PSS011676|
European Ancestry|
1,135 individuals
PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
Reported Trait: Immediate learning β: -0.07 [-0.12, -0.02] Sex, years of education, testing practice effects
PPM021282 PGS004898
(PRS_AD)
PSS011676|
European Ancestry|
1,135 individuals
PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
Reported Trait: Delayed recall β: -0.07 [-0.12, -0.02] Sex, years of education, testing practice effects
PPM021283 PGS004898
(PRS_AD)
PSS011676|
European Ancestry|
1,135 individuals
PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
Reported Trait: Executive function β: -0.06 [-0.11, -0.01] Sex, years of education, testing practice effects
PPM021284 PGS004898
(PRS_AD)
PSS011676|
European Ancestry|
1,135 individuals
PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
Reported Trait: Preclinical Alzheimer Cognitive Composite (PACC3) β: -0.08 [-0.13, -0.04] Sex, years of education, testing practice effects
PPM021384 PGS004918
(PRS8_Synapse)
PSS011719|
European Ancestry|
136 individuals
PGP000649 |
Lawingco T et al. Neurobiol Aging (2020)
Reported Trait: Late-onset Alzheimer's disease AUROC: 0.731

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011381
[
  • 281 cases
  • , 87 controls
]
European, Native American, African unspecified TANGL
PSS007746 2,429 individuals African American or Afro-Caribbean Carribean UKB
PSS008400 1,183 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009298 19,563 individuals European UK (+ Ireland) UKB
PSS000084 EFIGA recruited patients from families multiply affected by LOAD, but of Caribbean Hispanic ancestry from the Dominican Republic and New York. Families were recruited after confirming diagnoses in the probands. Family members with dementia were also interviewed and neurologically evaluated. Clinical diagnoses were made in a consensus diagnostic conference by a panel of neurologists, neuropsychologists, and psychiatrists. Detailed description is available elsewhere.14 For these family-based studies, we included data from families for which their members (1) were 60 years or older at the time of enrollment; (2) had a diagnosis of probable or possible LOAD according to National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association (NINDS-ADRDA) criteria; (3) had available pedigree information and covariates.
[
  • 2,155 cases
  • , 1,169 controls
]
,
34.0 % Male samples
Hispanic or Latin American Samples are described as "Carribbean Hispanic" EFIGA
PSS000085 Selection criteria included (1) a proband who received a dianosis of definite or probable late onset Alzheimer's Disease (LOAD) with age at onset of at least 60 years; (2) a full sibling with definite, probable, or possible LOAD with age at onset after 60 years; (3) a related family member (first-,second-,or third-degree relative) of theaffected sibling pair and 60 years or older if unaffected, or 50 years or older if dianosed with LOAD or mild cognitive impairment (MCI)
[
  • 2,128 cases
  • , 2,664 controls
]
,
38.0 % Male samples
European NIA-LOAD
PSS011330 196,368 individuals,
47.3 % Male samples
Mean = 64.1 years
Sd = 2.9 years
European UKB
PSS001080 Cases included incident Alzheimer's disease (AD) and other types of incident dementia. Of the 1,609 dementia cases, 1,262 were individuals with AD and 347 were individuals with other types of dementia excluding AD. A consensus panel led by a consultant neurologist established the final diagnosis according to standard criteria for dementia (Diagnostic and Statistical Manual of Mental Disorders III-revised) and Alzheimer’s disease (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association). Of the total 12,255 individuals, APOE genotypes were available for 11,375. From those genotyped, 261 individuals were homozygous for APOE ε4 (ε4/ε4). Of the 261 ε4/ε4 individuals, 72 had AD whilst 11 had other types of dementia excluding AD. Median = 10.9 years
[
  • 1,609 cases
  • , 10,646 controls
]
,
41.5 % Male samples
European
(Dutch)
RS
PSS001081 Cases were individuals with incident-all cause dementia. Dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Diagnosis date was recorded as date of trigger. Dementia cases were sub-classified into either 'probable Alzheimer's Disease (AD)', 'possible AD' or 'non-dementia AD' using the 2011 NIA-Alzheimer's Association core clinical criteria. Of the 324 cases, 143 were classified as 'probable AD', 176 were classified as 'possible AD' and 5 were classified as 'non-AD related dementia'. Median = 4.5 years
IQR = [2.1, 5.7] years
[
  • 324 cases
  • , 12,654 controls
]
,
45.0 % Male samples
Mean = 75.05 years
Sd = 4.2 years
European ASPREE
PSS004307
[
  • 11 cases
  • , 6,486 controls
]
African unspecified UKB
PSS004309
[
  • 45 cases
  • , 24,860 controls
]
European non-white British ancestry UKB
PSS004310
[
  • 11 cases
  • , 7,820 controls
]
South Asian UKB
PSS004311
[
  • 134 cases
  • , 67,291 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS011522
[
  • 104 cases
  • , 614 controls
]
South Asian
(Pakistani, Bangladeshi)
G&H
PSS001127 Cases included individuals with Alzheimer's disease.
[
  • 2,384 cases
  • , 6,031 controls
]
European 11 cohorts
  • ART
  • ,B58C
  • ,Bonn
  • ,GERAD
  • ,HNR
  • ,KORA
  • ,MRC
  • ,NIMH
  • ,UCL-LASER
  • ,UCL-PRION
  • ,WASHU
PSS011392 Used the following tests to assess memory performance: the total immediate recall and delayed recall of the Rey Auditory Verbal Learning Test (RAVLT), the twenty minute recall of the Rey Complex Figure Test (RCFT), the total errors of the Cambridge Neuropsychological Test Automated Battery (CANTAB) Paired Associate Learning (PAL) test, and the total score of the Face Name Associated Memory Examination (FNAME) names and occupations delayed recall. Mean = 2.0 years
Sd = 0.4 years
276 individuals,
37.0 % Male samples
Mean = 74.7 years
Sd = 9.7 years
European ACPRC, NTR Cognitively unimpaired. Includes 97 complete twin pairs.
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories.
[
  • 4,729 cases
  • , 360,150 controls
]
,
46.2 % Male samples
Mean = 56.8 years European
(white British)
UKB
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories.
[
  • 73 cases
  • , 6,592 controls
]
,
54.2 % Male samples
Mean = 53.4 years South Asian UKB
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories.
[
  • 87 cases
  • , 6,840 controls
]
,
43.6 % Male samples
Mean = 51.9 years African unspecified
(Black)
UKB
PSS009634 4,114 individuals European ADC DCN, FACE, HAN, UAN, UHA, AMC, ZIM
PSS009635 17,545 individuals European 3C, FHS, MAS, RS AgeCoDe, VITA
PSS011377
[
  • 159 cases
  • , 220 controls
]
,
39.3 % Male samples
Mean = 69.8 years
Sd = 9.3 years
East Asian
(Korean)
BICWALZS, PREMIER
PSS011336
[
  • 437 cases
  • , 66,991 controls
]
,
46.0 % Male samples
European
(White British)
UKB
PSS011523
[
  • 1,000 cases
  • , 1,000 controls
]
East Asian
(Japanese)
NCGG
PSS009072 4,062 individuals European Poland (NE Europe) UKB
PSS008180 6,205 individuals South Asian India (South Asia) UKB
PSS011179 1,005 individuals African unspecified MGBB
PSS011179 306 individuals Asian unspecified MGBB
PSS011179 20,348 individuals European MGBB
PSS011179 614 individuals Hispanic or Latin American MGBB
PSS011179 884 individuals Not reported MGBB
PSS011180 4,189 individuals Mean = 63.0 years Hispanic or Latin American
(Central American, South American, Mexican, Cuban, Dominican, Puerto-Rican)
SOL SOL-INCA: Study of Latinos-Investigation of Neurocognitive Aging
PSS007663 Cases were individuals with dementia. Of the 82 cases with dementia, 41 had all-type dementia, 25 had Alzheimer's disease (AD) dementia and 16 had other types of dementia.
[
  • 82 cases
  • , 450 controls
]
European AmDem, SCIENCe
PSS009642 G30.1 Alzheimer’s disease with late onset 497,087 individuals,
45.9 % Male samples
Mean = 57.1 years
Sd = 7.9 years
European UKB
PSS009559 AD: F00, F00.0, F00.1, F00.2, F00.9, G30, G30.0, G30.1, G30.8, G30.9 VaD: F01, F01.0, F01.1, F01.2, F01.3, F01.8, F01.9, I67.3 FTD: F02.0, G31.0, Other codes for all-cause dementia: A81.0, F02, F02.1, F02.2, F02.3, F02.4, F02.8, F03, F05.1, F10.6, G31.1, G31.8 Median = 8.0 years
[
  • 1,769 cases
  • , 194,614 controls
]
,
47.3 % Male samples
Mean = 64.1 years European UKB
PSS001167 Cases were individuals with pathologically or clinically diagnosed Alzheimer's disease (AD). Of the 1008 AD cases, 332 had been confirmed pathologically whilst 676 had been confirmed clinically. Pathological AD was confirmed by the Biobanc Hospital Clínic–IDIBAPS, whilst clinical diagnosis of AD was based on clinical criteria from Fundació ACE.
[
  • 1,008 cases
  • , 1,386 controls
]
,
29.2 % Male samples
European
(Spanish)
EADB
PSS011213
[
  • 555 cases
  • , 198,719 controls
]
European EB
PSS004614
[
  • 5 cases
  • , 6,492 controls
]
African unspecified UKB
PSS004615
[
  • 27 cases
  • , 24,878 controls
]
European non-white British ancestry UKB
PSS004616
[
  • 6 cases
  • , 7,825 controls
]
South Asian UKB
PSS004617
[
  • 80 cases
  • , 67,345 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS008850 3,836 individuals African unspecified Nigeria (West Africa) UKB
PSS011719 Samples used in this study were extracted from autopsied brain tissue. Samples were taken from cognitively normal individuals witth a dementia rating of 0 (controls) and from late-onset Alzheimer's disease (LOAD) patients who had a clinical diagnosis of dementia due to AD and neuropathological confirmation of AD.
[
  • 56 cases
  • , 80 controls
]
,
39.0 % Male samples
European BfDR
PSS011359 Alzheimer's (ICD10: F00, F00.0, F00.1, F00.2, F00.9, G30, G30.0, G30.1, G30.8, G30.9), Vascular dementia (ICD10: F01, F01.0, F01.1, F01.2, F01.3, F01.8, F01.9, I67.3), Frontotemporal dementia (ICD10: F02.0, G31.0), all-cause dementia (ICD10: A81.0, F02, F02.1, F02.2, F02.3, F02.4, F02.8, F03, F05.1, F10.6, G31.1, G31.8) Mean = 9.1 years
Sd = 1.7 years
60,298 individuals,
51.5 % Male samples
Mean = 63.8 years
Sd = 2.7 years
European UKB
PSS011307 1,638 individuals,
49.6 % Male samples
Not reported NSHD Outcomes tested were metabolite levels generated by Metabolon Inc, and metabolite modules generated using this data. All outcome (metabolite) data were collected at the 60-64 wave of the NSHD.
PSS011226 G6_AD_WIDE, ICD10: G30|F00, ICD9: 3310
[
  • 13,823 cases
  • , 375,181 controls
]
European FinnGen
PSS007965 1,802 individuals East Asian China (East Asia) UKB
PSS001052 The diagnosis of dementia at each examination was based on Diagnostic and Statistical Manual of Mental Disorders Third Edition‐Revised (DSM‐III‐R) criteria, using information from neuropsychiatric examinations and close informant interviews. Dementia diagnoses for individuals lost to follow‐up were based on information obtained from the Swedish Inpatient Registry until 2012. Age of dementia onset was based on information provided by close informants, the examinations, and the Swedish Inpatient Register. If no information could be obtained from these sources, the age of onset was determined as the mid‐point between the last examination at which dementia criteria were not fulfilled and the first with a dementia diagnosis. Information on deaths during follow‐up was obtained from the Swedish Population Registry until December 31, 2016. Of the 605 dementia cases, 182 were carriers of an APOE ɛ4 allele. Mean = 7.2 years
Sd = 4.7 years
[
  • 605 cases
  • , 1,447 controls
]
European NR Gothenburg H70 Birth Cohort studies
PSS004632
[
  • 11 cases
  • , 6,486 controls
]
African unspecified UKB
PSS009897 228 individuals,
49.6 % Male samples
Mean = 76.62 years
Sd = 4.55 years
Not reported ADNI
PSS004634
[
  • 47 cases
  • , 24,858 controls
]
European non-white British ancestry UKB
PSS009898 CN/MCI/AD: [573/124/83] 780 individuals Not reported NR AIBL
PSS009899 CN/MCI/AD: [412/66/24] 502 individuals Not reported NR AIBL
PSS009900 CN/MCI/AD: [161/58/59] 278 individuals Not reported NR AIBL
PSS004635
[
  • 13 cases
  • , 7,818 controls
]
South Asian UKB
PSS004636
[
  • 153 cases
  • , 67,272 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS009939 39,444 individuals European
(Finnish)
FinnGen
PSS010155 117 individuals,
50.0 % Male samples
Mean = 9.96 years Not reported NR ABCD
PSS010156 4,382 individuals,
50.0 % Male samples
Mean = 9.94 years Not reported NR ABCD
PSS011524
[
  • 191 cases
  • , 337 controls
]
East Asian
(Korean)
BICWALZS
PSS011525
[
  • 157 cases
  • , 539 controls
]
East Asian
(Korean)
BICWALZS
PSS011526
[
  • 2,923 cases
  • , 226,342 controls
]
European
(British)
UKB
PSS011676 1,135 individuals,
30.0 % Male samples
Mean = 59.0 years
Sd = 6.0 years
European WRAP
PSS011252
[
  • 1,562 cases
  • , 65,303 controls
]
European HUNT
PSS008626 6,544 individuals European Italy (South Europe) UKB
PSS001005 Cases include individuals with Alzheimer's disease (AD) The phenotypes of the participants were determined on the basis of the most recent diagnostic records (until December 2019).
[
  • 33 cases
  • , 79 controls
]
,
54.29 % Male samples
East Asian
(Chinese)
NR Participants recruited from the Specialist Outpatient Department of Prince of Wales Hospital.
PSS001006 Cases include individuals with Alzheimer's disease (AD). Patients with definite AD have been diagnosed according to established neuropathological criteria (CERAD, Braak, Khachaturian, NIA-RI, or other established criteria).
[
  • 464 cases
  • , 2,232 controls
]
,
37.62 % Male samples
European LOAD
PSS000033 Most of the studies used standard screening procedures based on history, medical review, screening questions, and cognitive assessments that flagged participants with potential cognitive impairment. These participants underwent complete neurological and neuropsychological evaluation. An initial decision was made regarding the presence or absence of dementia, using the DSM-IV criteria; a diagnosis of possible, probable, or definite AD was made as a second step using NINCDS-ADRDA (National Institute of Neurological Disorders and Stroke Alzheimer’s Disease and Related Disorders Association) criteria.
[
  • 2,782 cases
]
European 8 cohorts
  • 3C
  • ,ACT
  • ,AGES
  • ,CHS
  • ,FHS
  • ,ROSMAP
  • ,RS
  • ,WHICAP
As one SNP (rs9271192) was missing in FHS, WHICAP, and Rotterdam because of poor imputation quality, an 18 SNP-based GRS was computed in these cohorts. As the samples used in this project were partially overlapping with the ones used in the original IGAP study, we ran an additional IGAP meta-analysis after excluding those and did not find significant changes in the estimations of HRs for the SNPs considered
PSS000034 Most of the studies used standard screening procedures based on history, medical review, screening questions, and cognitive assessments that flagged participants with potential cognitive impairment. These participants underwent complete neurological and neuropsychological evaluation. An initial decision was made regarding the presence or absence of dementia, using the DSM-IV criteria; a diagnosis of possible, probable, or definite AD was made as a second step using NINCDS-ADRDA (National Institute of Neurological Disorders and Stroke Alzheimer’s Disease and Related Disorders Association) criteria. 4,353 individuals European 8 cohorts
  • 3C
  • ,ACT
  • ,AGES
  • ,CHS
  • ,FHS
  • ,ROSMAP
  • ,RS
  • ,WHICAP
As one SNP (rs9271192) was missing in FHS, WHICAP, and Rotterdam because of poor imputation quality, an 18 SNP-based GRS was computed in these cohorts. As the samples used in this project were partially overlapping with the ones used in the original IGAP study, we ran an additional IGAP meta-analysis after excluding those and did not find significant changes in the estimations of HRs for the SNPs considered
PSS000035 Most of the studies used standard screening procedures based on history, medical review, screening questions, and cognitive assessments that flagged participants with potential cognitive impairment. These participants underwent complete neurological and neuropsychological evaluation. An initial decision was made regarding the presence or absence of dementia, using the DSM-IV criteria; a diagnosis of possible, probable, or definite AD was made as a second step using NINCDS-ADRDA (National Institute of Neurological Disorders and Stroke Alzheimer’s Disease and Related Disorders Association) criteria. 15,334 individuals European 8 cohorts
  • 3C
  • ,ACT
  • ,AGES
  • ,CHS
  • ,FHS
  • ,ROSMAP
  • ,RS
  • ,WHICAP
As one SNP (rs9271192) was missing in FHS, WHICAP, and Rotterdam because of poor imputation quality, an 18 SNP-based GRS was computed in these cohorts. As the samples used in this project were partially overlapping with the ones used in the original IGAP study, we ran an additional IGAP meta-analysis after excluding those and did not find significant changes in the estimations of HRs for the SNPs considered
PSS000036 Cases are patients with clinically diagnosed AD and compared to cognitively normal older individuals
[
  • 6,984 cases
  • , 10,972 controls
]
,
40.51 % Male samples
European ADGC ADGC Phase 2
PSS001125 Cases included individuals with Alzheimer's disease.
[
  • 2,626 cases
  • , 7,277 controls
]
European 11 cohorts
  • ART
  • ,B58C
  • ,Bonn
  • ,GERAD
  • ,HNR
  • ,KORA
  • ,MRC
  • ,NIMH
  • ,UCL-LASER
  • ,UCL-PRION
  • ,WASHU
PSS001126 All individuals were aged 55 and above. Cases include individuals with Alzheimer's disease.
[
  • 2,575 cases
  • , 1,525 controls
]
European 11 cohorts
  • ART
  • ,B58C
  • ,Bonn
  • ,GERAD
  • ,HNR
  • ,KORA
  • ,MRC
  • ,NIMH
  • ,UCL-LASER
  • ,UCL-PRION
  • ,WASHU
PSS000449
[
  • 216 cases
  • , 631 controls
]
,
54.7 % Male samples
Mean (Cases) = 77.6 years
Sd (Cases) = 7.6 years
European ABIL
PSS000449
[
  • 77 cases
  • , 588 controls
]
,
44.4 % Male samples
Mean (Cases) = 86.8 years
Sd (Cases) = 4.6 years
European MAS
PSS000449
[
  • 383 cases
  • , 1,915 controls
]
,
47.0 % Male samples
Mean (Cases) = 64.4 years
Sd (Cases) = 4.5 years
European UKB