Trait: allergic disease

Trait Information
Identifier MONDO_0005271
Description An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures. [NCIT: C114476]
Trait category
Immune system disorder
Synonyms 9 synonyms
  • allergic disease or disorder
  • allergic form of disease or disorder
  • allergic form of immune system disease
  • allergic reaction
  • allergic response
  • allergy
  • disorder of type I hypersensitivity
  • hypersensitivity reaction type I disease
  • type I hypersensitivity disease
Mapped terms 8 mapped terms
  • DOID:1205
  • EFO:0003785
  • ICD9:995.3
  • ICD9:V15.09
  • MESH:D006967
  • NCIT:C114476
  • SCTID:609328004
  • UMLS:C1527304
Child trait(s) 5 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "allergic disease" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000780
(PRS135_allergy)
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Allergic diseases allergic disease 135
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000780/ScoringFiles/PGS000780.txt.gz
PGS000800
(GRSw_SHARE)
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Allergic disease allergic disease 133
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000800/ScoringFiles/PGS000800.txt.gz
PGS000810
(wGRS136_Allergy)
PGP000195 |
Ferreira MA et al. Nat Genet (2017)
Allergic disease (asthma, hay fever or eczema) allergic disease 136
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000810/ScoringFiles/PGS000810.txt.gz
PGS000867
(GRS10_Allergy)
PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
Allergy allergic disease 10
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000867/ScoringFiles/PGS000867.txt.gz
PGS001109
(GBE_HC1021)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Vasomotor and allergic rhinitis (time-to-event) allergic rhinitis,
vasomotor rhinitis
1,910
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001109/ScoringFiles/PGS001109.txt.gz
PGS001259
(GBE_HC49)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Hayfever/allergic rhinitis seasonal allergic rhinitis 349
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001259/ScoringFiles/PGS001259.txt.gz
PGS001283
(GBE_INI3761)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Allergic disease (hay fever, rhinitis or eczema) allergic disease 993
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001283/ScoringFiles/PGS001283.txt.gz
PGS001284
(GBE_BIN_FC10006152)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Allergic disease (hay fever, allergic rhinitis, or eczema) allergic disease 6,755
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001284/ScoringFiles/PGS001284.txt.gz
PGS001285
(GBE_BIN_FC5006152)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Allergic disease (hay fever, rhinitis, or eczema) (diagnosed by doctor) allergic disease 7,313
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001285/ScoringFiles/PGS001285.txt.gz
PGS001286
(GBE_BIN22126)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Allergic disease (hay fever or allergic rhinitis) (diagnosed by doctor) allergic disease 466
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001286/ScoringFiles/PGS001286.txt.gz
PGS001372
(GBE_INI22146)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Age hayfever or allergic rhinitis diagnosed by doctor allergic disease 255
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001372/ScoringFiles/PGS001372.txt.gz
PGS001773
(PRS_atopicDermatitis)
PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
Moderate-to-severe atopic dermatitis atopic eczema 25
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001773/ScoringFiles/PGS001773.txt.gz
PGS001885
(portability-PLR_960.2)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Allergy/adverse effect of penicillin drug allergy 95
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001885/ScoringFiles/PGS001885.txt.gz
PGS002097
(portability-ldpred2_960.2)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Allergy/adverse effect of penicillin drug allergy 742,904
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002097/ScoringFiles/PGS002097.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002024 PGS000780
(PRS135_allergy)
PSS001008|
Ancestry Not Reported|
897 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Atopic March Relative Risk Ratio (RRR): 1.89 [1.4, 2.55] Only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002025 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Atopic March Relative Risk Ratio (RRR): 1.99 [1.74, 2.29] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002026 PGS000780
(PRS135_allergy)
PSS001008|
Ancestry Not Reported|
897 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Persistent eczema and wheeze Relative Risk Ratio (RRR): 1.38 [1.01, 1.9] Only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002027 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Persistent eczema and wheeze Relative Risk Ratio (RRR): 1.39 [1.22, 1.6] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002028 PGS000780
(PRS135_allergy)
PSS001008|
Ancestry Not Reported|
897 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Persistent eczema with late-onset rhinitis Relative Risk Ratio (RRR): 1.35 [1.04, 1.76] Only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002029 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Persistent eczema with late-onset rhinitis Relative Risk Ratio (RRR): 1.51 [1.35, 1.68] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002030 PGS000780
(PRS135_allergy)
PSS001008|
Ancestry Not Reported|
897 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Persistent wheeze with late-onset rhinitis Relative Risk Ratio (RRR): 1.58 [1.22, 2.03] Only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002031 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Persistent wheeze with late-onset rhinitis Relative Risk Ratio (RRR): 1.44 [1.3, 1.6] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002032 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Transient wheeze Relative Risk Ratio (RRR): 1.11 [1.02, 1.21] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002033 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Eczema only Relative Risk Ratio (RRR): 1.16 [1.08, 1.24] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002034 PGS000780
(PRS135_allergy)
PSS001008|
Ancestry Not Reported|
897 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Rhinitis only Relative Risk Ratio (RRR): 1.32 [1.06, 1.64] Only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002035 PGS000780
(PRS135_allergy)
PSS001007|
Multi-ancestry (including European)|
7,242 individuals
PGP000184 |
Clark H et al. Clin Exp Allergy (2019)
Reported Trait: Rhinitis only Relative Risk Ratio (RRR): 1.21 [1.12, 1.31] For the MAAS cohort, only 134 SNPs from the 135 SNP PRS were utilised. Rs10305290 was not included as the SNP was monomorphic.
PPM002081 PGS000800
(GRSw_SHARE)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 1.72 [1.21, 2.44]
PPM002083 PGS000800
(GRSw_SHARE)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 4.75
PPM002082 PGS000800
(GRSw_SHARE)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.65 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g)
PPM002084 PGS000800
(GRSw_SHARE)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.7 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g)
PPM002160 PGS000810
(wGRS136_Allergy)
PSS001055|
European Ancestry|
22,029 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Asthma age of onset Percent (%) of cases with asthma prior to age 16 (bottom 10% of GRS): 14.0
PPM002161 PGS000810
(wGRS136_Allergy)
PSS001055|
European Ancestry|
22,029 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Asthma age of onset Percent (%) of cases with asthma prior to age 16 (top 10% of GRS): 35.0
PPM002162 PGS000810
(wGRS136_Allergy)
PSS001055|
European Ancestry|
22,029 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Asthma age of onset Median age of asthma onset in years (bottom 10% of GRS): 42.0
PPM002163 PGS000810
(wGRS136_Allergy)
PSS001055|
European Ancestry|
22,029 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Asthma age of onset Median age of asthma onset in years (top 10% of GRS): 30.0
PPM002164 PGS000810
(wGRS136_Allergy)
PSS001057|
European Ancestry|
14,474 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Hay fever age of onset Median age of onset in years (bottom 10% of GRS): 25.0
PPM002165 PGS000810
(wGRS136_Allergy)
PSS001057|
European Ancestry|
14,474 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Hay fever age of onset Median age of onset in years (top 10% of GRS): 18.0
PPM002166 PGS000810
(wGRS136_Allergy)
PSS001056|
European Ancestry|
3,969 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Eczema age of onset Median age of onset in years (bottom 10% of GRS): 30.0
PPM002167 PGS000810
(wGRS136_Allergy)
PSS001056|
European Ancestry|
3,969 individuals
PGP000199 |
Ferreira MAR et al. PLoS Genet (2020)
|Ext.
Reported Trait: Eczema age of onset Median age of onset in years (top 10% of GRS): 23.0
PPM002411 PGS000867
(GRS10_Allergy)
PSS001091|
European Ancestry|
1,330 individuals
PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
Reported Trait: Time to physician-diagnosed allergy in childhood HR: 1.79 [1.06, 3.02]
PPM002412 PGS000867
(GRS10_Allergy)
PSS001091|
European Ancestry|
1,330 individuals
PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
Reported Trait: Time to physician-diagnosed allergy in childhood HR: 1.89 [1.05, 3.41] Age, gender, breastfeeding, family history of asthma, family history of allergies
PPM008284 PGS001109
(GBE_HC1021)
PSS004069|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE vasomotor and allergic rhinitis AUROC: 0.5683 [0.54473, 0.59188] : 0.01206
Incremental AUROC (full-covars): 0.00409
PGS R2 (no covariates): 0.00275
PGS AUROC (no covariates): 0.53243 [0.50926, 0.55561]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008285 PGS001109
(GBE_HC1021)
PSS004070|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE vasomotor and allergic rhinitis AUROC: 0.54528 [0.51116, 0.5794] : 0.01457
Incremental AUROC (full-covars): 0.00387
PGS R2 (no covariates): 0.00105
PGS AUROC (no covariates): 0.51375 [0.47834, 0.54917]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008286 PGS001109
(GBE_HC1021)
PSS004071|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE vasomotor and allergic rhinitis AUROC: 0.6003 [0.58786, 0.61273] : 0.0217
Incremental AUROC (full-covars): 0.02658
PGS R2 (no covariates): 0.00981
PGS AUROC (no covariates): 0.56712 [0.55454, 0.57969]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008287 PGS001109
(GBE_HC1021)
PSS004072|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE vasomotor and allergic rhinitis AUROC: 0.55379 [0.53392, 0.57366] : 0.00762
Incremental AUROC (full-covars): 0.0079
PGS R2 (no covariates): 0.00254
PGS AUROC (no covariates): 0.53239 [0.51256, 0.55222]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008288 PGS001109
(GBE_HC1021)
PSS004073|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE vasomotor and allergic rhinitis AUROC: 0.59854 [0.59138, 0.6057] : 0.02303
Incremental AUROC (full-covars): 0.02878
PGS R2 (no covariates): 0.0118
PGS AUROC (no covariates): 0.56998 [0.56268, 0.57727]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008800 PGS001259
(GBE_HC49)
PSS004511|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever/allergic rhinitis AUROC: 0.58821 [0.55886, 0.61757] : 0.01784
Incremental AUROC (full-covars): -0.00253
PGS R2 (no covariates): 0.00082
PGS AUROC (no covariates): 0.51547 [0.48626, 0.54467]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008801 PGS001259
(GBE_HC49)
PSS004512|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever/allergic rhinitis AUROC: 0.56313 [0.52505, 0.60122] : 0.02281
Incremental AUROC (full-covars): 0.00075
PGS R2 (no covariates): 0.0011
PGS AUROC (no covariates): 0.52627 [0.48539, 0.56716]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008802 PGS001259
(GBE_HC49)
PSS004513|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever/allergic rhinitis AUROC: 0.60641 [0.59175, 0.62107] : 0.02043
Incremental AUROC (full-covars): 0.01519
PGS R2 (no covariates): 0.00564
PGS AUROC (no covariates): 0.55414 [0.53891, 0.56936]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008803 PGS001259
(GBE_HC49)
PSS004514|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever/allergic rhinitis AUROC: 0.60093 [0.57427, 0.6276] : 0.02041
Incremental AUROC (full-covars): 0.00631
PGS R2 (no covariates): 0.00266
PGS AUROC (no covariates): 0.54086 [0.51259, 0.56913]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008804 PGS001259
(GBE_HC49)
PSS004515|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever/allergic rhinitis AUROC: 0.60078 [0.59218, 0.60937] : 0.02042
Incremental AUROC (full-covars): 0.01922
PGS R2 (no covariates): 0.00737
PGS AUROC (no covariates): 0.5597 [0.55096, 0.56843]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008917 PGS001283
(GBE_INI3761)
PSS007255|
European Ancestry|
13,999 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hay fever, rhinitis or eczema diagnosed : 0.11512 [0.11059, 0.11965]
Incremental R2 (full-covars): 0.01247
PGS R2 (no covariates): 0.0125 [0.01084, 0.01417]
age, sex, UKB array type, Genotype PCs
PPM008913 PGS001283
(GBE_INI3761)
PSS007251|
African Ancestry|
1,401 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hay fever, rhinitis or eczema diagnosed : 0.14854 [0.13259, 0.16449]
Incremental R2 (full-covars): -0.0075
PGS R2 (no covariates): 0.00033 [-0.00055, 0.0012]
age, sex, UKB array type, Genotype PCs
PPM008914 PGS001283
(GBE_INI3761)
PSS007252|
East Asian Ancestry|
592 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hay fever, rhinitis or eczema diagnosed : 0.08793 [0.0623, 0.11356]
Incremental R2 (full-covars): 0.01315
PGS R2 (no covariates): 0.01568 [0.004, 0.02736]
age, sex, UKB array type, Genotype PCs
PPM008915 PGS001283
(GBE_INI3761)
PSS007253|
European Ancestry|
5,147 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hay fever, rhinitis or eczema diagnosed : 0.11614 [0.10866, 0.12362]
Incremental R2 (full-covars): 0.01049
PGS R2 (no covariates): 0.01087 [0.00831, 0.01343]
age, sex, UKB array type, Genotype PCs
PPM008916 PGS001283
(GBE_INI3761)
PSS007254|
South Asian Ancestry|
1,451 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hay fever, rhinitis or eczema diagnosed : 0.11629 [0.10294, 0.12963]
Incremental R2 (full-covars): 0.00477
PGS R2 (no covariates): 0.00527 [0.00207, 0.00846]
age, sex, UKB array type, Genotype PCs
PPM008918 PGS001284
(GBE_BIN_FC10006152)
PSS003736|
African Ancestry|
6,348 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever allergic rhinitis or eczema AUROC: 0.6114 [0.59586, 0.62694] : 0.04366
Incremental AUROC (full-covars): 0.00507
PGS R2 (no covariates): 0.0072
PGS AUROC (no covariates): 0.5418 [0.52577, 0.55784]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008919 PGS001284
(GBE_BIN_FC10006152)
PSS003737|
East Asian Ancestry|
1,640 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever allergic rhinitis or eczema AUROC: 0.6017 [0.57412, 0.62927] : 0.04656
Incremental AUROC (full-covars): 0.01162
PGS R2 (no covariates): 0.01108
PGS AUROC (no covariates): 0.55514 [0.52697, 0.58332]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008920 PGS001284
(GBE_BIN_FC10006152)
PSS003738|
European Ancestry|
24,838 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever allergic rhinitis or eczema AUROC: 0.63382 [0.62577, 0.64186] : 0.06149
Incremental AUROC (full-covars): 0.03904
PGS R2 (no covariates): 0.0337
PGS AUROC (no covariates): 0.60011 [0.59191, 0.60831]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008921 PGS001284
(GBE_BIN_FC10006152)
PSS003739|
South Asian Ancestry|
7,556 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever allergic rhinitis or eczema AUROC: 0.60105 [0.58571, 0.6164] : 0.03149
Incremental AUROC (full-covars): 0.04131
PGS R2 (no covariates): 0.02118
PGS AUROC (no covariates): 0.58123 [0.56584, 0.59661]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008922 PGS001284
(GBE_BIN_FC10006152)
PSS003740|
European Ancestry|
67,349 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever allergic rhinitis or eczema AUROC: 0.63735 [0.6325, 0.6422] : 0.06354
Incremental AUROC (full-covars): 0.05347
PGS R2 (no covariates): 0.04086
PGS AUROC (no covariates): 0.60988 [0.60494, 0.61483]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008923 PGS001285
(GBE_BIN_FC5006152)
PSS003979|
African Ancestry|
5,863 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever rhinitis or eczema diagnosed by doctor AUROC: 0.61988 [0.60418, 0.63557] : 0.05243
Incremental AUROC (full-covars): 0.00361
PGS R2 (no covariates): 0.00809
PGS AUROC (no covariates): 0.5435 [0.52719, 0.55982]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008924 PGS001285
(GBE_BIN_FC5006152)
PSS003980|
East Asian Ancestry|
1,575 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever rhinitis or eczema diagnosed by doctor AUROC: 0.60016 [0.57208, 0.62825] : 0.04666
Incremental AUROC (full-covars): 0.00725
PGS R2 (no covariates): 0.0103
PGS AUROC (no covariates): 0.55278 [0.52414, 0.58142]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008925 PGS001285
(GBE_BIN_FC5006152)
PSS003981|
European Ancestry|
22,705 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever rhinitis or eczema diagnosed by doctor AUROC: 0.64037 [0.63223, 0.64852] : 0.07055
Incremental AUROC (full-covars): 0.04919
PGS R2 (no covariates): 0.04448
PGS AUROC (no covariates): 0.61233 [0.60403, 0.62062]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008926 PGS001285
(GBE_BIN_FC5006152)
PSS003982|
South Asian Ancestry|
6,933 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever rhinitis or eczema diagnosed by doctor AUROC: 0.61 [0.59463, 0.62537] : 0.03824
Incremental AUROC (full-covars): 0.05029
PGS R2 (no covariates): 0.02803
PGS AUROC (no covariates): 0.59248 [0.57698, 0.60797]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008927 PGS001285
(GBE_BIN_FC5006152)
PSS003983|
European Ancestry|
61,525 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Hayfever rhinitis or eczema diagnosed by doctor AUROC: 0.64412 [0.63921, 0.64903] : 0.07281
Incremental AUROC (full-covars): 0.06352
PGS R2 (no covariates): 0.05108
PGS AUROC (no covariates): 0.62052 [0.61552, 0.62551]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008928 PGS001286
(GBE_BIN22126)
PSS003671|
African Ancestry|
516 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed hayfever or allergic rhinitis AUROC: 0.59048 [0.53845, 0.6425] : 0.04417
Incremental AUROC (full-covars): -0.00133
PGS R2 (no covariates): 0.0
PGS AUROC (no covariates): 0.49458 [0.44138, 0.54777]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008929 PGS001286
(GBE_BIN22126)
PSS003672|
East Asian Ancestry|
245 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed hayfever or allergic rhinitis AUROC: 0.64171 [0.57232, 0.7111] : 0.10104
Incremental AUROC (full-covars): 0.0021
PGS R2 (no covariates): 0.00195
PGS AUROC (no covariates): 0.53214 [0.45762, 0.60665]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008930 PGS001286
(GBE_BIN22126)
PSS003673|
European Ancestry|
5,959 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed hayfever or allergic rhinitis AUROC: 0.57725 [0.56045, 0.59405] : 0.02043
Incremental AUROC (full-covars): 0.01152
PGS R2 (no covariates): 0.00603
PGS AUROC (no covariates): 0.53991 [0.52259, 0.55722]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008931 PGS001286
(GBE_BIN22126)
PSS003674|
South Asian Ancestry|
707 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed hayfever or allergic rhinitis AUROC: 0.62831 [0.58265, 0.67397] : 0.06246
Incremental AUROC (full-covars): 0.0031
PGS R2 (no covariates): 0.00591
PGS AUROC (no covariates): 0.54034 [0.49224, 0.58845]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008932 PGS001286
(GBE_BIN22126)
PSS003675|
European Ancestry|
17,244 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed hayfever or allergic rhinitis AUROC: 0.59244 [0.58227, 0.60261] : 0.02888
Incremental AUROC (full-covars): 0.02256
PGS R2 (no covariates): 0.01469
PGS AUROC (no covariates): 0.56502 [0.55474, 0.5753]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005290 PGS001372
(GBE_INI22146)
PSS004956|
African Ancestry|
170 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hayfever or allergic rhinitis diagnosed by doctor : 0.13957 [0.12394, 0.15519]
Incremental R2 (full-covars): -0.01335
PGS R2 (no covariates): 0.00276 [0.00021, 0.00531]
age, sex, UKB array type, Genotype PCs
PPM005291 PGS001372
(GBE_INI22146)
PSS004957|
East Asian Ancestry|
106 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hayfever or allergic rhinitis diagnosed by doctor : 0.0439 [0.02492, 0.06289]
Incremental R2 (full-covars): -0.00185
PGS R2 (no covariates): 0.00016 [-0.00104, 0.00135]
age, sex, UKB array type, Genotype PCs
PPM005292 PGS001372
(GBE_INI22146)
PSS004958|
European Ancestry|
1,421 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hayfever or allergic rhinitis diagnosed by doctor : 0.098 [0.09099, 0.10502]
Incremental R2 (full-covars): 0.00684
PGS R2 (no covariates): 0.00657 [0.00457, 0.00857]
age, sex, UKB array type, Genotype PCs
PPM005293 PGS001372
(GBE_INI22146)
PSS004959|
South Asian Ancestry|
187 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hayfever or allergic rhinitis diagnosed by doctor : 0.20226 [0.18637, 0.21814]
Incremental R2 (full-covars): 0.01767
PGS R2 (no covariates): 0.01185 [0.00708, 0.01661]
age, sex, UKB array type, Genotype PCs
PPM005294 PGS001372
(GBE_INI22146)
PSS004960|
European Ancestry|
3,857 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age hayfever or allergic rhinitis diagnosed by doctor : 0.08334 [0.07935, 0.08734]
Incremental R2 (full-covars): 0.00599
PGS R2 (no covariates): 0.00511 [0.00404, 0.00619]
age, sex, UKB array type, Genotype PCs
PPM009229 PGS001773
(PRS_atopicDermatitis)
PSS007661|
Multi-ancestry (including European)|
676 individuals
PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
Reported Trait: Moderate-to-severe aotpic dermatitis AUROC: 0.93 : 0.49 Age, sex, father's ethnicity, mother ethnicity Nagelkerke's R^2, only unrelated individuals were considered in the analyses
PPM009230 PGS001773
(PRS_atopicDermatitis)
PSS007661|
Multi-ancestry (including European)|
676 individuals
PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
Reported Trait: Food allergy AUROC: 0.75 Age, sex, father's ethnicity, mother ethnicity Only unrelated individuals were considered in the analyses
PPM009231 PGS001773
(PRS_atopicDermatitis)
PSS007661|
Multi-ancestry (including European)|
676 individuals
PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
Reported Trait: Allergic asthma AUROC: 0.75 Age, sex, father's ethnicity, mother ethnicity Only unrelated individuals were considered in the analyses
PPM009232 PGS001773
(PRS_atopicDermatitis)
PSS007661|
Multi-ancestry (including European)|
676 individuals
PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
Reported Trait: Allergic rhinitis AUROC: 0.77 Age, sex, father's ethnicity, mother ethnicity Only unrelated individuals were considered in the analyses
PPM009964 PGS001885
(portability-PLR_960.2)
PSS009362|
European Ancestry|
19,352 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0296 [0.0155, 0.0436] sex, age, birth date, deprivation index, 16 PCs
PPM009966 PGS001885
(portability-PLR_960.2)
PSS008690|
European Ancestry|
6,493 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0196 [-0.0047, 0.044] sex, age, birth date, deprivation index, 16 PCs
PPM009967 PGS001885
(portability-PLR_960.2)
PSS008464|
Greater Middle Eastern Ancestry|
1,172 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): -0.0358 [-0.0933, 0.022] sex, age, birth date, deprivation index, 16 PCs
PPM009968 PGS001885
(portability-PLR_960.2)
PSS008244|
South Asian Ancestry|
6,180 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): -0.0111 [-0.036, 0.0139] sex, age, birth date, deprivation index, 16 PCs
PPM009969 PGS001885
(portability-PLR_960.2)
PSS008022|
East Asian Ancestry|
1,773 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): -0.0272 [-0.0739, 0.0196] sex, age, birth date, deprivation index, 16 PCs
PPM009970 PGS001885
(portability-PLR_960.2)
PSS007808|
African Ancestry|
2,406 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0141 [-0.0261, 0.0542] sex, age, birth date, deprivation index, 16 PCs
PPM009971 PGS001885
(portability-PLR_960.2)
PSS008912|
African Ancestry|
3,818 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0003 [-0.0315, 0.0321] sex, age, birth date, deprivation index, 16 PCs
PPM009965 PGS001885
(portability-PLR_960.2)
PSS009136|
European Ancestry|
4,025 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0128 [-0.0182, 0.0437] sex, age, birth date, deprivation index, 16 PCs
PPM011632 PGS002097
(portability-ldpred2_960.2)
PSS009362|
European Ancestry|
19,352 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0397 [0.0256, 0.0537] sex, age, birth date, deprivation index, 16 PCs
PPM011633 PGS002097
(portability-ldpred2_960.2)
PSS009136|
European Ancestry|
4,025 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0394 [0.0085, 0.0703] sex, age, birth date, deprivation index, 16 PCs
PPM011635 PGS002097
(portability-ldpred2_960.2)
PSS008464|
Greater Middle Eastern Ancestry|
1,172 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): -0.0396 [-0.0971, 0.0182] sex, age, birth date, deprivation index, 16 PCs
PPM011636 PGS002097
(portability-ldpred2_960.2)
PSS008244|
South Asian Ancestry|
6,180 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0264 [0.0015, 0.0514] sex, age, birth date, deprivation index, 16 PCs
PPM011637 PGS002097
(portability-ldpred2_960.2)
PSS008022|
East Asian Ancestry|
1,773 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): -0.0013 [-0.0481, 0.0455] sex, age, birth date, deprivation index, 16 PCs
PPM011638 PGS002097
(portability-ldpred2_960.2)
PSS007808|
African Ancestry|
2,406 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): -0.0128 [-0.0529, 0.0273] sex, age, birth date, deprivation index, 16 PCs
PPM011639 PGS002097
(portability-ldpred2_960.2)
PSS008912|
African Ancestry|
3,818 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0043 [-0.0275, 0.0361] sex, age, birth date, deprivation index, 16 PCs
PPM011634 PGS002097
(portability-ldpred2_960.2)
PSS008690|
European Ancestry|
6,493 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Allergy/adverse effect of penicillin Partial Correlation (partial-r): 0.0313 [0.0069, 0.0556] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008912 3,818 individuals African unspecified Nigeria (West Africa) UKB
PSS001028 Cases were children with asthma ever, at age 8 years. Cases were defined using an adjusted diagnosis of asthma ever at age 8 years based on (1) 1 or more attacks of wheeze in the last 12 months or (2) inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had at least 1 of these characteristics was categorized as having asthma.
[
  • 215 cases
  • , 212 controls
]
,
56.2 % Male samples
European
(Swedish)
BAMSE Possible sample overlap of up to 100% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS001029 Cases were children with asthma ever, at age 8 years, in which asthma was defined by the following characteristics: 1 or more attacks of wheeze in the last 12 months, 1 or more events of shortness of breath (dyspnea) in the last 12 months, or inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had 1 or more of these characteristics was categorized as having asthma.
[
  • 792 cases
  • , 1,066 controls
]
,
51.1 % Male samples
European PIAMA Possible sample overlap of up to 19% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS008022 1,773 individuals East Asian China (East Asia) UKB
PSS007251 1,401 individuals African unspecified UKB
PSS007252 592 individuals East Asian UKB
PSS007253 5,147 individuals European non-white British ancestry UKB
PSS007254 1,451 individuals South Asian UKB
PSS007255 13,999 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS003671
[
  • 170 cases
  • , 346 controls
]
African unspecified UKB
PSS003672
[
  • 106 cases
  • , 139 controls
]
East Asian UKB
PSS003673
[
  • 1,421 cases
  • , 4,538 controls
]
European non-white British ancestry UKB
PSS003674
[
  • 187 cases
  • , 520 controls
]
South Asian UKB
PSS003675
[
  • 3,857 cases
  • , 13,387 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004956 170 individuals African unspecified UKB
PSS004957 106 individuals East Asian UKB
PSS004958 1,421 individuals European non-white British ancestry UKB
PSS004959 187 individuals South Asian UKB
PSS004960 3,857 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS004069
[
  • 648 cases
  • , 5,849 controls
]
African unspecified UKB
PSS004070
[
  • 330 cases
  • , 1,374 controls
]
East Asian UKB
PSS004071
[
  • 2,149 cases
  • , 22,756 controls
]
European non-white British ancestry UKB
PSS004072
[
  • 893 cases
  • , 6,938 controls
]
South Asian UKB
PSS004073
[
  • 6,545 cases
  • , 60,880 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS008690 6,493 individuals European Italy (South Europe) UKB
PSS007661 For the CHILD Cohort Study, atopic dermatitis (AD) was from physician diagnosis at the one year follow-up. AD severity was defined as mild if there is a single site or no more than 2 sites, minor symptoms (little itching/rubbing), minor crusting and papules, not excoriated or oozing, not needing frequent medical attention; was defined as moderate if symptoms are neither mild nor severe or; was defined as severe if there are multiple sites, with extensive crusting or papules or excoriations or oozing or lichenification, sleep loss, needing frequent medical attention, and is a major concern to parents. In the SLSJ Cohort, atopic dermatitis was self-reported and considered as positive if past or present occurrence was reported. For children, cross validation was done using questionnaires filled by their parents. Moreover, validation in medical records of these self-reported phenotypes were done for a subset of the SLSJ Cohort (n = 217), giving 89% concordance.
[
  • 61 cases
  • , 615 controls
]
,
42.0 % Male samples
Mean = 9.0 years
Range = [0.0, 87.0] years
European, South East Asian, East Asian, South Asian, African American or Afro-Caribbean, Native American, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American, Not reported CHILD, SLSJ Also used to evaluate the PRS_atopicDermatitis for other diseases of the atopic march: food allergy, allergic asthma and rhinitis. Only unrelated individuals were selected for analyses.
PSS007808 2,406 individuals African American or Afro-Caribbean Carribean UKB
PSS001091 Cases were individuals who had been diagnosed by a phsyician with allergic symptoms. Allergic symptoms were diagnoised/defined using the International Classification of Primary Care (ICPC), allergic conjunctivitis (ICPC: F71), allergic rhinitis (ICPC: R97), or eczema/dermatitis (ICPC: S87, S88). Median = 3.6 years
IQR = [1.5, 6.7] years
[
  • 497 cases
  • , 833 controls
]
,
49.2 % Male samples
Median = 7.0 years
IQR = [4.0, 9.0] years
European
(Dutch, NR)
Dutch = 471, NR = 859 WHISTLER
PSS008464 1,172 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009362 19,352 individuals European UK (+ Ireland) UKB
PSS003979
[
  • 1,664 cases
  • , 4,199 controls
]
African unspecified UKB
PSS003980
[
  • 656 cases
  • , 919 controls
]
East Asian UKB
PSS003981
[
  • 5,888 cases
  • , 16,817 controls
]
European non-white British ancestry UKB
PSS003982
[
  • 1,629 cases
  • , 5,304 controls
]
South Asian UKB
PSS003983
[
  • 16,014 cases
  • , 45,511 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS003736
[
  • 1,664 cases
  • , 4,684 controls
]
African unspecified UKB
PSS003737
[
  • 656 cases
  • , 984 controls
]
East Asian UKB
PSS001055 All individuals suffered from asthma and no other allergic diseases. All individuals were identified from a questionnaire. Asthmatic individuals were those with (i) both a report of “Asthma” in field 6152 of questionnaire (self-reported medical conditions, specifically the question “Has a doctor ever told you that you have had any of the following conditions?”) and a code for asthma in field 20002 (verbal interview), or alternatively, an ICD10 code for asthma in fields 41202 (Diagnoses–main ICD10) or 41204 (Diagnoses–secondary ICD10); and (ii) no report of COPD in fields 6152 or 20002, nor of other respiratory diseases in field 20002. 22,029 individuals,
45.0 % Male samples
Mean = 56.6 years
Range = [38.0, 70.0] years
European UKB Possible sample overlap of up to 100% between this dataset and the dataset used to source wGRS136_Allergy.
PSS001056 All individuals suffered from eczema and no other allergic diseases. All individuals were identified from a questionnaire. The exact same approach (i.e. information from fields 20002, 41202 and 41204) was used to identify eczema cases. 3,969 individuals,
43.0 % Male samples
Mean = 55.4 years
Range = [40.0, 70.0] years
European UKB Possible sample overlap of up to 100% between this dataset and the dataset used to source wGRS136_Allergy.
PSS001057 All individuals suffered from hay fever and no other allergic diseases. All individuals were identified from a questionnaire. To identify individuals who reported suffering specifically from hay fever, information reported in the verbal interview (field 20002) and ICD10 codes (fields 41202 and 41204) were considered, as described for asthma 14,474 individuals,
49.0 % Male samples
Mean = 55.1 years
Range = [40.0, 70.0] years
European UKB Possible sample overlap of up to 100% between this dataset and the dataset used to source wGRS136_Allergy.
PSS003738
[
  • 5,888 cases
  • , 18,950 controls
]
European non-white British ancestry UKB
PSS003739
[
  • 1,629 cases
  • , 5,927 controls
]
South Asian UKB
PSS004511
[
  • 393 cases
  • , 6,104 controls
]
African unspecified UKB
PSS004512
[
  • 215 cases
  • , 1,489 controls
]
East Asian UKB
PSS004513
[
  • 1,438 cases
  • , 23,467 controls
]
European non-white British ancestry UKB
PSS004514
[
  • 435 cases
  • , 7,396 controls
]
South Asian UKB
PSS004515
[
  • 4,398 cases
  • , 63,027 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS003740
[
  • 16,014 cases
  • , 51,335 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS009136 4,025 individuals European Poland (NE Europe) UKB
PSS008244 6,180 individuals South Asian India (South Asia) UKB
PSS001007 Cases were individuals with latent classes of allergic diseases (LCADs). LCADs includes atopic march (defined as having a high probability of eczema from infancy to age 11 years with increased probability of wheeze overtime. For rhinitis, the probability increases from zero at age 1 year to almost 100% by 8 years. Eczema developed first, followed by wheeze, and then rhinitis) , persistent eczema and wheeze (defined as having a similar probability of wheeze and eczema throughout childhood, likely as co-morbidities, with a low probability of rhinitis throughout childhood), persistent eczema with late‐onset rhinitis (defined as having increased eczema prevalence from ~70% in early life to 95% at age 5 years, with little resolution at 11 years. The probability of rhinitis increases to almost 100% by age 8 years with low probability of wheeze throughout childhood), persistent wheeze with late‐onset rhinitis (definned as having a high probability of wheeze throughout childhood, with increasing probability of rhinitis to almost 100% by age 11 years. Probability of eczema being low, declining steadily at age 11 years), transient wheeze (defined as having a high probability of wheeze within the first 5 years, with remission by age 8 years, and a very low probability of eczema and rhinitis throughout childhood), eczema only (defined as having a high probability of eczema throughout life, peaking at ~80% at age 5 years, then declining steadily to a 50% probability at age 11 years) and rhinitis only (defined as having an increasing probability of rhinitis from age 5 to 11 years, but no wheeze or eczema). Of the 575 cases, 230 had atopic march, 227 had persistent eczema and wheeze, 380 had persistent eczema with late-onset rhinitis, 429 had persistent wheeze with late-onset rhinitis, 599 had transient wheeze, 1089 had eczema only and 791 had rhinitis only.
[
  • 3,745 cases
  • , 3,497 controls
]
,
51.45 % Male samples
European, NR European = 6345, NR = 897 ALSPAC, MAAS Possible sample overlap (up to 88%) between this dataset and the dataset used to source variants for the PRS.
PSS001008 Cases were individuals with latent classes of allergic diseases (LCADs). LCADs includes atopic march (defined as having a high probability of eczema from infancy to age 11 years with increased probability of wheeze overtime. For rhinitis, the probability increases from zero at age 1 year to almost 100% by 8 years. Eczema developed first, followed by wheeze, and then rhinitis) , persistent eczema and wheeze (defined as having a similar probability of wheeze and eczema throughout childhood, likely as co-morbidities, with a low probability of rhinitis throughout childhood), persistent eczema with late‐onset rhinitis (defined as having increased eczema prevalence from ~70% in early life to 95% at age 5 years, with little resolution at 11 years. The probability of rhinitis increases to almost 100% by age 8 years with low probability of wheeze throughout childhood), persistent wheeze with late‐onset rhinitis (definned as having a high probability of wheeze throughout childhood, with increasing probability of rhinitis to almost 100% by age 11 years. Probability of eczema being low, declining steadily at age 11 years), transient wheeze (defined as having a high probability of wheeze within the first 5 years, with remission by age 8 years, and a very low probability of eczema and rhinitis throughout childhood), eczema only (defined as having a high probability of eczema throughout life, peaking at ~80% at age 5 years, then declining steadily to a 50% probability at age 11 years) and rhinitis only (defined as having an increasing probability of rhinitis from age 5 to 11 years, but no wheeze or eczema). Of the 575 cases, 55 had atopic march, 46 had persistent eczema and wheeze, 73 had persistent eczema with late-onset rhinitis, 81 had persistent wheeze with late-onset rhinitis, 65 had transient wheeze, 141 had eczema only and 114 had rhinitis only.
[
  • 575 cases
  • , 322 controls
]
,
53.8 % Male samples
Not reported MAAS