Trait: atrial fibrillation

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000275
Description A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC) [NCIT: P378]
Trait category
Cardiovascular disease
Synonyms 14 synonyms
  • A-fib
  • AF
  • AF - Atrial fibrillation
  • AFib
  • Atrial Fibrillations
  • Atrial fibrillation (disorder)
  • Auricular Fibrillation
  • Auricular Fibrillations
  • Fibrillation, Atrial
  • Fibrillation, Auricular
  • Fibrillations, Atrial
  • Fibrillations, Auricular
  • atrial fibrillation
  • atrial fibrillation (disease)
Mapped terms 16 mapped terms
  • DOID:0060224
  • HP:0005110
  • ICD10:I48
  • ICD9:427.31
  • MESH:D001281
  • MONDO:0004981
  • MeSH:D001281
  • MedDRA:10003658
  • NCIT:C50466
  • NCIt:C50466
  • OMIM:611819
  • OMIM:613120
  • OMIM:615770
  • SCTID:49436004
  • SNOMEDCT:49436004
  • UMLS:C0004238

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000016
(GPS_AF)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Atrial fibrillation atrial fibrillation 6,730,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000016/ScoringFiles/PGS000016.txt.gz - Check Terms/Licenses
PGS000035
(PRS_AF)
PGP000022 |
Weng LC et al. Circulation (2017)
Atrial fibrillation atrial fibrillation 1,168
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000035/ScoringFiles/PGS000035.txt.gz
PGS000331
(PRS_AF)
PGP000100 |
Mars N et al. Nat Med (2020)
Atrial fibrillation atrial fibrillation 6,183,494
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000331/ScoringFiles/PGS000331.txt.gz
PGS000338
(GRS97_AF)
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Atrial fibrillation atrial fibrillation 97
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000338/ScoringFiles/PGS000338.txt.gz
PGS000727
(AF_PGS)
PGP000137 |
Ritchie SC et al. Nat Metab (2021)
Atrial fibrillation atrial fibrillation 2,210,336
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000727/ScoringFiles/PGS000727.txt.gz
PGS001339
(GBE_HC964)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Atrial fibrillation and flutter (time-to-event) atrial fibrillation,
atrial flutter
2,142
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001339/ScoringFiles/PGS001339.txt.gz
PGS001340
(GBE_HC281)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Atrial fibrillation atrial fibrillation 2,955
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001340/ScoringFiles/PGS001340.txt.gz
PGS001356
(AF_AnnoPred_PRS)
PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
Atrial fibrillation atrial fibrillation 2,996,793
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001356/ScoringFiles/PGS001356.txt.gz
PGS001841
(portability-PLR_427.2)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Atrial fibrillation and flutter atrial fibrillation,
atrial flutter
3,980
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001841/ScoringFiles/PGS001841.txt.gz
PGS002050
(portability-ldpred2_427.2)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Atrial fibrillation and flutter atrial fibrillation,
atrial flutter
554,908
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002050/ScoringFiles/PGS002050.txt.gz
PGS002756
(Atrial_fibrillation_prscs)
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Atrial fibrillation atrial fibrillation 1,091,491
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002756/ScoringFiles/PGS002756.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000385 PGS000016
(GPS_AF)
PSS000217|
European Ancestry|
10,303 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Atrial Fibrillation (personal history) OR: 1.277 [1.12, 1.46] AUROC: 0.78 age, sex
PPM000025 PGS000016
(GPS_AF)
PSS000013|
European Ancestry|
288,978 individuals
PGP000006 |
Khera AV et al. Nat Genet (2018)
Reported Trait: Atrial fibrillation AUROC: 0.77 [0.76, 0.77] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.029 age; sex; Ancestry PC 1-4; genotyping chip
PPM000389 PGS000016
(GPS_AF)
PSS000217|
European Ancestry|
10,303 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Atrial Fibrillation (personal history) AUROC: 0.57
PPM002019 PGS000016
(GPS_AF)
PSS000998|
Ancestry Not Reported|
368 individuals
PGP000182 |
Tadros R et al. Nat Genet (2021)
|Ext.
Reported Trait: Atrial fibrillation or atrial flutter in individuals with a pathogenic or likely pathogenic sarcomeric variant HR: 1.5 [1.17, 1.91]
β: 0.402 (0.124)
Genetic relatedness matrix, sex
PPM014988 PGS000016
(GPS_AF)
PSS009946|
European Ancestry|
36,662 individuals
PGP000368 |
Marston NA et al. Eur Heart J (2022)
|Ext.
Reported Trait: Atrial fibrillation HR: 1.4 [1.32, 1.49]
PPM014989 PGS000016
(GPS_AF)
PSS009947|
Multi-ancestry (excluding European)|
4,873 individuals
PGP000368 |
Marston NA et al. Eur Heart J (2022)
|Ext.
Reported Trait: Atrial fibrillation HR: 2.15 [1.57, 2.95]
PPM015520 PGS000016
(GPS_AF)
PSS009971|
Multi-ancestry (including European)|
36,422 individuals
PGP000381 |
Hao L et al. Nat Med (2022)
|Ext.
Reported Trait: Atrial fibrillation OR: 2.37 [2.12, 2.64] 4 genetic PCs
PPM000079 PGS000035
(PRS_AF)
PSS000053|
Multi-ancestry (including European)|
4,606 individuals
PGP000022 |
Weng LC et al. Circulation (2017)
Reported Trait: Incident atrial fibrillation HR: 1.14 [1.11, 1.16] Clinical risk (CHARGE-AF Score: height, weight, systolic and diastolic blood pressure, current smoking status, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure), age, sex, genotyping array, 1 PC of ancestry Unadjusted for Competing Risk of Death
PPM000898 PGS000331
(PRS_AF)
PSS000439|
European Ancestry|
10,561 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Incident atrial fibrillation C-index: 0.734 CHARGE-AF calculator (age, height, weight, SBP, DBP, smoking status, blood-pressure-lowering medication, diabetes, heart failure and history of myocardial infarction), FINRISK cohort, genotyping array/batch, 10 ancestry PCs 5-year risk
PPM000893 PGS000331
(PRS_AF)
PSS000439|
European Ancestry|
10,561 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Incident atrial fibrillation HR: 1.62 [1.54, 1.7] C-index: 0.751 age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs 5-year risk
PPM000888 PGS000331
(PRS_AF)
PSS000442|
European Ancestry|
135,300 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Atrial fibrillation (incident and prevalent cases) HR: 1.62 [1.59, 1.65] genotyping array/batch, 10 ancestry PCs, stratified by sex
PPM000916 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation OR: 2.13 [1.86, 2.44] age, sex, PCs (1-10) of ancestry
PPM000913 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation OR: 2.12 [1.84, 2.45] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000917 PGS000338
(GRS97_AF)
PSS000461|
European Ancestry|
2,262 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.12 [1.77, 2.54] age, sex, PCs (1-10) of ancestry
PPM000915 PGS000338
(GRS97_AF)
PSS000460|
European Ancestry|
530 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 2.02 [1.37, 2.99] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000914 PGS000338
(GRS97_AF)
PSS000461|
European Ancestry|
2,262 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.08 [1.72, 2.5] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000920 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation AUROC: 0.721 [0.704, 737.0] PCs (1-10) of ancestry, CHARGE-AF risk factors (age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, myocardial infarction, diabetes)
PPM000919 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation AUROC: 0.606 [0.588, 0.624] PCs (1-10) of ancestry
PPM000918 PGS000338
(GRS97_AF)
PSS000460|
European Ancestry|
530 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 1.82 [1.28, 2.59] age, sex, PCs (1-10) of ancestry
PPM001668 PGS000727
(AF_PGS)
PSS000867|
European Ancestry|
3,087 individuals
PGP000137 |
Ritchie SC et al. Nat Metab (2021)
Reported Trait: Incident atrial fibrillation HR: 1.72 [1.2, 2.47] age, sex, 10 genetic PCs
PPM009181 PGS001339
(GBE_HC964)
PSS004746|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.75135 [0.70951, 0.7932] : 0.09804
Incremental AUROC (full-covars): -0.00345
PGS R2 (no covariates): 0.00273
PGS AUROC (no covariates): 0.53955 [0.48964, 0.58946]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009182 PGS001339
(GBE_HC964)
PSS004747|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.8247 [0.75141, 0.898] : 0.15451
Incremental AUROC (full-covars): 0.0187
PGS R2 (no covariates): 0.01158
PGS AUROC (no covariates): 0.59663 [0.46689, 0.72636]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009183 PGS001339
(GBE_HC964)
PSS004748|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.77656 [0.76352, 0.7896] : 0.14023
Incremental AUROC (full-covars): 0.02188
PGS R2 (no covariates): 0.02447
PGS AUROC (no covariates): 0.613 [0.59591, 0.6301]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009184 PGS001339
(GBE_HC964)
PSS004749|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.73999 [0.70422, 0.77576] : 0.09669
Incremental AUROC (full-covars): -0.00357
PGS R2 (no covariates): 0.00629
PGS AUROC (no covariates): 0.56035 [0.51988, 0.60082]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009185 PGS001339
(GBE_HC964)
PSS004750|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE atrial fibrillation and flutter AUROC: 0.76362 [0.75604, 0.7712] : 0.133
Incremental AUROC (full-covars): 0.02354
PGS R2 (no covariates): 0.0246
PGS AUROC (no covariates): 0.6108 [0.60113, 0.62048]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009186 PGS001340
(GBE_HC281)
PSS004413|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Atrial fibrillation AUROC: 0.75367 [0.71087, 0.79646] : 0.10139
Incremental AUROC (full-covars): -0.00517
PGS R2 (no covariates): 0.00295
PGS AUROC (no covariates): 0.5427 [0.49184, 0.59356]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009187 PGS001340
(GBE_HC281)
PSS004414|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Atrial fibrillation AUROC: 0.82329 [0.75147, 0.89511] : 0.15391
Incremental AUROC (full-covars): 0.01729
PGS R2 (no covariates): 0.01132
PGS AUROC (no covariates): 0.5932 [0.45826, 0.72815]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009188 PGS001340
(GBE_HC281)
PSS004415|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Atrial fibrillation AUROC: 0.77562 [0.76201, 0.78924] : 0.13687
Incremental AUROC (full-covars): 0.02036
PGS R2 (no covariates): 0.02331
PGS AUROC (no covariates): 0.61305 [0.59537, 0.63074]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009189 PGS001340
(GBE_HC281)
PSS004416|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Atrial fibrillation AUROC: 0.73506 [0.69832, 0.7718] : 0.09299
Incremental AUROC (full-covars): -0.00714
PGS R2 (no covariates): 0.00594
PGS AUROC (no covariates): 0.56086 [0.51842, 0.60331]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009190 PGS001340
(GBE_HC281)
PSS004417|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Atrial fibrillation AUROC: 0.76157 [0.75368, 0.76945] : 0.12768
Incremental AUROC (full-covars): 0.02194
PGS R2 (no covariates): 0.02239
PGS AUROC (no covariates): 0.60727 [0.59722, 0.61733]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005188 PGS001356
(AF_AnnoPred_PRS)
PSS003604|
European Ancestry|
178,651 individuals
PGP000252 |
Ye Y et al. Circ Genom Precis Med (2021)
Reported Trait: Atrial fibrillation AUROC: 0.6321 Age, sex, PCs(1-10)
PPM009619 PGS001841
(portability-PLR_427.2)
PSS009087|
European Ancestry|
3,980 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0701 [0.039, 0.101] sex, age, birth date, deprivation index, 16 PCs
PPM009620 PGS001841
(portability-PLR_427.2)
PSS008641|
European Ancestry|
6,397 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0741 [0.0496, 0.0984] sex, age, birth date, deprivation index, 16 PCs
PPM009621 PGS001841
(portability-PLR_427.2)
PSS008415|
Greater Middle Eastern Ancestry|
1,151 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.091 [0.0329, 0.1485] sex, age, birth date, deprivation index, 16 PCs
PPM009622 PGS001841
(portability-PLR_427.2)
PSS008195|
South Asian Ancestry|
6,001 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0436 [0.0182, 0.0688] sex, age, birth date, deprivation index, 16 PCs
PPM009623 PGS001841
(portability-PLR_427.2)
PSS007977|
East Asian Ancestry|
1,768 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0317 [-0.0153, 0.0784] sex, age, birth date, deprivation index, 16 PCs
PPM009624 PGS001841
(portability-PLR_427.2)
PSS007760|
African Ancestry|
2,381 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0464 [0.0061, 0.0866] sex, age, birth date, deprivation index, 16 PCs
PPM009625 PGS001841
(portability-PLR_427.2)
PSS008864|
African Ancestry|
3,769 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0414 [0.0094, 0.0733] sex, age, birth date, deprivation index, 16 PCs
PPM009618 PGS001841
(portability-PLR_427.2)
PSS009313|
European Ancestry|
19,230 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.1026 [0.0885, 0.1165] sex, age, birth date, deprivation index, 16 PCs
PPM011263 PGS002050
(portability-ldpred2_427.2)
PSS009087|
European Ancestry|
3,980 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0689 [0.0379, 0.0999] sex, age, birth date, deprivation index, 16 PCs
PPM011264 PGS002050
(portability-ldpred2_427.2)
PSS008641|
European Ancestry|
6,397 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0839 [0.0594, 0.1082] sex, age, birth date, deprivation index, 16 PCs
PPM011265 PGS002050
(portability-ldpred2_427.2)
PSS008415|
Greater Middle Eastern Ancestry|
1,151 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0983 [0.0402, 0.1557] sex, age, birth date, deprivation index, 16 PCs
PPM011266 PGS002050
(portability-ldpred2_427.2)
PSS008195|
South Asian Ancestry|
6,001 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.043 [0.0177, 0.0683] sex, age, birth date, deprivation index, 16 PCs
PPM011267 PGS002050
(portability-ldpred2_427.2)
PSS007977|
East Asian Ancestry|
1,768 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.041 [-0.0059, 0.0877] sex, age, birth date, deprivation index, 16 PCs
PPM011268 PGS002050
(portability-ldpred2_427.2)
PSS007760|
African Ancestry|
2,381 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0475 [0.0072, 0.0877] sex, age, birth date, deprivation index, 16 PCs
PPM011269 PGS002050
(portability-ldpred2_427.2)
PSS008864|
African Ancestry|
3,769 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.0418 [0.0098, 0.0737] sex, age, birth date, deprivation index, 16 PCs
PPM011262 PGS002050
(portability-ldpred2_427.2)
PSS009313|
European Ancestry|
19,230 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation and flutter Partial Correlation (partial-r): 0.1034 [0.0894, 0.1174] sex, age, birth date, deprivation index, 16 PCs
PPM014956 PGS002756
(Atrial_fibrillation_prscs)
PSS009939|
European Ancestry|
39,444 individuals
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Reported Trait: Atrial fibrillation OR: 1.87 [1.79, 1.96] age, sex, 10 PCs, technical covariates

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004413
[
  • 132 cases
  • , 6,365 controls
]
African unspecified UKB
PSS004414
[
  • 24 cases
  • , 1,680 controls
]
East Asian UKB
PSS004415
[
  • 1,017 cases
  • , 23,888 controls
]
European non-white British ancestry UKB
PSS004416
[
  • 189 cases
  • , 7,642 controls
]
South Asian UKB
PSS004417
[
  • 3,228 cases
  • , 64,197 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS007760 2,381 individuals African American or Afro-Caribbean Carribean UKB
PSS003604
[
  • 4,025 cases
  • , 174,626 controls
]
Mean = 56.81 years European UKB
PSS000460 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. HFpEF defined as LVEF >/= 50%
[
  • 307 cases
  • , 223 controls
]
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000461 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.HFrEF defined as LVEF <40%
[
  • 1,125 cases
  • , 1,137 controls
]
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000462 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.
[
  • 1,976 cases
  • , 1,783 controls
]
,
70.0 % Male samples
Mean = 72.8 years
Sd = 11.5 years
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS008415 1,151 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009313 19,230 individuals European UK (+ Ireland) UKB
PSS000053 Participants were classified as having AF if an arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records during a median 9.4 years of follow-up.
[
  • 580 cases
  • , 4,026 controls
]
,
45.9 % Male samples
European, NR FHS is principally composed of individuals of European ancestry FHS Samples were obtained from the following FHS cohorts: Original, Offspring, and Third Generation. Participants were eligible for inclusion if they were AF free at an average age of 55.
PSS000217 Phenotypic information was self-reported by the individual through an online, interactive health history tool
[
  • 239 cases
  • , 10,064 controls
]
,
17.1 % Male samples
European CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS009971 30,716 individuals European MGBB
PSS009971 1,807 individuals African unspecified
(Black)
MGBB
PSS009971 786 individuals Asian unspecified MGBB
PSS009971 3,113 individuals Other MGBB
PSS009087 3,980 individuals European Poland (NE Europe) UKB
PSS008195 6,001 individuals South Asian India (South Asia) UKB
PSS000013 Atrial fibrillation ascertainment was based on self-report of atrial fibrillation, atrial flutter, or cardioversion in an interview with a trained nurse, an ICD-9 code of 427.3 or ICD-10 code of I48.X in hospitalization records, or a history of a percutaneous ablation or cardioversion based on the OPCS-4 coded procedure (K57.1, K62.1, K62.2, K62.3, or K 62.4), as performed previously
[
  • 4,576 cases
  • , 284,402 controls
]
European UKB UKB Phase 2
PSS004746
[
  • 136 cases
  • , 6,361 controls
]
African unspecified UKB
PSS004747
[
  • 24 cases
  • , 1,680 controls
]
East Asian UKB
PSS004748
[
  • 1,090 cases
  • , 23,815 controls
]
European non-white British ancestry UKB
PSS004749
[
  • 200 cases
  • , 7,631 controls
]
South Asian UKB
PSS004750
[
  • 3,483 cases
  • , 63,942 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS008864 3,769 individuals African unspecified Nigeria (West Africa) UKB
PSS000867 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I48 Median = 6.9 years
[
  • 33 cases
  • , 3,054 controls
]
,
51.0 % Male samples
Median = 44.0 years
IQR = [30.5, 54.7] years
European INTERVAL
PSS009939 39,444 individuals European
(Finnish)
FinnGen
PSS007977 1,768 individuals East Asian China (East Asia) UKB
PSS000998 All individuals were carriers of a pathogenic or likely pathogenic variant (MYBPC3 truncating variant, MYBPC3 non-truncating variant, MYH7 variant, MYL2 variant, other genetic variant). Cases included individuals who had experienced atrial fibrillation, defined as: time to atrial fibrillation or flutter.
[
  • 70 cases
  • , 298 controls
]
Not reported ERSPC
PSS009946 36,662 individuals,
75.0 % Male samples
Mean = 64.1 years European FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52
PSS009947 674 individuals Asian unspecified FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52
PSS009947 791 individuals East Asian FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52
PSS009947 687 individuals South Asian FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52
PSS009947 2,721 individuals Hispanic or Latin American
(Mixed American)
FOURIER, PEGASUS, SAVOR-TIMI_53, SOLID-TIMI_52
PSS000439 National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9.
[
  • 229 cases
  • , 10,332 controls
]
,
47.3 % Male samples
Mean (Age At Baseline) = 48.0 years European
(Finnish)
FINRISK FINRISK surveys from 1992, 1997, 2002 and 2007
PSS000442 National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9.
[
  • 12,809 cases
  • , 122,491 controls
]
,
43.7 % Male samples
Mean (Age At Baseline) = 59.2 years
Sd = 16.6 years
European
(Finnish)
FinnGen
PSS008641 6,397 individuals European Italy (South Europe) UKB