Latest Release - Aug. 29, 2024

New Publications (5)

PGS Publication/Study ID (PGP)	PGS Developed	PGS Evaluated	First Author	Title	Journal Name	Publication Date	Digital object identifier (doi)	PubMed ID (PMID)
PGP000656	1	22	Ritchie SC	Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score	medRxivPre	22/08/2024	10.1101/2024.08.22.24312440	—
PGP000668	3	3	China Kadoorie Biobank Collaborative Group.	Joint impact of polygenic risk score and lifestyles on early- and late-onset cardiovascular diseases.	Nat Hum Behav	10/07/2024	10.1038/s41562-024-01923-7	38987358
PGP000669	0	1	Saadatagah S	Polygenic Risk, Rare Variants, and Family History: Independent and Additive Effects on Coronary Heart Disease.	JACC Adv	26/08/2023	10.1016/j.jacadv.2023.100567	38939477
PGP000670	1	1	Sekimitsu S	Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.	JAMA Ophthalmol	01/09/2023	10.1001/jamaophthalmol.2023.3645	37589995
PGP000671	1	1	Gao P	Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study.	Int J Cancer	06/09/2023	10.1002/ijc.34719	37671773

New Polygenic Scores (6)

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Individuals included in:

Any Stage [G, D, E] All Stages combined [G + D + E] Development [G, D]   - GWAS [G]   - Score development [D] PGS Evaluation [E]

G - Source of Variant Associations (GWAS)

D - Score Development/Training

E - PGS Evaluation

List of ancestries includes:

--AfricanEast AsianSouth AsianAdditional Asian AncestriesEuropeanGreater Middle EasternHispanic or Latin AmericanAdditional Diverse AncestriesNot Reported

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Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS004923 (T2D_metaGRS)	PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre	Type 2 diabetes (T2D)	type 2 diabetes mellitus	1,349,896		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004923/ScoringFiles/PGS004923.txt.gz
PGS004941 (CAD_MetaPRS)	PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)	Coronary artery disease	coronary artery disease	3,711,629	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004941/ScoringFiles/PGS004941.txt.gz
PGS004942 (IS_MetaPRS)	PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)	Ischemic stroke	Ischemic stroke	4,765,243	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004942/ScoringFiles/PGS004942.txt.gz
PGS004943 (ICH_MetaPRS)	PGP000668 | China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)	Intracerebral hemorrhage	intracerebral hemorrhage	2,124,631	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004943/ScoringFiles/PGS004943.txt.gz
PGS004944 (lassosum_weights_POAG_CROSS_EUR)	PGP000670 | Sekimitsu S et al. JAMA Ophthalmol (2023)	Primary open-angle glaucoma	open-angle glaucoma	110,772	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004944/ScoringFiles/PGS004944.txt.gz
PGS004945 (PRS87_CRC)	PGP000671 | Gao P et al. Int J Cancer (2023)	Colorectal cancer	colorectal cancer	87	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004945/ScoringFiles/PGS004945.txt.gz