Trait: body mass index

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004340
Description
  • An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Trait category
Body measurement
Synonyms 2 synonyms
  • BMI
  • Quetelet's Index
Mapped term(s) 4 mapped terms
  • ICD9:V85-V85.99
  • MeSH:D015992
  • NCIt:C16358
  • SNOMEDCT:60621009

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000027
(GPS_BMI)
PGP000017 |
Khera AV et al. Cell (2019)
Body Mass Index body mass index 2,100,302
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses
PGS000034
(GRS_BMI)
PGP000021 |
Song M et al. Diabetes (2017)
Adult Body Mass Index body mass index 97
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000034/ScoringFiles/PGS000034.txt.gz
PGS000298
(GRS941_BMI)
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Body mass index body mass index 941
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000298/ScoringFiles/PGS000298.txt.gz
PGS000320
(PRS_BMI)
PGP000096 |
Chami N et al. PLoS Med (2020)
Body mass index body mass index 263,640
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000320/ScoringFiles/PGS000320.txt.gz
PGS000716
(PGS295_elbs)
PGP000132 |
Richardson TG et al. BMJ (2020)
Early life body size comparative body size at age 10, self-reported,
body mass index
295
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000716/ScoringFiles/PGS000716.txt.gz
PGS000717
(PGS557_albs)
PGP000132 |
Richardson TG et al. BMJ (2020)
Adult life body size body mass index 557
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000717/ScoringFiles/PGS000717.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001708 PGS000716
(PGS295_elbs)
PSS000883|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 30-69.9 AUROC: 0.569 [0.564, 0.574] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001709 PGS000716
(PGS295_elbs)
PSS000876|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 12-15.9 AUROC: 0.656 [0.626, 0.686] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001710 PGS000716
(PGS295_elbs)
PSS000878|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 16-17.9 AUROC: 0.623 [0.589, 0.657] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001711 PGS000716
(PGS295_elbs)
PSS000880|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 18-23.9 AUROC: 0.601 [0.589, 0.612] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001712 PGS000716
(PGS295_elbs)
PSS000882|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 14-29.9 AUROC: 0.591 [0.582, 0.6] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001713 PGS000716
(PGS295_elbs)
PSS000884|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 30-69.9 AUROC: 0.568 [0.563, 0.573] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001714 PGS000717
(PGS557_albs)
PSS000875|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 12-15.9 AUROC: 0.664 [0.574, 0.753] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001715 PGS000717
(PGS557_albs)
PSS000877|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 16-17.9 AUROC: 0.691 [0.589, 0.793] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001716 PGS000717
(PGS557_albs)
PSS000879|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 18-23.9 AUROC: 0.624 [0.601, 0.646] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM000054 PGS000027
(GPS_BMI)
PSS000037|
European Ancestry|
288,016 individuals
PGP000017 |
Khera AV et al. Cell (2019)
Reported Trait: Body mass index β: 1.41 : 0.08526 First 10 genetic PCs Beta is in units of kg/m^2
PPM001717 PGS000717
(PGS557_albs)
PSS000881|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 24-29.9 AUROC: 0.623 [0.607, 0.639] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001719 PGS000717
(PGS557_albs)
PSS000876|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 12-15.9 AUROC: 0.587 [0.556, 0.618] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001720 PGS000717
(PGS557_albs)
PSS000878|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 16-17.9 AUROC: 0.615 [0.58, 0.649] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM000791 PGS000298
(GRS941_BMI)
PSS000369|
European Ancestry|
334 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0671 Sex, age
PPM000792 PGS000298
(GRS941_BMI)
PSS000370|
European Ancestry|
329 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.057 Sex, age
PPM000793 PGS000298
(GRS941_BMI)
PSS000371|
European Ancestry|
288 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0886 Sex, age
PPM000794 PGS000298
(GRS941_BMI)
PSS000372|
European Ancestry|
265 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.092 Sex, age
PPM000795 PGS000298
(GRS941_BMI)
PSS000373|
European Ancestry|
245 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.1194 Sex, age
PPM001722 PGS000717
(PGS557_albs)
PSS000882|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 14-29.9 AUROC: 0.598 [0.589, 0.607] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001723 PGS000717
(PGS557_albs)
PSS000884|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 30-69.9 AUROC: 0.582 [0.578, 0.587] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM000072 PGS000034
(GRS_BMI)
PSS000050|
European Ancestry|
5,640 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): 0.17 [0.03, 0.31]
PPM001725 PGS000027
(GPS_BMI)
PSS000885|
European Ancestry|
19,588 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between male siblings OR: 2.21 [1.92, 2.54] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001726 PGS000027
(GPS_BMI)
PSS000886|
European Ancestry|
21,499 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within female siblings OR: 2.09 [1.74, 2.51] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM000071 PGS000034
(GRS_BMI)
PSS000048|
European Ancestry|
5,956 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): 0.54 [0.38, 0.71]
PPM001727 PGS000027
(GPS_BMI)
PSS000886|
European Ancestry|
21,499 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between female siblings OR: 2.13 [1.87, 2.43] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001728 PGS000027
(GPS_BMI)
PSS000887|
European Ancestry|
26,323 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within male siblings OR: 2.15 [1.91, 2.41] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM000073 PGS000034
(GRS_BMI)
PSS000051|
European Ancestry|
2,942 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): -0.22 [-0.39, -0.05]
PPM001730 PGS000027
(GPS_BMI)
PSS000888|
European Ancestry|
29,527 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within female siblings OR: 1.87 [1.68, 2.09] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001731 PGS000027
(GPS_BMI)
PSS000888|
European Ancestry|
29,527 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between female siblings OR: 2.05 [1.89, 2.22] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001707 PGS000716
(PGS295_elbs)
PSS000879|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 18-23.9 AUROC: 0.618 [0.594, 0.641] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001732 PGS000027
(GPS_BMI)
PSS000889|
European Ancestry|
21,187 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within male siblings OR: 2.0 [1.79, 2.23] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001733 PGS000027
(GPS_BMI)
PSS000889|
European Ancestry|
21,187 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between male siblings OR: 2.12 [1.96, 2.3] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001734 PGS000027
(GPS_BMI)
PSS000890|
European Ancestry|
25,096 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within female siblings OR: 2.0 [1.8, 2.21] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001735 PGS000027
(GPS_BMI)
PSS000890|
European Ancestry|
25,096 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between female siblings OR: 2.03 [1.88, 2.19] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001718 PGS000717
(PGS557_albs)
PSS000883|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 30-69.9 AUROC: 0.597 [0.591, 0.602] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM000074 PGS000034
(GRS_BMI)
PSS000049|
European Ancestry|
6,705 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): 0.6 [0.42, 0.77]
PPM000075 PGS000034
(GRS_BMI)
PSS000052|
European Ancestry|
6,436 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): 0.07 [-0.04, 0.19]
PPM000076 PGS000034
(GRS_BMI)
PSS000045|
European Ancestry|
1,699 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): 0.23 [0.02, 0.44]
PPM000077 PGS000034
(GRS_BMI)
PSS000046|
European Ancestry|
1,634 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): -0.1 [-0.29, 0.09]
PPM000078 PGS000034
(GRS_BMI)
PSS000047|
European Ancestry|
2,020 individuals
PGP000021 |
Song M et al. Diabetes (2017)
Reported Trait: mean BMI difference β (per 10-allele increment): -0.01 [-0.16, 0.14]
PPM001687 PGS000716
(PGS295_elbs)
PSS000879|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 18-23.9 AUROC: 0.619 [0.596, 0.643] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001688 PGS000716
(PGS295_elbs)
PSS000881|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 24-29.9 AUROC: 0.602 [0.585, 0.618] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001689 PGS000716
(PGS295_elbs)
PSS000883|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 30-69.9 AUROC: 0.569 [0.564, 0.574] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001690 PGS000716
(PGS295_elbs)
PSS000876|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 12-15.9 AUROC: 0.658 [0.628, 0.687] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001691 PGS000716
(PGS295_elbs)
PSS000878|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 16-17.9 AUROC: 0.624 [0.589, 0.658] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001692 PGS000716
(PGS295_elbs)
PSS000880|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 18-23.9 AUROC: 0.602 [0.59, 0.613] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001693 PGS000716
(PGS295_elbs)
PSS000882|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 14-29.9 AUROC: 0.591 [0.582, 0.6] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001695 PGS000717
(PGS557_albs)
PSS000875|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 12-15.9 AUROC: 0.66 [0.57, 0.75] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001696 PGS000717
(PGS557_albs)
PSS000877|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 16-17.9 AUROC: 0.661 [0.551, 0.77] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001736 PGS000027
(GPS_BMI)
PSS000891|
European Ancestry|
14,487 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within male siblings OR: 1.9 [1.68, 2.14] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM000761 PGS000298
(GRS941_BMI)
PSS000374|
European Ancestry|
1,318 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0579 Sex, age
PPM000762 PGS000298
(GRS941_BMI)
PSS000375|
European Ancestry|
1,313 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0612 Sex, age
PPM000763 PGS000298
(GRS941_BMI)
PSS000376|
European Ancestry|
1,354 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0647 Sex, age
PPM000764 PGS000298
(GRS941_BMI)
PSS000377|
European Ancestry|
1,174 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0655 Sex, age
PPM000765 PGS000298
(GRS941_BMI)
PSS000378|
European Ancestry|
1,095 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Body mass index (kg/m2) : 0.0591 Sex, age
PPM001699 PGS000717
(PGS557_albs)
PSS000883|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 30-69.9 AUROC: 0.6 [0.595, 0.605] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM000860 PGS000320
(PRS_BMI)
PSS000411|
European Ancestry|
104 individuals
PGP000096 |
Chami N et al. PLoS Med (2020)
Reported Trait: Body mass index (BMI; kg/m^2) in MC4R carriers Higher PRS in obese vs. normal weight MC4R mutation carriers (p-value): 1.70e-06 age, sex, 10 genetic PCs
PPM000859 PGS000320
(PRS_BMI)
PSS000412|
European Ancestry|
256,770 individuals
PGP000096 |
Chami N et al. PLoS Med (2020)
Reported Trait: Body mass index (BMI; kg/m^2) in MC4R non-carriers Higher PRS in obese vs. normal weight MC4R non-carriers (p-value): 2.00e-16 age, sex, 10 genetic PCs
PPM000858 PGS000320
(PRS_BMI)
PSS000413|
European Ancestry|
451,508 individuals
PGP000096 |
Chami N et al. PLoS Med (2020)
Reported Trait: Body mass index (BMI; kg/m^2) β: 1.29 : 0.0676 age, sex, 10 genetic PCs
PPM001769 PGS000027
(GPS_BMI)
PSS000911|
Greater Middle Eastern Ancestry|
13,989 individuals
PGP000147 |
Thareja G et al. Nat Commun (2021)
|Ext.
Reported Trait: Body mass index Pearson correlation coefficent (r): 0.22
PPM001633 PGS000716
(PGS295_elbs)
PSS000849|
European Ancestry|
5,898 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Childhood body mass index AUROC: 0.64
PPM001634 PGS000717
(PGS557_albs)
PSS000849|
European Ancestry|
5,898 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Childhood body mass index AUROC: 0.61
PPM001635 PGS000716
(PGS295_elbs)
PSS000847|
European Ancestry|
3,997 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Adolescent body mass index AUROC: 0.63
PPM001636 PGS000717
(PGS557_albs)
PSS000847|
European Ancestry|
3,997 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Adolescent body mass index AUROC: 0.63
PPM001637 PGS000716
(PGS295_elbs)
PSS000848|
European Ancestry|
2,199 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Adult body mass index AUROC: 0.57
PPM001638 PGS000717
(PGS557_albs)
PSS000848|
European Ancestry|
2,199 individuals
PGP000132 |
Richardson TG et al. BMJ (2020)
Reported Trait: Adult body mass index AUROC: 0.6
PPM001702 PGS000717
(PGS557_albs)
PSS000880|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 18-23.9 AUROC: 0.595 [0.583, 0.607] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001703 PGS000717
(PGS557_albs)
PSS000882|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 14-29.9 AUROC: 0.602 [0.593, 0.611] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001704 PGS000717
(PGS557_albs)
PSS000884|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 30-69.9 AUROC: 0.585 [0.58, 0.589] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001705 PGS000716
(PGS295_elbs)
PSS000875|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 12-15.9 AUROC: 0.739 [0.667, 0.811] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001706 PGS000716
(PGS295_elbs)
PSS000877|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 16-17.9 AUROC: 0.66 [0.566, 0.754] Due to a lack of information in the HUNT dataset, only 277 of the 295 common variants used to build the childhood score by Richardson et al were included.
PPM001737 PGS000027
(GPS_BMI)
PSS000891|
European Ancestry|
14,487 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between male siblings OR: 2.0 [1.83, 2.19] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001738 PGS000027
(GPS_BMI)
PSS000892|
European Ancestry|
17,740 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within female siblings OR: 1.72 [1.53, 1.93] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001739 PGS000027
(GPS_BMI)
PSS000892|
European Ancestry|
17,740 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between female siblings OR: 1.89 [1.74, 2.05] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001721 PGS000717
(PGS557_albs)
PSS000880|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 18-23.9 AUROC: 0.592 [0.58, 0.604] Due to a lack of information in the HUNT dataset, only 509 of the 557 common variants used to build the adult score by Richardson et al were included.
PPM001685 PGS000716
(PGS295_elbs)
PSS000875|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 12-15.9 AUROC: 0.735 [0.663, 0.806] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001686 PGS000716
(PGS295_elbs)
PSS000877|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 16-17.9 AUROC: 0.672 [0.577, 0.766] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001694 PGS000716
(PGS295_elbs)
PSS000884|
European Ancestry|
62,541 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 30-69.9 AUROC: 0.568 [0.563, 0.573] Due to a lack of information in the HUNT dataset, only 289 of the 295 common variants used to build the childhood score by Richardson et al were included. Additionally, 11 of the 289 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001697 PGS000717
(PGS557_albs)
PSS000879|
European Ancestry|
12,179 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 18-23.9 AUROC: 0.629 [0.606, 0.652] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001698 PGS000717
(PGS557_albs)
PSS000881|
European Ancestry|
17,139 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Obesity in individuals aged 24-29.9 AUROC: 0.627 [0.611, 0.643] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001700 PGS000717
(PGS557_albs)
PSS000876|
European Ancestry|
3,124 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 12-15.9 AUROC: 0.591 [0.559, 0.623] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001701 PGS000717
(PGS557_albs)
PSS000878|
European Ancestry|
2,896 individuals
PGP000140 |
Brandkvist M et al. Hum Mol Genet (2020)
|Ext.
Reported Trait: Overweight in individuals aged 16-17.9 AUROC: 0.618 [0.583, 0.653] Due to a lack of information in the HUNT dataset, only 546 of the 557 common variants used to build the adult score by Richardson et al were included. Additionally, 28 of the 546 common variants were proxies. Proxy SNPs were accepted if they had an R^2 ≥0.8 as well as a D’ ≥0.95 using publicly available reference haplotypes of a European British in England and Scotland population from Phase 3 (Version 5) of the 1000 Genomes Project.
PPM001724 PGS000027
(GPS_BMI)
PSS000885|
European Ancestry|
19,588 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity within male siblings OR: 2.02 [1.66, 2.46] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001729 PGS000027
(GPS_BMI)
PSS000887|
European Ancestry|
26,323 individuals
PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.
Reported Trait: Obesity between male siblings OR: 2.15 [1.97, 2.34] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000892 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 17,740 cases
]
,
0.0 % Male samples
Mean = 58.9 years
Sd = 11.9 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000849 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 5,898 individuals Mean = 9.9 years European ALSPAC ALSPAC offspring
PSS000911 13,989 individuals Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)
QBB
PSS000890 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 25,108 cases
]
,
0.0 % Male samples
Mean = 51.2 years
Sd = 15.0 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000045 BMI difference between ages 21 and 45 1,699 individuals,
100.0 % Male samples
European HPFS
PSS000046 BMI difference between ages 45 and 65 1,634 individuals,
100.0 % Male samples
European HPFS
PSS000047 BMI difference between ages 65 and 80 2,020 individuals,
100.0 % Male samples
European HPFS
PSS000048 BMI difference between ages 18 and 45 5,956 individuals,
0.0 % Male samples
European NHS
PSS000049 BMI difference between age 18 and Menopause 6,705 individuals,
0.0 % Male samples
European NHS
PSS000050 BMI difference between ages 45 and 65 5,640 individuals,
0.0 % Male samples
European NHS
PSS000051 BMI difference between ages 65 and 80 2,942 individuals,
0.0 % Male samples
European NHS
PSS000052 BMI difference between Menopause and age 65 6,436 individuals,
0.0 % Male samples
European NHS
PSS000369 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 334 individuals,
69.2 % Male samples
Mean = 11.1 years
Sd = 0.48 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000370 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 329 individuals,
69.2 % Male samples
Mean = 12.81 years
Sd = 0.59 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000371 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 288 individuals,
69.2 % Male samples
Mean = 15.83 years
Sd = 0.6 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000372 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 265 individuals,
69.2 % Male samples
Mean = 19.2 years
Sd = 0.66 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000373 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 245 individuals,
69.2 % Male samples
Mean = 22.04 years
Sd = 0.69 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000374 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,318 individuals,
47.6 % Male samples
Mean = 11.1 years European TRAILS
PSS000375 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,313 individuals,
47.6 % Male samples
Mean = 13.5 years European TRAILS
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years
European TRAILS
PSS000377 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,174 individuals,
47.6 % Male samples
Mean = 19.2 years European TRAILS
PSS000378 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,095 individuals,
47.6 % Male samples
Mean = 22.4 years European TRAILS
PSS000411 59 MC4R mutations that had previously been reported to play a role in obesity were included in our analyses (Table S2) All phenotypic data used for analyses were collected at the baseline visit. We provide a brief description here; more details can be found in S1 Text and elsewhere [18–21]. BMI, calculated as weight (kg) divided by height squared (m2), was used to categorize individuals with underweight (BMI < 18.5 kg/m2), normal weight (18.5 kg/m2 ≤ BMI < 25 kg/m2), overweight (25 kg/m2 ≤ BMI < 30 kg/m2), or obesity (BMI ≥ 30 kg/m2).
[
  • 76 cases
  • , 28 controls
]
European UKB
PSS000412 59 MC4R mutations that had previously been reported to play a role in obesity were included in our analyses (Table S2) All phenotypic data used for analyses were collected at the baseline visit. We provide a brief description here; more details can be found in S1 Text and elsewhere [18–21]. BMI, calculated as weight (kg) divided by height squared (m2), was used to categorize individuals with underweight (BMI < 18.5 kg/m2), normal weight (18.5 kg/m2 ≤ BMI < 25 kg/m2), overweight (25 kg/m2 ≤ BMI < 30 kg/m2), or obesity (BMI ≥ 30 kg/m2).
[
  • 109,216 cases
  • , 147,554 controls
]
European UKB
PSS000413 All phenotypic data used for analyses were collected at the baseline visit. We provide a brief description here; more details can be found in S1 Text and elsewhere [18–21]. BMI, calculated as weight (kg) divided by height squared (m2), was used to categorize individuals with underweight (BMI < 18.5 kg/m2), normal weight (18.5 kg/m2 ≤ BMI < 25 kg/m2), overweight (25 kg/m2 ≤ BMI < 30 kg/m2), or obesity (BMI ≥ 30 kg/m2). 206,612 individuals,
100.0 % Male samples
Mean = 57.0 years
Sd = 8.1 years
European UKB
PSS000413 All phenotypic data used for analyses were collected at the baseline visit. We provide a brief description here; more details can be found in S1 Text and elsewhere [18–21]. BMI, calculated as weight (kg) divided by height squared (m2), was used to categorize individuals with underweight (BMI < 18.5 kg/m2), normal weight (18.5 kg/m2 ≤ BMI < 25 kg/m2), overweight (25 kg/m2 ≤ BMI < 30 kg/m2), or obesity (BMI ≥ 30 kg/m2). 244,896 individuals,
0.0 % Male samples
Mean = 57.0 years
Sd = 7.9 years
European UKB
PSS000848 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 2,199 individuals,
0.0 % Male samples
Mean = 50.8 years European ALSPAC ALSPAC mothers
PSS000847 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 3,997 individuals Mean = 17.8 years European ALSPAC ALSPAC offspring
PSS000875 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 37 cases
  • , 3,087 controls
]
European HUNT
PSS000876 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 344 cases
  • , 2,780 controls
]
European HUNT
PSS000877 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 30 cases
  • , 2,866 controls
]
European HUNT
PSS000878 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth. To defiine corresponding cut-offs for obesity and overweight for participants younger than 18 years, BMI z score was calulated using age and sex specific reference from the International Obesity Task Force.
[
  • 274 cases
  • , 2,622 controls
]
European HUNT
PSS000879 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 542 cases
  • , 11,637 controls
]
European HUNT
PSS000880 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 2,898 cases
  • , 9,281 controls
]
European HUNT
PSS000881 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 1,240 cases
  • , 15,899 controls
]
European HUNT
PSS000882 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 5,775 cases
  • , 11,364 controls
]
European HUNT
PSS000883 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 15,112 cases
  • , 47,429 controls
]
European HUNT
PSS000884 BMI was calculated as weight in kilograms per height in metres squared. Weight was measured to the nearest half kilogram wih participants wearing light cloes and no shoes and height was measured to the nearest centimeter. WHO defines overweight as BMI greater than or equal to 25 and obesity as BMI greater than or equal to 30. BMI strongly related to longitudinal growth.
[
  • 43,408 cases
  • , 19,133 controls
]
European HUNT
PSS000885 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 19,588 cases
]
,
100.0 % Male samples
Mean = 42.4 years
Sd = 12.6 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000886 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 21,499 cases
]
,
0.0 % Male samples
Mean = 42.6 years
Sd = 12.8 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000887 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 26,336 cases
]
,
100.0 % Male samples
Mean = 47.6 years
Sd = 16.1 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000888 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 29,545 cases
]
,
0.0 % Male samples
Mean = 47.1 years
Sd = 16.5 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000889 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 21,192 cases
]
,
100.0 % Male samples
Mean = 52.3 years
Sd = 14.5 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000037 288,016 individuals,
45.0 % Male samples
European UKB
PSS000891 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 14,487 cases
]
,
100.0 % Male samples
Mean = 60.2 years
Sd = 11.5 years
European HUNT number o cases = number of observations (more than 1 pp)