Trait: intestinal disease

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009431
Description A non-neoplastic or neoplastic disorder that affects the small or large intestine. [NCIT: C26801]
Trait category
Digestive system disorder
Synonyms 10 synonyms
  • disease of intestine
  • disease or disorder of intestine
  • disease, intestinal
  • diseases, intestinal
  • disorder of intestine
  • intestinal disease
  • intestinal disorder
  • intestine disease
  • intestine disease or disorder
  • intestine disorder
Mapped terms 22 mapped terms
  • DOID:5295
  • ICD10:A04
  • ICD10:A08
  • ICD10:K63
  • ICD9:520-579.99
  • ICD9:560-569.99
  • ICD9:564
  • ICD9:564.4
  • ICD9:569
  • ICD9:569.4
  • ICD9:569.49
  • ICD9:569.89
  • ICD9:569.9
  • ICD9:570-579.99
  • ICD9:575
  • MEDGEN:7130
  • MESH:D007410
  • MONDO:0005020
  • NCIT:C26801
  • NCIt:C26801
  • SCTID:85919009
  • UMLS:C0021831
Child trait(s) 18 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "intestinal disease" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000017
(GPS_IBD)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Inflammatory bowel disease inflammatory bowel disease 6,907,112
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000017/ScoringFiles/PGS000017.txt.gz - Check Terms/Licenses
PGS000040
(GRS_CeD)
PGP000028 |
Abraham G et al. PLoS Genet (2014)
Coeliac disease celiac disease 228
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000040/ScoringFiles/PGS000040.txt.gz
PGS000041
(GRS-DQ2.5-CeD)
PGP000029 |
Abraham G et al. Genome Med (2015)
Coeliac disease celiac disease 2,513
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000041/ScoringFiles/PGS000041.txt.gz
PGS000042
(GRS-DQ2.5-CeD-imputed)
PGP000029 |
Abraham G et al. Genome Med (2015)
Coeliac disease celiac disease 3,317
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000042/ScoringFiles/PGS000042.txt.gz
PGS000055
(PRS_CRC)
PGP000040 |
Schmit SL et al. J Natl Cancer Inst (2019)
Colorectal cancer colorectal cancer 76
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000055/ScoringFiles/PGS000055.txt.gz
PGS000074
(CC_Colorectal)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Colorectal cancer colorectal cancer 103
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000074/ScoringFiles/PGS000074.txt.gz
PGS000146
(CRC_GRS_27)
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Colorectal cancer colorectal cancer 27
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000146/ScoringFiles/PGS000146.txt.gz
PGS000147
(CRC21)
PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
Colorectal cancer colorectal cancer 21
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000147/ScoringFiles/PGS000147.txt.gz
PGS000148
(CRC63)
PGP000071 |
Jeon J et al. Gastroenterology (2018)
Colorectal cancer colorectal cancer 63
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000148/ScoringFiles/PGS000148.txt.gz
PGS000149
(CRC41)
PGP000072 |
Smith T et al. Br J Cancer (2018)
Colorectal cancer colorectal cancer 41
-
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000149/ScoringFiles/PGS000149.txt.gz
PGS000150
(GRS48)
PGP000073 |
Weigl K et al. Gastroenterology (2018)
Colorectal cancer colorectal cancer 48
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000150/ScoringFiles/PGS000150.txt.gz
PGS000151
(SC_GRS)
PGP000074 |
Xin J et al. Gene (2018)
Colorectal cancer colorectal cancer 14
-
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000151/ScoringFiles/PGS000151.txt.gz
PGS000154
(cGRS_Colorectal)
PGP000075 |
Shi Z et al. Cancer Med (2019)
Colorectal cancer colorectal cancer 30
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000154/ScoringFiles/PGS000154.txt.gz
PGS000316
(GRS42_Coeliac)
PGP000093 |
Sharp SA et al. Aliment Pharmacol Ther (2020)
Coeliac disease celiac disease 53
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000316/ScoringFiles/PGS000316.txt.gz
PGS000367
(PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 74
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000367/ScoringFiles/PGS000367.txt.gz
PGS000368
(PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 74
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000368/ScoringFiles/PGS000368.txt.gz
PGS000369
(PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 81
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000369/ScoringFiles/PGS000369.txt.gz
PGS000370
(PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 87
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000370/ScoringFiles/PGS000370.txt.gz
PGS000371
(PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 18
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000371/ScoringFiles/PGS000371.txt.gz
PGS000372
(PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 27
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000372/ScoringFiles/PGS000372.txt.gz
PGS000373
(PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 1,119,238
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000373/ScoringFiles/PGS000373.txt.gz
PGS000374
(PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 41
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000374/ScoringFiles/PGS000374.txt.gz
PGS000375
(PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 370
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000375/ScoringFiles/PGS000375.txt.gz
PGS000376
(PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 1,111,490
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000376/ScoringFiles/PGS000376.txt.gz
PGS000377
(PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 5,740,814
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000377/ScoringFiles/PGS000377.txt.gz
PGS000378
(PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 1,111,399
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000378/ScoringFiles/PGS000378.txt.gz
PGS000379
(PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 5,715,093
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000379/ScoringFiles/PGS000379.txt.gz
PGS000380
(PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 1,119,238
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000380/ScoringFiles/PGS000380.txt.gz
PGS000381
(PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 12
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000381/ScoringFiles/PGS000381.txt.gz
PGS000382
(PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Colon cancer colon carcinoma 150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000382/ScoringFiles/PGS000382.txt.gz
PGS000383
(PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Malignant neoplasm of rectum, rectosigmoid junction, and anus rectum cancer,
rectosigmoid junction neoplasm
1,078,799
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000383/ScoringFiles/PGS000383.txt.gz
PGS000384
(PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608)
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Malignant neoplasm of rectum, rectosigmoid junction, and anus rectum cancer,
rectosigmoid junction neoplasm
1,104,018
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000384/ScoringFiles/PGS000384.txt.gz
PGS000720
(PRS_Colorectal)
PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
Colorectal cancer colorectal cancer 95
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000720/ScoringFiles/PGS000720.txt.gz
PGS000734
(PRS95_CRC)
PGP000142 |
Archambault AN et al. Gastroenterology (2019)
Colorectal cancer colorectal cancer 95
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000734/ScoringFiles/PGS000734.txt.gz
PGS000765
(PRS_CRC95)
PGP000170 |
Huyghe JR et al. Nat Genet (2018)
Colorectal cancer colorectal cancer 95
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000765/ScoringFiles/PGS000765.txt.gz
PGS000785
(CC_Colorectal_IV)
PGP000186 |
Kachuri L et al. Nat Commun (2020)
Colorectal cancer colorectal cancer 103
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000785/ScoringFiles/PGS000785.txt.gz
PGS000801
(GRS40_CRC)
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Colorectal cancer colorectal cancer 40
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000801/ScoringFiles/PGS000801.txt.gz
PGS000802
(CRC_19)
PGP000191 |
He CY et al. Genomics (2021)
Colorectal cancer colorectal cancer 19
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000802/ScoringFiles/PGS000802.txt.gz
PGS000996
(GBE_HC262)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Diverticular disease/diverticulitis diverticular disease,
diverticulitis
368
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000996/ScoringFiles/PGS000996.txt.gz
PGS000997
(GBE_HC1106)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Diverticular disease of intestine (time-to-event) diverticular disease 5,757
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000997/ScoringFiles/PGS000997.txt.gz
PGS001288
(GBE_HC95)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Inflammatory bowel disease inflammatory bowel disease 195
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001288/ScoringFiles/PGS001288.txt.gz
PGS001300
(GBE_BIN21068)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Celiac disease or gluten sensitivity, diagnosed celiac disease 9
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001300/ScoringFiles/PGS001300.txt.gz
PGS001301
(GBE_HC303)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Malabsorption/coeliac disease celiac disease 428
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001301/ScoringFiles/PGS001301.txt.gz
PGS001306
(GBE_HC201)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Ulcerative colitis ulcerative colitis 179
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001306/ScoringFiles/PGS001306.txt.gz
PGS001307
(GBE_HC1102)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Ulcerative colitis (time-to-event) ulcerative colitis 809
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001307/ScoringFiles/PGS001307.txt.gz
PGS001330
(GBE_HC1101)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Crohn's disease [regional enteritis] (time-to-event) Crohn's disease 220
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001330/ScoringFiles/PGS001330.txt.gz
PGS001331
(GBE_HC322)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Crohn's disease Crohn's disease 257
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001331/ScoringFiles/PGS001331.txt.gz
PGS001369
(GBE_HC1090)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Acute appendicitis (time-to-event) appendicitis 4
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001369/ScoringFiles/PGS001369.txt.gz
PGS001390
(GBE_HC1084)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Duodenal ulcer (time-to-event) duodenal ulcer 220
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001390/ScoringFiles/PGS001390.txt.gz
PGS001516
(GBE_HC1112)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Other diseases of intestine (time-to-event) intestinal disease 90
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001516/ScoringFiles/PGS001516.txt.gz
PGS001776
(PRS45_CC)
PGP000256 |
Gafni A et al. PLoS One (2021)
Colorectal cancer colorectal cancer 45
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001776/ScoringFiles/PGS001776.txt.gz
PGS001785
(1kgeur_gbmi_leaveUKBBout_AcApp_pst_eff_a1_b0.5_phiauto)
PGP000262 |
Wang Y et al. Cell Genom (2023)
Acute appendicitis appendicitis 911,334
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001785/ScoringFiles/PGS001785.txt.gz
PGS001802
(portability-PLR_153)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Colorectal cancer colorectal cancer 2,821
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001802/ScoringFiles/PGS001802.txt.gz
PGS001811
(portability-PLR_208)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Benign neoplasm of colon benign colon neoplasm 2,231
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001811/ScoringFiles/PGS001811.txt.gz
PGS001852
(portability-PLR_535.6)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Duodenitis duodenitis 191
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001852/ScoringFiles/PGS001852.txt.gz
PGS001853
(portability-PLR_540)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Appendiceal conditions disorder of appendix 19
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001853/ScoringFiles/PGS001853.txt.gz
PGS001855
(portability-PLR_555.2)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Ulcerative colitis ulcerative colitis 1,505
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001855/ScoringFiles/PGS001855.txt.gz
PGS001856
(portability-PLR_557.1)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Celiac disease celiac disease 1,661
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001856/ScoringFiles/PGS001856.txt.gz
PGS001859
(portability-PLR_565.1)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Anal and rectal polyp polyp of rectum,
anal polyp
789
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001859/ScoringFiles/PGS001859.txt.gz
PGS001894
(portability-PLR_celiac_gluten)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Diagnosed with coeliac disease or gluten sensitivity celiac disease 484
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001894/ScoringFiles/PGS001894.txt.gz
PGS002013
(portability-ldpred2_153)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Colorectal cancer colorectal cancer 648,559
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002013/ScoringFiles/PGS002013.txt.gz
PGS002019
(portability-ldpred2_208)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Benign neoplasm of colon benign colon neoplasm 667,546
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002019/ScoringFiles/PGS002019.txt.gz
PGS002064
(portability-ldpred2_540)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Appendiceal conditions disorder of appendix 497,422
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002064/ScoringFiles/PGS002064.txt.gz
PGS002066
(portability-ldpred2_555.2)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Ulcerative colitis ulcerative colitis 566,637
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002066/ScoringFiles/PGS002066.txt.gz
PGS002067
(portability-ldpred2_557.1)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Celiac disease celiac disease 58,231
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002067/ScoringFiles/PGS002067.txt.gz
PGS002070
(portability-ldpred2_565.1)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Anal and rectal polyp polyp of rectum,
anal polyp
584,133
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002070/ScoringFiles/PGS002070.txt.gz
PGS002107
(portability-ldpred2_celiac_gluten)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Diagnosed with coeliac disease or gluten sensitivity celiac disease 39,066
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002107/ScoringFiles/PGS002107.txt.gz
PGS002252
(PRS_CRC)
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Colorectal cancer colorectal cancer 141
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002252/ScoringFiles/PGS002252.txt.gz
PGS002265
(PRS140_CRC)
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 140
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002265/ScoringFiles/PGS002265.txt.gz
PGS002742
(PRS115_EAS)
PGP000354 |
Ping J et al. Int J Cancer (2022)
Colorectal cancer colorectal cancer 115
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002742/ScoringFiles/PGS002742.txt.gz
PGS002743
(PRS115_EUR)
PGP000354 |
Ping J et al. Int J Cancer (2022)
Colorectal cancer colorectal cancer 115
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002743/ScoringFiles/PGS002743.txt.gz
PGS002744
(PRS115_EUR_EAS)
PGP000354 |
Ping J et al. Int J Cancer (2022)
Colorectal cancer colorectal cancer 115
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002744/ScoringFiles/PGS002744.txt.gz
PGS002758
(Colorectal_cancer_prscs)
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Colorectal cancer colorectal cancer 1,087,843
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002758/ScoringFiles/PGS002758.txt.gz
PGS003386
(best_COADREAD)
PGP000413 |
Namba S et al. Cancer Res (2022)
Colorectal cancer colorectal carcinoma 61
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003386/ScoringFiles/PGS003386.txt.gz
PGS003395
(PRScsx_CRC)
PGP000414 |
Xin J et al. Genome Med (2023)
Colorectal cancer colorectal cancer 1,145,689
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003395/ScoringFiles/PGS003395.txt.gz
PGS003431
(LDPred2-inf)
PGP000438 |
Briggs SEW et al. BMJ (2022)
Colorectal cancer colorectal cancer 1,104,409
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003431/ScoringFiles/PGS003431.txt.gz
PGS003432
(LDPred2-grid)
PGP000438 |
Briggs SEW et al. BMJ (2022)
Colorectal cancer colorectal cancer 1,104,409
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003432/ScoringFiles/PGS003432.txt.gz
PGS003433
(LDPred2-grid-sp)
PGP000438 |
Briggs SEW et al. BMJ (2022)
Colorectal cancer colorectal cancer 616,956
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003433/ScoringFiles/PGS003433.txt.gz
PGS003434
(SCT)
PGP000438 |
Briggs SEW et al. BMJ (2022)
Colorectal cancer colorectal cancer 194,756
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003434/ScoringFiles/PGS003434.txt.gz
PGS003435
(CT)
PGP000438 |
Briggs SEW et al. BMJ (2022)
Colorectal cancer colorectal cancer 13,446
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003435/ScoringFiles/PGS003435.txt.gz
PGS003436
(GWAS-sig)
PGP000438 |
Briggs SEW et al. BMJ (2022)
Colorectal cancer colorectal cancer 50
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003436/ScoringFiles/PGS003436.txt.gz
PGS003439
(PRSCC_140)
PGP000441 |
Su YR et al. Cancer Epidemiol Biomarkers Prev (2023)
Colorectal cancer colorectal cancer 140
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003439/ScoringFiles/PGS003439.txt.gz
PGS003739
(PRS81_CoC)
PGP000470 |
Xin J et al. EBioMedicine (2023)
Colorectal cancer colorectal carcinoma 81
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003739/ScoringFiles/PGS003739.txt.gz
PGS003760
(PRS49_EOCRC)
PGP000480 |
Wang H et al. Genome Med (2023)
Early onset colorectal cancer colorectal cancer 49
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003760/ScoringFiles/PGS003760.txt.gz
PGS003850
(CRC_PRS_200loci)
PGP000491 |
Fernandez-Rozadilla C et al. Nat Genet (2022)
Colorectal cancer colorectal cancer 205
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003850/ScoringFiles/PGS003850.txt.gz
PGS003851
(CRC_PRS_EUR)
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Colorectal cancer colorectal cancer 1,180,765
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003851/ScoringFiles/PGS003851.txt.gz
PGS003852
(CRC_PRS_EUR_EAS)
PGP000492 |
Thomas M et al. Nat Commun (2023)
Colorectal cancer colorectal cancer 1,016,596
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003852/ScoringFiles/PGS003852.txt.gz
PGS003979
(CRC_PRSCS)
PGP000515 |
Tamlander M et al. Br J Cancer (2023)
Colorectal cancer colorectal carcinoma 1,088,133
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003979/ScoringFiles/PGS003979.txt.gz
PGS003981
(dbslmm.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 1,103,311
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003981/ScoringFiles/PGS003981.txt.gz
PGS003997
(lassosum.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 8,406
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003997/ScoringFiles/PGS003997.txt.gz
PGS004013
(lassosum.CV.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 22,690
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004013/ScoringFiles/PGS004013.txt.gz
PGS004023
(ldpred2.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 1,018,068
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004023/ScoringFiles/PGS004023.txt.gz
PGS004038
(ldpred2.CV.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 1,018,068
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004038/ScoringFiles/PGS004038.txt.gz
PGS004051
(megaprs.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 784,928
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004051/ScoringFiles/PGS004051.txt.gz
PGS004067
(megaprs.CV.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 784,928
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004067/ScoringFiles/PGS004067.txt.gz
PGS004081
(prscs.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 1,073,268
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004081/ScoringFiles/PGS004081.txt.gz
PGS004097
(prscs.CV.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 1,073,268
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004097/ScoringFiles/PGS004097.txt.gz
PGS004105
(pt_clump.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 139
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004105/ScoringFiles/PGS004105.txt.gz
PGS004121
(pt_clump_nested.CV.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 774
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004121/ScoringFiles/PGS004121.txt.gz
PGS004135
(sbayesr.auto.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 912,746
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004135/ScoringFiles/PGS004135.txt.gz
PGS004151
(UKBB_EnsPGS.GCST004131.IBD)
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Inflammatory bowel disease (IBD) inflammatory bowel disease 1,102,205
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004151/ScoringFiles/PGS004151.txt.gz
PGS004240
(PRS89_CRC)
PGP000541 |
Fan L et al. Int J Cancer (2023)
Colorectal cancer colorectal carcinoma 89
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004240/ScoringFiles/PGS004240.txt.gz
PGS004243
(PRS67_colorectum)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Colorectal cancer colorectal carcinoma 67
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004243/ScoringFiles/PGS004243.txt.gz
PGS004253
(uc_ldpred2)
PGP000545 |
Middha P et al. Nat Commun (2024)
Ulcerative colitis ulcerative colitis 744,575
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004253/ScoringFiles/PGS004253.txt.gz
PGS004254
(cd_ldpred2)
PGP000545 |
Middha P et al. Nat Commun (2024)
Crohn's disease Crohn's disease 744,682
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004254/ScoringFiles/PGS004254.txt.gz
PGS004270
(GenoBoost_inflammatory_bowel_disease_0)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Inflammatory bowel disease inflammatory bowel disease 20
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004270/ScoringFiles/PGS004270.txt.gz
PGS004271
(GenoBoost_inflammatory_bowel_disease_1)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Inflammatory bowel disease inflammatory bowel disease 20
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004271/ScoringFiles/PGS004271.txt.gz
PGS004272
(GenoBoost_inflammatory_bowel_disease_2)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Inflammatory bowel disease inflammatory bowel disease 100
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004272/ScoringFiles/PGS004272.txt.gz
PGS004273
(GenoBoost_inflammatory_bowel_disease_3)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Inflammatory bowel disease inflammatory bowel disease 110
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004273/ScoringFiles/PGS004273.txt.gz
PGS004274
(GenoBoost_inflammatory_bowel_disease_4)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Inflammatory bowel disease inflammatory bowel disease 40
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004274/ScoringFiles/PGS004274.txt.gz
PGS004300
(GenoBoost_colorectal_cancer_0)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 70
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004300/ScoringFiles/PGS004300.txt.gz
PGS004301
(GenoBoost_colorectal_cancer_1)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 600
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004301/ScoringFiles/PGS004301.txt.gz
PGS004302
(GenoBoost_colorectal_cancer_2)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 300
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004302/ScoringFiles/PGS004302.txt.gz
PGS004303
(GenoBoost_colorectal_cancer_3)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 200
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004303/ScoringFiles/PGS004303.txt.gz
PGS004304
(GenoBoost_colorectal_cancer_4)
PGP000546 |
Ohta R et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 700
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004304/ScoringFiles/PGS004304.txt.gz
PGS004445
(disease.D12.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
D12 (Benign neoplasm of colon, rectum, anus and anal canal) colorectal carcinoma 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004445/ScoringFiles/PGS004445.txt.gz
PGS004474
(disease.K57.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
K57 (Diverticular disease of intestine) diverticular disease 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004474/ScoringFiles/PGS004474.txt.gz
PGS004475
(disease.K59.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
K59 (Other functional intestinal disorders) intestinal disease 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004475/ScoringFiles/PGS004475.txt.gz
PGS004515
(meta.D12.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
D12 (Benign neoplasm of colon, rectum, anus and anal canal) colorectal carcinoma 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004515/ScoringFiles/PGS004515.txt.gz
PGS004544
(meta.K57.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
K57 (Diverticular disease of intestine) diverticular disease 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004544/ScoringFiles/PGS004544.txt.gz
PGS004545
(meta.K59.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
K59 (Other functional intestinal disorders) intestinal disease 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004545/ScoringFiles/PGS004545.txt.gz
PGS004580
(CRC_PRSCS)
PGP000562 |
Youssef O et al. Lab Invest (2024)
Colorectal cancer colorectal carcinoma 1,099,906
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004580/ScoringFiles/PGS004580.txt.gz
PGS004586
(PPS_CRC)
PGP000564 |
Xin J et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 287
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004586/ScoringFiles/PGS004586.txt.gz
PGS004614
(DivD_SNPWeights)
PGP000592 |
Wu Y et al. Cell Genom (2023)
Diverticular disease diverticular disease 1,082,282
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004614/ScoringFiles/PGS004614.txt.gz
PGS004689
(colorectal_cancer)
PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
Colorectal cancer colorectal carcinoma 1,077,789
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004689/ScoringFiles/PGS004689.txt.gz
PGS004876
(INTERVENE_MegaPRS_Appendicitis)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Appendicitis appendicitis 601,835
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004876/ScoringFiles/PGS004876.txt.gz
PGS004880
(INTERVENE_MegaPRS_Colorectal_cancer)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Colorectal cancer colorectal carcinoma 843,248
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004880/ScoringFiles/PGS004880.txt.gz
PGS004904
(PRS127_CRC)
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Colorectal cancer colorectal carcinoma 127
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004904/ScoringFiles/PGS004904.txt.gz
PGS004912
(PRS183)
PGP000643 |
Tian J et al. Genome Med (2024)
Colorectal neoplasm colorectal carcinoma 183
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004912/ScoringFiles/PGS004912.txt.gz
PGS004930
(celiac_disease_snpnet_combined)
PGP000665 |
Moreno-Grau S et al. Human Genomics (2024)
Celiac disease celiac disease 463
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004930/ScoringFiles/PGS004930.txt.gz
PGS004945
(PRS87_CRC)
PGP000671 |
Gao P et al. Int J Cancer (2023)
Colorectal cancer colorectal cancer 87
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004945/ScoringFiles/PGS004945.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000026 PGS000017
(GPS_IBD)
PSS000016|
European Ancestry|
288,978 individuals
PGP000006 |
Khera AV et al. Nat Genet (2018)
Reported Trait: Inflammatory bowel disease AUROC: 0.63 [0.62, 0.64] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.021 age; sex; Ancestry PC 1-4; genotyping chip
PPM012874 PGS000017
(GPS_IBD)
PSS009588|
European Ancestry|
1,433 individuals
PGP000288 |
Garcia-Etxebarria K et al. Sci Rep (2022)
|Ext.
Reported Trait: Inflammatory Bowel Disease AUROC: 0.69 [0.66, 0.72]
PPM000093 PGS000040
(GRS_CeD)
PSS000059|
European Ancestry|
2,476 individuals
PGP000028 |
Abraham G et al. PLoS Genet (2014)
Reported Trait: Coeliac disease AUROC: 0.9
PPM000094 PGS000040
(GRS_CeD)
PSS000061|
European Ancestry|
1,040 individuals
PGP000028 |
Abraham G et al. PLoS Genet (2014)
Reported Trait: Coeliac disease AUROC: 0.87
PPM000095 PGS000040
(GRS_CeD)
PSS000062|
European Ancestry|
1,649 individuals
PGP000028 |
Abraham G et al. PLoS Genet (2014)
Reported Trait: Coeliac disease AUROC: 0.86
PPM000096 PGS000040
(GRS_CeD)
PSS000063|
European Ancestry|
2,200 individuals
PGP000028 |
Abraham G et al. PLoS Genet (2014)
Reported Trait: Coeliac disease AUROC: 0.87
PPM000097 PGS000040
(GRS_CeD)
PSS000060|
European Ancestry|
10,304 individuals
PGP000028 |
Abraham G et al. PLoS Genet (2014)
Reported Trait: Coeliac disease AUROC: 0.87
PPM000098 PGS000040
(GRS_CeD)
PSS000064|
European Ancestry|
1,696 individuals
PGP000029 |
Abraham G et al. Genome Med (2015)
|Ext.
Reported Trait: Coeliac disease AUROC: 0.831 [0.808, 0.85]
PPM000099 PGS000040
(GRS_CeD)
PSS000065|
European Ancestry|
1,237 individuals
PGP000029 |
Abraham G et al. Genome Med (2015)
|Ext.
Reported Trait: Coeliac disease in HLA-DQ2.5 carriers AUROC: 0.669 [0.625, 0.713]
PPM000100 PGS000041
(GRS-DQ2.5-CeD)
PSS000065|
European Ancestry|
1,237 individuals
PGP000029 |
Abraham G et al. Genome Med (2015)
Reported Trait: Coeliac disease in HLA-DQ2.5 carriers AUROC: 0.718 [0.676, 0.761]
PPM000101 PGS000042
(GRS-DQ2.5-CeD-imputed)
PSS000065|
European Ancestry|
1,237 individuals
PGP000029 |
Abraham G et al. Genome Med (2015)
Reported Trait: Coeliac disease in HLA-DQ2.5 carriers AUROC: 0.73 [0.687, 0.772]
PPM000139 PGS000055
(PRS_CRC)
PSS000087|
European Ancestry|
61,335 individuals
PGP000040 |
Schmit SL et al. J Natl Cancer Inst (2019)
Reported Trait: Colorectal cancer Familial relative risk explained (%): 11.9 [9.2, 15.5]
PRS percentile threshold for Odds Ratio > 2: 95.7
age, sex, PCs, PC*study
PPM000140 PGS000055
(PRS_CRC)
PSS000086|
East Asian Ancestry|
21,630 individuals
PGP000040 |
Schmit SL et al. J Natl Cancer Inst (2019)
Reported Trait: Colorectal cancer PRS percentile threshold for Odds Ratio > 2: 99.1 age, sex, PCs, PC*study
PPM018698 PGS000055
(PRS_CRC)
PSS011070|
East Asian Ancestry|
332 individuals
PGP000494 |
Ho PJ et al. Elife (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.65 [0.62, 0.69] Hazard ratio (HR, high vs low tertile): 2.27 [1.6, 3.21] age at recruitment
PPM000194 PGS000074
(CC_Colorectal)
PSS000113|
European Ancestry|
416,249 individuals
PGP000050 |
Graff RE et al. Nat Commun (2021)
Reported Trait: Colorectal cancer OR: 1.37 [1.33, 1.4] Genotyping reagent kit (GERA cohort only), genotyping array (UK Biobank only), age, sex, 10 PCs. Results from meta-analysis of GERA and UKB
PPM002040 PGS000074
(CC_Colorectal)
PSS001013|
European Ancestry|
393,723 individuals
PGP000186 |
Kachuri L et al. Nat Commun (2020)
|Ext.
Reported Trait: Incident colorectal cancer HR: 1.32 [1.27, 1.37] AUROC: 0.704
C-index: 0.704 (0.006)
Age at assessment, sex, family history of bowel cancer, genotyping array, PCs(1-15), wasit to hip ratio, cigarette pack years, frequency of processed meat intake (<1 per week vs. ≥1 per week), moderate and/or strenuous physical activity (days per week), alcohol intake C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM017164 PGS000074
(CC_Colorectal)
PSS010144|
European Ancestry|
2,150 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.
Reported Trait: Colorectal cancer HR: 1.36 [1.31, 1.42] age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates
PPM000439 PGS000146
(CRC_GRS_27)
PSS000252|
European Ancestry|
3,269 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Distal colon cancer OR: 1.08 [1.06, 1.11] Study, age, endoscopy, family history
PPM000438 PGS000146
(CRC_GRS_27)
PSS000254|
European Ancestry|
3,292 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Proximal colon cancer OR: 1.07 [1.04, 1.1] Study, age, endoscopy, family history
PPM000445 PGS000146
(CRC_GRS_27)
PSS000257|
European Ancestry|
733 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Colorectal cancer AUROC: 0.56 [0.51, 0.61] Age, endoscopy, family history
PPM000444 PGS000146
(CRC_GRS_27)
PSS000258|
European Ancestry|
1,002 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Colorectal cancer AUROC: 0.59 [0.54, 0.64] Age, endoscopy, family history
PPM000443 PGS000146
(CRC_GRS_27)
PSS000255|
European Ancestry|
4,573 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Rectal cancer OR: 1.12 [1.08, 1.15] Study, age, endoscopy, family history
PPM000442 PGS000146
(CRC_GRS_27)
PSS000251|
European Ancestry|
4,886 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Distal colon cancer OR: 1.08 [1.05, 1.1] Study, age, endoscopy, family history
PPM000441 PGS000146
(CRC_GRS_27)
PSS000253|
European Ancestry|
5,530 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Proximal colon cancer OR: 1.06 [1.03, 1.08] Study, age, endoscopy, family history
PPM000440 PGS000146
(CRC_GRS_27)
PSS000256|
European Ancestry|
3,167 individuals
PGP000069 |
Hsu L et al. Gastroenterology (2015)
Reported Trait: Rectal cancer OR: 1.06 [1.03, 1.09] Study, age, endoscopy, family history
PPM000448 PGS000147
(CRC21)
PSS000259|
European Ancestry|
4,080 individuals
PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
Reported Trait: Colorectal cancer AUROC: 0.63 [0.6, 0.66] Odds Ratio (OR; per allele): 1.07 [1.04, 1.1] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history
PPM000447 PGS000147
(CRC21)
PSS000259|
European Ancestry|
4,080 individuals
PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
Reported Trait: Rectal cancer Odds Ratio (OR; per allele): 1.1 [1.06, 1.15] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history
PPM000446 PGS000147
(CRC21)
PSS000259|
European Ancestry|
4,080 individuals
PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
Reported Trait: Colon cancer Odds Ratio (OR; per allele): 1.06 [1.03, 1.09] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history
PPM000449 PGS000147
(CRC21)
PSS000259|
European Ancestry|
4,080 individuals
PGP000070 |
Ibáñez-Sanz G et al. Sci Rep (2017)
Reported Trait: Colorectal cancer AUROC: 0.56 [0.54, 0.58]
PPM000452 PGS000148
(CRC63)
PSS000260|
European Ancestry|
5,500 individuals
PGP000071 |
Jeon J et al. Gastroenterology (2018)
Reported Trait: Colorectal cancer AUROC: 0.59 [0.58, 0.6] age, family history, study, endoscopy history Risk prediction using Model III (Family History & G-score)
PPM000451 PGS000148
(CRC63)
PSS000261|
European Ancestry|
4,666 individuals
PGP000071 |
Jeon J et al. Gastroenterology (2018)
Reported Trait: Colorectal cancer AUROC: 0.63 [0.62, 0.64] age, family history, study, endoscopy history, E-score (height, body mass index, education, history of type 2 diabetes mellitus, smoking status, alcohol consumption, regular aspirin use, regular NSAIDs use, smoking pack-years, dietary factors, total-energy, physical activity) Risk prediction using Model IV (Family history & E-score & G-score)
PPM000450 PGS000148
(CRC63)
PSS000261|
European Ancestry|
4,666 individuals
PGP000071 |
Jeon J et al. Gastroenterology (2018)
Reported Trait: Colorectal cancer AUROC: 0.59 [0.58, 0.6] age, family history, study, endoscopy history Risk prediction using Model III (Family History & G-score)
PPM000453 PGS000148
(CRC63)
PSS000260|
European Ancestry|
5,500 individuals
PGP000071 |
Jeon J et al. Gastroenterology (2018)
Reported Trait: Colorectal cancer AUROC: 0.62 [0.61, 0.63] age, family history, study, endoscopy history, E-score (height, body mass index, education, history of type 2 diabetes mellitus, smoking status, alcohol consumption, regular aspirin use, regular NSAIDs use, regular use of post-menopausal hormones, smoking pack-years, dietary factors, total-energy, physical activity) Risk prediction using Model IV (Family history & E-score & G-score)
PPM000464 PGS000149
(CRC41)
PSS000263|
European Ancestry|
286,877 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals with a family history C-index: 0.68 [0.67, 0.7] Wells et al. model (age, diabetes, multi-vitamin usage, family history of colon cancer, years of education, body mass index, alcohol intake, physical activity, non-steroidal anti-inflammatory drug usage, red meat intake, smoking and oestrogen use [women only]) Fully recalibrated model
PPM000463 PGS000149
(CRC41)
PSS000263|
European Ancestry|
286,877 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer C-index: 0.68 [0.67, 0.7] Wells et al. model (age, diabetes, multi-vitamin usage, family history of colon cancer, years of education, body mass index, alcohol intake, physical activity, non-steroidal anti-inflammatory drug usage, red meat intake, smoking and oestrogen use [women only]) Fully recalibrated model
PPM000459 PGS000149
(CRC41)
PSS000262|
European Ancestry|
361,543 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals without a family history C-index: 0.66 [0.62, 0.69] Taylor et al. model (age-specific rates of CRC with estimated relative risks for different degrees of CRC family history) Fully recalibrated model
PPM000458 PGS000149
(CRC41)
PSS000262|
European Ancestry|
361,543 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals with a family history C-index: 0.69 [0.67, 0.7] Taylor et al. model (age-specific rates of CRC with estimated relative risks for different degrees of CRC family history) Fully recalibrated model
PPM000457 PGS000149
(CRC41)
PSS000262|
European Ancestry|
361,543 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer C-index: 0.68 [0.67, 0.7] Taylor et al. model (age-specific rates of CRC with estimated relative risks for different degrees of CRC family history) Fully recalibrated model
PPM000465 PGS000149
(CRC41)
PSS000263|
European Ancestry|
286,877 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals without a family history C-index: 0.67 [0.63, 0.71] Wells et al. model (age, diabetes, multi-vitamin usage, family history of colon cancer, years of education, body mass index, alcohol intake, physical activity, non-steroidal anti-inflammatory drug usage, red meat intake, smoking and oestrogen use [women only]) Fully recalibrated model
PPM000462 PGS000149
(CRC41)
PSS000263|
European Ancestry|
286,877 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals without a family history C-index: 0.57 [0.53, 0.6]
PPM000461 PGS000149
(CRC41)
PSS000263|
European Ancestry|
286,877 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals with a family history C-index: 0.56 [0.55, 0.58]
PPM000460 PGS000149
(CRC41)
PSS000263|
European Ancestry|
286,877 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer C-index: 0.57 [0.55, 0.58]
PPM000456 PGS000149
(CRC41)
PSS000262|
European Ancestry|
361,543 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals without a family history C-index: 0.55 [0.52, 0.59]
PPM000455 PGS000149
(CRC41)
PSS000262|
European Ancestry|
361,543 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer in individuals with a family history C-index: 0.57 [0.55, 0.58]
PPM000454 PGS000149
(CRC41)
PSS000262|
European Ancestry|
361,543 individuals
PGP000072 |
Smith T et al. Br J Cancer (2018)
Reported Trait: Incident colorectal cancer C-index: 0.56 [0.55, 0.58]
PPM000469 PGS000150
(GRS48)
PSS000269|
European Ancestry|
749 individuals
PGP000073 |
Weigl K et al. Gastroenterology (2018)
Reported Trait: advanced neoplasm (colorectal cancer) C-index: 0.615 Odds Ratio (OR; highest vs. lowest tertile of GRS): 2.74 [1.84, 4.09] sex, age, previous colonoscopy, physical activity
PPM000468 PGS000150
(GRS48)
PSS000269|
European Ancestry|
749 individuals
PGP000073 |
Weigl K et al. Gastroenterology (2018)
Reported Trait: advanced neoplasm (colorectal cancer) C-index: 0.599 Odds Ratio (OR; highest vs. lowest tertile of GRS): 2.64 [1.77, 3.92] sex, age
PPM000467 PGS000150
(GRS48)
PSS000268|
European Ancestry|
1,043 individuals
PGP000073 |
Weigl K et al. Gastroenterology (2018)
Reported Trait: non-advanced adenoma (colorectal) C-index: 0.596 Odds Ratio (OR; highest vs. lowest tertile of GRS): 1.05 [0.7, 1.55] sex, age, previous colonoscopy, physical activity
PPM000466 PGS000150
(GRS48)
PSS000268|
European Ancestry|
1,043 individuals
PGP000073 |
Weigl K et al. Gastroenterology (2018)
Reported Trait: non-advanced adenoma (colorectal) C-index: 0.584 Odds Ratio (OR; highest vs. lowest tertile of GRS): 1.04 [0.7, 1.55] sex, age
PPM000471 PGS000151
(SC_GRS)
PSS000271|
East Asian Ancestry|
3,523 individuals
PGP000074 |
Xin J et al. Gene (2018)
Reported Trait: Colorectal cancer AUROC: 0.607 [0.581, 0.633] smoking status
PPM000470 PGS000151
(SC_GRS)
PSS000271|
East Asian Ancestry|
3,523 individuals
PGP000074 |
Xin J et al. Gene (2018)
Reported Trait: Colorectal cancer AUROC: 0.6 [0.579, 0.622]
PPM000474 PGS000154
(cGRS_Colorectal)
PSS000274|
European Ancestry|
13,814 individuals
PGP000075 |
Shi Z et al. Cancer Med (2019)
Reported Trait: Colorectal cancer Mean realative risk: 1.08 [1.04, 1.12]
Wilcoxon test (case vs. control) p-value: 8.29e-06
PPM000485 PGS000154
(cGRS_Colorectal)
PSS000274|
European Ancestry|
13,814 individuals
PGP000075 |
Shi Z et al. Cancer Med (2019)
Reported Trait: Colorectal cancer Odds Ratio (OR; high vs. average risk groups): 1.18 [0.87, 1.61]
PPM000805 PGS000316
(GRS42_Coeliac)
PSS000381|
Ancestry Not Reported|
154 individuals
PGP000093 |
Sharp SA et al. Aliment Pharmacol Ther (2020)
Reported Trait: Coeliac disease AUROC: 0.835 [0.76, 0.911]
PPM000804 PGS000316
(GRS42_Coeliac)
PSS000382|
European Ancestry|
379,767 individuals
PGP000093 |
Sharp SA et al. Aliment Pharmacol Ther (2020)
Reported Trait: Coeliac disease AUROC: 0.879 [0.87, 0.888]
PPM001052 PGS000367
(PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608)
PSS000540|
European Ancestry|
6,633 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.198 [1.102, 1.302]
β: 0.181 (0.0425)
AUROC: 0.55 [0.522, 0.574] Nagelkerke's Pseudo-R²: 0.00586
Brier score: 0.0828
Odds Ratio (OR, top 1% vs. Rest): 2.2 [1.21, 4.0]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_MGI_20200608
PPM001053 PGS000368
(PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608)
PSS000564|
European Ancestry|
24,996 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.516 [1.451, 1.585]
β: 0.416 (0.0225)
AUROC: 0.612 [0.6, 0.625] Nagelkerke's Pseudo-R²: 0.0304
Brier score: 0.0813
Odds Ratio (OR, top 1% vs. Rest): 3.85 [2.99, 4.96]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608
PPM001054 PGS000369
(PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608)
PSS000540|
European Ancestry|
6,633 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.214 [1.117, 1.32]
β: 0.194 (0.0426)
AUROC: 0.553 [0.525, 0.577] Nagelkerke's Pseudo-R²: 0.00671
Brier score: 0.0828
Odds Ratio (OR, top 1% vs. Rest): 3.04 [1.79, 5.17]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_CRC-Huyghe_PT_MGI_20200608
PPM012887 PGS000370
(PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608)
PSS009593|
Ancestry Not Reported|
9,666 individuals
PGP000292 |
Saad M et al. Lancet Oncol (2022)
|Ext.
Reported Trait: Colorectal cancer OR: 1.543 [1.411, 1.686] AUROC: 0.621 [0.597, 0.645]
PPM001055 PGS000370
(PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608)
PSS000564|
European Ancestry|
24,996 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.547 [1.48, 1.617]
β: 0.436 (0.0226)
AUROC: 0.617 [0.605, 0.63] Nagelkerke's Pseudo-R²: 0.0332
Brier score: 0.0812
Odds Ratio (OR, top 1% vs. Rest): 4.0 [3.11, 5.13]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_CRC-Huyghe_PT_UKB_20200608
PPM001056 PGS000371
(PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608)
PSS000564|
European Ancestry|
24,996 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.254 [1.202, 1.309]
β: 0.226 (0.0217)
AUROC: 0.561 [0.548, 0.573] Nagelkerke's Pseudo-R²: 0.00946
Brier score: 0.0822
Odds Ratio (OR, top 1% vs. Rest): 1.79 [1.28, 2.51]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_P_5e-08_UKB_20200608
PPM001057 PGS000372
(PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608)
PSS000564|
European Ancestry|
24,996 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.279 [1.225, 1.335]
β: 0.246 (0.0218)
AUROC: 0.565 [0.551, 0.577] Nagelkerke's Pseudo-R²: 0.0111
Brier score: 0.0822
Odds Ratio (OR, top 1% vs. Rest): 2.1 [1.53, 2.89]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_GWAS-Catalog-r2019-05-03-X153_PT_UKB_20200608
PPM001058 PGS000373
(PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608)
PSS000540|
European Ancestry|
6,633 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.189 [1.093, 1.293]
β: 0.173 (0.0428)
AUROC: 0.548 [0.523, 0.572] Nagelkerke's Pseudo-R²: 0.00529
Brier score: 0.0829
Odds Ratio (OR, top 1% vs. Rest): 1.71 [0.882, 3.33]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PRS-CS_MGI_20200608
PPM001059 PGS000374
(PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608)
PSS000540|
European Ancestry|
6,633 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.091 [1.004, 1.185]
β: 0.0872 (0.0423)
AUROC: 0.517 [0.493, 0.541] Nagelkerke's Pseudo-R²: 0.00134
Brier score: 0.083
Odds Ratio (OR, top 1% vs. Rest): 1.88 [0.99, 3.55]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_PT_MGI_20200608
PPM001060 PGS000375
(PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608)
PSS000540|
European Ancestry|
6,633 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer OR: 1.113 [1.024, 1.21]
β: 0.107 (0.0425)
AUROC: 0.53 [0.503, 0.555] Nagelkerke's Pseudo-R²: 0.00205
Brier score: 0.083
Odds Ratio (OR, top 1% vs. Rest): 2.76 [1.59, 4.81]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_UKBB-SAIGE-HRC-X153_LASSOSUM_MGI_20200608
PPM001061 PGS000376
(PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.177 [1.069, 1.297]
β: 0.163 (0.0491)
AUROC: 0.547 [0.518, 0.576] Nagelkerke's Pseudo-R²: 0.0046
Brier score: 0.0832
Odds Ratio (OR, top 1% vs. Rest): 1.65 [0.753, 3.61]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_C18_PRS-CS_MGI_20200608
PPM001062 PGS000377
(PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.174 [1.066, 1.292]
β: 0.16 (0.049)
AUROC: 0.545 [0.518, 0.574] Nagelkerke's Pseudo-R²: 0.00441
Brier score: 0.0831
Odds Ratio (OR, top 1% vs. Rest): 1.4 [0.607, 3.22]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_C18_LASSOSUM_MGI_20200608
PPM001063 PGS000378
(PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.141 [1.038, 1.254]
β: 0.132 (0.0484)
AUROC: 0.536 [0.509, 0.565] Nagelkerke's Pseudo-R²: 0.00301
Brier score: 0.0832
Odds Ratio (OR, top 1% vs. Rest): 1.82 [0.867, 3.84]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_C3-COLON_PRS-CS_MGI_20200608
PPM001064 PGS000379
(PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.143 [1.038, 1.258]
β: 0.134 (0.049)
AUROC: 0.536 [0.51, 0.567] Nagelkerke's Pseudo-R²: 0.00302
Brier score: 0.0832
Odds Ratio (OR, top 1% vs. Rest): 0.757 [0.252, 2.28]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_C3-COLON_LASSOSUM_MGI_20200608
PPM001065 PGS000380
(PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.324 [1.203, 1.457]
β: 0.281 (0.0489)
AUROC: 0.569 [0.539, 0.599] Nagelkerke's Pseudo-R²: 0.0138
Brier score: 0.0827
Odds Ratio (OR, top 1% vs. Rest): 3.85 [2.19, 6.77]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PRS-CS_MGI_20200608
PPM001066 PGS000381
(PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.212 [1.105, 1.33]
β: 0.193 (0.0472)
AUROC: 0.55 [0.522, 0.577] Nagelkerke's Pseudo-R²: 0.00703
Brier score: 0.0831
Odds Ratio (OR, top 1% vs. Rest): 1.6 [0.733, 3.51]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_PT_MGI_20200608
PPM001067 PGS000382
(PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608)
PSS000538|
European Ancestry|
5,031 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Colon cancer OR: 1.247 [1.134, 1.371]
β: 0.221 (0.0483)
AUROC: 0.567 [0.54, 0.594] Nagelkerke's Pseudo-R²: 0.00899
Brier score: 0.083
Odds Ratio (OR, top 1% vs. Rest): 1.17 [0.477, 2.87]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.2_UKBB-SAIGE-HRC-X153.2_LASSOSUM_MGI_20200608
PPM001068 PGS000383
(PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608)
PSS000539|
European Ancestry|
3,557 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Malignant neoplasm of rectum, rectosigmoid junction, and anus OR: 1.126 [1.005, 1.262]
β: 0.119 (0.0579)
AUROC: 0.533 [0.5, 0.567] Nagelkerke's Pseudo-R²: 0.00257
Brier score: 0.0829
Odds Ratio (OR, top 1% vs. Rest): 1.34 [0.491, 3.65]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.3_C19_PRS-CS_MGI_20200608
PPM001069 PGS000384
(PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608)
PSS000539|
European Ancestry|
3,557 individuals
PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
Reported Trait: Malignant neoplasm of rectum, rectosigmoid junction, and anus OR: 1.122 [1.001, 1.257]
β: 0.115 (0.058)
AUROC: 0.531 [0.495, 0.563] Nagelkerke's Pseudo-R²: 0.00251
Brier score: 0.0829
Odds Ratio (OR, top 1% vs. Rest): 1.02 [0.334, 3.14]
age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608
PPM001648 PGS000720
(PRS_Colorectal)
PSS000855|
European Ancestry|
400,812 individuals
PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
Reported Trait: Incident colorectal cancer AUROC: 0.609 [0.598, 0.62] Genotyping array
PPM001649 PGS000720
(PRS_Colorectal)
PSS000855|
European Ancestry|
400,812 individuals
PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
Reported Trait: Incident colorectal cancer AUROC: 0.613 [0.602, 0.624] family history of cancer (in first-degree relatives), genotyping array
PPM001742 PGS000734
(PRS95_CRC)
PSS000896|
European Ancestry|
24,472 individuals
PGP000142 |
Archambault AN et al. Gastroenterology (2019)
Reported Trait: Early-onset colorectal cancer in individuals with no family history of colorectal cancer HR: 1.76 [1.11, 2.78] Sex, PCs
PPM001743 PGS000734
(PRS95_CRC)
PSS000895|
European Ancestry|
61,129 individuals
PGP000142 |
Archambault AN et al. Gastroenterology (2019)
Reported Trait: Late-onset colorectal cancer in individuals with no family history of colorectal cancer HR: 1.42 [1.33, 1.52] Sex, PCs
PPM001744 PGS000734
(PRS95_CRC)
PSS000897|
European Ancestry|
6,668 individuals
PGP000142 |
Archambault AN et al. Gastroenterology (2019)
Reported Trait: Late-onset colorectal cancer in individuals with a family history of colorectal cancer HR: 1.34 [1.17, 1.54] Sex, PCs
PPM001740 PGS000734
(PRS95_CRC)
PSS000894|
European Ancestry|
26,938 individuals
PGP000142 |
Archambault AN et al. Gastroenterology (2019)
Reported Trait: Early-onset colorectal cancer HR: 1.73 [1.17, 2.56] Sex, PCs
PPM001741 PGS000734
(PRS95_CRC)
PSS000893|
European Ancestry|
67,792 individuals
PGP000142 |
Archambault AN et al. Gastroenterology (2019)
Reported Trait: Late-onset colorectal cancer HR: 1.43 [1.34, 1.51] Sex, PCs
PPM018699 PGS000734
(PRS95_CRC)
PSS011071|
East Asian Ancestry|
409 individuals
PGP000494 |
Ho PJ et al. Elife (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.66 [0.63, 0.69] Hazard ratio (HR, high vs low tertile): 3.25 [2.24, 4.73] age at recruitment
PPM001961 PGS000765
(PRS_CRC95)
PSS000981|
Multi-ancestry (including European)|
48,807 individuals
PGP000171 |
Fahed AC et al. Nat Commun (2020)
|Ext.
Reported Trait: Prevalent colorectal cancer OR: 1.65 [1.48, 1.85] Age, sex, PCs (1-4)
PPM015518 PGS000765
(PRS_CRC95)
PSS009971|
Multi-ancestry (including European)|
36,422 individuals
PGP000381 |
Hao L et al. Nat Med (2022)
|Ext.
Reported Trait: Colorectal cancer OR: 2.37 [1.74, 3.24] 4 genetic PCs
PPM018551 PGS000765
(PRS_CRC95)
PSS011020|
Multi-ancestry (including European)|
163,516 individuals
PGP000482 |
Hassanin E et al. BMC Med Genomics (2023)
|Ext.
Reported Trait: Colorectal cancer with pathogenic variant carriers AUROC: 0.693 [0.66, 0.71]
C-index: 0.646
Odds ratio (OR, high vs low tertile): 17.5 [9.0, 32.4]
PPM018552 PGS000765
(PRS_CRC95)
PSS011020|
Multi-ancestry (including European)|
163,516 individuals
PGP000482 |
Hassanin E et al. BMC Med Genomics (2023)
|Ext.
Reported Trait: Incident colorectal cancer with pathogenic variant carriers Odds ratio (OR, high vs low tertile): 7.0 [2.04, 23.7]
PPM018553 PGS000765
(PRS_CRC95)
PSS011020|
Multi-ancestry (including European)|
163,516 individuals
PGP000482 |
Hassanin E et al. BMC Med Genomics (2023)
|Ext.
Reported Trait: Colorectal cancer with family history of cancer AUROC: 0.698 [0.67, 0.72]
C-index: 0.652
Odds ratio (OR, high vs low tertile): 3.1 [2.6, 3.8]
PPM018554 PGS000765
(PRS_CRC95)
PSS011020|
Multi-ancestry (including European)|
163,516 individuals
PGP000482 |
Hassanin E et al. BMC Med Genomics (2023)
|Ext.
Reported Trait: Colorectal cancer with family history of cancer and pathogenic variant carriers AUROC: 0.704 [0.68, 0.73]
C-index: 0.657
Odds ratio (OR, high vs low tertile): 39.9 [12.69, 125.41]
PPM018555 PGS000765
(PRS_CRC95)
PSS011020|
Multi-ancestry (including European)|
163,516 individuals
PGP000482 |
Hassanin E et al. BMC Med Genomics (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.688 [0.66, 0.71]
C-index: 0.64
PPM020769 PGS000765
(PRS_CRC95)
PSS011399|
European Ancestry|
1,428 individuals
PGP000583 |
Dueñas N et al. J Med Genet (2023)
|Ext.
Reported Trait: Colorectal cancer or advanced adenoma in individuals with Lynch syndrome HR: 1.019 [1.005, 1.032] Sex, birth cohort, other Lynch syndrome-related cancers
PPM020782 PGS000765
(PRS_CRC95)
PSS011409|
European Ancestry|
2,059 individuals
PGP000589 |
Mur P et al. Cancers (Basel) (2021)
|Ext.
Reported Trait: Familial / early-onset colorectal cancer OR: 1.12 [1.09, 1.14] Age, sex Only 92 SNPs were included. 3 SNPs had an R^2 lower than 0.3 and were excluded
PPM020783 PGS000765
(PRS_CRC95)
PSS011410|
European Ancestry|
2,719 individuals
PGP000589 |
Mur P et al. Cancers (Basel) (2021)
|Ext.
Reported Trait: Sporadic colorectal cancer OR: 1.08 [1.06, 1.09] Age, sex Only 92 SNPs were included. 3 SNPs had an R^2 lower than 0.3 and were excluded
PPM020784 PGS000765
(PRS_CRC95)
PSS011409|
European Ancestry|
2,059 individuals
PGP000589 |
Mur P et al. Cancers (Basel) (2021)
|Ext.
Reported Trait: Familial / early-onset colorectal cancer AUROC: 0.833 : 0.373 Age at cancer diagnosis, sex Only 92 SNPs were included. 3 SNPs had an R^2 lower than 0.3 and were excluded
PPM020785 PGS000765
(PRS_CRC95)
PSS011409|
European Ancestry|
2,059 individuals
PGP000589 |
Mur P et al. Cancers (Basel) (2021)
|Ext.
Reported Trait: Familial / early-onset colorectal cancer AUROC: 0.905 : 0.598 Age at cancer diagnosis, sex, family history of colorectal cancer Only 92 SNPs were included. 3 SNPs had an R^2 lower than 0.3 and were excluded. Only 405 cases and 1,094 controls were included in this analysis
PPM002056 PGS000785
(CC_Colorectal_IV)
PSS001013|
European Ancestry|
393,723 individuals
PGP000186 |
Kachuri L et al. Nat Commun (2020)
Reported Trait: Incident colorectal cancer HR: 1.48 [1.43, 1.54] AUROC: 0.716
C-index: 0.716 (0.006)
: 0.345 Age at assessment, sex, family history of bowel cancer, genotyping array, PCs(1-15), wasit to hip ratio, cigarette pack years, frequency of processed meat intake (<1 per week vs. ≥1 per week), moderate and/or strenuous physical activity (days per week), alcohol intake C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM002071 PGS000785
(CC_Colorectal_IV)
PSS001013|
European Ancestry|
393,723 individuals
PGP000186 |
Kachuri L et al. Nat Commun (2020)
Reported Trait: Incident colorectal cancer AUROC: 0.708
C-index: 0.708 (0.006)
: 0.319 Age, sex, genotyping array, PCs(1-15) C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM002087 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Advanced conventional adenoma OR: 1.22 [1.16, 1.28] Odds Ratio (OR, top 20% vs bottom 20%): 1.91 [1.59, 2.29] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002092 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Multiple conventional adenomas OR: 1.25 [1.17, 1.34] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002093 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Multiple serrated polyps OR: 1.09 [1.01, 1.18] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002085 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Conventional adeonma OR: 1.17 [1.12, 1.21] Odds Ratio (OR, top 20% vs bottom 20%): 1.63 [1.44, 1.83] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002086 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Non-advanced conventional adenoma OR: 1.12 [1.07, 1.18] Odds Ratio (OR, top 20% vs bottom 20%): 1.44 [1.23, 1.68] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002088 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Serrated polyp OR: 1.09 [1.03, 1.14] Odds Ratio (OR, top 20% vs bottom 20%): 1.24 [1.06, 1.45] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002089 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Serrated polyp with high risk of malignancy OR: 1.1 [1.01, 1.19] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002090 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Serrated polyp with low risk of malignancy OR: 1.08 [1.02, 1.15] Odds Ratio (OR, top 20% vs bottom 20%): 1.25 [1.03, 1.53] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002091 PGS000801
(GRS40_CRC)
PSS001030|
European Ancestry|
27,426 individuals
PGP000190 |
Hang D et al. Int J Epidemiol (2020)
Reported Trait: Synchronous conventional adenoma and serrated polyp OR: 1.24 [1.16, 1.32] Odds Ratio (OR, top 20% vs bottom 20%): 1.96 [1.54, 2.49] Study cohort (NHS, NHSII, HPFS), time period of endoscopy (in 2-year interval), number of previous endoscopies, time in years since the most recent endoscopy, age, PCs(1-3) Effect weights for SNPs within the PGS were obtained using the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) dataset. The GECCO dataset had no overlap with the dataset used to evaluate the score.
PPM002098 PGS000802
(CRC_19)
PSS001032|
East Asian Ancestry|
2,566 individuals
PGP000191 |
He CY et al. Genomics (2021)
Reported Trait: Colorectal cancer Odds Ratio (OR, top 75% vs bottom 25%): 2.53 [1.99, 3.22] Gender, age
PPM002099 PGS000802
(CRC_19)
PSS001031|
East Asian Ancestry|
2,269 individuals
PGP000191 |
He CY et al. Genomics (2021)
Reported Trait: Colorectal cancer Odds Ratio (OR, top 75% vs bottom 25%): 2.12 [1.63, 2.77] Gender, age
PPM002094 PGS000802
(CRC_19)
PSS001033|
East Asian Ancestry|
5,465 individuals
PGP000191 |
He CY et al. Genomics (2021)
Reported Trait: Colorectal cancer AUROC: 0.59 [0.57, 0.6] Possible overlap with score development samples
PPM002095 PGS000802
(CRC_19)
PSS001032|
East Asian Ancestry|
2,566 individuals
PGP000191 |
He CY et al. Genomics (2021)
Reported Trait: Colorectal cancer AUROC: 0.61 [0.59, 0.63]
PPM002096 PGS000802
(CRC_19)
PSS001031|
East Asian Ancestry|
2,269 individuals
PGP000191 |
He CY et al. Genomics (2021)
Reported Trait: Colorectal cancer AUROC: 0.59 [0.57, 0.61]
PPM002097 PGS000802
(CRC_19)
PSS001033|
East Asian Ancestry|
5,465 individuals
PGP000191 |
He CY et al. Genomics (2021)
Reported Trait: Colorectal cancer Odds Ratio (OR, top 75% vs bottom 25%): 2.27 [1.95, 2.64] Gender, age possible overlap with score development samples
PPM007743 PGS000996
(GBE_HC262)
PSS004389|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.86271 [0.73099, 0.99443] : 0.12936
Incremental AUROC (full-covars): 0.00213
PGS R2 (no covariates): 0.00894
PGS AUROC (no covariates): 0.62053 [0.46342, 0.77764]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007744 PGS000996
(GBE_HC262)
PSS004390|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.91481 [0.74874, 1.0] : 0.2785
Incremental AUROC (full-covars): 0.00029
PGS R2 (no covariates): 0.03618
PGS AUROC (no covariates): 0.74736 [0.4992, 0.99551]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007745 PGS000996
(GBE_HC262)
PSS004391|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.70041 [0.67086, 0.72996] : 0.04948
Incremental AUROC (full-covars): 0.0039
PGS R2 (no covariates): 0.00095
PGS AUROC (no covariates): 0.52419 [0.48988, 0.55849]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007746 PGS000996
(GBE_HC262)
PSS004392|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.80455 [0.70545, 0.90364] : 0.1
Incremental AUROC (full-covars): 0.00844
PGS R2 (no covariates): 0.00928
PGS AUROC (no covariates): 0.62862 [0.53202, 0.72522]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007747 PGS000996
(GBE_HC262)
PSS004393|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.67555 [0.65884, 0.69227] : 0.03898
Incremental AUROC (full-covars): 0.00841
PGS R2 (no covariates): 0.00372
PGS AUROC (no covariates): 0.55186 [0.53326, 0.57047]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007748 PGS000997
(GBE_HC1106)
PSS004124|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE diverticular disease of intestine AUROC: 0.70831 [0.67789, 0.73873] : 0.07998
Incremental AUROC (full-covars): -0.0081
PGS R2 (no covariates): 0.00158
PGS AUROC (no covariates): 0.52939 [0.49423, 0.56454]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007749 PGS000997
(GBE_HC1106)
PSS004125|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE diverticular disease of intestine AUROC: 0.75551 [0.65982, 0.85119] : 0.08781
Incremental AUROC (full-covars): -0.01168
PGS R2 (no covariates): 0.00059
PGS AUROC (no covariates): 0.52785 [0.41459, 0.64111]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007750 PGS000997
(GBE_HC1106)
PSS004126|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE diverticular disease of intestine AUROC: 0.7155 [0.70514, 0.72586] : 0.10502
Incremental AUROC (full-covars): 0.01733
PGS R2 (no covariates): 0.01777
PGS AUROC (no covariates): 0.59105 [0.57889, 0.60321]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007751 PGS000997
(GBE_HC1106)
PSS004127|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE diverticular disease of intestine AUROC: 0.73365 [0.70818, 0.75911] : 0.09377
Incremental AUROC (full-covars): 0.01275
PGS R2 (no covariates): 0.01222
PGS AUROC (no covariates): 0.57957 [0.54784, 0.6113]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007752 PGS000997
(GBE_HC1106)
PSS004128|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE diverticular disease of intestine AUROC: 0.68053 [0.67412, 0.68694] : 0.07483
Incremental AUROC (full-covars): 0.01974
PGS R2 (no covariates): 0.01533
PGS AUROC (no covariates): 0.5794 [0.57219, 0.58662]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008938 PGS001288
(GBE_HC95)
PSS004741|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Inflammatory bowel disease AUROC: 0.64251 [0.54711, 0.73791] : 0.05914
Incremental AUROC (full-covars): 0.00245
PGS R2 (no covariates): 0.00027
PGS AUROC (no covariates): 0.52101 [0.42335, 0.61867]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008939 PGS001288
(GBE_HC95)
PSS004742|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Inflammatory bowel disease AUROC: 0.89429 [0.79091, 0.99767] : 0.2051
Incremental AUROC (full-covars): -0.0033
PGS R2 (no covariates): 0.0
PGS AUROC (no covariates): 0.48687 [0.28135, 0.6924]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008940 PGS001288
(GBE_HC95)
PSS004743|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Inflammatory bowel disease AUROC: 0.63478 [0.60168, 0.66787] : 0.02287
Incremental AUROC (full-covars): 0.02492
PGS R2 (no covariates): 0.0102
PGS AUROC (no covariates): 0.58475 [0.55242, 0.61708]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008941 PGS001288
(GBE_HC95)
PSS004744|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Inflammatory bowel disease AUROC: 0.66934 [0.62525, 0.71343] : 0.03759
Incremental AUROC (full-covars): 0.004
PGS R2 (no covariates): 0.00311
PGS AUROC (no covariates): 0.55448 [0.50125, 0.6077]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008942 PGS001288
(GBE_HC95)
PSS004745|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Inflammatory bowel disease AUROC: 0.59461 [0.57544, 0.61378] : 0.01221
Incremental AUROC (full-covars): 0.06405
PGS R2 (no covariates): 0.01191
PGS AUROC (no covariates): 0.59586 [0.5768, 0.61492]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008997 PGS001300
(GBE_BIN21068)
PSS003667|
African Ancestry|
969 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity AUROC: 0.77521 [0.67165, 0.87877] : 0.10494
Incremental AUROC (full-covars): 0.00391
PGS R2 (no covariates): 0.00465
PGS AUROC (no covariates): 0.54048 [0.39518, 0.68579]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008998 PGS001300
(GBE_BIN21068)
PSS003668|
European Ancestry|
9,024 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity AUROC: 0.67118 [0.63561, 0.70676] : 0.04801
Incremental AUROC (full-covars): 0.03638
PGS R2 (no covariates): 0.02217
PGS AUROC (no covariates): 0.58541 [0.54195, 0.62888]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008999 PGS001300
(GBE_BIN21068)
PSS003669|
South Asian Ancestry|
1,145 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity AUROC: 0.78803 [0.69728, 0.87878] : 0.09336
Incremental AUROC (full-covars): 0.00365
PGS R2 (no covariates): 0.00127
PGS AUROC (no covariates): 0.56184 [0.43287, 0.6908]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009000 PGS001300
(GBE_BIN21068)
PSS003670|
European Ancestry|
24,310 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity AUROC: 0.6734 [0.64935, 0.69745] : 0.04185
Incremental AUROC (full-covars): 0.08398
PGS R2 (no covariates): 0.02957
PGS AUROC (no covariates): 0.62888 [0.60094, 0.65683]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009001 PGS001301
(GBE_HC303)
PSS004423|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Malabsorption/coeliac disease AUROC: 0.84259 [0.73437, 0.95081] : 0.12308
Incremental AUROC (full-covars): 0.02463
PGS R2 (no covariates): 0.03018
PGS AUROC (no covariates): 0.68151 [0.48835, 0.87467]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009002 PGS001301
(GBE_HC303)
PSS004424|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Malabsorption/coeliac disease AUROC: 0.81472 [0.7798, 0.84965] : 0.15108
Incremental AUROC (full-covars): 0.1791
PGS R2 (no covariates): 0.14221
PGS AUROC (no covariates): 0.80994 [0.77441, 0.84547]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009003 PGS001301
(GBE_HC303)
PSS004425|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Malabsorption/coeliac disease AUROC: 0.81699 [0.73267, 0.9013] : 0.11397
Incremental AUROC (full-covars): 0.06035
PGS R2 (no covariates): 0.07098
PGS AUROC (no covariates): 0.76239 [0.65258, 0.87221]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009004 PGS001301
(GBE_HC303)
PSS004426|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Malabsorption/coeliac disease AUROC: 0.83351 [0.81372, 0.85329] : 0.14905
Incremental AUROC (full-covars): 0.25775
PGS R2 (no covariates): 0.14224
PGS AUROC (no covariates): 0.82867 [0.80826, 0.84908]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009024 PGS001306
(GBE_HC201)
PSS004339|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ulcerative colitis AUROC: 0.62904 [0.5093, 0.74878] : 0.04535
Incremental AUROC (full-covars): -0.00864
PGS R2 (no covariates): 0.00044
PGS AUROC (no covariates): 0.51081 [0.37987, 0.64174]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009025 PGS001306
(GBE_HC201)
PSS004340|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ulcerative colitis AUROC: 0.89429 [0.79357, 0.99502] : 0.20499
Incremental AUROC (full-covars): -0.0033
PGS R2 (no covariates): 2e-05
PGS AUROC (no covariates): 0.49111 [0.35854, 0.62368]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009026 PGS001306
(GBE_HC201)
PSS004341|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ulcerative colitis AUROC: 0.66162 [0.6277, 0.69554] : 0.03336
Incremental AUROC (full-covars): 0.04247
PGS R2 (no covariates): 0.02036
PGS AUROC (no covariates): 0.63006 [0.5958, 0.66432]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009027 PGS001306
(GBE_HC201)
PSS004342|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ulcerative colitis AUROC: 0.67522 [0.62537, 0.72506] : 0.03696
Incremental AUROC (full-covars): 0.01011
PGS R2 (no covariates): 0.00545
PGS AUROC (no covariates): 0.56552 [0.50815, 0.62289]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009028 PGS001306
(GBE_HC201)
PSS004343|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Ulcerative colitis AUROC: 0.6157 [0.59481, 0.63659] PGS R2 (no covariates): 0.0193
: 0.01676
Incremental AUROC (full-covars): 0.08728
PGS AUROC (no covariates): 0.62452 [0.60374, 0.6453]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009029 PGS001307
(GBE_HC1102)
PSS004119|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE ulcerative colitis AUROC: 0.62873 [0.51002, 0.74744] : 0.04344
Incremental AUROC (full-covars): -0.00895
PGS R2 (no covariates): 0.00027
PGS AUROC (no covariates): 0.50641 [0.39121, 0.62161]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009030 PGS001307
(GBE_HC1102)
PSS004120|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE ulcerative colitis AUROC: 0.89582 [0.79576, 0.99588] : 0.20607
Incremental AUROC (full-covars): -0.00177
PGS R2 (no covariates): 0.00203
PGS AUROC (no covariates): 0.55433 [0.4473, 0.66136]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009031 PGS001307
(GBE_HC1102)
PSS004121|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE ulcerative colitis AUROC: 0.65578 [0.62353, 0.68804] : 0.03272
Incremental AUROC (full-covars): 0.04212
PGS R2 (no covariates): 0.0169
PGS AUROC (no covariates): 0.6106 [0.57717, 0.64402]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009032 PGS001307
(GBE_HC1102)
PSS004122|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE ulcerative colitis AUROC: 0.66008 [0.61042, 0.70974] : 0.03192
Incremental AUROC (full-covars): 0.00203
PGS R2 (no covariates): 0.0036
PGS AUROC (no covariates): 0.55808 [0.506, 0.61016]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009033 PGS001307
(GBE_HC1102)
PSS004123|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE ulcerative colitis AUROC: 0.63965 [0.62036, 0.65895] : 0.02376
Incremental AUROC (full-covars): 0.1085
PGS R2 (no covariates): 0.02383
PGS AUROC (no covariates): 0.63847 [0.61861, 0.65833]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009137 PGS001330
(GBE_HC1101)
PSS004114|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE crohn's disease [regional enteritis] AUROC: 0.66243 [0.55234, 0.77252] : 0.05286
Incremental AUROC (full-covars): -0.02175
PGS R2 (no covariates): 0.00138
PGS AUROC (no covariates): 0.46272 [0.36718, 0.55826]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009138 PGS001330
(GBE_HC1101)
PSS004115|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE crohn's disease [regional enteritis] AUROC: 0.86369 [0.7806, 0.94678] : 0.13339
Incremental AUROC (full-covars): 0.0
PGS R2 (no covariates): 0.14319
PGS AUROC (no covariates): 0.10664 [0.0, 0.28372]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009139 PGS001330
(GBE_HC1101)
PSS004116|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE crohn's disease [regional enteritis] AUROC: 0.60269 [0.55209, 0.65328] : 0.01102
Incremental AUROC (full-covars): 0.02413
PGS R2 (no covariates): 0.00621
PGS AUROC (no covariates): 0.57593 [0.52318, 0.62867]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009140 PGS001330
(GBE_HC1101)
PSS004117|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE crohn's disease [regional enteritis] AUROC: 0.69933 [0.63548, 0.76318] : 0.0344
Incremental AUROC (full-covars): 0.00201
PGS R2 (no covariates): 0.00147
PGS AUROC (no covariates): 0.53846 [0.46042, 0.6165]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009141 PGS001330
(GBE_HC1101)
PSS004118|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE crohn's disease [regional enteritis] AUROC: 0.55852 [0.52842, 0.58862] : 0.00474
Incremental AUROC (full-covars): 0.07412
PGS R2 (no covariates): 0.00669
PGS AUROC (no covariates): 0.5714 [0.54073, 0.60207]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009142 PGS001331
(GBE_HC322)
PSS004442|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Crohns disease AUROC: 0.65892 [0.54485, 0.77299] : 0.05502
Incremental AUROC (full-covars): -0.02526
PGS R2 (no covariates): 4e-05
PGS AUROC (no covariates): 0.49152 [0.37858, 0.60446]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009143 PGS001331
(GBE_HC322)
PSS004444|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Crohns disease AUROC: 0.61269 [0.55802, 0.66736] : 0.01161
Incremental AUROC (full-covars): 0.02705
PGS R2 (no covariates): 0.00677
PGS AUROC (no covariates): 0.57919 [0.52051, 0.63786]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009144 PGS001331
(GBE_HC322)
PSS004445|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Crohns disease AUROC: 0.71 [0.64649, 0.7735] : 0.03928
Incremental AUROC (full-covars): 0.01378
PGS R2 (no covariates): 0.00366
PGS AUROC (no covariates): 0.56349 [0.47905, 0.64793]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009145 PGS001331
(GBE_HC322)
PSS004446|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Crohns disease AUROC: 0.56362 [0.53297, 0.59427] : 0.00529
Incremental AUROC (full-covars): 0.06267
PGS R2 (no covariates): 0.0063
PGS AUROC (no covariates): 0.57326 [0.54246, 0.60406]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005205 PGS001369
(GBE_HC1090)
PSS004099|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE acute appendicitis AUROC: 0.62041 [0.53518, 0.70564] : 0.03016
Incremental AUROC (full-covars): -0.00198
PGS R2 (no covariates): 0.00105
PGS AUROC (no covariates): 0.47489 [0.37525, 0.57453]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005206 PGS001369
(GBE_HC1090)
PSS004100|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE acute appendicitis AUROC: 0.8493 [0.77779, 0.9208] : 0.14577
Incremental AUROC (full-covars): 0.00105
PGS R2 (no covariates): 0.00332
PGS AUROC (no covariates): 0.51032 [0.33889, 0.68176]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005207 PGS001369
(GBE_HC1090)
PSS004101|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE acute appendicitis AUROC: 0.56849 [0.52835, 0.60862] : 0.00702
Incremental AUROC (full-covars): -0.00219
PGS R2 (no covariates): 0.0
PGS AUROC (no covariates): 0.49616 [0.45378, 0.53854]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005208 PGS001369
(GBE_HC1090)
PSS004102|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE acute appendicitis AUROC: 0.72977 [0.65912, 0.80042] Incremental AUROC (full-covars): 0.00039
PGS R2 (no covariates): 0.00096
: 0.05613
PGS AUROC (no covariates): 0.5334 [0.44427, 0.62254]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005209 PGS001369
(GBE_HC1090)
PSS004103|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE acute appendicitis AUROC: 0.57413 [0.55138, 0.59688] : 0.00617
Incremental AUROC (full-covars): 0.00987
PGS R2 (no covariates): 0.00332
PGS AUROC (no covariates): 0.55036 [0.52746, 0.57326]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005200 PGS001390
(GBE_HC1084)
PSS004094|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE duodenal ulcer AUROC: 0.71018 [0.66062, 0.75975] : 0.05605
Incremental AUROC (full-covars): 0.00294
PGS R2 (no covariates): 0.00399
PGS AUROC (no covariates): 0.5623 [0.50635, 0.61825]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005201 PGS001390
(GBE_HC1084)
PSS004095|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE duodenal ulcer AUROC: 0.66565 [0.55325, 0.77805] : 0.04606
Incremental AUROC (full-covars): 0.00253
PGS R2 (no covariates): 0.006
PGS AUROC (no covariates): 0.56376 [0.43513, 0.6924]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005202 PGS001390
(GBE_HC1084)
PSS004096|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE duodenal ulcer AUROC: 0.71045 [0.68829, 0.73261] : 0.06289
Incremental AUROC (full-covars): 0.0043
PGS R2 (no covariates): 0.0047
PGS AUROC (no covariates): 0.55991 [0.53425, 0.58556]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005203 PGS001390
(GBE_HC1084)
PSS004097|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE duodenal ulcer AUROC: 0.70619 [0.66443, 0.74795] : 0.0567
Incremental AUROC (full-covars): 0.00581
PGS R2 (no covariates): 0.00168
PGS AUROC (no covariates): 0.54031 [0.491, 0.58961]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005204 PGS001390
(GBE_HC1084)
PSS004098|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE duodenal ulcer AUROC: 0.68746 [0.67261, 0.70231] : 0.04811
Incremental AUROC (full-covars): 0.00644
PGS R2 (no covariates): 0.00484
PGS AUROC (no covariates): 0.56101 [0.54453, 0.5775]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005210 PGS001516
(GBE_HC1112)
PSS004129|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE other diseases of intestine AUROC: 0.71458 [0.68087, 0.7483] : 0.07935
Incremental AUROC (full-covars): 0.00184
PGS R2 (no covariates): 0.00206
PGS AUROC (no covariates): 0.53644 [0.50022, 0.57266]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005211 PGS001516
(GBE_HC1112)
PSS004130|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE other diseases of intestine AUROC: 0.71022 [0.64099, 0.77946] : 0.09409
Incremental AUROC (full-covars): 0.00324
PGS R2 (no covariates): 0.00207
PGS AUROC (no covariates): 0.53358 [0.4606, 0.60656]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005212 PGS001516
(GBE_HC1112)
PSS004131|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE other diseases of intestine AUROC: 0.65457 [0.63994, 0.6692] : 0.04465
Incremental AUROC (full-covars): 0.00302
PGS R2 (no covariates): 0.00297
PGS AUROC (no covariates): 0.54106 [0.52507, 0.55705]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005213 PGS001516
(GBE_HC1112)
PSS004132|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE other diseases of intestine AUROC: 0.70984 [0.68398, 0.7357] : 0.07373
Incremental AUROC (full-covars): -0.001
PGS R2 (no covariates): 0.00026
PGS AUROC (no covariates): 0.48728 [0.45689, 0.51767]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005214 PGS001516
(GBE_HC1112)
PSS004133|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE other diseases of intestine AUROC: 0.62222 [0.6128, 0.63164] : 0.02673
Incremental AUROC (full-covars): 0.00391
PGS R2 (no covariates): 0.0026
PGS AUROC (no covariates): 0.53789 [0.5278, 0.54798]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009239 PGS001776
(PRS45_CC)
PSS007664|
European Ancestry|
403,998 individuals
PGP000256 |
Gafni A et al. PLoS One (2021)
Reported Trait: Full lifetime risk of colorectal cancer β: 1.848 AUROC: 0.673 [0.664, 0.682] Family history
PPM009240 PGS001776
(PRS45_CC)
PSS007664|
European Ancestry|
403,998 individuals
PGP000256 |
Gafni A et al. PLoS One (2021)
Reported Trait: 10-year risk of colorectal cancer β: 1.088 AUROC: 0.674 [0.665, 0.683] Family history
PPM009289 PGS001785
(1kgeur_gbmi_leaveUKBBout_AcApp_pst_eff_a1_b0.5_phiauto)
PSS007708|
European Ancestry|
359,031 individuals
PGP000262 |
Wang Y et al. Cell Genom (2023)
Reported Trait: Acute appendicitis AUROC: 0.584 Nagelkerke's R2 (covariates regressed out): 0.00406 sex,age,age2,age*sex,age^2*sex, 20PCs
PPM009322 PGS001802
(portability-PLR_153)
PSS009272|
European Ancestry|
18,722 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0376 [0.0233, 0.0519] sex, age, birth date, deprivation index, 16 PCs
PPM009323 PGS001802
(portability-PLR_153)
PSS009046|
European Ancestry|
3,922 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0422 [0.0108, 0.0735] sex, age, birth date, deprivation index, 16 PCs
PPM009324 PGS001802
(portability-PLR_153)
PSS008600|
European Ancestry|
6,241 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0237 [-0.0012, 0.0485] sex, age, birth date, deprivation index, 16 PCs
PPM009325 PGS001802
(portability-PLR_153)
PSS008378|
Greater Middle Eastern Ancestry|
1,123 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0416 [-0.0175, 0.1004] sex, age, birth date, deprivation index, 16 PCs
PPM009326 PGS001802
(portability-PLR_153)
PSS008154|
South Asian Ancestry|
6,010 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0135 [-0.0118, 0.0389] sex, age, birth date, deprivation index, 16 PCs
PPM009327 PGS001802
(portability-PLR_153)
PSS007942|
East Asian Ancestry|
1,719 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0226 [-0.025, 0.0701] sex, age, birth date, deprivation index, 16 PCs
PPM009328 PGS001802
(portability-PLR_153)
PSS007724|
African Ancestry|
2,362 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0193 [-0.0212, 0.0598] sex, age, birth date, deprivation index, 16 PCs
PPM009329 PGS001802
(portability-PLR_153)
PSS008826|
African Ancestry|
3,757 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0259 [-0.0062, 0.0579] sex, age, birth date, deprivation index, 16 PCs
PPM009388 PGS001811
(portability-PLR_208)
PSS009281|
European Ancestry|
19,812 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0643 [0.0504, 0.0782] sex, age, birth date, deprivation index, 16 PCs
PPM009389 PGS001811
(portability-PLR_208)
PSS009055|
European Ancestry|
4,121 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0651 [0.0345, 0.0955] sex, age, birth date, deprivation index, 16 PCs
PPM009390 PGS001811
(portability-PLR_208)
PSS008609|
European Ancestry|
6,617 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0584 [0.0343, 0.0824] sex, age, birth date, deprivation index, 16 PCs
PPM009391 PGS001811
(portability-PLR_208)
PSS008385|
Greater Middle Eastern Ancestry|
1,194 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0914 [0.0344, 0.1478] sex, age, birth date, deprivation index, 16 PCs
PPM009392 PGS001811
(portability-PLR_208)
PSS008163|
South Asian Ancestry|
6,307 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.023 [-0.0017, 0.0477] sex, age, birth date, deprivation index, 16 PCs
PPM009393 PGS001811
(portability-PLR_208)
PSS007950|
East Asian Ancestry|
1,800 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0293 [-0.0171, 0.0757] sex, age, birth date, deprivation index, 16 PCs
PPM009394 PGS001811
(portability-PLR_208)
PSS007731|
African Ancestry|
2,469 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0518 [0.0122, 0.0912] sex, age, birth date, deprivation index, 16 PCs
PPM009395 PGS001811
(portability-PLR_208)
PSS008834|
African Ancestry|
3,905 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0459 [0.0145, 0.0772] sex, age, birth date, deprivation index, 16 PCs
PPM009706 PGS001852
(portability-PLR_535.6)
PSS009327|
European Ancestry|
18,600 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): 0.0198 [0.0055, 0.0342] sex, age, birth date, deprivation index, 16 PCs
PPM009707 PGS001852
(portability-PLR_535.6)
PSS009101|
European Ancestry|
3,868 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): 0.0235 [-0.0081, 0.0551] sex, age, birth date, deprivation index, 16 PCs
PPM009708 PGS001852
(portability-PLR_535.6)
PSS008655|
European Ancestry|
6,233 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): -0.0217 [-0.0465, 0.0032] sex, age, birth date, deprivation index, 16 PCs
PPM009709 PGS001852
(portability-PLR_535.6)
PSS008429|
Greater Middle Eastern Ancestry|
1,076 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): 0.002 [-0.0583, 0.0623] sex, age, birth date, deprivation index, 16 PCs
PPM009710 PGS001852
(portability-PLR_535.6)
PSS008209|
South Asian Ancestry|
5,720 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): 0.0315 [0.0055, 0.0574] sex, age, birth date, deprivation index, 16 PCs
PPM009711 PGS001852
(portability-PLR_535.6)
PSS007991|
East Asian Ancestry|
1,684 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): 0.0278 [-0.0203, 0.0757] sex, age, birth date, deprivation index, 16 PCs
PPM009712 PGS001852
(portability-PLR_535.6)
PSS007774|
African Ancestry|
2,298 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): -0.0208 [-0.0618, 0.0203] sex, age, birth date, deprivation index, 16 PCs
PPM009713 PGS001852
(portability-PLR_535.6)
PSS008878|
African Ancestry|
3,648 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Duodenitis Partial Correlation (partial-r): 0.0077 [-0.0249, 0.0402] sex, age, birth date, deprivation index, 16 PCs
PPM009715 PGS001853
(portability-PLR_540)
PSS009102|
European Ancestry|
4,136 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0345 [0.0039, 0.0649] sex, age, birth date, deprivation index, 16 PCs
PPM009716 PGS001853
(portability-PLR_540)
PSS008656|
European Ancestry|
6,660 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0198 [-0.0043, 0.0438] sex, age, birth date, deprivation index, 16 PCs
PPM009717 PGS001853
(portability-PLR_540)
PSS008430|
Greater Middle Eastern Ancestry|
1,200 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): -0.0243 [-0.0813, 0.0328] sex, age, birth date, deprivation index, 16 PCs
PPM009718 PGS001853
(portability-PLR_540)
PSS008210|
South Asian Ancestry|
6,331 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0024 [-0.0223, 0.0271] sex, age, birth date, deprivation index, 16 PCs
PPM009719 PGS001853
(portability-PLR_540)
PSS007992|
East Asian Ancestry|
1,810 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0008 [-0.0455, 0.0471] sex, age, birth date, deprivation index, 16 PCs
PPM009720 PGS001853
(portability-PLR_540)
PSS007775|
African Ancestry|
2,484 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): -0.0062 [-0.0457, 0.0333] sex, age, birth date, deprivation index, 16 PCs
PPM009721 PGS001853
(portability-PLR_540)
PSS008879|
African Ancestry|
3,924 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): -0.0204 [-0.0517, 0.011] sex, age, birth date, deprivation index, 16 PCs
PPM009714 PGS001853
(portability-PLR_540)
PSS009328|
European Ancestry|
20,000 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0242 [0.0104, 0.0381] sex, age, birth date, deprivation index, 16 PCs
PPM009730 PGS001855
(portability-PLR_555.2)
PSS009330|
European Ancestry|
16,188 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0625 [0.0471, 0.0778] sex, age, birth date, deprivation index, 16 PCs
PPM009732 PGS001855
(portability-PLR_555.2)
PSS008658|
European Ancestry|
5,477 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0453 [0.0188, 0.0717] sex, age, birth date, deprivation index, 16 PCs
PPM009733 PGS001855
(portability-PLR_555.2)
PSS008432|
Greater Middle Eastern Ancestry|
1,007 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0175 [-0.0449, 0.0799] sex, age, birth date, deprivation index, 16 PCs
PPM009734 PGS001855
(portability-PLR_555.2)
PSS008212|
South Asian Ancestry|
5,337 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0407 [0.0139, 0.0676] sex, age, birth date, deprivation index, 16 PCs
PPM009735 PGS001855
(portability-PLR_555.2)
PSS007994|
East Asian Ancestry|
1,630 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0382 [-0.0107, 0.0868] sex, age, birth date, deprivation index, 16 PCs
PPM009736 PGS001855
(portability-PLR_555.2)
PSS007777|
African Ancestry|
2,105 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.031 [-0.0119, 0.0738] sex, age, birth date, deprivation index, 16 PCs
PPM009737 PGS001855
(portability-PLR_555.2)
PSS008881|
African Ancestry|
3,465 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): -0.0003 [-0.0337, 0.0331] sex, age, birth date, deprivation index, 16 PCs
PPM009731 PGS001855
(portability-PLR_555.2)
PSS009104|
European Ancestry|
3,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0367 [0.0036, 0.0698] sex, age, birth date, deprivation index, 16 PCs
PPM009738 PGS001856
(portability-PLR_557.1)
PSS009331|
European Ancestry|
16,106 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.1196 [0.1043, 0.1348] sex, age, birth date, deprivation index, 16 PCs
PPM009739 PGS001856
(portability-PLR_557.1)
PSS009105|
European Ancestry|
3,509 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0779 [0.0448, 0.1108] sex, age, birth date, deprivation index, 16 PCs
PPM009740 PGS001856
(portability-PLR_557.1)
PSS008659|
European Ancestry|
5,445 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.097 [0.0706, 0.1233] sex, age, birth date, deprivation index, 16 PCs
PPM009741 PGS001856
(portability-PLR_557.1)
PSS008433|
Greater Middle Eastern Ancestry|
998 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0652 [0.0025, 0.1273] sex, age, birth date, deprivation index, 16 PCs
PPM009742 PGS001856
(portability-PLR_557.1)
PSS008213|
South Asian Ancestry|
5,277 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0535 [0.0265, 0.0805] sex, age, birth date, deprivation index, 16 PCs
PPM009743 PGS001856
(portability-PLR_557.1)
PSS007778|
African Ancestry|
2,091 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0261 [-0.017, 0.0691] sex, age, birth date, deprivation index, 16 PCs
PPM009744 PGS001856
(portability-PLR_557.1)
PSS008882|
African Ancestry|
3,455 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.028 [-0.0054, 0.0614] sex, age, birth date, deprivation index, 16 PCs
PPM009761 PGS001859
(portability-PLR_565.1)
PSS009334|
European Ancestry|
19,196 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0212 [0.007, 0.0353] sex, age, birth date, deprivation index, 16 PCs
PPM009762 PGS001859
(portability-PLR_565.1)
PSS009108|
European Ancestry|
4,008 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0361 [0.005, 0.067] sex, age, birth date, deprivation index, 16 PCs
PPM009763 PGS001859
(portability-PLR_565.1)
PSS008662|
European Ancestry|
6,382 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0161 [-0.0085, 0.0406] sex, age, birth date, deprivation index, 16 PCs
PPM009764 PGS001859
(portability-PLR_565.1)
PSS008436|
Greater Middle Eastern Ancestry|
1,135 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0633 [0.0047, 0.1216] sex, age, birth date, deprivation index, 16 PCs
PPM009765 PGS001859
(portability-PLR_565.1)
PSS008216|
South Asian Ancestry|
5,990 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): -0.0037 [-0.029, 0.0217] sex, age, birth date, deprivation index, 16 PCs
PPM009766 PGS001859
(portability-PLR_565.1)
PSS007997|
East Asian Ancestry|
1,770 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0417 [-0.0051, 0.0884] sex, age, birth date, deprivation index, 16 PCs
PPM009767 PGS001859
(portability-PLR_565.1)
PSS007781|
African Ancestry|
2,363 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0309 [-0.0096, 0.0713] sex, age, birth date, deprivation index, 16 PCs
PPM009768 PGS001859
(portability-PLR_565.1)
PSS008885|
African Ancestry|
3,762 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0059 [-0.0261, 0.0379] sex, age, birth date, deprivation index, 16 PCs
PPM010037 PGS001894
(portability-PLR_celiac_gluten)
PSS009164|
European Ancestry|
1,354 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0796 [0.026, 0.1327] sex, age, birth date, deprivation index, 16 PCs
PPM010038 PGS001894
(portability-PLR_celiac_gluten)
PSS008718|
European Ancestry|
2,442 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0358 [-0.0041, 0.0755] sex, age, birth date, deprivation index, 16 PCs
PPM010039 PGS001894
(portability-PLR_celiac_gluten)
PSS008492|
Greater Middle Eastern Ancestry|
208 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0295 [-0.1141, 0.1719] sex, age, birth date, deprivation index, 16 PCs
PPM010040 PGS001894
(portability-PLR_celiac_gluten)
PSS008270|
South Asian Ancestry|
908 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0219 [-0.0439, 0.0876] sex, age, birth date, deprivation index, 16 PCs
PPM010041 PGS001894
(portability-PLR_celiac_gluten)
PSS007834|
African Ancestry|
400 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): -0.0127 [-0.1132, 0.088] sex, age, birth date, deprivation index, 16 PCs
PPM010042 PGS001894
(portability-PLR_celiac_gluten)
PSS008938|
African Ancestry|
526 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0162 [-0.0711, 0.1032] sex, age, birth date, deprivation index, 16 PCs
PPM010036 PGS001894
(portability-PLR_celiac_gluten)
PSS009390|
European Ancestry|
7,142 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0993 [0.0763, 0.1223] sex, age, birth date, deprivation index, 16 PCs
PPM010978 PGS002013
(portability-ldpred2_153)
PSS009272|
European Ancestry|
18,722 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0397 [0.0254, 0.054] sex, age, birth date, deprivation index, 16 PCs
PPM010979 PGS002013
(portability-ldpred2_153)
PSS009046|
European Ancestry|
3,922 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0419 [0.0105, 0.0732] sex, age, birth date, deprivation index, 16 PCs
PPM010980 PGS002013
(portability-ldpred2_153)
PSS008600|
European Ancestry|
6,241 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0234 [-0.0015, 0.0482] sex, age, birth date, deprivation index, 16 PCs
PPM010981 PGS002013
(portability-ldpred2_153)
PSS008378|
Greater Middle Eastern Ancestry|
1,123 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0315 [-0.0276, 0.0904] sex, age, birth date, deprivation index, 16 PCs
PPM010982 PGS002013
(portability-ldpred2_153)
PSS008154|
South Asian Ancestry|
6,010 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0275 [0.0021, 0.0528] sex, age, birth date, deprivation index, 16 PCs
PPM010983 PGS002013
(portability-ldpred2_153)
PSS007942|
East Asian Ancestry|
1,719 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.026 [-0.0215, 0.0735] sex, age, birth date, deprivation index, 16 PCs
PPM010984 PGS002013
(portability-ldpred2_153)
PSS007724|
African Ancestry|
2,362 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0053 [-0.0352, 0.0458] sex, age, birth date, deprivation index, 16 PCs
PPM010985 PGS002013
(portability-ldpred2_153)
PSS008826|
African Ancestry|
3,757 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer Partial Correlation (partial-r): 0.0265 [-0.0056, 0.0585] sex, age, birth date, deprivation index, 16 PCs
PPM011026 PGS002019
(portability-ldpred2_208)
PSS009281|
European Ancestry|
19,812 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0716 [0.0577, 0.0854] sex, age, birth date, deprivation index, 16 PCs
PPM011027 PGS002019
(portability-ldpred2_208)
PSS009055|
European Ancestry|
4,121 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0761 [0.0456, 0.1065] sex, age, birth date, deprivation index, 16 PCs
PPM011028 PGS002019
(portability-ldpred2_208)
PSS008609|
European Ancestry|
6,617 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0659 [0.0418, 0.0899] sex, age, birth date, deprivation index, 16 PCs
PPM011029 PGS002019
(portability-ldpred2_208)
PSS008385|
Greater Middle Eastern Ancestry|
1,194 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0966 [0.0396, 0.153] sex, age, birth date, deprivation index, 16 PCs
PPM011030 PGS002019
(portability-ldpred2_208)
PSS008163|
South Asian Ancestry|
6,307 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0398 [0.0151, 0.0645] sex, age, birth date, deprivation index, 16 PCs
PPM011031 PGS002019
(portability-ldpred2_208)
PSS007950|
East Asian Ancestry|
1,800 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0601 [0.0137, 0.1063] sex, age, birth date, deprivation index, 16 PCs
PPM011032 PGS002019
(portability-ldpred2_208)
PSS007731|
African Ancestry|
2,469 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0409 [0.0012, 0.0803] sex, age, birth date, deprivation index, 16 PCs
PPM011033 PGS002019
(portability-ldpred2_208)
PSS008834|
African Ancestry|
3,905 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Benign neoplasm of colon Partial Correlation (partial-r): 0.0603 [0.0289, 0.0916] sex, age, birth date, deprivation index, 16 PCs
PPM011374 PGS002064
(portability-ldpred2_540)
PSS009328|
European Ancestry|
20,000 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0149 [0.0011, 0.0288] sex, age, birth date, deprivation index, 16 PCs
PPM011375 PGS002064
(portability-ldpred2_540)
PSS009102|
European Ancestry|
4,136 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): -0.0011 [-0.0317, 0.0294] sex, age, birth date, deprivation index, 16 PCs
PPM011376 PGS002064
(portability-ldpred2_540)
PSS008656|
European Ancestry|
6,660 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0284 [0.0043, 0.0524] sex, age, birth date, deprivation index, 16 PCs
PPM011377 PGS002064
(portability-ldpred2_540)
PSS008430|
Greater Middle Eastern Ancestry|
1,200 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): -0.0502 [-0.1069, 0.0069] sex, age, birth date, deprivation index, 16 PCs
PPM011378 PGS002064
(portability-ldpred2_540)
PSS008210|
South Asian Ancestry|
6,331 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0161 [-0.0085, 0.0408] sex, age, birth date, deprivation index, 16 PCs
PPM011379 PGS002064
(portability-ldpred2_540)
PSS007992|
East Asian Ancestry|
1,810 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0333 [-0.0131, 0.0795] sex, age, birth date, deprivation index, 16 PCs
PPM011380 PGS002064
(portability-ldpred2_540)
PSS007775|
African Ancestry|
2,484 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): -0.0115 [-0.051, 0.028] sex, age, birth date, deprivation index, 16 PCs
PPM011381 PGS002064
(portability-ldpred2_540)
PSS008879|
African Ancestry|
3,924 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Appendiceal conditions Partial Correlation (partial-r): 0.0213 [-0.0101, 0.0526] sex, age, birth date, deprivation index, 16 PCs
PPM011390 PGS002066
(portability-ldpred2_555.2)
PSS009330|
European Ancestry|
16,188 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0641 [0.0487, 0.0794] sex, age, birth date, deprivation index, 16 PCs
PPM011391 PGS002066
(portability-ldpred2_555.2)
PSS009104|
European Ancestry|
3,520 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0466 [0.0135, 0.0796] sex, age, birth date, deprivation index, 16 PCs
PPM011392 PGS002066
(portability-ldpred2_555.2)
PSS008658|
European Ancestry|
5,477 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0426 [0.0161, 0.0691] sex, age, birth date, deprivation index, 16 PCs
PPM011393 PGS002066
(portability-ldpred2_555.2)
PSS008432|
Greater Middle Eastern Ancestry|
1,007 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0056 [-0.0568, 0.068] sex, age, birth date, deprivation index, 16 PCs
PPM011395 PGS002066
(portability-ldpred2_555.2)
PSS007994|
East Asian Ancestry|
1,630 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0398 [-0.009, 0.0885] sex, age, birth date, deprivation index, 16 PCs
PPM011396 PGS002066
(portability-ldpred2_555.2)
PSS007777|
African Ancestry|
2,105 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0272 [-0.0157, 0.0701] sex, age, birth date, deprivation index, 16 PCs
PPM011397 PGS002066
(portability-ldpred2_555.2)
PSS008881|
African Ancestry|
3,465 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0058 [-0.0276, 0.0392] sex, age, birth date, deprivation index, 16 PCs
PPM011394 PGS002066
(portability-ldpred2_555.2)
PSS008212|
South Asian Ancestry|
5,337 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ulcerative colitis Partial Correlation (partial-r): 0.0388 [0.0119, 0.0656] sex, age, birth date, deprivation index, 16 PCs
PPM021728 PGS002066
(portability-ldpred2_555.2)
PSS011762|
European Ancestry|
8,417 individuals
PGP000665 |
Moreno-Grau S et al. Human Genomics (2024)
|Ext.
Reported Trait: Ulcerative colitis OR: 1.11 [0.97, 1.28] AUROC: 0.57
PPM011398 PGS002067
(portability-ldpred2_557.1)
PSS009331|
European Ancestry|
16,106 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.1241 [0.1088, 0.1393] sex, age, birth date, deprivation index, 16 PCs
PPM011400 PGS002067
(portability-ldpred2_557.1)
PSS008659|
European Ancestry|
5,445 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0979 [0.0714, 0.1242] sex, age, birth date, deprivation index, 16 PCs
PPM011401 PGS002067
(portability-ldpred2_557.1)
PSS008433|
Greater Middle Eastern Ancestry|
998 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0718 [0.0092, 0.1339] sex, age, birth date, deprivation index, 16 PCs
PPM011402 PGS002067
(portability-ldpred2_557.1)
PSS008213|
South Asian Ancestry|
5,277 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0512 [0.0242, 0.0781] sex, age, birth date, deprivation index, 16 PCs
PPM011403 PGS002067
(portability-ldpred2_557.1)
PSS007778|
African Ancestry|
2,091 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0094 [-0.0337, 0.0525] sex, age, birth date, deprivation index, 16 PCs
PPM011404 PGS002067
(portability-ldpred2_557.1)
PSS008882|
African Ancestry|
3,455 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0241 [-0.0093, 0.0575] sex, age, birth date, deprivation index, 16 PCs
PPM011399 PGS002067
(portability-ldpred2_557.1)
PSS009105|
European Ancestry|
3,509 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Celiac disease Partial Correlation (partial-r): 0.0695 [0.0364, 0.1024] sex, age, birth date, deprivation index, 16 PCs
PPM011421 PGS002070
(portability-ldpred2_565.1)
PSS009334|
European Ancestry|
19,196 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0342 [0.02, 0.0483] sex, age, birth date, deprivation index, 16 PCs
PPM011422 PGS002070
(portability-ldpred2_565.1)
PSS009108|
European Ancestry|
4,008 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0435 [0.0125, 0.0745] sex, age, birth date, deprivation index, 16 PCs
PPM011423 PGS002070
(portability-ldpred2_565.1)
PSS008662|
European Ancestry|
6,382 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0224 [-0.0022, 0.047] sex, age, birth date, deprivation index, 16 PCs
PPM011424 PGS002070
(portability-ldpred2_565.1)
PSS008436|
Greater Middle Eastern Ancestry|
1,135 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0438 [-0.015, 0.1022] sex, age, birth date, deprivation index, 16 PCs
PPM011425 PGS002070
(portability-ldpred2_565.1)
PSS008216|
South Asian Ancestry|
5,990 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0084 [-0.017, 0.0338] sex, age, birth date, deprivation index, 16 PCs
PPM011426 PGS002070
(portability-ldpred2_565.1)
PSS007997|
East Asian Ancestry|
1,770 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0501 [0.0032, 0.0967] sex, age, birth date, deprivation index, 16 PCs
PPM011427 PGS002070
(portability-ldpred2_565.1)
PSS007781|
African Ancestry|
2,363 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): 0.0457 [0.0052, 0.086] sex, age, birth date, deprivation index, 16 PCs
PPM011428 PGS002070
(portability-ldpred2_565.1)
PSS008885|
African Ancestry|
3,762 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Anal and rectal polyp Partial Correlation (partial-r): -0.0102 [-0.0422, 0.0219] sex, age, birth date, deprivation index, 16 PCs
PPM011712 PGS002107
(portability-ldpred2_celiac_gluten)
PSS009390|
European Ancestry|
7,142 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0964 [0.0733, 0.1193] sex, age, birth date, deprivation index, 16 PCs
PPM011713 PGS002107
(portability-ldpred2_celiac_gluten)
PSS009164|
European Ancestry|
1,354 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0848 [0.0313, 0.1379] sex, age, birth date, deprivation index, 16 PCs
PPM011714 PGS002107
(portability-ldpred2_celiac_gluten)
PSS008718|
European Ancestry|
2,442 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.041 [0.0012, 0.0807] sex, age, birth date, deprivation index, 16 PCs
PPM011715 PGS002107
(portability-ldpred2_celiac_gluten)
PSS008492|
Greater Middle Eastern Ancestry|
208 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0206 [-0.1229, 0.1632] sex, age, birth date, deprivation index, 16 PCs
PPM011716 PGS002107
(portability-ldpred2_celiac_gluten)
PSS008270|
South Asian Ancestry|
908 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0237 [-0.0422, 0.0893] sex, age, birth date, deprivation index, 16 PCs
PPM011717 PGS002107
(portability-ldpred2_celiac_gluten)
PSS007834|
African Ancestry|
400 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): -0.0242 [-0.1245, 0.0766] sex, age, birth date, deprivation index, 16 PCs
PPM011718 PGS002107
(portability-ldpred2_celiac_gluten)
PSS008938|
African Ancestry|
526 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity Partial Correlation (partial-r): 0.0172 [-0.0701, 0.1042] sex, age, birth date, deprivation index, 16 PCs
PPM012805 PGS002252
(PRS_CRC)
PSS009566|
European Ancestry|
7,376 individuals
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Reported Trait: Early-onset colorectal cancer OR: 1.59 [1.51, 1.68] AUROC: 0.628 [0.613, 0.644] Age, sex, genotype platform, family history, principal components
PPM012806 PGS002252
(PRS_CRC)
PSS009566|
European Ancestry|
7,376 individuals
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Reported Trait: Early-onset colorectal cancer (men) AUROC: 0.61 [0.592, 0.651] Age, family history, genotype platform, principal components
PPM012807 PGS002252
(PRS_CRC)
PSS009566|
European Ancestry|
7,376 individuals
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Reported Trait: Early-onset colorectal cancer (women) AUROC: 0.633 [0.612, 0.655] Age, family history, genotype platform, principal components
PPM012808 PGS002252
(PRS_CRC)
PSS009566|
European Ancestry|
7,376 individuals
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Reported Trait: Proximal colon cancer OR: 1.38 [1.27, 1.5] AUROC: 0.592 [0.554, 0.63] Age, family history, genotype platform, principal components
PPM012809 PGS002252
(PRS_CRC)
PSS009566|
European Ancestry|
7,376 individuals
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Reported Trait: Distal colon cancer OR: 1.73 [1.6, 1.87] AUROC: 0.643 [0.614, 0.671] Age, family history, genotype platform, principal components
PPM012810 PGS002252
(PRS_CRC)
PSS009566|
European Ancestry|
7,376 individuals
PGP000279 |
Archambault AN et al. J Natl Cancer Inst (2022)
Reported Trait: Rectal cancer OR: 1.67 [1.55, 1.8] AUROC: 0.654 [0.63, 0.68] Age, family history, genotype platform, principal components
PPM013009 PGS002265
(PRS140_CRC)
PSS009645|
Ancestry Not Reported|
8,405 individuals
PGP000319 |
Guo F et al. Clin Gastroenterol Hepatol (2022)
|Ext.
Reported Trait: Risk of colorectal cancer Odds ratio (OR, high vs low): 2.61 [2.33, 2.93] Age, sex, education, body mass index, participation in a health check-up, family history of colorectal cancer, smoking, ever regular use of nonsteroidal anti-inflammatory drugs, and ever regular use of hormone replacement therapy
PPM014884 PGS002265
(PRS140_CRC)
PSS009918|
European Ancestry|
5,306 individuals
PGP000350 |
Niedermaier T et al. Cancer Prev Res (Phila) (2022)
|Ext.
Reported Trait: Advanced colorectal neoplasia (Ridascreen model) OR: 1.025
β: 0.02451
AUROC: 0.524 [0.499, 0.55]
PPM014885 PGS002265
(PRS140_CRC)
PSS009918|
European Ancestry|
5,306 individuals
PGP000350 |
Niedermaier T et al. Cancer Prev Res (Phila) (2022)
|Ext.
Reported Trait: Advanced colorectal neoplasia (FOB Gold model) OR: 1.036
β: 0.03518
AUROC: 0.53 [0.516, 0.545]
PPM018664 PGS002265
(PRS140_CRC)
PSS011059|
European Ancestry|
72,791 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.629 [0.613, 0.645] Hazard Ratio (HR, top 30% of PGS vs. remainder): 1.92 [1.75, 2.23] age, sex
PPM018665 PGS002265
(PRS140_CRC)
PSS011058|
East Asian Ancestry|
6,966 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.591 [0.536, 0.625] age, sex
PPM018666 PGS002265
(PRS140_CRC)
PSS011060|
Hispanic or Latin American Ancestry|
6,660 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.592 [0.531, 0.652] age, sex
PPM018667 PGS002265
(PRS140_CRC)
PSS011057|
African Ancestry|
5,249 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.581 [0.5, 0.645] age, sex
PPM018668 PGS002265
(PRS140_CRC)
PSS011061|
European Ancestry|
38,214 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.591 age, sex
PPM020729 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.615 [0.529, 0.7]
PPM020730 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Advanced adenoma AUROC: 0.589 [0.562, 0.616]
PPM020731 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Non-advanced adenoma AUROC: 0.555 [0.534, 0.576]
PPM020732 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms AUROC: 0.591 [0.564, 0.617]
PPM020733 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (50 - 59 years) AUROC: 0.586 [0.544, 0.628]
PPM020734 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (60 - 79 years) AUROC: 0.597 [0.563, 0.631]
PPM020735 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (men) AUROC: 0.593 [0.558, 0.629]
PPM020736 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (women) AUROC: 0.593 [0.553, 0.633]
PPM020737 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (family history) AUROC: 0.555 [0.471 - 0.639
PPM020738 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (non family history) AUROC: 0.599 [0.57, 0.627]
PPM020739 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (previous colonoscopy) AUROC: 0.607 [0.551, 0.663]
PPM020740 PGS002265
(PRS140_CRC)
PSS011386|
Ancestry Not Reported|
3,025 individuals
PGP000573 |
Niedermaier T et al. Cancer Commun (Lond) (2023)
|Ext.
Reported Trait: Any advanced neoplasms (no previous colonoscopy) AUROC: 0.585 [0.555, 0.616]
PPM020902 PGS002265
(PRS140_CRC)
PSS011444|
Multi-ancestry (including European)|
4,035 individuals
PGP000601 |
Niedermaier T et al. Clin Transl Gastroenterol (2022)
|Ext.
Reported Trait: Advanced neoplasia (colorectal cancer or advanced adenoma) Positive predictive value (PPV, highest PRS tertile): 39.0 [36.0, 42.0] Intermediate (90% specificity) FIT cutoff.
PPM020901 PGS002265
(PRS140_CRC)
PSS011445|
Multi-ancestry (including European)|
1,271 individuals
PGP000601 |
Niedermaier T et al. Clin Transl Gastroenterol (2022)
|Ext.
Reported Trait: Advanced neoplasia (colorectal cancer or advanced adenoma) Positive predictive value (PPV, highest PRS tertile): 37.0 [31.0, 43.0] Intermediate (90% specificity) FIT cutoff.
PPM014906 PGS002742
(PRS115_EAS)
PSS009924|
East Asian Ancestry|
1,454 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancer OR: 1.63 [1.46, 1.83] AUROC: 0.63 [0.6, 0.66]
PPM014909 PGS002742
(PRS115_EAS)
PSS009923|
East Asian Ancestry|
1,736 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancer OR: 1.51 [1.37, 1.67] AUROC: 0.61 [0.59, 0.64]
PPM014907 PGS002743
(PRS115_EUR)
PSS009924|
East Asian Ancestry|
1,454 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancer OR: 1.44 [1.29, 1.6] AUROC: 0.6 [0.57, 0.63]
PPM014910 PGS002743
(PRS115_EUR)
PSS009923|
East Asian Ancestry|
1,736 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancer OR: 1.39 [1.26, 1.53] AUROC: 0.59 [0.56, 0.61]
PPM014908 PGS002744
(PRS115_EUR_EAS)
PSS009924|
East Asian Ancestry|
1,454 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancer OR: 1.68 [1.5, 1.89] AUROC: 0.64 [0.61, 0.67]
PPM014911 PGS002744
(PRS115_EUR_EAS)
PSS009923|
East Asian Ancestry|
1,736 individuals
PGP000354 |
Ping J et al. Int J Cancer (2022)
Reported Trait: Colorectal cancer OR: 1.5 [1.36, 1.66] AUROC: 0.61 [0.58, 0.64]
PPM014958 PGS002758
(Colorectal_cancer_prscs)
PSS009939|
European Ancestry|
39,444 individuals
PGP000364 |
Mars N et al. Am J Hum Genet (2022)
Reported Trait: Colorectal cancer OR: 1.61 [1.46, 1.77] age, sex, 10 PCs, technical covariates
PPM016261 PGS003386
(best_COADREAD)
PSS010076|
European Ancestry|
274,069 individuals
PGP000413 |
Namba S et al. Cancer Res (2022)
Reported Trait: colorectal cancer AUROC: 0.724 : 0.0115 age, sex, top 20 genetic principal components
PPM016277 PGS003395
(PRScsx_CRC)
PSS010093|
East Asian Ancestry|
2,179 individuals
PGP000414 |
Xin J et al. Genome Med (2023)
Reported Trait: Incident colorectal cancer OR: 1.73 [1.56, 1.91] AUROC: 0.646 sex, age and principal components
PPM016278 PGS003395
(PRScsx_CRC)
PSS010092|
European Ancestry|
2,573 individuals
PGP000414 |
Xin J et al. Genome Med (2023)
Reported Trait: Incident colorectal cancer OR: 1.48 [1.36, 1.62] AUROC: 0.608 sex, age and principal components
PPM016279 PGS003395
(PRScsx_CRC)
PSS010094|
European Ancestry|
355,543 individuals
PGP000414 |
Xin J et al. Genome Med (2023)
Reported Trait: Incident colorectal cancer HR: 1.42 [1.37, 1.48] AUROC: 0.597 sex, age, center and principal components
PPM017117 PGS003431
(LDPred2-inf)
PSS010132|
European Ancestry|
34,152 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.726 [0.704, 0.748] : 7.0 [5.7, 8.4] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017123 PGS003431
(LDPred2-inf)
PSS010133|
European Ancestry|
33,893 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.715 [0.686, 0.743] : 27.0 [21.7, 32.1] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017129 PGS003431
(LDPred2-inf)
PSS010134|
Multi-ancestry (excluding European)|
27,503 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.588 [0.545, 0.627] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017135 PGS003431
(LDPred2-inf)
PSS010135|
Multi-ancestry (excluding European)|
27,310 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.647 [0.593, 0.7] : 17.2 [9.2, 27.9] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017105 PGS003431
(LDPred2-inf)
PSS010130|
European Ancestry|
280,664 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer OR: 1.435 [1.391, 1.48] AUROC: 0.704 [0.697, 0.712] : 5.5 [5.1, 5.9] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy and scaled Brier available in source publication
PPM017111 PGS003431
(LDPred2-inf)
PSS010131|
European Ancestry|
278,493 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer HR: 1.368 [1.31, 1.428] C-index: 0.696 [0.685, 0.707] : 22.0 [20.1, 24.0] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017106 PGS003432
(LDPred2-grid)
PSS010130|
European Ancestry|
280,664 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer OR: 1.584 [1.536, 1.633] AUROC: 0.717 [0.711, 0.725] : 6.3 [5.9, 6.8] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy and scaled Brier available in source publication
PPM017118 PGS003432
(LDPred2-grid)
PSS010132|
European Ancestry|
34,152 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.732 [0.71, 0.752] : 7.6 [6.1, 8.9] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017124 PGS003432
(LDPred2-grid)
PSS010133|
European Ancestry|
33,893 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.724 [0.696, 0.751] : 28.3 [23.2, 33.3] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017130 PGS003432
(LDPred2-grid)
PSS010134|
Multi-ancestry (excluding European)|
27,503 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.602 [0.558, 0.64] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017136 PGS003432
(LDPred2-grid)
PSS010135|
Multi-ancestry (excluding European)|
27,310 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.666 [0.61, 0.72] : 20.3 [11.5, 31.1] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017112 PGS003432
(LDPred2-grid)
PSS010131|
European Ancestry|
278,493 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer HR: 1.563 [1.498, 1.631] C-index: 0.714 [0.704, 0.726] : 25.6 [23.8, 27.8] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017107 PGS003433
(LDPred2-grid-sp)
PSS010130|
European Ancestry|
280,664 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer OR: 1.571 [1.524, 1.62] AUROC: 0.716 [0.71, 0.723] : 6.2 [5.8, 6.7] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy and scaled Brier available in source publication
PPM017119 PGS003433
(LDPred2-grid-sp)
PSS010132|
European Ancestry|
34,152 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.733 [0.71, 0.753] : 7.6 [6.1, 8.9] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017125 PGS003433
(LDPred2-grid-sp)
PSS010133|
European Ancestry|
33,893 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.725 [0.696, 0.752] : 28.5 [23.4, 33.7] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017131 PGS003433
(LDPred2-grid-sp)
PSS010134|
Multi-ancestry (excluding European)|
27,503 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.601 [0.559, 0.64] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017137 PGS003433
(LDPred2-grid-sp)
PSS010135|
Multi-ancestry (excluding European)|
27,310 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.664 [0.609, 0.718] : 20.2 [11.4, 30.7] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017141 PGS003433
(LDPred2-grid-sp)
PSS010129|
Multi-ancestry (excluding European)|
196,091 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer in men C-index: 0.73 [0.72, 0.741] : 28.2 [26.3, 30.1]
For top 20% absolute risk sensitivity: 47.8 %
specificty: 80.3 %
QCancer-10 score Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017142 PGS003433
(LDPred2-grid-sp)
PSS010128|
Multi-ancestry (excluding European)|
238,496 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer in females C-index: 0.687 [0.673, 0.702] : 21.0 [18.7, 23.7]
For top 20% absolute risk sensitivity: 42.7 %
specificty: 80.1 %
QCancer-10 score Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017113 PGS003433
(LDPred2-grid-sp)
PSS010131|
European Ancestry|
278,493 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer HR: 1.545 [1.48, 1.612] C-index: 0.712 [0.702, 0.723] : 25.3 [23.4, 27.3] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017108 PGS003434
(SCT)
PSS010130|
European Ancestry|
280,664 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer OR: 1.417 [1.375, 1.461] AUROC: 0.702 [0.695, 0.711] : 5.4 [5.0, 5.9] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy and scaled Brier available in source publication
PPM017114 PGS003434
(SCT)
PSS010131|
European Ancestry|
278,493 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer HR: 1.378 [1.321, 1.438] C-index: 0.695 [0.685, 0.706] : 22.3 [20.3, 24.4] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017120 PGS003434
(SCT)
PSS010132|
European Ancestry|
34,152 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.718 [0.696, 0.739] : 6.4 [5.0, 7.7] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017126 PGS003434
(SCT)
PSS010133|
European Ancestry|
33,893 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.713 [0.686, 0.74] : 25.1 [20.2, 30.2] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017132 PGS003434
(SCT)
PSS010134|
Multi-ancestry (excluding European)|
27,503 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.589 [0.546, 0.626] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017138 PGS003434
(SCT)
PSS010135|
Multi-ancestry (excluding European)|
27,310 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.65 [0.596, 0.705] : 17.4 [8.9, 28.1] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017109 PGS003435
(CT)
PSS010130|
European Ancestry|
280,664 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer OR: 1.425 [1.382, 1.47] AUROC: 0.704 [0.697, 0.711] : 5.4 [5.1, 5.9] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy and scaled Brier available in source publication
PPM017115 PGS003435
(CT)
PSS010131|
European Ancestry|
278,493 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer HR: 1.397 [1.338, 1.459] C-index: 0.698 [0.689, 0.709] : 22.4 [20.6, 24.4] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017121 PGS003435
(CT)
PSS010132|
European Ancestry|
34,152 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.719 [0.696, 0.74] : 6.6 [5.2, 7.9] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017127 PGS003435
(CT)
PSS010133|
European Ancestry|
33,893 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.707 [0.681, 0.734] : 25.1 [20.0, 30.3] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017133 PGS003435
(CT)
PSS010134|
Multi-ancestry (excluding European)|
27,503 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.597 [0.554, 0.636] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017139 PGS003435
(CT)
PSS010135|
Multi-ancestry (excluding European)|
27,310 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.658 [0.606, 0.71] : 18.7 [10.0, 29.4] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017110 PGS003436
(GWAS-sig)
PSS010130|
European Ancestry|
280,664 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer OR: 1.39 [1.348, 1.433] AUROC: 0.7 [0.693, 0.707] : 5.3 [4.9, 5.7] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy and scaled Brier available in source publication
PPM017116 PGS003436
(GWAS-sig)
PSS010131|
European Ancestry|
278,493 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer HR: 1.377 [1.32, 1.436] C-index: 0.695 [0.685, 0.706] : 22.2 [20.2, 24.4] age, sex, PC1-4, array Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017122 PGS003436
(GWAS-sig)
PSS010132|
European Ancestry|
34,152 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.703 [0.679, 0.724] : 5.4 [4.0, 6.7] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017128 PGS003436
(GWAS-sig)
PSS010133|
European Ancestry|
33,893 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.701 [0.675, 0.729] : 23.8 [19.0, 29.4] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017134 PGS003436
(GWAS-sig)
PSS010134|
Multi-ancestry (excluding European)|
27,503 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Colorectal cancer AUROC: 0.587 [0.543, 0.624] age, sex, PC1-4, array Dxy, scaled Brier, calibration slope and CITL available in source publication
PPM017140 PGS003436
(GWAS-sig)
PSS010135|
Multi-ancestry (excluding European)|
27,310 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer C-index: 0.659 [0.605, 0.715] : 19.1 [10.3, 29.9] age, sex, PC1-4, array Dxy, D statistic, scaled Brier, calibration slope, available in source publication
PPM017143 PGS003436
(GWAS-sig)
PSS010129|
Multi-ancestry (excluding European)|
196,091 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: Incident Colorectal cancer in men C-index: 0.715 [0.706, 0.726] : 25.6 [23.9, 27.5]
For top 20% absolute risk sensitivity: 44.4 %
specificty: 80.2 %
QCancer-10 score Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017144 PGS003436
(GWAS-sig)
PSS010128|
Multi-ancestry (excluding European)|
238,496 individuals
PGP000438 |
Briggs SEW et al. BMJ (2022)
Reported Trait: incident Colorectal cancer in females C-index: 0.669 [0.655, 0.683] : 17.0 [14.8, 19.3]
For top 20% absolute risk sensitivity: 39.2 %
specificty: 80.1 %
QCancer-10 score Apparent performance presented, results for internal validation presented in source publication. Dxy, D statistic, and scaled Brier available in source publication
PPM017158 PGS003439
(PRSCC_140)
PSS010138|
European Ancestry|
66,282 individuals
PGP000441 |
Su YR et al. Cancer Epidemiol Biomarkers Prev (2023)
Reported Trait: 5 year colorectal cancer risk AUROC: 0.73 [0.71, 0.76] age, first-degree CRC family history, sex, endoscopy history
PPM017159 PGS003439
(PRSCC_140)
PSS010138|
European Ancestry|
66,282 individuals
PGP000441 |
Su YR et al. Cancer Epidemiol Biomarkers Prev (2023)
Reported Trait: 10 year colorectal cancer risk AUROC: 0.72 [0.7, 0.74] age, first-degree CRC family history, sex, endoscopy history
PPM018495 PGS003739
(PRS81_CoC)
PSS010988|
European Ancestry|
470 individuals
PGP000470 |
Xin J et al. EBioMedicine (2023)
Reported Trait: Colorectal cancer OR: 1.37 [1.24, 1.51]
PPM018549 PGS003760
(PRS49_EOCRC)
PSS011018|
Multi-ancestry (including European)|
25,150 individuals
PGP000480 |
Wang H et al. Genome Med (2023)
Reported Trait: Early onset colorectal cancer Odds ratio (OR, Quartile 4 vs Quartile 1): 1.64 [1.32, 2.03] Sex, ethnicity, drinking frequency, smoke status, and family history
PPM018677 PGS003850
(CRC_PRS_200loci)
PSS011062|
Additional Asian Ancestries|
12,025 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer OR: 1.3 AUROC: 0.6 [0.59, 0.62] Age, sex, PCs 1-4
PPM018678 PGS003850
(CRC_PRS_200loci)
PSS011063|
African Ancestry|
13,823 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer OR: 1.25 AUROC: 0.58 [0.56, 0.59] Age, sex, PCs 1-4
PPM018679 PGS003850
(CRC_PRS_200loci)
PSS011064|
Hispanic or Latin American Ancestry|
10,377 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer OR: 1.37 AUROC: 0.59 [0.57, 0.6] Age, sex, PCs 1-4
PPM018680 PGS003850
(CRC_PRS_200loci)
PSS011065|
European Ancestry|
118,756 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer OR: 1.62 AUROC: 0.61 [0.6, 0.62] Age, sex, PCs 1-4
PPM018681 PGS003851
(CRC_PRS_EUR)
PSS011062|
Additional Asian Ancestries|
12,025 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.619 [0.547, 0.689] Age, sex, PCs 1-10
PPM018682 PGS003851
(CRC_PRS_EUR)
PSS011063|
African Ancestry|
13,823 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.526 [0.419, 0.62] Age, sex, PCs 1-10
PPM018683 PGS003851
(CRC_PRS_EUR)
PSS011064|
Hispanic or Latin American Ancestry|
10,377 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.584 [0.511, 0.656] Age, sex, PCs 1-10
PPM018684 PGS003851
(CRC_PRS_EUR)
PSS011065|
European Ancestry|
118,756 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
|Ext.
Reported Trait: Colorectal cancer AUROC: 0.638 [0.624, 0.652] Age, sex, PCs 1-10
PPM018669 PGS003851
(CRC_PRS_EUR)
PSS011059|
European Ancestry|
72,791 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.654 [0.639, 0.669] age, sex
PPM018670 PGS003851
(CRC_PRS_EUR)
PSS011058|
East Asian Ancestry|
6,966 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.601 [0.538, 0.664] age, sex
PPM018671 PGS003851
(CRC_PRS_EUR)
PSS011057|
African Ancestry|
5,249 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.543 [0.5, 0.6241] age, sex
PPM018672 PGS003851
(CRC_PRS_EUR)
PSS011060|
Hispanic or Latin American Ancestry|
6,660 individuals
PGP000294 |
Thomas M et al. Am J Hum Genet (2020)
Reported Trait: Colorectal cancer AUROC: 0.602 [0.542, 0.662] age, sex
PPM018673 PGS003852
(CRC_PRS_EUR_EAS)
PSS011062|
Additional Asian Ancestries|
12,025 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
Reported Trait: Colorectal cancer OR: 1.64 [1.55, 1.74] AUROC: 0.63 [0.62, 0.64] Age, sex, PCs 1-4
PPM018674 PGS003852
(CRC_PRS_EUR_EAS)
PSS011063|
African Ancestry|
13,823 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
Reported Trait: Colorectal cancer OR: 1.39 [1.31, 1.47] AUROC: 0.59 [0.57, 0.61] Age, sex, PCs 1-4
PPM018675 PGS003852
(CRC_PRS_EUR_EAS)
PSS011064|
Hispanic or Latin American Ancestry|
10,377 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
Reported Trait: Colorectal cancer OR: 1.62 [1.51, 1.73] AUROC: 0.62 [0.6, 0.63] Age, sex, PCs 1-4
PPM018676 PGS003852
(CRC_PRS_EUR_EAS)
PSS011065|
European Ancestry|
118,756 individuals
PGP000492 |
Thomas M et al. Nat Commun (2023)
Reported Trait: Colorectal cancer OR: 1.67 [1.6, 1.75] AUROC: 0.65 [0.64, 0.66] Age, sex, PCs 1-4
PPM019147 PGS003979
(CRC_PRSCS)
PSS011211|
European Ancestry|
453,733 individuals
PGP000515 |
Tamlander M et al. Br J Cancer (2023)
Reported Trait: Colorectal cancer OR: 1.63 [1.6, 1.67] AUROC: 0.795 [0.791, 0.799] year of birth, sex, ten first principal components of ancestry, genotyping batch, genotyping array
PPM019233 PGS003981
(dbslmm.auto.GCST004131.IBD)
PSS011220|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.33244 [1.27636372, 1.39097687]
β: 0.28701 [0.24401519, 0.33000628]
AUROC: 0.57783 [0.56512605, 0.59053543] : 0.01296 [0.00925469, 0.01730226] 0 beta = log(or)/sd_pgs
PPM019234 PGS003981
(dbslmm.auto.GCST004131.IBD)
PSS011231|
European Ancestry|
396,819 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.89729 [1.85459133, 1.94097411]
β: 0.64043 [0.61766436, 0.66318997]
AUROC: 0.67371 [0.66774486, 0.67966784] : 0.06325 [0.05894778, 0.06769876] 0 beta = log(or)/sd_pgs
PPM019235 PGS003981
(dbslmm.auto.GCST004131.IBD)
PSS011244|
South Asian Ancestry|
44,057 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.82983 [1.67934751, 1.99380176]
β: 0.60422 [0.51840533, 0.69004325]
AUROC: 0.67951 [0.6554003, 0.70362688] : 0.06185 [0.04504691, 0.07994757] 0 beta = log(or)/sd_pgs
PPM019236 PGS003981
(dbslmm.auto.GCST004131.IBD)
PSS011260|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.51174 [1.44162473, 1.58525957]
β: 0.41326 [0.36577076, 0.46074816]
AUROC: 0.61196 [0.59842833, 0.62548631] : 0.02672 [0.02061732, 0.03338123] 0 beta = log(or)/sd_pgs
PPM019237 PGS003981
(dbslmm.auto.GCST004131.IBD)
PSS011288|
South Asian Ancestry|
9,326 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.62008 [1.39671425, 1.87915576]
β: 0.48247 [0.33412251, 0.63082261]
AUROC: 0.63378 [0.58989144, 0.67766932] : 0.03702 [0.01608167, 0.06421945] 0 beta = log(or)/sd_pgs
PPM019238 PGS003981
(dbslmm.auto.GCST004131.IBD)
PSS011273|
European Ancestry|
90,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.8704 [1.77207759, 1.97418775]
β: 0.62615 [0.57215264, 0.68015705]
AUROC: 0.6725 [0.65793656, 0.68706996] : 0.06214 [0.05189291, 0.07413997] 0 beta = log(or)/sd_pgs
PPM019287 PGS003997
(lassosum.auto.GCST004131.IBD)
PSS011220|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.35075 [1.2938079, 1.41020626]
β: 0.30066 [0.25758973, 0.34373598]
AUROC: 0.57941 [0.5666597, 0.59215135] : 0.01418 [0.01023193, 0.01900507] 0 beta = log(or)/sd_pgs
PPM019288 PGS003997
(lassosum.auto.GCST004131.IBD)
PSS011231|
European Ancestry|
396,819 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.94603 [1.90231852, 1.99073726]
β: 0.66579 [0.64307341, 0.68850505]
AUROC: 0.67873 [0.67277732, 0.68467331] : 0.06881 [0.06412546, 0.07367853] 0 beta = log(or)/sd_pgs
PPM019289 PGS003997
(lassosum.auto.GCST004131.IBD)
PSS011244|
South Asian Ancestry|
44,057 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.83801 [1.67998664, 2.01090769]
β: 0.60869 [0.51878584, 0.69858621]
AUROC: 0.66965 [0.64499602, 0.69430838] : 0.05739 [0.04006869, 0.07674132] 0 beta = log(or)/sd_pgs
PPM019290 PGS003997
(lassosum.auto.GCST004131.IBD)
PSS011260|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.53922 [1.46791286, 1.61399308]
β: 0.43128 [0.38384157, 0.47871128]
AUROC: 0.61798 [0.60434303, 0.63161432] : 0.0292 [0.02256932, 0.03644038] 0 beta = log(or)/sd_pgs
PPM019291 PGS003997
(lassosum.auto.GCST004131.IBD)
PSS011288|
South Asian Ancestry|
9,326 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.73594 [1.48902968, 2.02379137]
β: 0.55155 [0.39812468, 0.70497267]
AUROC: 0.6478 [0.60413485, 0.69145565] : 0.04539 [0.0233246, 0.07450202] 0 beta = log(or)/sd_pgs
PPM019292 PGS003997
(lassosum.auto.GCST004131.IBD)
PSS011273|
European Ancestry|
90,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.84612 [1.74826591, 1.94945659]
β: 0.61309 [0.55862439, 0.66755066]
AUROC: 0.66875 [0.65403523, 0.68346144] : 0.05865 [0.04924178, 0.07070982] 0 beta = log(or)/sd_pgs
PPM019281 PGS004013
(lassosum.CV.GCST004131.IBD)
PSS011220|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.37266 [1.31475201, 1.43311018]
β: 0.31675 [0.27364806, 0.35984703]
AUROC: 0.58423 [0.57151504, 0.59693644] : 0.01572 [0.01144703, 0.0206319] 0 beta = log(or)/sd_pgs
PPM019282 PGS004013
(lassosum.CV.GCST004131.IBD)
PSS011231|
European Ancestry|
396,819 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.95504 [1.91104715, 2.00004635]
β: 0.67041 [0.64765134, 0.69317036]
AUROC: 0.68013 [0.67419992, 0.68606655] : 0.06951 [0.06473689, 0.07421464] 0 beta = log(or)/sd_pgs
PPM019283 PGS004013
(lassosum.CV.GCST004131.IBD)
PSS011244|
South Asian Ancestry|
44,057 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.88804 [1.72579599, 2.06553911]
β: 0.63554 [0.54568839, 0.72539126]
AUROC: 0.67769 [0.65323253, 0.70214214] : 0.06269 [0.04522405, 0.0823871] 0 beta = log(or)/sd_pgs
PPM019284 PGS004013
(lassosum.CV.GCST004131.IBD)
PSS011260|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease β: 0.42927 [0.38184872, 0.47669506]
OR: 1.53614 [1.46499045, 1.61074219]
AUROC: 0.61822 [0.60458955, 0.63184308] : 0.02892 [0.02253997, 0.03616631] 0 beta = log(or)/sd_pgs
PPM019285 PGS004013
(lassosum.CV.GCST004131.IBD)
PSS011288|
South Asian Ancestry|
9,326 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.72939 [1.48187459, 2.01823757]
β: 0.54777 [0.3933079, 0.70222464]
AUROC: 0.64845 [0.60401758, 0.69288196] : 0.04418 [0.02133967, 0.07419211] 0 beta = log(or)/sd_pgs
PPM019286 PGS004013
(lassosum.CV.GCST004131.IBD)
PSS011273|
European Ancestry|
90,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.8643 [1.76523033, 1.96893154]
β: 0.62289 [0.56828118, 0.67749103]
AUROC: 0.66977 [0.65505775, 0.68448936] : 0.06022 [0.05064197, 0.07255608] 0 beta = log(or)/sd_pgs
PPM019252 PGS004023
(ldpred2.auto.GCST004131.IBD)
PSS011231|
European Ancestry|
396,819 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.98269 [1.93792696, 2.02848131]
β: 0.68445 [0.66161882, 0.70728739]
AUROC: 0.68464 [0.67874717, 0.6905373] : 0.072 [0.06730218, 0.0770144] 0 beta = log(or)/sd_pgs
PPM019253 PGS004023
(ldpred2.auto.GCST004131.IBD)
PSS011244|
South Asian Ancestry|
44,057 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: Inflammatory bowel disease OR: 1.96487 [1.79443565, 2.15148758]
β: 0.67543 [0.58469057, 0.7661595]
AUROC: 0.68609 [0.6621402, 0.71004923] : 0.06963 [0.05194957, 0.09014172] 0 beta = log(or)/sd_pgs
PPM019254 PGS004023
(ldpred2.auto.GCST004131.IBD)
PSS011260|