Trait: asthma

Trait Information
Identifier MONDO_0004979
Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. [EFO: 0000270]
Trait category
Other disease
Synonyms 3 synonyms
  • bronchial hyperreactivity
  • chronic obstructive asthma
  • chronic obstructive asthma with status asthmaticus
Mapped terms 13 mapped terms
  • DOID:2841
  • EFO:0000270
  • GARD:0010246
  • HP:0002099
  • ICD10CM:J45
  • ICD9:493
  • ICD9:493.81
  • ICD9:493.9
  • KEGG:05310
  • MESH:D001249
  • NCIT:C28397
  • SCTID:31387002
  • UMLS:C0004096
Child trait(s) childhood onset asthma

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "asthma" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000037
(PGS_AST)
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Asthma asthma 15
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000037/ScoringFiles/PGS000037.txt.gz
PGS000799
(GRSw_TAGC)
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Asthma asthma 22
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000799/ScoringFiles/PGS000799.txt.gz
PGS001341
(GBE_HC382)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Asthma asthma 6,430
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001341/ScoringFiles/PGS001341.txt.gz
PGS001343
(GBE_HC1581)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Asthma (algorithmically-defined) asthma 6,425
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001343/ScoringFiles/PGS001343.txt.gz
PGS001344
(GBE_BIN_FC4006152)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Asthma (diagnosed by doctor) asthma 6,139
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001344/ScoringFiles/PGS001344.txt.gz
PGS001345
(GBE_BIN22127)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Asthma (diagnosed by doctor) asthma 435
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001345/ScoringFiles/PGS001345.txt.gz
PGS001346
(GBE_HC1036)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Asthma (time-to-event) asthma 8,508
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001346/ScoringFiles/PGS001346.txt.gz
PGS001370
(GBE_INI3786)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Age asthma diagnosed asthma 922
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001370/ScoringFiles/PGS001370.txt.gz
PGS001849
(portability-PLR_495)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Asthma asthma 22,679
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001849/ScoringFiles/PGS001849.txt.gz
PGS002061
(portability-ldpred2_495)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Asthma asthma 793,375
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002061/ScoringFiles/PGS002061.txt.gz
PGS002248
(PRSice_asthma)
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Childhood asthma childhood onset asthma 105
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002248/ScoringFiles/PGS002248.txt.gz
PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002311/ScoringFiles/PGS002311.txt.gz
PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 920,922
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002358/ScoringFiles/PGS002358.txt.gz
PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 3,893
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002383/ScoringFiles/PGS002383.txt.gz
PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 15,843
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002432/ScoringFiles/PGS002432.txt.gz
PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 95,252
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002481/ScoringFiles/PGS002481.txt.gz
PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 817
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002530/ScoringFiles/PGS002530.txt.gz
PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 503
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002579/ScoringFiles/PGS002579.txt.gz
PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 205,286
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002628/ScoringFiles/PGS002628.txt.gz
PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Asthma asthma 934,369
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002677/ScoringFiles/PGS002677.txt.gz
PGS002727
(PRS_PA)
PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
Asthma asthma 985,837
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002727/ScoringFiles/PGS002727.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000082 PGS000037
(PGS_AST)
PSS000055|
European Ancestry|
880 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Asthma onset, up to age 38 years HR: 1.12 [1.01, 1.26] sex
PPM000083 PGS000037
(PGS_AST)
PSS000055|
European Ancestry|
880 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Life-course-persistent asthma RR: 1.36 [1.14, 1.63] sex
PPM000084 PGS000037
(PGS_AST)
PSS000056|
European Ancestry|
187 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Asthma onset HR: 1.17 [1.01, 1.34] AUROC: 0.61 [0.53, 0.7] sex
PPM000085 PGS000037
(PGS_AST)
PSS000056|
European Ancestry|
187 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Life-course-persistent asthma RR: 1.2 [1.05, 1.38] sex
PPM000086 PGS000037
(PGS_AST)
PSS000055|
European Ancestry|
880 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Atopy (skin test for common allergen 2mm > control) RR: 1.07 [1.01, 1.14] sex
PPM000087 PGS000037
(PGS_AST)
PSS000055|
European Ancestry|
880 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Airway hyper-responsiveness to methacholine or albuterol RR: 1.16 [1.03, 1.32] sex
PPM000088 PGS000037
(PGS_AST)
PSS000055|
European Ancestry|
880 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Incompletely reversible airflow obstruction (IRAO, post-bronchodilator FEV1:FVC more than 2SD below mean) RR: 1.28 [1.04, 1.57] sex
PPM000089 PGS000037
(PGS_AST)
PSS000055|
European Ancestry|
880 individuals
PGP000025 |
Belsky DW et al. Lancet Respir Med (2013)
Reported Trait: Admitted to hospital for asthma RR: 1.38 [1.07, 1.79] sex
PPM002079 PGS000799
(GRSw_TAGC)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 1.52 [1.19, 1.96] Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data.
PPM002077 PGS000799
(GRSw_TAGC)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 1.23 [1.1, 1.38]
PPM002078 PGS000799
(GRSw_TAGC)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.66 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g)
PPM002080 PGS000799
(GRSw_TAGC)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.69 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data.
PPM009191 PGS001341
(GBE_HC382)
PSS004466|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma AUROC: 0.61763 [0.59798, 0.63728] : 0.03727
Incremental AUROC (full-covars): 0.0081
PGS R2 (no covariates): 0.00847
PGS AUROC (no covariates): 0.55669 [0.53574, 0.57763]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009192 PGS001341
(GBE_HC382)
PSS004467|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma AUROC: 0.57795 [0.53557, 0.62032] : 0.02196
Incremental AUROC (full-covars): -0.01536
PGS R2 (no covariates): 0.00014
PGS AUROC (no covariates): 0.51559 [0.47138, 0.55979]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009193 PGS001341
(GBE_HC382)
PSS004468|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma AUROC: 0.63649 [0.62628, 0.6467] : 0.04868
Incremental AUROC (full-covars): 0.06379
PGS R2 (no covariates): 0.0373
PGS AUROC (no covariates): 0.6175 [0.60705, 0.62795]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009194 PGS001341
(GBE_HC382)
PSS004469|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma AUROC: 0.60865 [0.59116, 0.62614] : 0.03337
Incremental AUROC (full-covars): 0.03258
PGS R2 (no covariates): 0.01973
PGS AUROC (no covariates): 0.58188 [0.5641, 0.59966]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009195 PGS001341
(GBE_HC382)
PSS004470|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma AUROC: 0.62569 [0.61945, 0.63192] : 0.04404
Incremental AUROC (full-covars): 0.07406
PGS R2 (no covariates): 0.03731
PGS AUROC (no covariates): 0.61664 [0.61037, 0.62291]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009196 PGS001343
(GBE_HC1581)
PSS004292|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD asthma AUROC: 0.61862 [0.59895, 0.63828] : 0.038
Incremental AUROC (full-covars): 0.00982
PGS R2 (no covariates): 0.00928
PGS AUROC (no covariates): 0.55801 [0.53701, 0.579]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009197 PGS001343
(GBE_HC1581)
PSS004293|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD asthma AUROC: 0.57145 [0.52876, 0.61414] : 0.02036
Incremental AUROC (full-covars): -0.02169
PGS R2 (no covariates): 2e-05
PGS AUROC (no covariates): 0.50757 [0.46343, 0.55171]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009198 PGS001343
(GBE_HC1581)
PSS004294|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD asthma AUROC: 0.63661 [0.62631, 0.6469] : 0.04847
Incremental AUROC (full-covars): 0.06318
PGS R2 (no covariates): 0.03703
PGS AUROC (no covariates): 0.61732 [0.60678, 0.62786]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009199 PGS001343
(GBE_HC1581)
PSS004295|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD asthma AUROC: 0.61078 [0.59322, 0.62833] : 0.03413
Incremental AUROC (full-covars): 0.03417
PGS R2 (no covariates): 0.02015
PGS AUROC (no covariates): 0.58309 [0.56524, 0.60095]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009200 PGS001343
(GBE_HC1581)
PSS004296|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: AD asthma AUROC: 0.62553 [0.61925, 0.63182] : 0.04393
Incremental AUROC (full-covars): 0.07302
PGS R2 (no covariates): 0.03704
PGS AUROC (no covariates): 0.6162 [0.60989, 0.62251]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009201 PGS001344
(GBE_BIN_FC4006152)
PSS003954|
African Ancestry|
4,956 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma diagnosed by doctor AUROC: 0.64534 [0.62387, 0.66681] : 0.059
Incremental AUROC (full-covars): 0.00716
PGS R2 (no covariates): 0.01177
PGS AUROC (no covariates): 0.56449 [0.5415, 0.58748]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009202 PGS001344
(GBE_BIN_FC4006152)
PSS003955|
East Asian Ancestry|
1,072 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma diagnosed by doctor AUROC: 0.61098 [0.56503, 0.65693] : 0.04365
Incremental AUROC (full-covars): -0.00964
PGS R2 (no covariates): 0.00128
PGS AUROC (no covariates): 0.53103 [0.48086, 0.5812]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009203 PGS001344
(GBE_BIN_FC4006152)
PSS003956|
European Ancestry|
19,857 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma diagnosed by doctor AUROC: 0.66621 [0.65552, 0.67691] : 0.07596
Incremental AUROC (full-covars): 0.07977
PGS R2 (no covariates): 0.05973
PGS AUROC (no covariates): 0.64568 [0.63475, 0.65662]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009204 PGS001344
(GBE_BIN_FC4006152)
PSS003957|
South Asian Ancestry|
6,229 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma diagnosed by doctor AUROC: 0.61016 [0.59026, 0.63007] : 0.03328
Incremental AUROC (full-covars): 0.04929
PGS R2 (no covariates): 0.02494
PGS AUROC (no covariates): 0.59646 [0.57624, 0.61668]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009205 PGS001344
(GBE_BIN_FC4006152)
PSS003958|
European Ancestry|
53,936 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Asthma diagnosed by doctor AUROC: 0.65364 [0.64713, 0.66016] : 0.06727
Incremental AUROC (full-covars): 0.09037
PGS R2 (no covariates): 0.05689
PGS AUROC (no covariates): 0.64265 [0.63609, 0.64921]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009206 PGS001345
(GBE_BIN22127)
PSS003676|
African Ancestry|
516 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed asthma AUROC: 0.66261 [0.59914, 0.72609] : 0.07843
Incremental AUROC (full-covars): 0.01462
PGS R2 (no covariates): 0.00704
PGS AUROC (no covariates): 0.54765 [0.47414, 0.62116]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009207 PGS001345
(GBE_BIN22127)
PSS003677|
East Asian Ancestry|
245 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed asthma AUROC: 0.67066 [0.56822, 0.7731] : 0.10676
Incremental AUROC (full-covars): 0.02219
PGS R2 (no covariates): 0.03135
PGS AUROC (no covariates): 0.60951 [0.50092, 0.71811]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009208 PGS001345
(GBE_BIN22127)
PSS003678|
European Ancestry|
5,959 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed asthma AUROC: 0.59515 [0.57415, 0.61614] : 0.02426
Incremental AUROC (full-covars): 0.0264
PGS R2 (no covariates): 0.01031
PGS AUROC (no covariates): 0.56199 [0.54029, 0.58369]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009209 PGS001345
(GBE_BIN22127)
PSS003679|
South Asian Ancestry|
707 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed asthma AUROC: 0.63251 [0.57541, 0.68961] : 0.04811
Incremental AUROC (full-covars): 0.0046
PGS R2 (no covariates): 0.00714
PGS AUROC (no covariates): 0.53871 [0.47553, 0.60189]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009210 PGS001345
(GBE_BIN22127)
PSS003680|
European Ancestry|
17,244 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Doctor diagnosed asthma AUROC: 0.60258 [0.58999, 0.61516] : 0.02879
Incremental AUROC (full-covars): 0.03437
PGS R2 (no covariates): 0.01667
PGS AUROC (no covariates): 0.57923 [0.56641, 0.59204]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009215 PGS001346
(GBE_HC1036)
PSS004088|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE asthma AUROC: 0.62361 [0.61737, 0.62985] : 0.04277
Incremental AUROC (full-covars): 0.07368
PGS R2 (no covariates): 0.03644
PGS AUROC (no covariates): 0.61489 [0.60862, 0.62117]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009211 PGS001346
(GBE_HC1036)
PSS004084|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE asthma AUROC: 0.60891 [0.58896, 0.62886] : 0.03181
Incremental AUROC (full-covars): 0.00272
PGS R2 (no covariates): 0.00692
PGS AUROC (no covariates): 0.55171 [0.53052, 0.5729]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009212 PGS001346
(GBE_HC1036)
PSS004085|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE asthma AUROC: 0.58384 [0.54229, 0.62539] : 0.02359
Incremental AUROC (full-covars): -0.00999
PGS R2 (no covariates): 0.00084
PGS AUROC (no covariates): 0.52195 [0.47679, 0.5671]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009213 PGS001346
(GBE_HC1036)
PSS004086|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE asthma AUROC: 0.63612 [0.62588, 0.64636] : 0.04845
Incremental AUROC (full-covars): 0.06586
PGS R2 (no covariates): 0.03759
PGS AUROC (no covariates): 0.61803 [0.60759, 0.62848]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009214 PGS001346
(GBE_HC1036)
PSS004087|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: TTE asthma AUROC: 0.6095 [0.59223, 0.62677] : 0.03284
Incremental AUROC (full-covars): 0.03317
PGS R2 (no covariates): 0.01873
PGS AUROC (no covariates): 0.58128 [0.56371, 0.59884]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007090 PGS001370
(GBE_INI3786)
PSS007256|
African Ancestry|
613 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age asthma diagnosed : 0.25693 [0.23862, 0.27524]
Incremental R2 (full-covars): -0.00562
PGS R2 (no covariates): 0.00183 [-0.00025, 0.0039]
age, sex, UKB array type, Genotype PCs
PPM007091 PGS001370
(GBE_INI3786)
PSS007257|
East Asian Ancestry|
120 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age asthma diagnosed : 0.16159 [0.12965, 0.19353]
Incremental R2 (full-covars): -0.02341
PGS R2 (no covariates): 0.00419 [-0.00192, 0.0103]
age, sex, UKB array type, Genotype PCs
PPM007092 PGS001370
(GBE_INI3786)
PSS007258|
European Ancestry|
2,597 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age asthma diagnosed : 0.17449 [0.16593, 0.18306]
Incremental R2 (full-covars): 0.01793
PGS R2 (no covariates): 0.02331 [0.01961, 0.02702]
age, sex, UKB array type, Genotype PCs
PPM007093 PGS001370
(GBE_INI3786)
PSS007259|
South Asian Ancestry|
807 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age asthma diagnosed : 0.16307 [0.14811, 0.17804]
Incremental R2 (full-covars): -0.00111
PGS R2 (no covariates): 0.00547 [0.00221, 0.00873]
age, sex, UKB array type, Genotype PCs
PPM007094 PGS001370
(GBE_INI3786)
PSS007260|
European Ancestry|
7,052 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Age asthma diagnosed : 0.15588 [0.15084, 0.16091]
Incremental R2 (full-covars): 0.02498
PGS R2 (no covariates): 0.02714 [0.02472, 0.02956]
age, sex, UKB array type, Genotype PCs
PPM009682 PGS001849
(portability-PLR_495)
PSS009324|
European Ancestry|
19,551 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.1135 [0.0997, 0.1274] sex, age, birth date, deprivation index, 16 PCs
PPM009683 PGS001849
(portability-PLR_495)
PSS009098|
European Ancestry|
4,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0477 [0.017, 0.0784] sex, age, birth date, deprivation index, 16 PCs
PPM009684 PGS001849
(portability-PLR_495)
PSS008652|
European Ancestry|
6,537 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0847 [0.0606, 0.1088] sex, age, birth date, deprivation index, 16 PCs
PPM009685 PGS001849
(portability-PLR_495)
PSS008426|
Greater Middle Eastern Ancestry|
1,183 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0818 [0.0244, 0.1386] sex, age, birth date, deprivation index, 16 PCs
PPM009686 PGS001849
(portability-PLR_495)
PSS008206|
South Asian Ancestry|
6,270 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.098 [0.0734, 0.1225] sex, age, birth date, deprivation index, 16 PCs
PPM009687 PGS001849
(portability-PLR_495)
PSS007988|
East Asian Ancestry|
1,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0312 [-0.0153, 0.0775] sex, age, birth date, deprivation index, 16 PCs
PPM009688 PGS001849
(portability-PLR_495)
PSS007771|
African Ancestry|
2,462 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0528 [0.0132, 0.0923] sex, age, birth date, deprivation index, 16 PCs
PPM009689 PGS001849
(portability-PLR_495)
PSS008875|
African Ancestry|
3,892 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0161 [-0.0154, 0.0476] sex, age, birth date, deprivation index, 16 PCs
PPM011350 PGS002061
(portability-ldpred2_495)
PSS009324|
European Ancestry|
19,551 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.1184 [0.1045, 0.1322] sex, age, birth date, deprivation index, 16 PCs
PPM011351 PGS002061
(portability-ldpred2_495)
PSS009098|
European Ancestry|
4,078 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0394 [0.0087, 0.0701] sex, age, birth date, deprivation index, 16 PCs
PPM011352 PGS002061
(portability-ldpred2_495)
PSS008652|
European Ancestry|
6,537 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0945 [0.0704, 0.1185] sex, age, birth date, deprivation index, 16 PCs
PPM011353 PGS002061
(portability-ldpred2_495)
PSS008426|
Greater Middle Eastern Ancestry|
1,183 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.079 [0.0216, 0.1359] sex, age, birth date, deprivation index, 16 PCs
PPM011354 PGS002061
(portability-ldpred2_495)
PSS008206|
South Asian Ancestry|
6,270 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.097 [0.0723, 0.1215] sex, age, birth date, deprivation index, 16 PCs
PPM011355 PGS002061
(portability-ldpred2_495)
PSS007988|
East Asian Ancestry|
1,803 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0355 [-0.0109, 0.0818] sex, age, birth date, deprivation index, 16 PCs
PPM011356 PGS002061
(portability-ldpred2_495)
PSS007771|
African Ancestry|
2,462 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0521 [0.0125, 0.0916] sex, age, birth date, deprivation index, 16 PCs
PPM011357 PGS002061
(portability-ldpred2_495)
PSS008875|
African Ancestry|
3,892 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Asthma Partial Correlation (partial-r): 0.0221 [-0.0094, 0.0536] sex, age, birth date, deprivation index, 16 PCs
PPM012792 PGS002248
(PRSice_asthma)
PSS009557|
European Ancestry|
898 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 11 AUROC: 0.61
PPM012793 PGS002248
(PRSice_asthma)
PSS009558|
European Ancestry|
1,018 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 8 AUROC: 0.65 [0.53, 0.77] CAPE model
PPM012791 PGS002248
(PRSice_asthma)
PSS009558|
European Ancestry|
1,018 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 8 AUROC: 0.61
PPM012794 PGS002248
(PRSice_asthma)
PSS009557|
European Ancestry|
898 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 11 AUROC: 0.71 [0.61, 0.8] CAPE model
PPM012795 PGS002248
(PRSice_asthma)
PSS009558|
European Ancestry|
1,018 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 8 AUROC: 0.85 [0.77, 0.92] CAPP model
PPM012796 PGS002248
(PRSice_asthma)
PSS009557|
European Ancestry|
898 individuals
PGP000275 |
Kothalawala DM et al. J Pers Med (2022)
Reported Trait: Childhood asthma by age 11 AUROC: 0.81 [0.72, 0.89] CAPP model
PPM013076 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0055 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013125 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013174 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0238 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013223 PGS002311
(disease_ASTHMA_DIAGNOSED.BOLT-LMM)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0106 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013270 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013293 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0016 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013316 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013339 PGS002358
(disease_ASTHMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013364 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013413 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013462 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013511 PGS002383
(disease_ASTHMA_DIAGNOSED.P+T.0.0001)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013560 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013609 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013658 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013707 PGS002432
(disease_ASTHMA_DIAGNOSED.P+T.0.001)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013756 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013805 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013854 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013903 PGS002481
(disease_ASTHMA_DIAGNOSED.P+T.0.01)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013952 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014001 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014050 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0077 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014099 PGS002530
(disease_ASTHMA_DIAGNOSED.P+T.1e-06)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014148 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014197 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0022 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014246 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0073 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014295 PGS002579
(disease_ASTHMA_DIAGNOSED.P+T.5e-08)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0036 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014491 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0106 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014344 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0059 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014393 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014442 PGS002628
(disease_ASTHMA_DIAGNOSED.PolyFun-pred)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0253 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ASTHMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014540 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
PSS009687|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0048 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014589 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
PSS009688|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014638 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
PSS009689|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0212 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014687 PGS002677
(disease_ASTHMA_DIAGNOSED.SBayesR)
PSS009690|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Asthma Incremental R2 (full model vs. covariates alone): 0.0103 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014751 PGS002727
(PRS_PA)
PSS009886|
European Ancestry|
391,820 individuals
PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
Reported Trait: Pediatric asthma OR: 1.57 [1.55, 1.6] AUROC: 0.66 [0.65, 0.67] : 0.04
PPM014752 PGS002727
(PRS_PA)
PSS009884|
African Ancestry|
7,818 individuals
PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
Reported Trait: Pediatric asthma OR: 1.43 [1.24, 1.65] AUROC: 0.66 [0.63, 0.69] : 0.03
PPM014753 PGS002727
(PRS_PA)
PSS009888|
Hispanic or Latin American Ancestry|
5,225 individuals
PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
Reported Trait: Pediatric asthma OR: 1.63 [1.36, 1.95] AUROC: 0.7 [0.67, 0.74] : 0.07
PPM014754 PGS002727
(PRS_PA)
PSS009885|
East Asian Ancestry|
1,671 individuals
PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
Reported Trait: Pediatric asthma OR: 1.32 [0.99, 1.77] AUROC: 0.73 [0.66, 0.8] : 0.08
PPM014755 PGS002727
(PRS_PA)
PSS009887|
South Asian Ancestry|
8,736 individuals
PGP000335 |
Namjou B et al. J Allergy Clin Immunol (2022)
Reported Trait: Pediatric asthma OR: 1.32 [1.18, 1.48] AUROC: 0.65 [0.62, 0.68] : 0.03

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004292
[
  • 869 cases
  • , 5,628 controls
]
African unspecified UKB
PSS004293
[
  • 165 cases
  • , 1,539 controls
]
East Asian UKB
PSS004294
[
  • 3,193 cases
  • , 21,712 controls
]
European non-white British ancestry UKB
PSS004295
[
  • 1,164 cases
  • , 6,667 controls
]
South Asian UKB
PSS004296
[
  • 8,797 cases
  • , 58,628 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS001028 Cases were children with asthma ever, at age 8 years. Cases were defined using an adjusted diagnosis of asthma ever at age 8 years based on (1) 1 or more attacks of wheeze in the last 12 months or (2) inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had at least 1 of these characteristics was categorized as having asthma.
[
  • 215 cases
  • , 212 controls
]
,
56.2 % Male samples
European
(Swedish)
BAMSE Possible sample overlap of up to 100% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS001029 Cases were children with asthma ever, at age 8 years, in which asthma was defined by the following characteristics: 1 or more attacks of wheeze in the last 12 months, 1 or more events of shortness of breath (dyspnea) in the last 12 months, or inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had 1 or more of these characteristics was categorized as having asthma.
[
  • 792 cases
  • , 1,066 controls
]
,
51.1 % Male samples
European PIAMA Possible sample overlap of up to 19% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS008652 6,537 individuals European Italy (South Europe) UKB
PSS007771 2,462 individuals African American or Afro-Caribbean Carribean UKB
PSS007256 613 individuals African unspecified UKB
PSS007257 120 individuals East Asian UKB
PSS007258 2,597 individuals European non-white British ancestry UKB
PSS007259 807 individuals South Asian UKB
PSS003676
[
  • 80 cases
  • , 436 controls
]
African unspecified UKB
PSS003677
[
  • 29 cases
  • , 216 controls
]
East Asian UKB
PSS003678
[
  • 793 cases
  • , 5,166 controls
]
European non-white British ancestry UKB
PSS003679
[
  • 99 cases
  • , 608 controls
]
South Asian UKB
PSS003680
[
  • 2,213 cases
  • , 15,031 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS007260 7,052 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS008426 1,183 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009324 19,551 individuals European UK (+ Ireland) UKB
PSS000055 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. Median = 38.0 years
Range = [0.0, 38.0] years
[
  • 305 cases
  • , 575 controls
]
,
51.0 % Male samples
European DMHDS
PSS000056 Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. 187 individuals European DMHDS Subset of children from DMHDS with asthma onset in childhood (before age 13 years)
PSS004466
[
  • 871 cases
  • , 5,626 controls
]
African unspecified UKB
PSS003955
[
  • 135 cases
  • , 937 controls
]
East Asian UKB
PSS003956
[
  • 2,872 cases
  • , 16,985 controls
]
European non-white British ancestry UKB
PSS004467
[
  • 166 cases
  • , 1,538 controls
]
East Asian UKB
PSS003958
[
  • 7,869 cases
  • , 46,067 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004468
[
  • 3,243 cases
  • , 21,662 controls
]
European non-white British ancestry UKB
PSS004469
[
  • 1,171 cases
  • , 6,660 controls
]
South Asian UKB
PSS004470
[
  • 8,934 cases
  • , 58,491 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS003954
[
  • 730 cases
  • , 4,226 controls
]
African unspecified UKB
PSS003957
[
  • 901 cases
  • , 5,328 controls
]
South Asian UKB
PSS004088
[
  • 8,933 cases
  • , 58,492 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004084
[
  • 851 cases
  • , 5,646 controls
]
African unspecified UKB
PSS004085
[
  • 166 cases
  • , 1,538 controls
]
East Asian UKB
PSS004086
[
  • 3,237 cases
  • , 21,668 controls
]
European non-white British ancestry UKB
PSS004087
[
  • 1,196 cases
  • , 6,635 controls
]
South Asian UKB
PSS009557 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last
[
  • 116 cases
  • , 782 controls
]
European MAAS
PSS009098 4,078 individuals European Poland (NE Europe) UKB
PSS009558 School-age asthma diagnosis, evaluated at age 10, was defined as “a doctor diagnosis of asthma ever and at least one episode of wheezing or use of asthma medication in the last
[
  • 144 cases
  • , 874 controls
]
European MAAS
PSS008206 6,270 individuals South Asian India (South Asia) UKB
PSS009687 6,423 individuals African unspecified UKB
PSS009688 905 individuals East Asian UKB
PSS009689 43,398 individuals European Non-British European UKB
PSS009690 7,942 individuals South Asian UKB
PSS009886
[
  • 15,586 cases
  • , 376,234 controls
]
European UKB
PSS009884
[
  • 310 cases
  • , 7,508 controls
]
African unspecified UKB
PSS009888
[
  • 205 cases
  • , 5,020 controls
]
Hispanic or Latin American
(Admixed American)
UKB
PSS009885
[
  • 49 cases
  • , 1,622 controls
]
East Asian UKB
PSS009887
[
  • 312 cases
  • , 8,424 controls
]
South Asian UKB
PSS008875 3,892 individuals African unspecified Nigeria (West Africa) UKB
PSS007988 1,803 individuals East Asian China (East Asia) UKB