Trait: coronary artery disease

Experimental Factor Ontology (EFO) Information
Identifier EFO_0001645
Description Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC) [NCIT: C26732]
Trait category
Cardiovascular disease
Synonyms 37 synonyms
  • Arterioscleroses, Coronary
  • Arteriosclerosis, Coronary
  • Artery Disease, Coronary
  • Artery Diseases, Coronary
  • Atheroscleroses, Coronary
  • Atherosclerosis, Coronary
  • CAD
  • CHD
  • CHD (coronary heart disease)
  • CHD - Coronary heart disease
  • CORONARY ARTERY DIS
  • CORONARY DIS
  • CORONARY HEART DIS
  • Coronary Arterioscleroses
  • Coronary Arteriosclerosis
  • Coronary Artery Disease
  • Coronary Artery Diseases
  • Coronary Atheroscleroses
  • Coronary Atherosclerosis
  • Coronary Disease
  • Coronary Diseases
  • Coronary Heart Diseases
  • Disease, Coronary
  • Disease, Coronary Artery
  • Disease, Coronary Heart
  • Diseases, Coronary
  • Diseases, Coronary Artery
  • Diseases, Coronary Heart
  • Heart Disease, Coronary
  • Heart Diseases, Coronary
  • coronary artery disease
  • coronary artery disease or disorder
  • coronary disease
  • coronary heart disease
  • disease of coronary artery
  • disease or disorder of coronary artery
  • disorder of coronary artery
Mapped term(s) 29 mapped terms
  • COHD:317576
  • DOID:3393
  • GARD:0011944
  • ICD10:I20-I25
  • ICD10:I25
  • ICD10:I25.1
  • ICD10:I25.10
  • ICD10:I25.9
  • ICD10:K76.1
  • ICD9:410-414.99
  • ICD9:414.0
  • ICD9:414.9
  • MESH:D003324
  • MONDO:0005010
  • MeSH:D003324
  • MeSH:D003327
  • NCIT:C26732
  • NCIt:C26732
  • NCIt:C50625
  • OMIM:608320
  • OMIM:608901
  • OMIM:610938
  • OMIM:614466
  • OMIM:617347
  • SCTID:414024009
  • SNOMEDCT:414545008
  • SNOMEDCT:443502000
  • SNOMEDCT:53741008
  • UMLS:C1956346

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000010
(GRS27)
 PGP000003 |
Mega JL et al. Lancet (2015)
 Coronary heart disease coronary artery disease 27
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000010/ScoringFiles/PGS000010.txt.gz
PGS000011
(GRS50)
 PGP000004 |
Tada H et al. Eur Heart J (2015)
 Coronary artery disease coronary artery disease 50
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000012
(GRS49K)
 PGP000005 |
Abraham G et al. Eur Heart J (2016)
 Coronary artery disease coronary artery disease 49,310
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000019
(GRS_CAD)
 PGP000009 |
Paquette M et al. J Clin Lipidol (2017)
 Coronary artery disease coronary artery disease 192
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000019/ScoringFiles/PGS000019.txt.gz
PGS000057
(CHD57)
 PGP000042 |
Natarajan P et al. Circulation (2017)
 Coronary heart disease coronary artery disease 57
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000057/ScoringFiles/PGS000057.txt.gz
PGS000058
(CAD_GRS_204)
 PGP000043 |
Morieri ML et al. Diabetes Care (2018)
 Coronary artery disease coronary artery disease 204
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000058/ScoringFiles/PGS000058.txt.gz
PGS000059
(CHD46)
 PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
 Coronary heart disease coronary artery disease 46
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000059/ScoringFiles/PGS000059.txt.gz
PGS000116
(CAD_EJ2020)
 PGP000054 |
Elliott J et al. JAMA (2020)
 Coronary Artery Disease coronary artery disease 40,079
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000116/ScoringFiles/PGS000116.txt.gz - Check Terms/Licenses
PGS000200
(GRS28)
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Coronary heart disease coronary artery disease 28
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz
PGS000296
(GPS_CAD_SA)
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
 Coronary artery disease coronary artery disease 6,630,150
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000296/ScoringFiles/PGS000296.txt.gz - Check Terms/Licenses
PGS000329
(PRS_CHD)
 PGP000100 |
Mars N et al. Nat Med (2020)
 Coronary heart disease coronary artery disease 6,423,165
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000329/ScoringFiles/PGS000329.txt.gz
PGS000337
(MetaPRS_CAD)
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Coronary artery disease coronary artery disease 75,028
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000337/ScoringFiles/PGS000337.txt.gz - Check Terms/Licenses
PGS000349
(PRS70_CAD)
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Coronary artery disease coronary artery disease 70
-
 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000349/ScoringFiles/PGS000349.txt.gz
PGS000746
(PRS_UKB)
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Coronary artery disease coronary artery disease 1,940
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000746/ScoringFiles/PGS000746.txt.gz
PGS000747
(PRS_EB)
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Coronary artery disease coronary artery disease 375,822
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000747/ScoringFiles/PGS000747.txt.gz
PGS000748
(PRS_DE)
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Coronary artery disease coronary artery disease 3,423,987
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000748/ScoringFiles/PGS000748.txt.gz
PGS000749
(PRS_COMBINED)
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Coronary artery disease coronary artery disease 1,056,021
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000749/ScoringFiles/PGS000749.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000014 PGS000010
(GRS27)
 PSS000008|
European Ancestry|
42,998 individuals
 PGP000003 |
Mega JL et al. Lancet (2015)
 Reported Trait: Coronary heart disease HR: 1.21 [1.17, 1.26] — — age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PGS000010
(GRS27)
 PSS000009|
European Ancestry|
4,877 individuals
 PGP000003 |
Mega JL et al. Lancet (2015)
 Reported Trait: Coronary heart disease HR: 1.14 [1.02, 1.28] — — age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000018 PGS000012
(GRS49K)
 PSS000012|
European Ancestry|
12,676 individuals
 PGP000005 |
Abraham G et al. Eur Heart J (2016)
 Reported Trait: Incident coronary artery disease HR: 1.74 [1.61, 1.86]
OR: 1.74 [1.61, 1.89]		 — — sex, sub-cohort, location (east/west), 5 genetic PCs Used only the 42,364 SNPs that were available in FINRISK
PPM000020 PGS000012
(GRS49K)
 PSS000011|
European Ancestry|
3,406 individuals
 PGP000005 |
Abraham G et al. Eur Heart J (2016)
 Reported Trait: Incident coronary artery disease HR: 1.28 [1.18, 1.38]
OR: 1.28 [1.17, 1.41]		 — — sex, sub-cohort, 5 genetic PCs Used only the 46,773 SNPs that were available in FHS
PPM001620 PGS000013
(GPS_CAD)
 PSS000837|
European Ancestry|
4,847 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Incident coronary heart disease (10-year risk) — C-index: 0.7 [0.677, 0.721] Δ C-index (PRS+covariates vs. covariates alone): -0.001 [-0.009, 0.006] Pooled cohort risk percentile, age, sex, PCs (1-5) —
PPM000027 PGS000018
(metaGRS_CAD)
 PSS000018|
Multi-ancestry (including European)|
482,629 individuals
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Reported Trait: Incident coronary artery disease HR: 1.706 [1.682, 1.73] AUROC: 0.79
C-index: 0.623 [0.615, 0.631]		 AUPRC: 0.161 sex, genetic PCs (1-10), genotyping array age-as-time-scale Cox regression
PPM000028 PGS000012
(GRS49K)
 PSS000018|
Multi-ancestry (including European)|
482,629 individuals
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.524 [1.498, 1.551] — — sex, genetic PCs (1-10), genotyping array Used GRS46K (excludes A/T and C/G SNPs, with performance similar to GRS49K)
PPM000038 PGS000019
(GRS_CAD)
 PSS000023|
European Ancestry|
725 individuals
 PGP000009 |
Paquette M et al. J Clin Lipidol (2017)
 Reported Trait: Coronary artery disease in familial hypercholesterolemia patients OR: 1.66 [1.06, 2.62] — — age, gender, prior statin use, smoking, diabetes, hypertension, BMI, LDL-C, HDL-C, TGs, Lp(a), and type of LDLR mutation Performance metrics are from Model 2 (adjusted for cardiovascular risk factors)
PPM000039 PGS000019
(GRS_CAD)
 PSS000024|
European Ancestry|
725 individuals
 PGP000009 |
Paquette M et al. J Clin Lipidol (2017)
 Reported Trait: Coronary artery disease in familial hypercholesterolemia patients OR: 1.8 [1.14, 2.85] — — age, gender, prior statin use, smoking, diabetes, hypertension, BMI, LDL-C, HDL-C, TGs, Lp(a), and type of LDLR mutation Performance metrics are from Model 2 (adjusted for cardiovascular risk factors)
PPM000016 PGS000011
(GRS50)
 PSS000010|
European Ancestry|
23,595 individuals
 PGP000004 |
Tada H et al. Eur Heart J (2015)
 Reported Trait: Incident coronary heart disease HR: 1.23 [1.18, 1.28] — — age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes —
PPM001011 PGS000013
(GPS_CAD)
 PSS000515|
African Ancestry|
6,979 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease — AUROC: 0.58 — PCs (1-10) of ancestry —
PPM001010 PGS000013
(GPS_CAD)
 PSS000517|
Hispanic or Latin American Ancestry|
7,048 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease — AUROC: 0.63 — PCs (1-10) of ancestry —
PPM001009 PGS000013
(GPS_CAD)
 PSS000516|
European Ancestry|
10,344 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease — AUROC: 0.53 — PCs (1-10) of ancestry —
PPM001008 PGS000013
(GPS_CAD)
 PSS000515|
African Ancestry|
6,979 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.29 [1.23, 1.34] — — age, sex, PCs (1-10) of ancestry —
PPM001007 PGS000013
(GPS_CAD)
 PSS000517|
Hispanic or Latin American Ancestry|
7,048 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.5 [1.44, 1.57] — — age, sex, PCs (1-10) of ancestry —
PPM001006 PGS000013
(GPS_CAD)
 PSS000516|
European Ancestry|
10,344 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.52 [1.46, 1.58] — — age, sex, PCs (1-10) of ancestry —
PPM001005 PGS000013
(GPS_CAD)
 PSS000514|
Multi-ancestry (including European)|
24,371 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease — AUROC: 0.61 — PCs (1-10) of ancestry —
PPM001004 PGS000013
(GPS_CAD)
 PSS000519|
Multi-ancestry (including European)|
9,070 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease — AUROC: 0.6 — PCs (1-10) of ancestry —
PPM001003 PGS000013
(GPS_CAD)
 PSS000518|
Multi-ancestry (including European)|
13,667 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease — AUROC: 0.59 — PCs (1-10) of ancestry —
PPM001002 PGS000013
(GPS_CAD)
 PSS000514|
Multi-ancestry (including European)|
24,371 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.35, 1.48] — — age, sex, PCs (1-10) of ancestry —
PPM001001 PGS000013
(GPS_CAD)
 PSS000519|
Multi-ancestry (including European)|
9,070 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.45 [1.38, 1.52] — — age, sex, PCs (1-10) of ancestry, genotyping array —
PPM001000 PGS000013
(GPS_CAD)
 PSS000518|
Multi-ancestry (including European)|
13,667 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.41 [1.34, 1.47] — — age, sex, PCs (1-10) of ancestry, genotyping array —
PPM000583 PGS000200
(GRS28)
 PSS000330|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident cardiovascular disease HR: 1.18 [1.12, 1.24] — — sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000150 PGS000059
(CHD46)
 PSS000094|
European Ancestry|
1,320 individuals
 PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
 Reported Trait: Incident coronary heart disease — — HR (top vs. bottom quartiles of GRS): 0.76 [0.41, 1.39]
p-value (association between risk and incidence): 0.31		 NR —
PPM000999 PGS000013
(GPS_CAD)
 PSS000520|
Multi-ancestry (including European)|
47,108 individuals
 PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.38, 1.46] — — age, sex, PCs (1-10) of ancestry, genotyping array —
PPM000589 PGS000011
(GRS50)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] C-index: 0.698 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000588 PGS000200
(GRS28)
 PSS000328|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident acute coronary syndrome — C-index: 0.859 ΔC-index (over covariate only model): 0.004 [0.003, 0.005] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000587 PGS000200
(GRS28)
 PSS000329|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident coronary heart disease — C-index: 0.856 ΔC-index (over covariate only model): 0.005 [0.004, 0.006] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000586 PGS000200
(GRS28)
 PSS000330|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident cardiovascular disease — C-index: 0.84 ΔC-index (over covariate only model): 0.003 [0.002, 0.004] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000585 PGS000200
(GRS28)
 PSS000328|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident acute coronary syndrome HR: 1.27 [1.18, 1.37] — — sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000597 PGS000018
(metaGRS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.53 [1.23, 1.9] C-index: 0.683 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000596 PGS000013
(GPS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.16 [0.96, 1.41] C-index: 0.659 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000595 PGS000011
(GRS50)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.13 [0.93, 1.36] C-index: 0.654 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000594 PGS000018
(metaGRS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.27 [1.13, 1.43] C-index: 0.663 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000593 PGS000013
(GPS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.19 [1.07, 1.33] C-index: 0.656 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000592 PGS000011
(GRS50)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.05 [0.94, 1.17] C-index: 0.649 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000591 PGS000018
(metaGRS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.53 [1.46, 1.6] C-index: 0.719 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000619 PGS000013
(GPS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.17 [1.04, 1.31] C-index: 0.712 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000618 PGS000011
(GRS50)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.05 [0.94, 1.18] C-index: 0.704 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000617 PGS000200
(GRS28)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.11 [0.99, 1.25] C-index: 0.706 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000616 PGS000018
(metaGRS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.49 [1.43, 1.56] C-index: 0.75 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000615 PGS000013
(GPS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.47 [1.41, 1.54] C-index: 0.75 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000614 PGS000011
(GRS50)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] C-index: 0.736 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000613 PGS000200
(GRS28)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.17 [1.12, 1.22] C-index: 0.735 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000620 PGS000018
(metaGRS_CAD)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.25 [1.12, 1.41] C-index: 0.723 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000624 PGS000018
(metaGRS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.5 [1.21, 1.87] C-index: 0.725 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000623 PGS000013
(GPS_CAD)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.39] C-index: 0.708 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000622 PGS000011
(GRS50)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.12 [0.93, 1.36] C-index: 0.708 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000621 PGS000200
(GRS28)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.13 [0.93, 1.37] C-index: 0.709 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM001666 PGS000018
(metaGRS_CAD)
 PSS000868|
European Ancestry|
3,087 individuals
 PGP000137 |
Ritchie SC et al. bioRxiv (2019)
|Ext.|Pre		 Reported Trait: Incident myocardial infarction HR: 2.89 [1.66, 5.04] — — age, sex, 10 genetic PCs —
PPM000590 PGS000013
(GPS_CAD)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.5 [1.43, 1.56] C-index: 0.719 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000584 PGS000200
(GRS28)
 PSS000329|
European Ancestry|
24,124 individuals
 PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
 Reported Trait: Incident coronary heart disease HR: 1.27 [1.2, 1.35] — — sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000496 PGS000011
(GRS50)
 PSS000285|
European Ancestry|
22,389 individuals
 PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		 Reported Trait: Incident coronary artery disease — — Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.98 [1.76, 2.23] age, sex, self reported education level —
PPM000495 PGS000011
(GRS50)
 PSS000286|
European Ancestry|
21,222 individuals
 PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		 Reported Trait: Incident coronary artery disease — — Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.94 [1.58, 2.39] age, self reported education level, treatment (vitamin E vs aspirin), 5 genetic principal components —
PPM000494 PGS000011
(GRS50)
 PSS000283|
European Ancestry|
7,814 individuals
 PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		 Reported Trait: Incident coronary artery disease — — Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.75 [1.46, 2.1] age, sex, self reported education level, 5 genetic principal components —
PPM001839 PGS000747
(PRS_EB)
 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6043 [0.6004, 0.6082] Area under the Precision-Recall curve (AUPRC): 0.0712 [0.0703, 0.076] — —
PPM001841 PGS000748
(PRS_DE)
 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6156 [0.5963, 0.6349] Area under the Precision-Recall curve (AUPRC): 0.0506 [0.0504, 0.0508] — —
PPM001842 PGS000748
(PRS_DE)
 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.5989 [0.595, 0.6028] Area under the Precision-Recall curve (AUPRC): 0.0696 [0.0694, 0.0698] — —
PPM001843 PGS000749
(PRS_COMBINED)
 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6112 [0.5919, 0.6305] Area under the Precision-Recall curve (AUPRC): 0.048 [0.0473, 0.0487] — —
PPM001845 PGS000018
(metaGRS_CAD)
 PSS000929|
European Ancestry|
5,581 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.5015 [0.483, 0.514] Area under the Precision-Recall curve (AUPRC): 0.5205 [0.5201, 0.521] — —
PPM001846 PGS000018
(metaGRS_CAD)
 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.6597 [0.6405, 0.6789] Area under the Precision-Recall curve (AUPRC): 0.0673 [0.0668, 0.0679] — —
PPM000017 PGS000010
(GRS27)
 PSS000010|
European Ancestry|
23,595 individuals
 PGP000004 |
Tada H et al. Eur Heart J (2015)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] — — age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes —
PPM000022 PGS000013
(GPS_CAD)
 PSS000015|
European Ancestry|
288,978 individuals
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Reported Trait: Coronary artery disease — AUROC: 0.81 [0.81, 0.81] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.04 age; sex; Ancestry PC 1-4; genotyping chip —
PPM000029 PGS000011
(GRS50)
 PSS000018|
Multi-ancestry (including European)|
482,629 individuals
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.263 [1.247, 1.28] — — sex, genetic PCs (1-10), genotyping array —
PPM000030 PGS000013
(GPS_CAD)
 PSS000021|
European Ancestry|
1,964 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.64 [1.48, 1.81] AUROC: 0.72 [0.7, 0.74] — age, sex, first four genetic PCs —
PPM000031 PGS000013
(GPS_CAD)
 PSS000022|
European Ancestry|
3,309 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.55 [1.38, 1.73] AUROC: 0.89 [0.88, 0.91] — age, sex, first four genetic PCs —
PPM000032 PGS000013
(GPS_CAD)
 PSS000019|
European Ancestry|
5,762 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.69 [1.44, 1.99] AUROC: 0.84 [0.81, 0.87] — age, sex, first four genetic PCs, cohort recruitment centre —
PPM000033 PGS000013
(GPS_CAD)
 PSS000020|
European Ancestry|
3,195 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Reccurent coronary artery disease events OR: 1.13 [1.06, 1.22] — — age, sex, first four genetic PCs —
PPM000034 PGS000018
(metaGRS_CAD)
 PSS000021|
European Ancestry|
1,964 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.74 [1.57, 1.93] AUROC: 0.72 [0.7, 0.75] — age, sex, first four genetic PCs —
PPM000035 PGS000018
(metaGRS_CAD)
 PSS000022|
European Ancestry|
3,309 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.6 [1.43, 1.8] AUROC: 0.89 [0.88, 0.91] — age, sex, first four genetic PCs —
PPM000036 PGS000018
(metaGRS_CAD)
 PSS000019|
European Ancestry|
5,762 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.75 [1.49, 2.05] AUROC: 0.84 [0.81, 0.87] — age, sex, first four genetic PCs, cohort recruitment centre —
PPM000037 PGS000018
(metaGRS_CAD)
 PSS000020|
European Ancestry|
3,195 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Reccurent coronary artery disease events OR: 1.17 [1.08, 1.26] — — age, sex, first four genetic PCs —
PPM000144 PGS000057
(CHD57)
 PSS000091|
Ancestry Not Reported|
2,440 individuals
 PGP000042 |
Natarajan P et al. Circulation (2017)
 Reported Trait: Coronary heart disease (incident) — — HR (highest vs. lowest quintile of PGS): 1.66 [1.21, 2.29] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD —
PPM000145 PGS000057
(CHD57)
 PSS000090|
Ancestry Not Reported|
1,154 individuals
 PGP000042 |
Natarajan P et al. Circulation (2017)
 Reported Trait: Coronary artery calcification OR: 1.32 [1.04, 1.68] — OR (highest vs. lowest quintile of PGS): 2.51 [1.08, 5.85] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD —
PPM000146 PGS000057
(CHD57)
 PSS000089|
Ancestry Not Reported|
4,392 individuals
 PGP000042 |
Natarajan P et al. Circulation (2017)
 Reported Trait: Carotid artery plaque burden β: 1.097 [1.022, 1.178] — — age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD —
PPM000147 PGS000058
(CAD_GRS_204)
 PSS000092|
European Ancestry|
5,360 individuals
 PGP000043 |
Morieri ML et al. Diabetes Care (2018)
 Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.27 [1.18, 1.37] — — age, sex, ACCORD study covariates (randomized treament assignement, clinical network, genotyping platform, PCs of genetic ancestry) —
PPM000148 PGS000058
(CAD_GRS_204)
 PSS000093|
European Ancestry|
1,931 individuals
 PGP000043 |
Morieri ML et al. Diabetes Care (2018)
 Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.35 [1.16, 1.58] — — age, sex, ORIGIN study covariates (randomized treament assignement, PCs of genetic ancestry) —
PPM000149 PGS000059
(CHD46)
 PSS000095|
European Ancestry|
1,206 individuals
 PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
 Reported Trait: Incident coronary heart disease — — HR (top vs. bottom quartiles of GRS): 1.92 [1.19, 3.11]
p-value (association between risk and incidence): 0.029		 NR —
PPM000896 PGS000329
(PRS_CHD)
 PSS000440|
European Ancestry|
20,165 individuals
 PGP000100 |
Mars N et al. Nat Med (2020)
 Reported Trait: Incident coronary heart disease — C-index: 0.82 — ASCVD risk calculator(age, sex, total cholesterol, HDL, SBP, blood-pressure-lowering medication, diabetes and smoking status), FINRISK cohort, genotyping array/batch, 10 ancestry PCs 10-year risk
PPM000891 PGS000329
(PRS_CHD)
 PSS000440|
European Ancestry|
20,165 individuals
 PGP000100 |
Mars N et al. Nat Med (2020)
 Reported Trait: Incident coronary heart disease HR: 1.25 [1.18, 1.32] C-index: 0.832 — age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs 10-year risk
PPM000909 PGS000337
(MetaPRS_CAD)
 PSS000456|
East Asian Ancestry|
49,230 individuals
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Reported Trait: Mortality (diseases of the circulatory system) HR: 1.10351 [1.057, 1.152] — — Sex, age, age^2, PCs (1-10), disease status —
PPM000908 PGS000337
(MetaPRS_CAD)
 PSS000454|
East Asian Ancestry|
49,230 individuals
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Reported Trait: All-cause Mortality HR: 1.03159 [1.011, 1.052] — — Sex, age, age^2, PCs (1-10), disease status —
PPM000383 PGS000013
(GPS_CAD)
 PSS000219|
European Ancestry|
11,010 individuals
 PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (personal history) OR: 1.589 [1.32, 1.92] AUROC: 0.86 — age, sex —
PPM000402 PGS000013
(GPS_CAD)
 PSS000227|
Additional Asian Ancestries|
544 individuals
 PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.		 Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.16 [1.35, 1.59] — Odds Ratio (OR; top 5% vs. rest): 3.33 [0.82, 13.51] 4 genetic PCs —
PPM000401 PGS000013
(GPS_CAD)
 PSS000229|
Hispanic or Latin American Ancestry|
919 individuals
 PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.		 Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.56 [1.29, 1.88] — Odds Ratio (OR; top 5% vs. rest): 3.38 [2.03, 5.64] 4 genetic PCs —
PPM000400 PGS000013
(GPS_CAD)
 PSS000228|
African Ancestry|
1,298 individuals
 PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.		 Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.46 [1.28, 1.66] — Odds Ratio (OR; top 5% vs. rest): 2.02 [1.29, 3.16] 4 genetic PCs —
PPM000399 PGS000013
(GPS_CAD)
 PSS000230|
European Ancestry|
3,081 individuals
 PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.		 Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.06 [1.89, 2.25] — Odds Ratio (OR; top 5% vs. rest): 5.09 [3.82, 6.78] 4 genetic PCs —
PPM000518 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Plaque vulnerability score β: 0.07 [0.003, 0.137] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000517 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Microvessels β: 0.037 [-0.006, 0.08] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000516 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Number of smoooth muscle cells β: -0.004 [-0.038, 0.031] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000515 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Number of macrophages β: 0.01 [-0.015, 0.036] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000514 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy macrophages OR: 1.103 [0.983, 1.237] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000513 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy smooth muscle cells OR: 1.004 [0.88, 1.145] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000512 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Presence of IPH OR: 1.126 [0.999, 1.27] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000511 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Presence of lipid core >10% OR: 1.171 [1.026, 1.337] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000510 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy collagen OR: 1.064 [0.919, 1.231] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000509 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy calficiations OR: 0.94 [0.826, 1.07] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000508 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Plaque vulnerability score OR: 0.198 [0.003, 0.364] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000507 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Microvessels — — Beta (top 20% vs. rest): 0.072 [-0.037, 0.182] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000506 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Number of smoooth muscle cells — — Beta (top 20% vs. rest): -0.056 [-0.143, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000505 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Number of macrophages — — Beta (top 20% vs. rest): 0.55 [-0.012, 0.121] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000504 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy macrophages — — Odds Ratio (OR; top 20% vs. rest): 1.49 [1.118, 1.986] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000503 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy smooth muscle cells — — Odds Ratio (OR; top 20% vs. rest): 0.908 [0.652, 1.265] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000502 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Presence of IPH — — Odds Ratio (OR; top 20% vs. rest): 1.112 [0.821, 1.506] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000501 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Presence of lipid core >10% — — Odds Ratio (OR; top 20% vs. rest): 1.591 [1.105, 2.291] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000500 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy collagen — — Odds Ratio (OR; top 20% vs. rest): 1.091 [0.755, 1.577] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000499 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Moderate/heavy calficiations — — Odds Ratio (OR; top 20% vs. rest): 1.001 [0.754, 1.33] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000498 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre		 Reported Trait: Secondary cardiovascular events HR: 1.15 [1.02, 1.29] — — Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs —
PPM000019 PGS000010
(GRS27)
 PSS000012|
European Ancestry|
12,676 individuals
 PGP000005 |
Abraham G et al. Eur Heart J (2016)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.21 [1.12, 1.3] — — — —
PPM000021 PGS000010
(GRS27)
 PSS000011|
European Ancestry|
3,406 individuals
 PGP000005 |
Abraham G et al. Eur Heart J (2016)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.2 [1.07, 1.26] — — — —
PPM000387 PGS000013
(GPS_CAD)
 PSS000219|
European Ancestry|
11,010 individuals
 PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (personal history) — AUROC: 0.6 — — —
PPM000497 PGS000011
(GRS50)
 PSS000284|
European Ancestry|
4,260 individuals
 PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.		 Reported Trait: Coronary artery calcification — — Agatston score (mean, top 20% of GRS): 46.0 [9.0, 54.0]
Agatston score (mean, btttom 25% of GRS): 21.0 [18.0, 25.0]		 — —
PPM000911 PGS000337
(MetaPRS_CAD)
 PSS000457|
East Asian Ancestry|
49,230 individuals
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Reported Trait: Mortality (ischemic heart disease) HR: 1.2158 [1.109, 1.333] — — Sex, age, age^2, PCs (1-10), disease status —
PPM000912 PGS000337
(MetaPRS_CAD)
 PSS000455|
East Asian Ancestry|
49,230 individuals
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Reported Trait: Mortality (congestive heart failure) HR: 1.15604 [1.042, 1.2283] — — Sex, age, age^2, PCs (1-10), disease status —
PPM000910 PGS000337
(MetaPRS_CAD)
 PSS000458|
East Asian Ancestry|
49,230 individuals
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Reported Trait: Mortality (diseases of the respiratory system) HR: 1.07133 [1.012, 1.134] — — Sex, age, age^2, PCs (1-10), disease status —
PPM000907 PGS000337
(MetaPRS_CAD)
 PSS000459|
East Asian Ancestry|
10,999 individuals
 PGP000104 |
Koyama S et al. Nat Genet (2020)
 Reported Trait: Coronary artery disease OR: 1.84 [1.744, 1.943] AUROC: 0.674 [0.661, 0.687] R²: 0.087 [0.074, 0.101] — —
PPM000933 PGS000013
(GPS_CAD)
 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease — C-index: 0.768 [0.76, 0.776] — age, sex, PCs (1-10), Pooled Cohort Equations risk estimator —
PPM000932 PGS000013
(GPS_CAD)
 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease — C-index: 0.756 [0.75, 0.762] — age, sex, PCs (1-10) —
PPM000929 PGS000013
(GPS_CAD)
 PSS000468|
Multi-ancestry (including European)|
5,685 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease — C-index: 0.802 [0.763, 0.8841] — age, sex, PCs (1-10), Pooled Cohort Equations risk estimator —
PPM000928 PGS000013
(GPS_CAD)
 PSS000468|
Multi-ancestry (including European)|
5,685 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease — C-index: 0.759 [0.724, 0.794] — age, sex, PCs (1-10) —
PPM000927 PGS000013
(GPS_CAD)
 PSS000468|
Multi-ancestry (including European)|
5,685 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.45 [1.34, 1.56] — — age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD —
PPM000930 PGS000013
(GPS_CAD)
 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.53 [1.49, 1.56] — — age, sex —
PPM000926 PGS000013
(GPS_CAD)
 PSS000467|
Multi-ancestry (including European)|
28,556 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.45 [1.4, 1.49] — — age, sex —
PPM000931 PGS000013
(GPS_CAD)
 PSS000469|
Multi-ancestry (including European)|
325,003 individuals
 PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.		 Reported Trait: Incident coronary artery disease HR: 1.46 [1.42, 1.49] — — age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD —
PPM000996 PGS000349
(PRS70_CAD)
 PSS000508|
European Ancestry|
3,748 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Coronary artery calcification OR: 1.19 [1.1, 1.29] — — age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes). —
PPM000995 PGS000349
(PRS70_CAD)
 PSS000505|
European Ancestry|
4,041 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Coronary artery calcification OR: 1.18 [1.1, 1.27] — — age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes). —
PPM000993 PGS000349
(PRS70_CAD)
 PSS000509|
European Ancestry|
2,560 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Incident Coronary Heart Disease in indiviuals with coronary artery calcification > 0 HR: 1.21 [1.08, 1.36] — — age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes). —
PPM000992 PGS000349
(PRS70_CAD)
 PSS000510|
European Ancestry|
1,765 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Incident Coronary Heart Disease in males HR: 1.23 [1.07, 1.41] — — age, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes) and coronary artery calcification. —
PPM000991 PGS000349
(PRS70_CAD)
 PSS000506|
European Ancestry|
1,919 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Incident Coronary Heart Disease in males HR: 1.25 [1.1, 1.42] — — age —
PPM000990 PGS000349
(PRS70_CAD)
 PSS000507|
European Ancestry|
3,748 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Incident Coronary Heart Disease HR: 1.18 [1.06, 1.31] — — age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes) and coronary artery calcification. —
PPM000989 PGS000349
(PRS70_CAD)
 PSS000504|
European Ancestry|
4,041 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Incident Coronary Heart Disease HR: 1.18 [1.06, 1.31] — — age, sex —
PPM000994 PGS000349
(PRS70_CAD)
 PSS000511|
European Ancestry|
1,426 individuals
 PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
 Reported Trait: Incident Coronary Heart Disease in males with coronary artery calcification > 0 HR: 1.26 [1.09, 1.46] — — age, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes). —
PPM000605 PGS000013
(GPS_CAD)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.42 [1.25, 1.61] AUROC: 0.776 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000604 PGS000011
(GRS50)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.2 [1.06, 1.35] AUROC: 0.769 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000603 PGS000018
(metaGRS_CAD)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.4 [1.3, 1.52] AUROC: 0.775 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000602 PGS000013
(GPS_CAD)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.3 [1.21, 1.41] AUROC: 0.771 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000601 PGS000011
(GRS50)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.05 [0.98, 1.14] AUROC: 0.763 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000600 PGS000018
(metaGRS_CAD)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.73 [1.68, 1.78] AUROC: 0.772 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000599 PGS000013
(GPS_CAD)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.66 [1.62, 1.71] AUROC: 0.77 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000598 PGS000011
(GRS50)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.28 [1.25, 1.32] AUROC: 0.75 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000612 PGS000200
(GRS28)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.27 [1.12, 1.42] AUROC: 0.771 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000611 PGS000200
(GRS28)
 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.07 [0.99, 1.16] AUROC: 0.763 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000610 PGS000200
(GRS28)
 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.24 [1.21, 1.28] AUROC: 0.748 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000609 PGS000200
(GRS28)
 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.37] C-index: 0.655 — sex, eMERGE site, first five ancestry-specific principal components —
PPM000608 PGS000200
(GRS28)
 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.11 [0.99, 1.24] C-index: 0.652 — sex, eMERGE site, first five ancestry-specific principal components —
PPM000607 PGS000200
(GRS28)
 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.18 [1.13, 1.23] C-index: 0.697 — sex, eMERGE site, first five ancestry-specific principal components —
PPM001746 PGS000013
(GPS_CAD)
 PSS000898|
African Ancestry|
16,755 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.25 [1.12, 1.4] — — PCs(1-4) —
PPM001747 PGS000013
(GPS_CAD)
 PSS000902|
South Asian Ancestry|
8,102 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.47 [1.36, 1.59] — — PCs(1-4) —
PPM000606 PGS000018
(metaGRS_CAD)
 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.93 [1.67, 2.22] AUROC: 0.794 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000836 PGS000116
(CAD_EJ2020)
 PSS000401|
Multi-ancestry (including European)|
350,730 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease — C-index: 0.74 [0.73, 0.75] — QRISK3 —
PPM000837 PGS000116
(CAD_EJ2020)
 PSS000389|
Multi-ancestry (including European)|
203,620 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.75 [0.74, 0.76] — QRISK3 —
PPM000838 PGS000116
(CAD_EJ2020)
 PSS000385|
Multi-ancestry (including European)|
147,110 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.83 [0.81, 0.84] — QRISK3 —
PPM000839 PGS000116
(CAD_EJ2020)
 PSS000393|
Multi-ancestry (including European)|
146,573 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.73 [0.72, 0.74] — QRISK3 —
PPM000840 PGS000116
(CAD_EJ2020)
 PSS000397|
Multi-ancestry (including European)|
204,157 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.78 [0.76, 0.79] — QRISK3 —
PPM000743 PGS000296
(GPS_CAD_SA)
 PSS000365|
South Asian Ancestry|
491 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
 Reported Trait: Myocardial infarction (first-ever) OR: 1.6 [1.32, 1.94] AUROC: 0.6632 — age, sex, top 5 genetic PCs —
PPM000745 PGS000296
(GPS_CAD_SA)
 PSS000366|
South Asian Ancestry|
2,963 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
 Reported Trait: Coronary artery disease OR: 1.66 [1.53, 1.81] AUROC: 0.712 — age, sex, top 5 genetic PCs —
PPM001749 PGS000013
(GPS_CAD)
 PSS000901|
Hispanic or Latin American Ancestry|
9,085 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.52 [1.43, 1.62] — — PCs(1-4) —
PPM000746 PGS000296
(GPS_CAD_SA)
 PSS000366|
South Asian Ancestry|
2,963 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
 Reported Trait: Coronary artery disease OR: 1.58 [1.42, 1.75] — — age, sex, top 5 genetic PCs, diabetes, hypertension, hypercholesterolemia, smoking, body mass index —
PPM000747 PGS000013
(GPS_CAD)
 PSS000367|
South Asian Ancestry|
7,244 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.5302 AUROC: 0.8021 — age, sex, top 5 genetic PCs —
PPM000748 PGS000013
(GPS_CAD)
 PSS000365|
South Asian Ancestry|
491 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Myocardial infarction (first-ever) OR: 1.4605 AUROC: 0.6482 — age, sex, top 5 genetic PCs —
PPM000749 PGS000013
(GPS_CAD)
 PSS000366|
South Asian Ancestry|
2,963 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.5793 AUROC: 0.7066 — age, sex, top 5 genetic PCs —
PPM000886 PGS000329
(PRS_CHD)
 PSS000445|
European Ancestry|
135,300 individuals
 PGP000100 |
Mars N et al. Nat Med (2020)
 Reported Trait: Coronary heart disease (incident and prevalent cases) HR: 1.31 [1.29, 1.33] — — genotyping array/batch, 10 ancestry PCs, stratified by sex —
PPM000807 PGS000116
(CAD_EJ2020)
 PSS000399|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease — C-index: 0.76 [0.75, 0.76] — age,sex —
PPM000808 PGS000116
(CAD_EJ2020)
 PSS000399|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease — C-index: 0.78 [0.77, 0.79] — pooled cohort equations —
PPM000810 PGS000116
(CAD_EJ2020)
 PSS000387|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.71 [0.7, 0.72] — age,sex —
PPM000811 PGS000116
(CAD_EJ2020)
 PSS000387|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.74 [0.73, 0.74] — pooled cohort equations —
PPM000813 PGS000116
(CAD_EJ2020)
 PSS000383|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.76 [0.75, 0.78] — age,sex —
PPM000814 PGS000116
(CAD_EJ2020)
 PSS000383|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.8 [0.79, 0.82] — pooled cohort equations —
PPM000816 PGS000116
(CAD_EJ2020)
 PSS000391|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.68 [0.67, 0.69] — age,sex —
PPM000817 PGS000116
(CAD_EJ2020)
 PSS000391|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.71 [0.7, 0.72] — pooled cohort equations —
PPM000819 PGS000116
(CAD_EJ2020)
 PSS000395|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.71 [0.7, 0.73] — age,sex —
PPM000820 PGS000116
(CAD_EJ2020)
 PSS000395|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.76 [0.74, 0.77] — pooled cohort equations —
PPM000744 PGS000296
(GPS_CAD_SA)
 PSS000365|
South Asian Ancestry|
491 individuals
 PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
 Reported Trait: Myocardial infarction (first-ever) OR: 1.51 [1.22, 1.88] — — age, sex, top 5 genetic PCs, diabetes, hypertension, hypercholesterolemia, family history of heart disease, current smoking, family history of myocardial infarction —
PPM000806 PGS000116
(CAD_EJ2020)
 PSS000399|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease HR: 1.32 [1.3, 1.34] C-index: 0.61 [0.6, 0.62] — — —
PPM000809 PGS000116
(CAD_EJ2020)
 PSS000387|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.6 [0.59, 0.61] — — —
PPM000812 PGS000116
(CAD_EJ2020)
 PSS000383|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.64 [0.63, 0.66] — — —
PPM000815 PGS000116
(CAD_EJ2020)
 PSS000391|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.61 [0.6, 0.62] — — —
PPM000818 PGS000116
(CAD_EJ2020)
 PSS000395|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.61 [0.6, 0.63] — — —
PPM001617 PGS000013
(GPS_CAD)
 PSS000839|
European Ancestry|
4,847 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Prevalent and incident coronary heart disease OR: 1.89 [1.75, 2.03] — — Age, sex, PCs (1-5) —
PPM001618 PGS000013
(GPS_CAD)
 PSS000837|
European Ancestry|
4,847 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.24 [1.15, 1.34] C-index: 0.669 [0.644, 0.691] — Age, sex, PCs (1-5) —
PPM001619 PGS000013
(GPS_CAD)
 PSS000838|
European Ancestry|
2,390 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.38 [1.21, 1.58] C-index: 0.672 [0.627, 0.705] — Age, sex, PCs (1-5) —
PPM001621 PGS000013
(GPS_CAD)
 PSS000838|
European Ancestry|
2,390 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Incident coronary heart disease (10-year risk) — C-index: 0.681 [0.637, 0.715] Δ C-index (PRS+covariates vs. covariates alone): 0.021 [-0.0004, 0.043] Pooled cohort risk percentile, age, sex, PCs (1-5) —
PPM001622 PGS000013
(GPS_CAD)
 PSS000837|
European Ancestry|
4,847 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Incident coronary heart disease (10-year risk) — C-index: 0.549 [0.521, 0.571] — PCs (1-5) —
PPM001623 PGS000013
(GPS_CAD)
 PSS000838|
European Ancestry|
2,390 individuals
 PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.		 Reported Trait: Incident coronary heart disease (10-year risk) — C-index: 0.587 [0.532, 0.623] — PCs (1-5) —
PPM001745 PGS000013
(GPS_CAD)
 PSS000900|
European Ancestry|
474,498 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.6 [1.44, 1.78] — — PCs(1-4) —
PPM001748 PGS000013
(GPS_CAD)
 PSS000899|
East Asian Ancestry|
3,988 individuals
 PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.66 [1.47, 1.86] — — PCs(1-4) —
PPM001848 PGS000013
(GPS_CAD)
 PSS000929|
European Ancestry|
5,581 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.6699 [0.6557, 0.684] — — —
PPM001849 PGS000013
(GPS_CAD)
 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.5617 [0.5402, 0.5833] — — —
PPM001850 PGS000013
(GPS_CAD)
 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.6374 [0.6335, 0.6412] — — May be an overlap between score development and testing samples
PPM001836 PGS000746
(PRS_UKB)
 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6133 [0.6094, 0.6172] Area under the Precision-Recall curve (AUPRC): 0.0752 [0.0745, 0.076] — —
PPM001837 PGS000747
(PRS_EB)
 PSS000929|
European Ancestry|
5,581 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.5407 [0.5253, 0.5561] Area under the Precision-Recall curve (AUPRC): 0.498 [0.4962, 0.4998] — —
PPM001838 PGS000747
(PRS_EB)
 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6565 [0.6369, 0.676] Area under the Precision-Recall curve (AUPRC): 0.0765 [0.0755, 0.0774] — —
PPM001840 PGS000748
(PRS_DE)
 PSS000929|
European Ancestry|
5,581 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6752 [0.6612, 0.6891] Area under the Precision-Recall curve (AUPRC): 0.6891 [0.6887, 0.6895] — —
PPM001844 PGS000749
(PRS_COMBINED)
 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.5988 [0.5949, 0.6027] Area under the Precision-Recall curve (AUPRC): 0.0697 [0.0688, 0.0705] — —
PPM001834 PGS000746
(PRS_UKB)
 PSS000929|
European Ancestry|
5,581 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.5143 [0.4992, 0.5294] Area under the Precision-Recall curve (AUPRC): 0.5607 [0.5593, 0.5621] — —
PPM001835 PGS000746
(PRS_UKB)
 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
 Reported Trait: Coronary artery disease — AUROC: 0.6049 [0.5857, 0.6241] Area under the Precision-Recall curve (AUPRC): 0.046 [0.0454, 0.0466] — —
PPM001847 PGS000018
(metaGRS_CAD)
 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.6377 [0.6339, 0.6416] Area under the Precision-Recall curve (AUPRC): 0.0832 [0.083, 0.0835] — May be an overlap between score development and testing sample

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention — 27,271 individuals,
38.7 % Male samples
 — European
(Swedish)		 — MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention —
[
  • 108 cases
  • , 8,641 controls
]
,
67.8 % Male samples
 — European — JUPITER Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention —
[
  • 149 cases
  • , 6,829 controls
]
,
79.7 % Male samples
 — European — ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention —
[
  • 320 cases
  • , 2,558 controls
]
,
86.1 % Male samples
 — European — CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention —
[
  • 229 cases
  • , 1,770 controls
]
,
77.5 % Male samples
 — European — PROVEIT Secondary prevention cohorts
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease. —
[
  • 2,213 cases
  • , 21,382 controls
]
,
38.03 % Male samples
 — European
(Swedish)		 — MDC Prospective study
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24) —
[
  • 587 cases
  • , 2,819 controls
]
,
45.0 % Male samples
 — European — FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures. —
[
  • 757 cases
  • , 11,919 controls
]
,
46.0 % Male samples
 — European
(Finnish)		 — FINRISK FR92, FR97, FR02
PSS000015 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). —
[
  • 8,676 cases
  • , 280,302 controls
]
 — European — UKB UKB Phase 2
PSS000018 CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75. —
[
  • 22,242 cases
  • , 460,387 controls
]
,
45.6 % Male samples
 — European, NR ~95% European ancestry samples, <5% non-European ancestry UKB —
PSS000019 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 173 cases
  • , 5,589 controls
]
,
41.29 % Male samples
 — European
(French Canadian)		 — CARTaGENE —
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 446 cases
  • , 416 controls
]
 — European
(French Canadian)		 — MHI Phase 1
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 937 cases
  • , 1,396 controls
]
 — European
(French Canadian)		 — MHI Phase 2
PSS000021 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 974 cases
  • , 976 controls
]
,
72.7 % Male samples
 — European
(French Canadian)		 — MHI Phase 1
PSS000022 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 2,492 cases
  • , 817 controls
]
,
72.38 % Male samples
 — European
(French Canadian)		 — MHI Phase 2
PSS000023 CAD case endpoints were defined as: angina, myocardial infarction, coronary angioplasty, and coronary bypass surgery. Participants are described as Caucasian with diagnosed Familial hypercholesterolemia(FH; Dutch Lipid Criteria score >= 3 [possible, probable, or definite FH]) and carriers of classical French Canadian mutations in the LDLR gene including del .15 kb of the promoter and exon 1, del .5 kb of exons 2 and 3, W66G (exon 3), E207K (exon 4), Y468X (exon 10), and C646Y (exon 14). —
[
  • 206 cases
  • , 519 controls
]
,
42.8 % Male samples
 — European CNMA Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) of Institut de recherches cliniques de Montréal
PSS000024 Cerebrovascular disease (CVD) case endpoints were defined as: transient ischemic attack, stroke, and carotid endarterectomy. Participants are described as Caucasian with diagnosed Familial hypercholesterolemia(FH; Dutch Lipid Criteria score >= 3 [possible, probable, or definite FH]) and carriers of classical French Canadian mutations in the LDLR gene including del .15 kb of the promoter and exon 1, del .5 kb of exons 2 and 3, W66G (exon 3), E207K (exon 4), Y468X (exon 10), and C646Y (exon 14). —
[
  • 231 cases
  • , 494 controls
]
,
42.8 % Male samples
 — European — CNMA Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) of Institut de recherches cliniques de Montréal
PSS000440 Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complications following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. —
[
  • 1,209 cases
  • , 18,956 controls
]
,
47.3 % Male samples
 Mean (Age At Baseline) = 48.0 years European
(Finnish)		 — FINRISK FINRISK surveys from 1992, 1997, 2002 and 2007
PSS000445 Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complications following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. —
[
  • 20,179 cases
  • , 115,121 controls
]
,
43.7 % Male samples
 Mean (Age At Baseline) = 59.2 years
Sd = 16.6 years		 European
(Finnish)		 — FinnGen —
PSS000454 Cause of death under ICD-10 code Median = 7.7 years
[
  • 9,816 cases
  • , 39,414 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS000455 Cause of death under ICD-10.CHF code Median = 7.7 years
[
  • 362 cases
  • , 48,868 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS000456 Cause of death under ICD-10.I codes Median = 7.7 years
[
  • 2,122 cases
  • , 47,108 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS000457 Cause of death under ICD-10.IHD code Median = 7.7 years
[
  • 464 cases
  • , 48,766 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS000458 Cause of death under ICD-10.J codes Median = 7.7 years
[
  • 1,193 cases
  • , 48,037 controls
]
 — East Asian
(Japanese)		 — BBJ —
PSS000459 CAD was defined as a composite of stable angina, unstable angina and myocardial infarction. The disease definitions are dependent on the physician's diagnosis based on general medical practices following relevant guidelines and according to the clinical symptoms and diagnotic tests. —
[
  • 1,827 cases
  • , 9,172 controls
]
,
84.0 % Male samples
 — East Asian
(Japanese)		 — BBJ —
PSS000837 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Median = 15.5 years
[
  • 696 cases
  • , 4,151 controls
]
,
43.6 % Male samples
 Mean = 62.9 years European — ARIC —
PSS000838 Incident CHD cases were defined as MI, resuscitated cardiac arrest, definite or probable angina if followed by a revascularization, and CHD dead occuring by visit 5. Median = 14.2 years
[
  • 227 cases
  • , 2,163 controls
]
,
47.8 % Male samples
 Mean = 61.8 years European — MESA —
PSS000839 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Prevalent CHD cases were participants with a reported history of MI, heart or arterial surgery, coronary artery bypass graft surgery, or angioplasty; or evidence of having had an MI based on electrocardiogram taken at their visit 1 examination. —
[
  • 1,005 cases
  • , 3,842 controls
]
,
43.6 % Male samples
 Mean = 62.9 years European — ARIC —
PSS000467 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. Median = 21.3 years
Iqr = [16.1, 23.1] years
[
  • 4,122 cases
  • , 24,434 controls
]
,
38.7 % Male samples
 Mean = 57.9 years European, NR European=28286, NR=270 MDC —
PSS000468 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. All individuals included had measured cholesterol concentrations. Median = 23.2 years
Iqr = [17.6, 24.2] years
[
  • 815 cases
  • , 4,870 controls
]
,
41.16 % Male samples
 — European, NR European=5640, NR=45 MDC-CC Cardiovascular Cohort
PSS000469 Individuals were free of CAD at time of enrollment. CAD was defined based on hospitalisation with or death due to ICD-10 codes for acute or subsequent myocaridal infarction (I21, I22, I23, I24.1, and I25.2); or hospitalisation with ICD-9 codes for myocaridal. infarction (410, 411, and 412); or hospitalisation with OPCS-4 (Office of Population Censuses and Surveys) codes. for coronary artery bypass grafting (K40, K41, and K45) or coronary angioplasty with or without stenting (K49, K50.2, and K75). Median = 8.1 years
Iqr = [7.4, 8.8] years
[
  • 7,708 cases
  • , 317,295 controls
]
,
44.2 % Male samples
 Mean = 56.8 years European, African unspecified, South Asian, East Asian, NR European=304270, African unspecified=5760, South Asian=6832, East Asian (Chinese)=1117, NR=7024 UKB —
PSS000219 Phenotypic information was self-reported by the individual through an online, interactive health history tool —
[
  • 126 cases
  • , 10,884 controls
]
,
17.1 % Male samples
 — European — CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS000227 — —
[
  • 40 cases
  • , 504 controls
]
 — Asian unspecified — MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000228 — —
[
  • 336 cases
  • , 962 controls
]
 — African American or Afro-Caribbean — MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000229 — —
[
  • 168 cases
  • , 751 controls
]
 — Hispanic or Latin American — MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000230 — —
[
  • 1,537 cases
  • , 1,544 controls
]
 — European — MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 19.0 years
[
  • 235 cases
  • , 4,869 controls
]
,
44.8 % Male samples
 Mean = 43.9 years
Sd = 11.3 years		 European
(Finnish)		 — FINRISK FINRISK 1992
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 14.0 years
[
  • 229 cases
  • , 6,338 controls
]
,
45.8 % Male samples
 Mean = 46.8 years
Sd = 12.9 years		 European
(Finnish)		 — FINRISK97 FINRISK 1997
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 9.0 years
[
  • 148 cases
  • , 7,182 controls
]
,
45.0 % Male samples
 Mean = 47.5 years
Sd = 13.0 years		 European
(Finnish)		 — FINRISK FINRISK 2002
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 8.0 years
[
  • 119 cases
  • , 5,004 controls
]
,
46.3 % Male samples
 Mean = 50.0 years
Sd = 11.7 years		 European
(Finnish)		 — Health 2000 —
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 19.0 years
[
  • 343 cases
  • , 4,761 controls
]
,
44.8 % Male samples
 Mean = 43.9 years
Sd = 11.3 years		 European
(Finnish)		 — FINRISK FINRISK 1992
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 14.0 years
[
  • 344 cases
  • , 6,223 controls
]
,
45.8 % Male samples
 Mean = 46.8 years
Sd = 12.9 years		 European
(Finnish)		 — FINRISK97 FINRISK 1997
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 9.0 years
[
  • 209 cases
  • , 7,121 controls
]
,
45.0 % Male samples
 Mean = 47.5 years
Sd = 13.0 years		 European
(Finnish)		 — FINRISK FINRISK 2002
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 8.0 years
[
  • 197 cases
  • , 4,926 controls
]
,
46.3 % Male samples
 Mean = 50.0 years
Sd = 11.7 years		 European
(Finnish)		 — Health 2000 —
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 19.0 years
[
  • 501 cases
  • , 4,603 controls
]
,
44.8 % Male samples
 Mean = 43.9 years
Sd = 11.3 years		 European
(Finnish)		 — FINRISK FINRISK 1992
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 14.0 years
[
  • 499 cases
  • , 6,068 controls
]
,
45.8 % Male samples
 Mean = 46.8 years
Sd = 12.9 years		 European
(Finnish)		 — FINRISK97 FINRISK 1997
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 9.0 years
[
  • 291 cases
  • , 7,039 controls
]
,
45.0 % Male samples
 Mean = 47.5 years
Sd = 13.0 years		 European
(Finnish)		 — FINRISK FINRISK 2002
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 8.0 years
[
  • 261 cases
  • , 4,862 controls
]
,
46.3 % Male samples
 Mean = 50.0 years
Sd = 11.7 years		 European
(Finnish)		 — Health 2000 —
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
 Mean = 43.6 years
Sd = 12.5 years		 African American or Afro-Caribbean — 7 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
 Mean = 43.6 years
Sd = 12.5 years		 African American or Afro-Caribbean — 7 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
 Mean = 49.0 years
Sd = 14.1 years		 European — 11 cohorts
  • BioVu
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
 Mean = 49.0 years
Sd = 14.1 years		 European — 11 cohorts
  • BioVu
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
 Mean = 41.1 years
Sd = 13.2 years		 Hispanic or Latin American — 8 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
 Mean = 41.1 years
Sd = 13.2 years		 Hispanic or Latin American — 8 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000868 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I21-I23, I24.1, I25.2 Median = 6.9 years
[
  • 15 cases
  • , 3,072 controls
]
,
51.0 % Male samples
 Median = 44.0 years
Iqr = [30.5, 54.7] years		 European — INTERVAL —
PSS000898 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 1,370 cases
  • , 15,385 controls
]
 — African unspecified — BMBB, MESA, PHB, UKB, VIRGO —
PSS000899 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 435 cases
  • , 3,553 controls
]
 — East Asian — TaiChi, UKB —
PSS000900 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 26,462 cases
  • , 448,036 controls
]
 — European — BMBB, MESA, PHB, UKB, VIRGO —
PSS000901 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 1,224 cases
  • , 7,861 controls
]
 — Hispanic or Latin American — BMBB, MESA, PHB, VIRGO —
PSS000902 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization. —
[
  • 874 cases
  • , 7,228 controls
]
 — South Asian — BRAVE, UKB —
PSS000504 Participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Median = 11.6 years
Sd = 3.7 years
[
  • 343 cases
  • , 3,698 controls
]
,
47.5 % Male samples
 Mean = 58.9 years
Sd = 7.6 years		 European — HNR —
PSS000505 — —
[
  • 2,734 cases
  • , 1,307 controls
]
 — European — HNR —
PSS000506 Male participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. —
[
  • 219 cases
  • , 1,700 controls
]
,
100.0 % Male samples
 — European — HNR —
PSS000507 Participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater. —
[
  • 321 cases
  • , 3,427 controls
]
 — European — HNR —
PSS000508 — —
[
  • 2,536 cases
  • , 1,212 controls
]
 — European — HNR —
PSS000509 Participants with no prior Coronary Heart Disease (CHD) at the time of enrollment with coronary artery calcification>0 were included. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater. —
[
  • 278 cases
  • , 2,282 controls
]
 — European — HNR —
PSS000510 Male participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater. —
[
  • 202 cases
  • , 1,563 controls
]
,
100.0 % Male samples
 — European — HNR —
PSS000511 Male participants with no prior Coronary Heart Disease (CHD) at the time of enrollment with coronary artery calcification>0 were included. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater. —
[
  • 186 cases
  • , 1,240 controls
]
,
100.0 % Male samples
 — European — HNR —
PSS000089 Total carotid plaque burden (mm2) — 4,392 individuals Range = [55.0, 80.0] years NR — BioImage —
PSS000090 Total coronary arterial clacification (CAC) was coded as a a dichotomous outcome variable (CAC>0 versus CAC=0), and quantified by the Agatston method Mean = 15.0 years 1,154 individuals Range = [32.0, 47.0] years NR — CARDIA —
PSS000091 Nonfatal myocardial infarction or death from CHD Mean = 13.5 years
Sd = 2.8 years		 2,440 individuals,
100.0 % Male samples
 Mean = 55.1 years
Sd = 5.5 years		 NR — Participants were all men hypercholesterolemia but without a history of myocardial infarction, allocated to the placebo group
PSS000514 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) —
[
  • 2,824 cases
  • , 21,547 controls
]
,
42.7 % Male samples
 Mean = 57.0 years European, Hispanic or Latin American, African unspecified African unspecified=6979, European=10344, Hispanic or Latin American=7048 Mount Sinai —
PSS000515 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) — 6,979 individuals — African unspecified — Mount Sinai —
PSS000516 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) — 10,344 individuals — European — Mount Sinai —
PSS000517 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) — 7,048 individuals — Hispanic or Latin American — Mount Sinai —
PSS000518 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) —
[
  • 3,538 cases
  • , 10,129 controls
]
,
45.0 % Male samples
 Mean = 60.0 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=867, East Asian=167, European=11725, Hispanic or Latin American=799, South Asian=109 PHB —
PSS000519 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) —
[
  • 4,658 cases
  • , 4,412 controls
]
,
59.0 % Male samples
 Mean = 68.0 years European, African unspecified African unspecified=1927, European=7143 PMB —
PSS000520 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) —
[
  • 11,020 cases
  • , 36,088 controls
]
,
46.52 % Male samples
 Mean = 59.6 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=9773, East Asian=167, European=29212, Hispanic or Latin America=7847, South Asian=109 Mount Sinai, PHB, PMB —
PSS000092 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina Median = 4.7 years
[
  • 675 cases
  • , 4,685 controls
]
,
64.8 % Male samples
 Mean = 62.8 years European Self reported white ACCORD Type 2 Diabetes patients
PSS000093 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina Median = 6.2 years
[
  • 163 cases
  • , 1,768 controls
]
 — European Self reported white ORIGIN Participants are from the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial and were enrolled based on having some combination of impaired fasting glucose, impaired glucose tolerance or type 2 diabetes, and high cardiovascular risk
PSS000094 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death —
[
  • 86 cases
  • , 1,234 controls
]
 Mean = 62.6 years European Analysis restricted to "White participants" MESA —
PSS000095 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death —
[
  • 144 cases
  • , 1,062 controls
]
 Mean = 62.7 years European Analysis restricted to "White participants" MESA —
PSS000929 For GERMIFSI and GERMIFSII, CAD was defined as Myocardinal infarction before the age of 60 and 1 or more 1st- degree relative with CAD. In GERMIFSIII CAD was defined as myocardial infarction between the ages of 26 and 74. In GERMIFSIV, cases were based on a CAD diagnosis before age 65 in men or age 70 in women. In Luric, cases were ascertained as >50% angiographic confirmation of vascular obstruction in 1 or more coronary vessel —
[
  • 2,919 cases
  • , 2,662 controls
]
 — European — 6 cohorts
  • GERMIFSI
  • ,GERMIFSII
  • ,GERMIFSIII
  • ,GERMIFSIV
  • ,GERMIFSV
  • ,LURIC
 —
PSS000930 CAD ascertainment was based on myocardial infarction diagnosis or death cause using ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2 —
[
  • 840 cases
  • , 26,208 controls
]
 — European — EB —
PSS000931 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on ICD-9 codes 410.X, 411.X, 412.X, or 429.79, or ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2. Coronary revascularization was assessed based on OPCS-4 coded procedure for coronary artery bypass grafting (K40.1-40-4, K41.1-41.4, or K45.1-45.5), or coronary angioplasty with or without stenting (K49.1-49.2, K49.0-49.9, K50.2, K75.1-75.4, or K75.8-75.9) —
[
  • 21,025 cases
  • , 410,789 controls
]
 — European — UKB —
PSS000365 Case-control study of first-onset acute myocardial infarction —
[
  • 247 cases
]
,
90.7 % Male samples
 Mean = 34.0 years
Iqr = [30.0, 35.0] years		 South Asian — BRAVE —
PSS000365 Case-control study of first-onset acute myocardial infarction — 244 individuals,
90.2 % Male samples
 Mean = 33.0 years
Iqr = [30.0, 35.0] years		 South Asian — BRAVE —
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease. —
[
  • 1,800 cases
]
,
90.2 % Male samples
 Mean = 54.0 years
Iqr = [46.0, 60.0] years		 South Asian — MedGenome —
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease. — 1,163 individuals,
76.4 % Male samples
 Mean = 55.0 years
Iqr = [49.0, 62.0] years		 South Asian — MedGenome —
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). —
[
  • 398 cases
]
,
86.7 % Male samples
 Mean = 60.6 years
Iqr = [54.4, 66.1] years		 South Asian — UKB —
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). — 6,846 individuals,
52.1 % Male samples
 Mean = 52.8 years
Iqr = [46.3, 60.2] years		 South Asian — UKB —
PSS000383 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,350 cases
  • , 146,635 controls
]
 Range = [40.0, 55.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000385 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,339 cases
  • , 145,771 controls
]
 Range = [40.0, 55.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000387 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,922 cases
  • , 199,753 controls
]
 Range = [55.0, 69.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000389 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,900 cases
  • , 198,720 controls
]
 Range = [55.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000391 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,493 cases
  • , 142,870 controls
]
,
100.0 % Male samples
 Mean = 55.79 years
Sd = 8.35 years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000393 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,471 cases
  • , 142,102 controls
]
,
100.0 % Male samples
 Mean = 55.8 years
Sd = 8.3 years		 European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000395 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,779 cases
  • , 203,518 controls
]
,
0.0 % Male samples
 Mean = 56.0 years
Sd = 8.01 years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000397 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,768 cases
  • , 202,389 controls
]
,
0.0 % Male samples
 Mean = 56.0 years
Sd = 8.0 years		 European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000399 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,272 cases
  • , 346,388 controls
]
,
41.8 % Male samples
 Mean = 55.9 years
Range = [40.0, 69.0] years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000401 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,239 cases
  • , 344,491 controls
]
,
41.0 % Male samples
 Range = [40.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000283 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 18.8 years
[
  • 1,230 cases
  • , 6,584 controls
]
,
45.0 % Male samples
 Mean = 54.0 years
Sd = 5.7 years		 European — ARIC —
PSS000284 Cross-sectional analysis of baseline scores for coronary artery calcification (Agatston score) — 4,260 individuals,
44.0 % Male samples
 Mean = 69.1 years
Sd = 6.0 years		 European — BioImage —
PSS000285 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 19.4 years
[
  • 2,902 cases
  • , 19,487 controls
]
,
38.0 % Male samples
 Mean = 58.0 years
Sd = 7.7 years		 European — MDC-CC —
PSS000286 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 20.5 years
[
  • 971 cases
  • , 20,251 controls
]
,
0.0 % Male samples
 Mean = 54.2 years
Sd = 7.1 years		 European — WGHS —
PSS000287 (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics Mean = 3.0 years 1,319 individuals,
69.3 % Male samples
 Mean = 68.8 years
Sd = 9.3 years		 European
(Dutch)		 — AEGS1 —