Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004882
(INTERVENE_MegaPRS_Hip_osteoarthritis)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Hip osteoarthritis osteoarthritis, hip 773,587
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004882/ScoringFiles/PGS004882.txt.gz
PGS004883
(INTERVENE_MegaPRS_Knee_osteoarthritis)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Knee osteoarthritis osteoarthritis, knee 952,133
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004883/ScoringFiles/PGS004883.txt.gz
PGS004884
(INTERVENE_MegaPRS_Lung_cancer)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Lung cancer lung carcinoma 655,479
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004884/ScoringFiles/PGS004884.txt.gz
PGS004885
(INTERVENE_MegaPRS_MDD)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Major depressive disorder major depressive disorder 801,544
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004885/ScoringFiles/PGS004885.txt.gz
PGS004886
(INTERVENE_MegaPRS_Melanoma)
PGP000618 |
Jermy B et al. Nat Commun (2024)
Melanoma melanoma 692,834
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004886/ScoringFiles/PGS004886.txt.gz
PGS004887
(T2D_gePGS)
PGP000619 |
Mandla R et al. Genome Med (2024)
Type 2 diabetes (T2D) type 2 diabetes mellitus 1,117,628
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004887/ScoringFiles/PGS004887.txt.gz
PGS004888
(CAD_gePGS)
PGP000619 |
Mandla R et al. Genome Med (2024)
Coronary artery diseae coronary artery disease 1,110,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004888/ScoringFiles/PGS004888.txt.gz
PGS004889
(CKD_gePGS)
PGP000619 |
Mandla R et al. Genome Med (2024)
Chronic kidney disease chronic kidney disease 1,117,375
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004889/ScoringFiles/PGS004889.txt.gz
PGS004890
(CC-GWAS_PRS)
PGP000620 |
Sun X et al. Cancer Res (2024)
Triple negative breast cancer versus luminal breast cancer triple-negative breast cancer 25
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004890/ScoringFiles/PGS004890.txt.gz
PGS004891
(TNBC_PRS25)
PGP000620 |
Sun X et al. Cancer Res (2024)
Triple negative breast cancer triple-negative breast cancer 25
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004891/ScoringFiles/PGS004891.txt.gz
PGS004892
(TNBC_PRS41)
PGP000620 |
Sun X et al. Cancer Res (2024)
Triple negative breast cancer triple-negative breast cancer 41
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004892/ScoringFiles/PGS004892.txt.gz
PGS004893
(overall.hybrid.prs)
PGP000621 |
Gao G et al. Hum Mol Genet (2022)
Breast cancer breast carcinoma 56,943
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004893/ScoringFiles/PGS004893.txt.gz
PGS004894
(ERpos.prs)
PGP000621 |
Gao G et al. Hum Mol Genet (2022)
Estrogen receptor positive breast cancer estrogen-receptor positive breast cancer 29,309
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004894/ScoringFiles/PGS004894.txt.gz
PGS004895
(ERneg.prs)
PGP000621 |
Gao G et al. Hum Mol Genet (2022)
Estrogen receptor negative breast cancer estrogen-receptor negative breast cancer 28,405
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004895/ScoringFiles/PGS004895.txt.gz
PGS004896
(mAlb)
PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
Microalbuminuria Moderate albuminuria 29
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004896/ScoringFiles/PGS004896.txt.gz
PGS004897
(UACR)
PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
Urinary albumin-to-creatinine ratio urinary albumin to creatinine ratio 28
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004897/ScoringFiles/PGS004897.txt.gz
PGS004898
(PRS_AD)
PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
Alzheimer's disease Alzheimer disease 44
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004898/ScoringFiles/PGS004898.txt.gz
PGS004899
(PRS_SCAD)
PGP000629 |
Saw J et al. Nat Commun (2020)
Spontaneous coronary artery dissection spontaneous coronary artery dissection 7
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004899/ScoringFiles/PGS004899.txt.gz
PGS004900
(GRS_BMI_males)
PGP000630 |
Wu Y et al. PLoS Genet (2020)
Body mass index (BMI) body mass index 94
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004900/ScoringFiles/PGS004900.txt.gz
PGS004901
(GRS_BMI_females)
PGP000630 |
Wu Y et al. PLoS Genet (2020)
Body mass index (BMI) body mass index 94
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004901/ScoringFiles/PGS004901.txt.gz
PGS004903
(PRS_ALL)
PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
Atopic dermatitis atopic eczema 38
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004903/ScoringFiles/PGS004903.txt.gz
PGS004904
(PRS127_CRC)
PGP000636 |
Jiang F et al. Int J Cancer (2023)
Colorectal cancer colorectal carcinoma 127
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004904/ScoringFiles/PGS004904.txt.gz
PGS004905
(PRS155_AF)
PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
Atrial fibrillation atrial fibrillation 155
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004905/ScoringFiles/PGS004905.txt.gz
PGS004906
(PRS60_TSH)
PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
Thyroid stimulating hormone concentration thyroid stimulating hormone measurement 60
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004906/ScoringFiles/PGS004906.txt.gz
PGS004907
(PRS31_FT4)
PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
Free thyroxine concentration thyroxine measurement 31
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004907/ScoringFiles/PGS004907.txt.gz
PGS004908
(PRS107_KC)
PGP000640 |
Purdue MP et al. Nat Genet (2024)
Kidney cancer renal carcinoma 107
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004908/ScoringFiles/PGS004908.txt.gz
PGS004909
(EUR_wGRS7)
PGP000641 |
El-Boraie A et al. Addict Biol (2019)
Nicotine metabolite ratio nicotine metabolite ratio 7
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004909/ScoringFiles/PGS004909.txt.gz
PGS004912
(PRS183)
PGP000643 |
Tian J et al. Genome Med (2024)
Colorectal neoplasm colorectal carcinoma 183
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004912/ScoringFiles/PGS004912.txt.gz
PGS004913
(PRSALC)
PGP000645 |
Schwantes-An TH et al. Hepatol Commun (2024)
Alcohol-associated liver cirrhosis alcoholic liver cirrhosis 20
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004913/ScoringFiles/PGS004913.txt.gz
PGS004914
(HDL-C_PGS)
PGP000647 |
Trinder M et al. Arterioscler Thromb Vasc Biol (2019)
HDL cholesterol high density lipoprotein cholesterol measurement 223
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004914/ScoringFiles/PGS004914.txt.gz
PGS004915
(LDL-C_PGS)
PGP000647 |
Trinder M et al. Arterioscler Thromb Vasc Biol (2019)
LDL cholesterol low density lipoprotein cholesterol measurement 223
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004915/ScoringFiles/PGS004915.txt.gz
PGS004916
(Triglycerides_PGS)
PGP000647 |
Trinder M et al. Arterioscler Thromb Vasc Biol (2019)
Triglycerides triglyceride measurement 223
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004916/ScoringFiles/PGS004916.txt.gz
PGS004917
(wGRS)
PGP000648 |
Cui J et al. Arthritis Rheumatol (2020)
Systemic lupus erythematosus systemic lupus erythematosus 97
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004917/ScoringFiles/PGS004917.txt.gz
PGS004918
(PRS8_Synapse)
PGP000649 |
Lawingco T et al. Neurobiol Aging (2020)
Late-onset Alzheimers disease (based on SNPs in genes involved in synaptic function) late-onset Alzheimer's disease 8
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004918/ScoringFiles/PGS004918.txt.gz
PGS004919
(CAD_GRS_50)
PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Coronary artery disease coronary artery disease 50
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004919/ScoringFiles/PGS004919.txt.gz
PGS004920
(GRS166_AF)
PGP000652 |
Wang N et al. Eur Heart J (2021)
Atrial fibrillation atrial fibrillation 166
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004920/ScoringFiles/PGS004920.txt.gz
PGS004921
(CAD-GRS)
PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
Coronary artery disease coronary artery disease 161
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004921/ScoringFiles/PGS004921.txt.gz
PGS004922
(wGRS_AFR)
PGP000655 |
El-Boraie A et al. Clin Pharmacol Ther (2021)
Nicotine metabolite ratio nicotine metabolite ratio 14
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004922/ScoringFiles/PGS004922.txt.gz