| Trait Information | |
| Identifier | MONDO_0005148 |
| Description | A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity. [NCIT: P378] | Trait categories |
Digestive system disorder
Metabolic disorder
|
| Synonyms |
35 synonyms
|
| Mapped terms |
9 mapped terms
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000014 (GPS_T2D) |
PGP000006 | Khera AV et al. Nat Genet (2018) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,917,436 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000014/ScoringFiles/PGS000014.txt.gz | |
| PGS000020 (dGRS1000) |
PGP000010 | Läll K et al. Genet Med (2016) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 7,502 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000020/ScoringFiles/PGS000020.txt.gz |
| PGS000031 (GRSt) |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 62 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000031/ScoringFiles/PGS000031.txt.gz |
| PGS000032 (GRSB) |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Type 2 diabetes (based on SNPs involved in β-cell function) | type 2 diabetes mellitus | 20 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000032/ScoringFiles/PGS000032.txt.gz |
| PGS000033 (GRSIR) |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Type 2 diabetes (based on SNPs involved in insulin resistance) | type 2 diabetes mellitus | 10 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000033/ScoringFiles/PGS000033.txt.gz |
| PGS000036 (gePS_T2D) |
PGP000023 | Mahajan A et al. Nat Genet (2018) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 171,249 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000036/ScoringFiles/PGS000036.txt.gz | |
| PGS000125 (Qi_T2D_2017) |
PGP000062 | Qi Q et al. Diabetes (2017) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 80 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000125/ScoringFiles/PGS000125.txt.gz |
| PGS000330 (PRS_T2D) |
PGP000100 | Mars N et al. Nat Med (2020) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,437,380 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000330/ScoringFiles/PGS000330.txt.gz | |
| PGS000712 (T2D_HbA1c_39) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
T2D (cases vs HbA1c filtered controls) | type 2 diabetes mellitus | 183,695 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000712/ScoringFiles/PGS000712.txt.gz |
| PGS000713 (T2D) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 183,830 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000713/ScoringFiles/PGS000713.txt.gz |
| PGS000729 (T2D_PGS) |
PGP000137 | Ritchie SC et al. Nat Metab (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 2,017,388 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000729/ScoringFiles/PGS000729.txt.gz |
| PGS000804 (GRS582_T2Dmulti) |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 582 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000804/ScoringFiles/PGS000804.txt.gz |
| PGS000805 (GRS582_T2Deur) |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 582 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000805/ScoringFiles/PGS000805.txt.gz |
| PGS000806 (GRS582_T2Dafr) |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 582 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000806/ScoringFiles/PGS000806.txt.gz |
| PGS000807 (GRS582_T2Dasn) |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 582 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000807/ScoringFiles/PGS000807.txt.gz |
| PGS000808 (GRS582_T2Dhis) |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 582 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000808/ScoringFiles/PGS000808.txt.gz |
| PGS000832 (T2D-GRS) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 384 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000832/ScoringFiles/PGS000832.txt.gz |
| PGS000848 (T2D_Adiposity) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with adiposity) | type 2 diabetes mellitus | 6 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000848/ScoringFiles/PGS000848.txt.gz |
| PGS000849 (T2D_Impaired_Lipids) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with impaired lipids) | type 2 diabetes mellitus | 3 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000849/ScoringFiles/PGS000849.txt.gz |
| PGS000850 (T2D_Insulin_Action) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with insulin action) | type 2 diabetes mellitus | 16 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000850/ScoringFiles/PGS000850.txt.gz |
| PGS000851 (T2D_Insulin_Action_Secretion) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with insulin action/secretion) | type 2 diabetes mellitus | 37 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000851/ScoringFiles/PGS000851.txt.gz |
| PGS000852 (T2D_Insulin_Secretion_1) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with insulin secretion) | type 2 diabetes mellitus | 8 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000852/ScoringFiles/PGS000852.txt.gz |
| PGS000853 (T2D_Insulin_Secretion_2) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with insulin secretion) | type 2 diabetes mellitus | 21 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000853/ScoringFiles/PGS000853.txt.gz |
| PGS000854 (T2D_BetaCell) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with beta cell function) | type 2 diabetes mellitus | 27 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000854/ScoringFiles/PGS000854.txt.gz |
| PGS000855 (T2D_Lipodystrophy) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with lipodystrophy) | type 2 diabetes mellitus | 18 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000855/ScoringFiles/PGS000855.txt.gz |
| PGS000856 (T2D_LiverLipids) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with liver lipids) | type 2 diabetes mellitus | 3 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000856/ScoringFiles/PGS000856.txt.gz |
| PGS000857 (T2D_Obesity) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with obesity) | type 2 diabetes mellitus | 4 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000857/ScoringFiles/PGS000857.txt.gz |
| PGS000858 (T2D_Proinsulin) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (based on SNPs associated with proinsulin levels) | type 2 diabetes mellitus | 6 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000858/ScoringFiles/PGS000858.txt.gz |
| PGS000864 (T2D-gPRS) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 389,243 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000864/ScoringFiles/PGS000864.txt.gz |
| PGS000868 (T2D_221) |
PGP000214 | Aksit MA et al. J Clin Endocrinol Metab (2020) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 221 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000868/ScoringFiles/PGS000868.txt.gz |
| PGS001294 (GBE_HC649) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Non-insulin-dependent diabetes (time-to-event) | type 2 diabetes mellitus | 3,496 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001294/ScoringFiles/PGS001294.txt.gz |
| PGS001295 (GBE_HC165) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 385 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001295/ScoringFiles/PGS001295.txt.gz |
| PGS001357 (T2D_AnnoPred_PRS) |
PGP000252 | Ye Y et al. Circ Genom Precis Med (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 2,996,761 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001357/ScoringFiles/PGS001357.txt.gz | |
| PGS001781 (T2D_PRSCS) |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,091,673 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001781/ScoringFiles/PGS001781.txt.gz |
| PGS001818 (portability-PLR_250.2) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 30,745 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001818/ScoringFiles/PGS001818.txt.gz |
| PGS002026 (portability-ldpred2_250.2) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 830,783 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002026/ScoringFiles/PGS002026.txt.gz |
| PGS002243 (ldpred_t2d) |
PGP000271 | Mars N et al. Cell Genom (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,431,973 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002243/ScoringFiles/PGS002243.txt.gz | |
| PGS002277 (pPS_Insulin_secretion_1) |
PGP000305 | Siddiqui MK et al. Diabetologia (2022) |
Type 2 diabetes (based on SNPs associated with insulin secretion) | type 2 diabetes mellitus | 8 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002277/ScoringFiles/PGS002277.txt.gz |
| PGS002308 (PRScsx_T2D) |
PGP000331 | Ge T et al. Genome Med (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,259,754 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002308/ScoringFiles/PGS002308.txt.gz |
| PGS002354 (disease_T2D.BOLT-LMM) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,109,311 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002354/ScoringFiles/PGS002354.txt.gz |
| PGS002379 (disease_T2D.BOLT-LMM-BBJ) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 920,930 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002379/ScoringFiles/PGS002379.txt.gz |
| PGS002426 (disease_T2D.P+T.0.0001) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 3,947 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002426/ScoringFiles/PGS002426.txt.gz |
| PGS002475 (disease_T2D.P+T.0.001) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 16,275 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002475/ScoringFiles/PGS002475.txt.gz |
| PGS002524 (disease_T2D.P+T.0.01) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 95,287 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002524/ScoringFiles/PGS002524.txt.gz |
| PGS002573 (disease_T2D.P+T.1e-06) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 673 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002573/ScoringFiles/PGS002573.txt.gz |
| PGS002622 (disease_T2D.P+T.5e-08) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 293 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002622/ScoringFiles/PGS002622.txt.gz |
| PGS002671 (disease_T2D.PolyFun-pred) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 258,382 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002671/ScoringFiles/PGS002671.txt.gz |
| PGS002720 (disease_T2D.SBayesR) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 911,809 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002720/ScoringFiles/PGS002720.txt.gz |
| PGS002733 (GRS17_T2D) |
PGP000342 | Pezzilli S et al. Diabetes Metab (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 17 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002733/ScoringFiles/PGS002733.txt.gz |
| PGS002771 (Type_2_diabetes_prscs) |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,091,608 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002771/ScoringFiles/PGS002771.txt.gz |
| PGS002779 (GTG_T2D_maxCT) |
PGP000365 | Wong CK et al. PLoS One (2022) |
Incident type 2 diabetes | type 2 diabetes mellitus | 46,353 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002779/ScoringFiles/PGS002779.txt.gz | |
| PGS002780 (GTG_T2D_SCT) |
PGP000365 | Wong CK et al. PLoS One (2022) |
Incident type 2 diabetes | type 2 diabetes mellitus | 419,209 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002780/ScoringFiles/PGS002780.txt.gz | |
| PGS003089 (ExPRSweb_T2D_2443_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 488,969 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003089/ScoringFiles/PGS003089.txt.gz | |
| PGS003090 (ExPRSweb_T2D_2443_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,888 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003090/ScoringFiles/PGS003090.txt.gz | |
| PGS003091 (ExPRSweb_T2D_2443_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 2,707 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003091/ScoringFiles/PGS003091.txt.gz | |
| PGS003092 (ExPRSweb_T2D_2443_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 10,304,000 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003092/ScoringFiles/PGS003092.txt.gz | |
| PGS003093 (ExPRSweb_T2D_2443_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,113,832 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003093/ScoringFiles/PGS003093.txt.gz | |
| PGS003094 (ExPRSweb_T2D_29358691-GCST005413_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 266,890 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003094/ScoringFiles/PGS003094.txt.gz | |
| PGS003095 (ExPRSweb_T2D_29358691-GCST005413_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 45 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003095/ScoringFiles/PGS003095.txt.gz | |
| PGS003096 (ExPRSweb_T2D_29358691-GCST005413_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 46 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003096/ScoringFiles/PGS003096.txt.gz | |
| PGS003097 (ExPRSweb_T2D_29358691-GCST005413_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 229 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003097/ScoringFiles/PGS003097.txt.gz | |
| PGS003098 (ExPRSweb_T2D_29358691-GCST005413_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,116,101 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003098/ScoringFiles/PGS003098.txt.gz | |
| PGS003099 (ExPRSweb_T2D_30054458-GCST006867_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 555,512 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003099/ScoringFiles/PGS003099.txt.gz | |
| PGS003100 (ExPRSweb_T2D_30054458-GCST006867_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5,693 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003100/ScoringFiles/PGS003100.txt.gz | |
| PGS003101 (ExPRSweb_T2D_30054458-GCST006867_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5,693 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003101/ScoringFiles/PGS003101.txt.gz | |
| PGS003102 (ExPRSweb_T2D_30054458-GCST006867_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5,052,574 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003102/ScoringFiles/PGS003102.txt.gz | |
| PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 945,820 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003103/ScoringFiles/PGS003103.txt.gz | |
| PGS003104 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_LASSOSUM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 374,510 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003104/ScoringFiles/PGS003104.txt.gz | |
| PGS003105 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PT_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 187 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003105/ScoringFiles/PGS003105.txt.gz | |
| PGS003106 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PLINK_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 187 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003106/ScoringFiles/PGS003106.txt.gz | |
| PGS003107 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_DBSLMM_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 995 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003107/ScoringFiles/PGS003107.txt.gz | |
| PGS003108 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,118,480 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003108/ScoringFiles/PGS003108.txt.gz | |
| PGS003109 (ExPRSweb_T2D_29358691-GCST005413_LASSOSUM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 311,565 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003109/ScoringFiles/PGS003109.txt.gz | |
| PGS003110 (ExPRSweb_T2D_29358691-GCST005413_PT_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 118 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003110/ScoringFiles/PGS003110.txt.gz | |
| PGS003111 (ExPRSweb_T2D_29358691-GCST005413_PLINK_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 143 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003111/ScoringFiles/PGS003111.txt.gz | |
| PGS003112 (ExPRSweb_T2D_29358691-GCST005413_DBSLMM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 222 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003112/ScoringFiles/PGS003112.txt.gz | |
| PGS003113 (ExPRSweb_T2D_29358691-GCST005413_PRSCS_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,117,087 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003113/ScoringFiles/PGS003113.txt.gz | |
| PGS003114 (ExPRSweb_T2D_30054458-GCST006867_LASSOSUM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 555,528 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003114/ScoringFiles/PGS003114.txt.gz | |
| PGS003115 (ExPRSweb_T2D_30054458-GCST006867_PT_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 31,462 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003115/ScoringFiles/PGS003115.txt.gz | |
| PGS003116 (ExPRSweb_T2D_30054458-GCST006867_PLINK_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 31,462 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003116/ScoringFiles/PGS003116.txt.gz | |
| PGS003117 (ExPRSweb_T2D_30054458-GCST006867_DBSLMM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5,052,993 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003117/ScoringFiles/PGS003117.txt.gz | |
| PGS003118 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 945,921 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003118/ScoringFiles/PGS003118.txt.gz | |
| PGS003119 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_LASSOSUM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 407,553 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003119/ScoringFiles/PGS003119.txt.gz | |
| PGS003120 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PT_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 193 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003120/ScoringFiles/PGS003120.txt.gz | |
| PGS003121 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PLINK_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 193 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003121/ScoringFiles/PGS003121.txt.gz | |
| PGS003122 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_DBSLMM_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 264 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003122/ScoringFiles/PGS003122.txt.gz | |
| PGS003123 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PRSCS_UKB_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,119,522 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003123/ScoringFiles/PGS003123.txt.gz | |
| PGS003353 (GRS_T2D) |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 287 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003353/ScoringFiles/PGS003353.txt.gz |
| PGS003402 (PRS_T2D) |
PGP000419 | Lamri A et al. Elife (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,838 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003402/ScoringFiles/PGS003402.txt.gz | |
| PGS003443 (PRScsx_T2D_LAT_EURweights) |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,092,496 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003443/ScoringFiles/PGS003443.txt.gz | |
| PGS003444 (PRScsx_T2D_LAT_EASweights) |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,001,579 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003444/ScoringFiles/PGS003444.txt.gz | |
| PGS003445 (PRScsx_T2D_LAT_LATweights) |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,149,210 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003445/ScoringFiles/PGS003445.txt.gz | |
| PGS003728 (PS_T2D_183-AGEN) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 183 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003728/ScoringFiles/PGS003728.txt.gz |
| PGS003729 (PS_T2D_293-DIAGRAM) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 293 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003729/ScoringFiles/PGS003729.txt.gz |
| PGS003730 (PS_T2D_287-DIAMANTE) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 287 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003730/ScoringFiles/PGS003730.txt.gz |
| PGS003731 (PS_T2D_282-SAS-DIAMANTE) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 282 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003731/ScoringFiles/PGS003731.txt.gz |
| PGS003732 (PS_T2D_287-HIS-DIAMANTE) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 287 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003732/ScoringFiles/PGS003732.txt.gz |
| PGS003733 (PS_T2D_287-EUR-DIAMANTE) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 287 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003733/ScoringFiles/PGS003733.txt.gz |
| PGS003734 (PS_T2D_280-EAS-DIAMANTE) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 280 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003734/ScoringFiles/PGS003734.txt.gz |
| PGS003735 (PS_T2D_276-AFR-DIAMANTE) |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 276 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003735/ScoringFiles/PGS003735.txt.gz |
| PGS003751 (ModelT2D_over45) |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 354 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003751/ScoringFiles/PGS003751.txt.gz | |
| PGS003752 (ModelT2D) |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 333 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003752/ScoringFiles/PGS003752.txt.gz | |
| PGS003867 (T2D_PRScs_ARB) |
PGP000501 | Shim I et al. Nature Communications (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,068,166 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003867/ScoringFiles/PGS003867.txt.gz |
| PGS003982 (dbslmm.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,071,764 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003982/ScoringFiles/PGS003982.txt.gz | |
| PGS003998 (lassosum.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5,548 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003998/ScoringFiles/PGS003998.txt.gz | |
| PGS004014 (lassosum.CV.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 95,649 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004014/ScoringFiles/PGS004014.txt.gz | |
| PGS004024 (ldpred2.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 958,046 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004024/ScoringFiles/PGS004024.txt.gz | |
| PGS004039 (ldpred2.CV.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 958,046 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004039/ScoringFiles/PGS004039.txt.gz | |
| PGS004052 (megaprs.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 800,598 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004052/ScoringFiles/PGS004052.txt.gz | |
| PGS004068 (megaprs.CV.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 800,598 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004068/ScoringFiles/PGS004068.txt.gz | |
| PGS004082 (prscs.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,043,329 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004082/ScoringFiles/PGS004082.txt.gz | |
| PGS004106 (pt_clump.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 35 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004106/ScoringFiles/PGS004106.txt.gz | |
| PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 297 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004122/ScoringFiles/PGS004122.txt.gz | |
| PGS004136 (sbayesr.auto.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 930,497 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004136/ScoringFiles/PGS004136.txt.gz | |
| PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,071,786 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004152/ScoringFiles/PGS004152.txt.gz | |
| PGS004181 (t2d_1) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 10,202 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004181/ScoringFiles/PGS004181.txt.gz |
| PGS004182 (t2d_2) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 10,778 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004182/ScoringFiles/PGS004182.txt.gz |
| PGS004183 (t2d_3) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 8,154 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004183/ScoringFiles/PGS004183.txt.gz |
| PGS004184 (t2d_4) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 9,645 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004184/ScoringFiles/PGS004184.txt.gz |
| PGS004185 (t2d_5) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 3,277 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004185/ScoringFiles/PGS004185.txt.gz |
| PGS004223 (PRS139_T2D) |
PGP000523 | Lin J et al. Sci Total Environ (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 139 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004223/ScoringFiles/PGS004223.txt.gz |
| PGS004225 (PRS46_T2DEastAsia) |
PGP000526 | Liu J et al. Nutrients (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 46 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004225/ScoringFiles/PGS004225.txt.gz |
| PGS004226 (PRS50_T2DEur) |
PGP000526 | Liu J et al. Nutrients (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 50 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004226/ScoringFiles/PGS004226.txt.gz |
| PGS004310 (GenoBoost_type_2_diabetes_0) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 7,000 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004310/ScoringFiles/PGS004310.txt.gz |
| PGS004311 (GenoBoost_type_2_diabetes_1) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 4,000 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004311/ScoringFiles/PGS004311.txt.gz |
| PGS004312 (GenoBoost_type_2_diabetes_2) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 7,000 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004312/ScoringFiles/PGS004312.txt.gz |
| PGS004313 (GenoBoost_type_2_diabetes_3) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 8,000 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004313/ScoringFiles/PGS004313.txt.gz |
| PGS004314 (GenoBoost_type_2_diabetes_4) |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,000 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004314/ScoringFiles/PGS004314.txt.gz |
| PGS004323 (PRS91_T2D) |
PGP000557 | Tan Q et al. J Hazard Mater (2023) |
Type 2 diabetes | type 2 diabetes mellitus | 91 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004323/ScoringFiles/PGS004323.txt.gz |
| PGS004499 (disease.T2D.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004499/ScoringFiles/PGS004499.txt.gz |
| PGS004569 (meta.T2D.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004569/ScoringFiles/PGS004569.txt.gz |
| PGS004602 (PRS424_T2D) |
PGP000580 | Zhuang P et al. Diabetes Care (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 424 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004602/ScoringFiles/PGS004602.txt.gz |
| PGS004615 (PGS_weights_TMM_All_of_1group) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 855,161 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004615/ScoringFiles/PGS004615.txt.gz |
| PGS004616 (PGS_weights_TMM_HighBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 855,161 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004616/ScoringFiles/PGS004616.txt.gz |
| PGS004617 (PGS_weights_TMM_LowBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 855,161 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004617/ScoringFiles/PGS004617.txt.gz |
| PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 728,824 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004618/ScoringFiles/PGS004618.txt.gz |
| PGS004619 (PGS_weights_BBJ2nd_HighBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 728,824 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004619/ScoringFiles/PGS004619.txt.gz |
| PGS004620 (PGS_weights_BBJ2nd_LowBMI_of_2groups) |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 728,824 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004620/ScoringFiles/PGS004620.txt.gz |
| PGS004837 (t2d_PRSmix_eur) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 3,306,136 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004837/ScoringFiles/PGS004837.txt.gz |
| PGS004838 (t2d_PRSmix_sas) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,586,458 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004838/ScoringFiles/PGS004838.txt.gz |
| PGS004839 (t2d_PRSmixPlus_eur) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 4,594,694 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004839/ScoringFiles/PGS004839.txt.gz |
| PGS004840 (t2d_PRSmixPlus_sas) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,586,458 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004840/ScoringFiles/PGS004840.txt.gz |
| PGS004859 (T2D_PRS_CS) |
PGP000605 | Deutsch AJ et al. Diabetes Care (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,108,235 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004859/ScoringFiles/PGS004859.txt.gz |
| PGS004868 (T2DPGS) |
PGP000617 | Yun JS et al. Cardiovasc Diabetol (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,580,804 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004868/ScoringFiles/PGS004868.txt.gz |
| PGS004870 (INTERVENE_MegaPRS_T2D) |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 930,506 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004870/ScoringFiles/PGS004870.txt.gz | |
| PGS004887 (T2D_gePGS) |
PGP000619 | Mandla R et al. Genome Med (2024) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,117,628 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004887/ScoringFiles/PGS004887.txt.gz | |
| PGS004923 (T2D_metaGRS) |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,349,896 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004923/ScoringFiles/PGS004923.txt.gz | |
| PGS005021 (Phe_250_2_ldpred_AFRss_afrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,286,612 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005021/ScoringFiles/PGS005021.txt.gz |
| PGS005022 (Phe_250_2_ldpred_EURss_eurld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,286,612 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005022/ScoringFiles/PGS005022.txt.gz |
| PGS005023 (Phe_250_2_ldpred_HISss_amrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,286,612 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005023/ScoringFiles/PGS005023.txt.gz |
| PGS005024 (Phe_250_2_ldpred_METAss_afrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,286,612 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005024/ScoringFiles/PGS005024.txt.gz |
| PGS005025 (Phe_250_2_ldpred_METAss_amrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,286,612 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005025/ScoringFiles/PGS005025.txt.gz |
| PGS005026 (Phe_250_2_ldpred_METAss_eurld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,286,612 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005026/ScoringFiles/PGS005026.txt.gz |
| PGS005027 (Phe_250_2_prscs_AFRss_afrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,273,897 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005027/ScoringFiles/PGS005027.txt.gz |
| PGS005028 (Phe_250_2_prscs_EURss_eurld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,273,897 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005028/ScoringFiles/PGS005028.txt.gz |
| PGS005029 (Phe_250_2_prscs_HISss_amrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,273,897 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005029/ScoringFiles/PGS005029.txt.gz |
| PGS005030 (Phe_250_2_prscs_METAss_afrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,273,897 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005030/ScoringFiles/PGS005030.txt.gz |
| PGS005031 (Phe_250_2_prscs_METAss_amrld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,273,897 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005031/ScoringFiles/PGS005031.txt.gz |
| PGS005032 (Phe_250_2_prscs_METAss_eurld) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,273,897 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005032/ScoringFiles/PGS005032.txt.gz |
| PGS005033 (Phe_250_2_prscsx_METAweight) |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Type 2 diabetes (T2D) (PheCode 250.2) | type 2 diabetes mellitus | 1,277,826 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005033/ScoringFiles/PGS005033.txt.gz |
| PGS005108 (PRSdiabetes) |
PGP000697 | Takase M et al. J Atheroscler Thromb (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 42,845 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005108/ScoringFiles/PGS005108.txt.gz | |
| PGS005110 (PGS_T2D_gw) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,114,950 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005110/ScoringFiles/PGS005110.txt.gz |
| PGS005111 (PGS_T2D_gwas) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 150 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005111/ScoringFiles/PGS005111.txt.gz |
| PGS005115 (PGS_T2D_beta_cell) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 30 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005115/ScoringFiles/PGS005115.txt.gz |
| PGS005116 (PGS_T2D_lipodystrophy) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 20 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005116/ScoringFiles/PGS005116.txt.gz |
| PGS005117 (PGS_T2D_liver_lipid) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005117/ScoringFiles/PGS005117.txt.gz |
| PGS005118 (PGS_T2D_obesity) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 5 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005118/ScoringFiles/PGS005118.txt.gz |
| PGS005119 (PGS_T2D_proinsulin) |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 7 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005119/ScoringFiles/PGS005119.txt.gz |
| PGS005147 (Type 2 diabetes (PRS-CS; EAS)) |
PGP000704 | Jung HU et al. Commun Biol (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 908,465 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005147/ScoringFiles/PGS005147.txt.gz |
| PGS005157 (Type 2 diabetes (CT-SLEB; EAS+EUR)) |
PGP000704 | Jung HU et al. Commun Biol (2025) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 502,115 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005157/ScoringFiles/PGS005157.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000040 | PGS000020 (dGRS1000) |
PSS000025| European Ancestry| 6,280 individuals |
PGP000010 | Läll K et al. Genet Med (2016) |
Reported Trait: Incident type 2 diabetes | HR: 1.48 [1.32, 1.66] | C-index: 0.79 [0.771, 0.812] | — | BMI category, smoking level, waist-to-hip ratio, waist circumference, physical activity level, history of high blood glucose, fruit and vegetable consumption, and sex. | Cox age-as-time-scale |
| PPM000062 | PGS000031 (GRSt) |
PSS000044| European Ancestry| 3,471 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.06 [1.04, 1.08] | C-index: 0.906 [0.892, 0.92] | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model" |
| PPM000063 | PGS000031 (GRSt) |
PSS000043| European Ancestry| 1,650 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.06 [1.02, 1.1] | C-index: 0.853 [0.81, 0.896] | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model" |
| PPM000064 | PGS000031 (GRSt) |
PSS000042| African Ancestry| 820 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.05 [1.0, 1.09] | C-index: 0.771 [0.727, 0.814] | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model", SNPs were not weighted by their effect size as the betas were measure in Europeans |
| PPM000065 | PGS000032 (GRSB) |
PSS000044| European Ancestry| 3,471 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.1 [1.06, 1.14] | — | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model" |
| PPM000066 | PGS000032 (GRSB) |
PSS000043| European Ancestry| 1,650 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.09 [1.02, 1.17] | — | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model" |
| PPM000067 | PGS000032 (GRSB) |
PSS000042| African Ancestry| 820 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.06 [0.99, 1.15] | — | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model", SNPs were not weighted by their effect size as the betas were measure in Europeans |
| PPM000068 | PGS000033 (GRSIR) |
PSS000044| European Ancestry| 3,471 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 0.98 [0.93, 1.04] | — | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model" |
| PPM000069 | PGS000033 (GRSIR) |
PSS000043| European Ancestry| 1,650 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.01 [0.91, 1.12] | — | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model" |
| PPM000070 | PGS000033 (GRSIR) |
PSS000042| African Ancestry| 820 individuals |
PGP000020 | Vassy JL et al. Diabetes (2014) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.06 [0.99, 1.15] | — | — | age, sex, family history (parents), body mass index, systolic blood pressure, fasting glucose, log-HDL cholesterol, log-triglyceride levels | Results from the "Clinical model", SNPs were not weighted by their effect size as the betas were measure in Europeans |
| PPM000080 | PGS000036 (gePS_T2D) |
PSS000054| European Ancestry| 324,870 individuals |
PGP000024 | Udler MS et al. Endocr Rev (2019) |Ext. |
Reported Trait: Type 2 diabetes | — | AUROC: 0.66 | — | genotyping array, first 6 PCs of ancestry | — |
| PPM000081 | PGS000036 (gePS_T2D) |
PSS000054| European Ancestry| 324,870 individuals |
PGP000024 | Udler MS et al. Endocr Rev (2019) |Ext. |
Reported Trait: Type 2 diabetes | — | AUROC: 0.73 | — | age, sex, genotyping array, first 6 PCs of ancestry | — |
| PPM001667 | PGS000729 (T2D_PGS) |
PSS000869| European Ancestry| 3,087 individuals |
PGP000137 | Ritchie SC et al. Nat Metab (2021) |
Reported Trait: Incident type 2 diabetes | HR: 2.0 [1.36, 2.94] | — | — | age, sex, 10 genetic PCs | — |
| PPM000404 | PGS000125 (Qi_T2D_2017) |
PSS000232| Hispanic or Latin American Ancestry| 7,746 individuals |
PGP000062 | Qi Q et al. Diabetes (2017) |
Reported Trait: Type 2 Diabetes | — | — | OR (Odds Ratio, per risk allele): 1.07 [1.06, 1.08] | center, age, sex, 5 PCs of ancestry | Covariance matrices corresponding to genetic relatedness (kinship), household, and census block group were included as random effects in the mixed model analysis |
| PPM000023 | PGS000014 (GPS_T2D) |
PSS000017| European Ancestry| 288,978 individuals |
PGP000006 | Khera AV et al. Nat Genet (2018) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.73 [0.72, 0.73] | Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.029 | age; sex; Ancestry PC 1-4; genotyping chip | — |
| PPM000897 | PGS000330 (PRS_T2D) |
PSS000441| European Ancestry| 21,030 individuals |
PGP000100 | Mars N et al. Nat Med (2020) |
Reported Trait: Incident type 2 diabetes | — | C-index: 0.845 | — | age, sex, BMI, history of stroke or CHD, parental history of diabetes, SBP, DBP, HDL, triglycerides, FINRISK cohort, genotyping array/batch, 10 ancestry PCs | 10-year risk |
| PPM000892 | PGS000330 (PRS_T2D) |
PSS000441| European Ancestry| 21,030 individuals |
PGP000100 | Mars N et al. Nat Med (2020) |
Reported Trait: Incident type 2 diabetes | HR: 1.7 [1.63, 1.78] | C-index: 0.763 | — | age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs | 10-year risk |
| PPM002240 | PGS000832 (T2D-GRS) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.24 [1.16, 1.34] | — | — | PC1-10 | — |
| PPM002242 | PGS000832 (T2D-GRS) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.77 [1.67, 1.88] | — | — | PC1-10 | — |
| PPM000887 | PGS000330 (PRS_T2D) |
PSS000448| European Ancestry| 135,300 individuals |
PGP000100 | Mars N et al. Nat Med (2020) |
Reported Trait: Type 2 diabetes (incident and prevalent cases) | HR: 1.74 [1.72, 1.77] | — | — | genotyping array/batch, 10 ancestry PCs, stratified by sex | — |
| PPM001604 | PGS000712 (T2D_HbA1c_39) |
PSS000755| European Ancestry| 87,413 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.68713 | — | Age, sex, PCs(1-10) | — |
| PPM001605 | PGS000713 (T2D) |
PSS000754| European Ancestry| 87,413 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.688 | — | Age, sex, PCs(1-10) | — |
| PPM001615 | PGS000713 (T2D) |
PSS000756| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Type 2 diabetes | HR: 1.49 [1.47, 1.51] | C-index: 0.669 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM002116 | PGS000806 (GRS582_T2Dafr) |
PSS001044| African Ancestry| 15,609 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6656 [0.6569, 0.6743] | Odds Ratio (OR, top 10% vs middle 20%): 1.53 [1.36, 1.73] | Age, sex, body mass index, study, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002117 | PGS000804 (GRS582_T2Dmulti) |
PSS001044| African Ancestry| 15,609 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.568 [0.5588, 0.5772] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002118 | PGS000806 (GRS582_T2Dafr) |
PSS001044| African Ancestry| 15,609 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.5592 [0.5499, 0.5684] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002119 | PGS000804 (GRS582_T2Dmulti) |
PSS001046| European Ancestry| 423,729 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.825 [0.8222, 0.8279] | Odds Ratio (OR, top 10% vs middle 20%): 2.94 [2.8, 3.08] | Age, sex, body mass index, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002120 | PGS000805 (GRS582_T2Deur) |
PSS001046| European Ancestry| 423,729 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.8253 [0.8224, 0.8281] | Odds Ratio (OR, top 10% vs middle 20%): 2.95 [2.81, 3.1] | Age, sex, body mass index, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002121 | PGS000804 (GRS582_T2Dmulti) |
PSS001046| European Ancestry| 423,729 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6586 [0.6547, 0.6624] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002122 | PGS000805 (GRS582_T2Deur) |
PSS001046| European Ancestry| 423,729 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6593 [0.6555, 0.6632] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002123 | PGS000804 (GRS582_T2Dmulti) |
PSS001047| Hispanic or Latin American Ancestry| 20,486 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.7293 [0.721, 0.7376] | Odds Ratio (OR, top 10% vs middle 20%): 2.39 [2.1, 2.73] | Age, sex, body mass index, study, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002124 | PGS000808 (GRS582_T2Dhis) |
PSS001047| Hispanic or Latin American Ancestry| 20,486 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.7202 [0.7118, 0.7286] | Odds Ratio (OR, top 10% vs middle 20%): 2.04 [1.79, 2.32] | Age, sex, body mass index, study, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002125 | PGS000804 (GRS582_T2Dmulti) |
PSS001047| Hispanic or Latin American Ancestry| 20,486 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6249 [0.6156, 0.6342] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002126 | PGS000808 (GRS582_T2Dhis) |
PSS001047| Hispanic or Latin American Ancestry| 20,486 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6098 [0.6004, 0.6192] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002127 | PGS000804 (GRS582_T2Dmulti) |
PSS001045| Additional Asian Ancestries| 4,576 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.8411 [0.8298, 0.8523] | Odds Ratio (OR, top 10% vs middle 20%): 3.08 [2.4, 3.95] | Age, sex, body mass index, study, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002128 | PGS000807 (GRS582_T2Dasn) |
PSS001045| Additional Asian Ancestries| 4,576 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.8388 [0.8274, 0.8502] | Odds Ratio (OR, top 10% vs middle 20%): 2.84 [2.21, 3.65] | Age, sex, body mass index, study, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002129 | PGS000804 (GRS582_T2Dmulti) |
PSS001045| Additional Asian Ancestries| 4,576 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6263 [0.6101, 0.6425] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002130 | PGS000807 (GRS582_T2Dasn) |
PSS001045| Additional Asian Ancestries| 4,576 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6161 [0.5998, 0.6324] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002131 | PGS000804 (GRS582_T2Dmulti) |
PSS001048| Additional Diverse Ancestries| 3,551 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.7989 [0.7845, 0.8133] | Odds Ratio (OR, top 10% vs middle 20%): 2.02 [1.54, 2.65] | Age, sex, body mass index, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002133 | PGS000804 (GRS582_T2Dmulti) |
PSS001048| Additional Diverse Ancestries| 3,551 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6214 [0.603, 0.6399] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM002134 | PGS000805 (GRS582_T2Deur) |
PSS001048| Additional Diverse Ancestries| 3,551 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6213 [0.6029, 0.6397] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. Population-specific weights were not available for indiviuals of an Oceanian ancestry (Native Hawaiian). Therefore, GRS582_T2Deur was utilised to predict type 2 diabetes in individuals of an Oceanian ancestry. |
| PPM002135 | PGS000807 (GRS582_T2Dasn) |
PSS001048| Additional Diverse Ancestries| 3,551 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.7909 [0.7763, 0.8056] | Odds Ratio (OR, top 10% vs middle 20%): 1.62 [1.23, 2.14] | Age, sex, body mass index, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. Population-specific weights were not available for indiviuals of an Oceanian ancestry (Native Hawaiian). Therefore, GRS582_T2Dasn was utilised to predict type 2 diabetes in individuals of an Oceanian ancestry. |
| PPM002136 | PGS000807 (GRS582_T2Dasn) |
PSS001048| Additional Diverse Ancestries| 3,551 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.5768 [0.558, 0.5956] | — | — | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. Population-specific weights were not available for indiviuals of an Oceanian ancestry (Native Hawaiian). Therefore, GRS582_T2Dasn was utilised to predict type 2 diabetes in individuals of an Oceanian ancestry. |
| PPM002115 | PGS000804 (GRS582_T2Dmulti) |
PSS001044| African Ancestry| 15,609 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6701 [0.6615, 0.6788] | Odds Ratio (OR, top 10% vs middle 20%): 1.57 [1.39, 1.77] | Age, sex, body mass index, study, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. |
| PPM012948 | PGS002277 (pPS_Insulin_secretion_1) |
PSS009629| South Asian Ancestry| 5,806 individuals |
PGP000305 | Siddiqui MK et al. Diabetologia (2022) |
Reported Trait: Age at diagnosis (normal BMI) | β: 37.31 (16.7) | — | R²: 0.012 | — | — |
| PPM002132 | PGS000805 (GRS582_T2Deur) |
PSS001048| Additional Diverse Ancestries| 3,551 individuals |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.7985 [0.7842, 0.8129] | Odds Ratio (OR, top 10% vs middle 20%): 2.13 [1.63, 2.79] | Age, sex, body mass index, PCs(1-10) | Only 579 SNPs from the 582 SNP GRS, were utilised with imputation INFO scores > 0.45. 3 SNPs were not included as they were not present in the cohorts. Population-specific weights were not available for indiviuals of an Oceanian ancestry (Native Hawaiian). Therefore, GRS582_T2Deur was utilised to predict type 2 diabetes in individuals of an Oceanian ancestry. |
| PPM002323 | PGS000848 (T2D_Adiposity) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.11 [1.0, 1.23] | — | — | PC1-10 | — |
| PPM002324 | PGS000848 (T2D_Adiposity) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.1 [1.02, 1.18] | — | — | PC1-10 | — |
| PPM002325 | PGS000848 (T2D_Adiposity) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.11 [1.03, 1.19] | — | — | PC1-10 | — |
| PPM002326 | PGS000848 (T2D_Adiposity) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.2 [1.12, 1.28] | — | — | PC1-10 | — |
| PPM002327 | PGS000848 (T2D_Adiposity) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.06 [1.0, 1.12] | — | — | PC1-10 | — |
| PPM002329 | PGS000849 (T2D_Impaired_Lipids) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.07 [1.0, 1.15] | — | — | PC1-10 | — |
| PPM002330 | PGS000849 (T2D_Impaired_Lipids) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.09 [1.01, 1.17] | — | — | PC1-10 | — |
| PPM002331 | PGS000849 (T2D_Impaired_Lipids) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.0 [0.93, 1.07] | — | — | PC1-10 | — |
| PPM002332 | PGS000849 (T2D_Impaired_Lipids) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.06 [1.0, 1.12] | — | — | PC1-10 | — |
| PPM002333 | PGS000850 (T2D_Insulin_Action) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.08 [0.98, 1.2] | — | — | PC1-10 | — |
| PPM002334 | PGS000850 (T2D_Insulin_Action) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.17 [1.09, 1.25] | — | — | PC1-10 | — |
| PPM002335 | PGS000850 (T2D_Insulin_Action) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.17 [1.09, 1.26] | — | — | PC1-10 | — |
| PPM002337 | PGS000850 (T2D_Insulin_Action) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.16 [1.1, 1.23] | — | — | PC1-10 | — |
| PPM002338 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.24 [1.12, 1.37] | — | — | PC1-10 | — |
| PPM002339 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.23 [1.15, 1.32] | — | — | PC1-10 | — |
| PPM002340 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.04 [0.97, 1.11] | — | — | PC1-10 | — |
| PPM002341 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.19 [1.12, 1.28] | — | — | PC1-10 | — |
| PPM002342 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.19 [1.13, 1.26] | — | — | PC1-10 | — |
| PPM002343 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.01 [0.91, 1.12] | — | — | PC1-10 | — |
| PPM002344 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.31 [1.22, 1.41] | — | — | PC1-10 | — |
| PPM002345 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.04 [0.97, 1.12] | — | — | PC1-10 | — |
| PPM002347 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.29 [1.22, 1.37] | — | — | PC1-10 | — |
| PPM002348 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 0.99 [0.9, 1.1] | — | — | PC1-10 | — |
| PPM002349 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.26 [1.18, 1.36] | — | — | PC1-10 | — |
| PPM002350 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.02 [0.95, 1.09] | — | — | PC1-10 | — |
| PPM002351 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.18 [1.11, 1.27] | — | — | PC1-10 | — |
| PPM002352 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.23 [1.17, 1.3] | — | — | PC1-10 | — |
| PPM002353 | PGS000854 (T2D_BetaCell) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.0 [0.91, 1.11] | — | — | PC1-10 | — |
| PPM002354 | PGS000854 (T2D_BetaCell) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.32 [1.23, 1.42] | — | — | PC1-10 | — |
| PPM002355 | PGS000854 (T2D_BetaCell) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.01 [0.94, 1.08] | — | — | PC1-10 | — |
| PPM002357 | PGS000854 (T2D_BetaCell) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.27 [1.2, 1.34] | — | — | PC1-10 | — |
| PPM002358 | PGS000855 (T2D_Lipodystrophy) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.12 [1.01, 1.25] | — | — | PC1-10 | — |
| PPM002359 | PGS000855 (T2D_Lipodystrophy) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.23 [1.15, 1.33] | — | — | PC1-10 | — |
| PPM002360 | PGS000855 (T2D_Lipodystrophy) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.15 [1.07, 1.24] | — | — | PC1-10 | — |
| PPM002361 | PGS000855 (T2D_Lipodystrophy) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.14 [1.06, 1.22] | — | — | PC1-10 | — |
| PPM002362 | PGS000855 (T2D_Lipodystrophy) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.18 [1.11, 1.24] | — | — | PC1-10 | — |
| PPM002363 | PGS000856 (T2D_LiverLipids) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.35 [1.22, 1.51] | — | — | PC1-10 | — |
| PPM002364 | PGS000856 (T2D_LiverLipids) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.01 [0.94, 1.08] | — | — | PC1-10 | — |
| PPM002366 | PGS000856 (T2D_LiverLipids) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.02 [0.95, 1.09] | — | — | PC1-10 | — |
| PPM002367 | PGS000856 (T2D_LiverLipids) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 0.95 [0.9, 1.01] | — | — | PC1-10 | — |
| PPM002368 | PGS000857 (T2D_Obesity) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.07 [0.97, 1.19] | — | — | PC1-10 | — |
| PPM002369 | PGS000857 (T2D_Obesity) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.08 [1.01, 1.16] | — | — | PC1-10 | — |
| PPM002370 | PGS000857 (T2D_Obesity) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.13 [1.05, 1.22] | — | — | PC1-10 | — |
| PPM002371 | PGS000857 (T2D_Obesity) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.19 [1.11, 1.27] | — | — | PC1-10 | — |
| PPM002372 | PGS000857 (T2D_Obesity) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.04 [0.99, 1.1] | — | — | PC1-10 | — |
| PPM002373 | PGS000858 (T2D_Proinsulin) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 0.94 [0.85, 1.04] | — | — | PC1-10 | — |
| PPM002374 | PGS000858 (T2D_Proinsulin) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.14 [1.06, 1.22] | — | — | PC1-10 | — |
| PPM002376 | PGS000858 (T2D_Proinsulin) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.06 [0.99, 1.13] | — | — | PC1-10 | — |
| PPM002377 | PGS000858 (T2D_Proinsulin) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.1 [1.04, 1.16] | — | — | PC1-10 | — |
| PPM002413 | PGS000868 (T2D_221) |
PSS001092| Ancestry Not Reported| 5,740 individuals |
PGP000214 | Aksit MA et al. J Clin Endocrinol Metab (2020) |
Reported Trait: Cystic-fibrosis related diabetes | HR: 1.285 | — | — | PCs(1-4), site of recruitment | — |
| PPM002415 | PGS000032 (GRSB) |
PSS001092| Ancestry Not Reported| 5,740 individuals |
PGP000214 | Aksit MA et al. J Clin Endocrinol Metab (2020) |Ext. |
Reported Trait: Cystic-fibrosis related diabetes onset | HR: 1.192 | — | — | PCs(1-4), site of recruitment | — |
| PPM002403 | PGS000864 (T2D-gPRS) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.42 [1.28, 1.58] | — | — | PC1-10 | — |
| PPM002404 | PGS000864 (T2D-gPRS) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.93 [1.79, 2.09] | — | — | PC1-10 | — |
| PPM002406 | PGS000864 (T2D-gPRS) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 2.12 [1.96, 2.29] | — | — | PC1-10 | — |
| PPM002407 | PGS000864 (T2D-gPRS) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.59 [1.5, 1.69] | — | — | PC1-10 | — |
| PPM017036 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: Fasting glucose x BMI interaction | β: 89.0 | — | — | age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 | — |
| PPM017037 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: Fasting glucose x Born in South Asia interaction | β: 84.0 | — | — | age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 | — |
| PPM017038 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: Fasting glucose x Low diet quality interaction (only in START cohort) | β: 0.141 [0.053, 0.228] | — | — | age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 | — |
| PPM002477 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes | — | C-index: 0.709 [0.696, 0.722] | Hazard ratio (HR, top 10% vs. remaining 90%): 2.0 [1.73, 2.31] | Sex, age, principal components, assessment center | — |
| PPM002478 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in males | — | C-index: 0.68 [0.663, 0.697] | — | Age, principal components and assessment center | — |
| PPM002479 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in females | — | C-index: 0.705 [0.682, 0.728] | — | Age, principal components and assessment center | — |
| PPM002480 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes | — | C-index: 0.776 [0.764, 0.788] | — | Sex, age, principal components, assessment center, polyexposure score | — |
| PPM002481 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes | — | C-index: 0.844 [0.834, 0.854] | — | Sex, age, principal components, assessment center, clinical risk score | — |
| PPM002482 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes | — | C-index: 0.855 [0.845, 0.865] | — | Sex, age, principal components, assessment center, polyexposure socre, clinical risk score | — |
| PPM002483 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in females | — | C-index: 0.786 [0.765, 0.807] | — | Age, principal components, assessment center, polyexposure score | — |
| PPM002485 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in females | — | C-index: 0.859 [0.842, 0.876] | — | Sex, age, principal components, assessment center, clinical risk score | — |
| PPM002486 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in males | — | C-index: 0.749 [0.734, 0.764] | — | Age, principal components, assessment center, polyexposure score | — |
| PPM002487 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in males | — | C-index: 0.821 [0.808, 0.834] | — | Age, principal components, assessment center, polyexposure socre, clinical risk score | — |
| PPM002488 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in males | — | C-index: 0.834 [0.821, 0.847] | — | Sex, age, principal components, assessment center, clinical risk score | — |
| PPM017039 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: AUC glucose x BMI interaction | β: 77.0 | — | — | age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 | — |
| PPM017040 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: GDM (IADPSG criteria) x BMI interaction | OR: 0.0 | — | — | age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 | — |
| PPM002484 | PGS000014 (GPS_T2D) |
PSS001117| European Ancestry| 68,229 individuals |
PGP000218 | He Y et al. Diabetes Care (2021) |Ext. |
Reported Trait: Incident type II diabetes in females | — | C-index: 0.869 [0.853, 0.885] | — | Age, principal components, assessment center, polyexposure socre, clinical risk score | — |
| PPM002239 | PGS000832 (T2D-GRS) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.96 [1.81, 2.12] | — | — | PC1-10 | — |
| PPM002238 | PGS000832 (T2D-GRS) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.28 [1.16, 1.42] | — | — | PC1-10 | — |
| PPM002241 | PGS000832 (T2D-GRS) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.73 [1.61, 1.86] | — | — | PC1-10 | — |
| PPM002328 | PGS000849 (T2D_Impaired_Lipids) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.08 [0.97, 1.2] | — | — | PC1-10 | — |
| PPM002336 | PGS000850 (T2D_Insulin_Action) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.14 [1.07, 1.22] | — | — | PC1-10 | — |
| PPM002346 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.26 [1.18, 1.35] | — | — | PC1-10 | — |
| PPM002356 | PGS000854 (T2D_BetaCell) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.21 [1.13, 1.3] | — | — | PC1-10 | — |
| PPM005189 | PGS001357 (T2D_AnnoPred_PRS) |
PSS003606| European Ancestry| 178,138 individuals |
PGP000252 | Ye Y et al. Circ Genom Precis Med (2021) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.6446 | — | Age, sex, PCs(1-10) | — |
| PPM002365 | PGS000856 (T2D_LiverLipids) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 0.97 [0.91, 1.05] | — | — | PC1-10 | — |
| PPM002375 | PGS000858 (T2D_Proinsulin) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 0.93 [0.87, 1.0] | — | — | PC1-10 | — |
| PPM002405 | PGS000864 (T2D-gPRS) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.56 [1.45, 1.69] | — | — | PC1-10 | — |
| PPM009277 | PGS001781 (T2D_PRSCS) |
PSS007684| European Ancestry| 309,154 individuals |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Reported Trait: Type 2 diabetes (incident and prevalent) | OR: 1.59 [1.57, 1.61] | AUROC: 0.758 [0.756, 0.761] | — | year of birth, sex, ten first principal components of Finnish ancestry, batch, genotyping array | — |
| PPM009281 | PGS001781 (T2D_PRSCS) |
PSS007685| European Ancestry| 279,879 individuals |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Reported Trait: Incident type 2 diabetes | OR: 1.52 [1.49, 1.55] | AUROC: 0.852 [0.849, 0.855] | — | year of birth, sex, ten first principal components of Finnish ancestry, batch, genotyping array | — |
| PPM008968 | PGS001294 (GBE_HC649) |
PSS004575| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE non-insulin-dependent diabetes mellitus | — | AUROC: 0.70052 [0.68094, 0.7201] | R²: 0.10493 Incremental AUROC (full-covars): 0.00213 PGS R2 (no covariates): 0.00615 PGS AUROC (no covariates): 0.54526 [0.52378, 0.56673] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008969 | PGS001294 (GBE_HC649) |
PSS004576| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE non-insulin-dependent diabetes mellitus | — | AUROC: 0.75536 [0.71488, 0.79584] | R²: 0.1242 Incremental AUROC (full-covars): 0.01544 PGS R2 (no covariates): 0.01604 PGS AUROC (no covariates): 0.5808 [0.52621, 0.63538] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008970 | PGS001294 (GBE_HC649) |
PSS004577| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE non-insulin-dependent diabetes mellitus | — | AUROC: 0.72888 [0.71557, 0.7422] | R²: 0.10344 Incremental AUROC (full-covars): 0.03534 PGS R2 (no covariates): 0.03413 PGS AUROC (no covariates): 0.63582 [0.62119, 0.65045] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008971 | PGS001294 (GBE_HC649) |
PSS004578| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE non-insulin-dependent diabetes mellitus | — | AUROC: 0.68707 [0.67293, 0.70121] | R²: 0.11343 Incremental AUROC (full-covars): 0.01724 PGS R2 (no covariates): 0.02384 PGS AUROC (no covariates): 0.58532 [0.56986, 0.60078] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008972 | PGS001294 (GBE_HC649) |
PSS004579| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE non-insulin-dependent diabetes mellitus | — | AUROC: 0.71038 [0.70256, 0.71821] | R²: 0.08854 Incremental AUROC (full-covars): 0.04133 PGS R2 (no covariates): 0.03493 PGS AUROC (no covariates): 0.63323 [0.62453, 0.64194] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008973 | PGS001295 (GBE_HC165) |
PSS004312| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.68145 [0.62426, 0.73864] | R²: 0.04466 Incremental AUROC (full-covars): 0.00427 PGS R2 (no covariates): 0.00162 PGS AUROC (no covariates): 0.5359 [0.47698, 0.59482] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008974 | PGS001295 (GBE_HC165) |
PSS004313| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.83509 [0.71831, 0.95186] | R²: 0.20575 Incremental AUROC (full-covars): -0.00085 PGS R2 (no covariates): 0.00265 PGS AUROC (no covariates): 0.56328 [0.47919, 0.64736] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008975 | PGS001295 (GBE_HC165) |
PSS004314| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.69318 [0.65625, 0.73011] | R²: 0.04603 Incremental AUROC (full-covars): 0.0115 PGS R2 (no covariates): 0.00675 PGS AUROC (no covariates): 0.58258 [0.54116, 0.62401] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008976 | PGS001295 (GBE_HC165) |
PSS004315| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.65806 [0.61856, 0.69756] | R²: 0.0392 Incremental AUROC (full-covars): 0.01243 PGS R2 (no covariates): 0.00618 PGS AUROC (no covariates): 0.5613 [0.5184, 0.60421] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008977 | PGS001295 (GBE_HC165) |
PSS004316| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.68247 [0.66155, 0.70338] | R²: 0.03772 Incremental AUROC (full-covars): 0.01405 PGS R2 (no covariates): 0.00633 PGS AUROC (no covariates): 0.57592 [0.55208, 0.59975] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009444 | PGS001818 (portability-PLR_250.2) |
PSS009288| European Ancestry| 19,931 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1246 [0.1109, 0.1382] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009445 | PGS001818 (portability-PLR_250.2) |
PSS009062| European Ancestry| 4,121 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0862 [0.0557, 0.1165] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009447 | PGS001818 (portability-PLR_250.2) |
PSS008392| Greater Middle Eastern Ancestry| 1,197 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1735 [0.1176, 0.2284] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009448 | PGS001818 (portability-PLR_250.2) |
PSS008170| South Asian Ancestry| 6,312 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1556 [0.1314, 0.1796] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009449 | PGS001818 (portability-PLR_250.2) |
PSS007957| East Asian Ancestry| 1,808 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0665 [0.0202, 0.1125] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009450 | PGS001818 (portability-PLR_250.2) |
PSS007738| African Ancestry| 2,476 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0956 [0.0562, 0.1346] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009451 | PGS001818 (portability-PLR_250.2) |
PSS008841| African Ancestry| 3,896 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0522 [0.0208, 0.0836] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011082 | PGS002026 (portability-ldpred2_250.2) |
PSS009288| European Ancestry| 19,931 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1304 [0.1168, 0.1441] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011083 | PGS002026 (portability-ldpred2_250.2) |
PSS009062| European Ancestry| 4,121 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0862 [0.0558, 0.1165] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011084 | PGS002026 (portability-ldpred2_250.2) |
PSS008616| European Ancestry| 6,646 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1134 [0.0896, 0.1371] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011085 | PGS002026 (portability-ldpred2_250.2) |
PSS008392| Greater Middle Eastern Ancestry| 1,197 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1764 [0.1205, 0.2312] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011087 | PGS002026 (portability-ldpred2_250.2) |
PSS007957| East Asian Ancestry| 1,808 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0786 [0.0324, 0.1246] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011088 | PGS002026 (portability-ldpred2_250.2) |
PSS007738| African Ancestry| 2,476 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.1001 [0.0607, 0.1391] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011089 | PGS002026 (portability-ldpred2_250.2) |
PSS008841| African Ancestry| 3,896 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.0806 [0.0493, 0.1118] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009446 | PGS001818 (portability-PLR_250.2) |
PSS008616| European Ancestry| 6,646 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.108 [0.0842, 0.1317] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM014802 | PGS000036 (gePS_T2D) |
PSS009895| European Ancestry| 1,168 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.661 [0.606, 0.716] | — | — | — |
| PPM011086 | PGS002026 (portability-ldpred2_250.2) |
PSS008170| South Asian Ancestry| 6,312 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Partial Correlation (partial-r): 0.158 [0.1338, 0.182] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012733 | PGS002243 (ldpred_t2d) |
PSS009522| European Ancestry| 258,402 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.58 [1.56, 1.6] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012737 | PGS002243 (ldpred_t2d) |
PSS009518| European Ancestry| 110,597 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.51, 1.59] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012741 | PGS002243 (ldpred_t2d) |
PSS009514| East Asian Ancestry| 178,726 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.37 [1.36, 1.39] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012745 | PGS002243 (ldpred_t2d) |
PSS009526| European Ancestry| 69,422 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.64 [1.6, 1.69] | — | — | birth year, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012749 | PGS002243 (ldpred_t2d) |
PSS009534| European Ancestry| 25,696 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.41, 1.51] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012753 | PGS002243 (ldpred_t2d) |
PSS009530| African Ancestry| 1,535 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.24 [1.09, 1.42] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012757 | PGS002243 (ldpred_t2d) |
PSS009542| European Ancestry| 343,676 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.78 [1.75, 1.81] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012762 | PGS002243 (ldpred_t2d) |
PSS009538| African Ancestry| 7,618 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.32, 1.62] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM012767 | PGS002243 (ldpred_t2d) |
PSS009546| South Asian Ancestry| 7,628 individuals |
PGP000271 | Mars N et al. Cell Genom (2022) |
Reported Trait: Type 2 diabetes | OR: 1.66 [1.55, 1.79] | — | — | age, sex, 10 PCs (+/- dataset-specific technical covariates) | — |
| PPM009287 | PGS001781 (T2D_PRSCS) |
PSS007692| European Ancestry| 343,672 individuals |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Reported Trait: Prevalent type 2 diabetes | OR: 1.75 [1.72, 1.78] | AUROC: 0.725 [0.721, 0.729] | — | year of birth, sex | — |
| PPM009283 | PGS001781 (T2D_PRSCS) |
PSS007691| European Ancestry| 328,115 individuals |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.48, 1.54] | AUROC: 0.669 [0.664, 0.675] | — | year of birth, sex | — |
| PPM009285 | PGS001781 (T2D_PRSCS) |
PSS007686| European Ancestry| 309,154 individuals |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Reported Trait: Prevalent type 2 diabetes | OR: 1.59 [1.57, 1.61] | AUROC: 0.81 [0.808, 0.813] | — | year of birth, sex, ten first principal components of Finnish ancestry, batch, genotyping array | — |
| PPM009279 | PGS001781 (T2D_PRSCS) |
PSS007690| European Ancestry| 343,672 individuals |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Reported Trait: Type 2 diabetes (incident and prevalent) | OR: 1.68 [1.65, 1.7] | AUROC: 0.708 [0.705, 0.711] | — | year of birth, sex | — |
| PPM012947 | PGS002277 (pPS_Insulin_secretion_1) |
PSS009629| South Asian Ancestry| 5,806 individuals |
PGP000305 | Siddiqui MK et al. Diabetologia (2022) |
Reported Trait: Age at diagnosis | — | — | Z: 5.2 | — | Z-score p-value < 0.0001 |
| PPM012949 | PGS002277 (pPS_Insulin_secretion_1) |
PSS009629| South Asian Ancestry| 5,806 individuals |
PGP000305 | Siddiqui MK et al. Diabetologia (2022) |
Reported Trait: Age at diagnosis (overweight BMI) | β: 32.68 (20.7) | — | R²: 0.0097 | — | — |
| PPM012950 | PGS002277 (pPS_Insulin_secretion_1) |
PSS009629| South Asian Ancestry| 5,806 individuals |
PGP000305 | Siddiqui MK et al. Diabetologia (2022) |
Reported Trait: Age at diagnosis (obese BMI) | β: 18.9 (10.76) | — | R²: 0.0036 | — | — |
| PPM013067 | PGS002308 (PRScsx_T2D) |
PSS009671| African Ancestry| 6,745 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 1.7 [1.58, 1.84] | AUROC: 0.631 | R²: 0.046 | age, sex, top 10 PCs | — |
| PPM014804 | PGS000036 (gePS_T2D) |
PSS009893| African Ancestry| 366 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.574 [0.506, 0.643] | — | — | — |
| PPM014806 | PGS000036 (gePS_T2D) |
PSS009894| Hispanic or Latin American Ancestry| 412 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.722 [0.667, 0.778] | — | — | — |
| PPM014808 | PGS000036 (gePS_T2D) |
PSS009896| Ancestry Not Reported| 99 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.677 [0.532, 0.822] | — | — | — |
| PPM013064 | PGS002308 (PRScsx_T2D) |
PSS009677| European Ancestry| 54,793 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 1.96 [1.91, 2.02] | AUROC: 0.793 | R²: 0.092 | age, sex, top 10 PCs, study site | — |
| PPM013065 | PGS002308 (PRScsx_T2D) |
PSS009676| African Ancestry| 12,472 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 1.54 [1.46, 1.64] | AUROC: 0.848 | R²: 0.028 | age, sex, top 10 PCs, study site | — |
| PPM013066 | PGS002308 (PRScsx_T2D) |
PSS009678| Hispanic or Latin American Ancestry| 2,374 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 2.08 [1.84, 2.35] | AUROC: 0.851 | R²: 0.08 | age, sex, top 10 PCs, study site | — |
| PPM013068 | PGS002308 (PRScsx_T2D) |
PSS009669| African Ancestry| 5,498 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 1.85 [1.7, 2.01] | AUROC: 0.633 | R²: 0.036 | age, sex, top 10 PCs | — |
| PPM013069 | PGS002308 (PRScsx_T2D) |
PSS009670| African Ancestry| 1,896 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 1.75 [1.52, 2.02] | AUROC: 0.757 | R²: 0.062 | age, sex, top 10 PCs | — |
| PPM013070 | PGS002308 (PRScsx_T2D) |
PSS009675| African Ancestry| 655 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 1.37 [1.13, 1.65] | AUROC: 0.631 | R²: 0.015 | age, sex, top 10 PCs | — |
| PPM013071 | PGS002308 (PRScsx_T2D) |
PSS009672| East Asian Ancestry| 25,110 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 2.19 [2.05, 2.33] | AUROC: 0.81 | R²: 0.151 | age, sex, top 10 PCs | — |
| PPM013072 | PGS002308 (PRScsx_T2D) |
PSS009673| East Asian Ancestry| 54,078 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 2.01 [1.93, 2.1] | AUROC: 0.781 | R²: 0.129 | age, sex, top 10 PCs | — |
| PPM013073 | PGS002308 (PRScsx_T2D) |
PSS009674| East Asian Ancestry| 10,378 individuals |
PGP000331 | Ge T et al. Genome Med (2022) |
Reported Trait: Type 2 diabetes | OR: 2.16 [1.96, 2.38] | AUROC: 0.802 | R²: 0.153 | age, sex, top 10 PCs | — |
| PPM014821 | PGS002733 (GRS17_T2D) |
PSS009902| European Ancestry| 600 individuals |
PGP000342 | Pezzilli S et al. Diabetes Metab (2022) |
Reported Trait: Early-onset type 2 diabetes | OR: 1.09 [1.01, 1.18] | — | — | — | — |
| PPM014822 | PGS002733 (GRS17_T2D) |
PSS009902| European Ancestry| 600 individuals |
PGP000342 | Pezzilli S et al. Diabetes Metab (2022) |
Reported Trait: Early-onset type 2 diabetes in rare variant carriers | OR: 1.45 [1.15, 1.57] | — | — | — | — |
| PPM014823 | PGS002733 (GRS17_T2D) |
PSS009902| European Ancestry| 600 individuals |
PGP000342 | Pezzilli S et al. Diabetes Metab (2022) |
Reported Trait: Early-onset type 2 diabetes in rare variant non-carriers | OR: 1.06 [1.01, 1.13] | — | — | — | — |
| PPM017184 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS010157| Hispanic or Latin American Ancestry| 1,484 individuals |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Reported Trait: type 2 diabetes | OR: 1.9 [1.65, 2.19] | AUROC: 0.7475 | R²: 0.207 | sex, age, PCs(1-10), PRScsx_T2D_LAT_EURweights, PRScsx_T2D_LAT_EASweights | NOTE: Performance is based on a linear combination of this PGS with PRScsx_T2D_LAT_EASweights and PRScsx_T2D_LAT_LATweights (metascore=(zscoreEUR* 0.531117)+(zscoreEAS*0.5690198)+(zscoreLAT*0.1465538)). See score development details for how to apply |
| PPM014979 | PGS002779 (GTG_T2D_maxCT) |
PSS009943| European Ancestry| 5,472 individuals |
PGP000365 | Wong CK et al. PLoS One (2022) |
Reported Trait: Incident type 2 diabetes | OR: 1.35 [1.25, 1.45] | AUROC: 0.585 [0.564, 0.605] | — | — | — |
| PPM014980 | PGS002780 (GTG_T2D_SCT) |
PSS009943| European Ancestry| 5,472 individuals |
PGP000365 | Wong CK et al. PLoS One (2022) |
Reported Trait: Incident type 2 diabetes | OR: 1.41 [1.31, 1.51] | AUROC: 0.595 [0.575, 0.615] | — | — | — |
| PPM015522 | PGS000014 (GPS_T2D) |
PSS009971| Multi-ancestry (including European)| 36,422 individuals |
PGP000381 | Hao L et al. Nat Med (2022) |Ext. |
Reported Trait: Type 2 diabetes mellitus | OR: 1.75 [1.57, 1.95] | — | — | 4 genetic PCs | — |
| PPM014971 | PGS002771 (Type_2_diabetes_prscs) |
PSS009939| European Ancestry| 39,444 individuals |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 diabetes | OR: 1.88 [1.82, 1.95] | — | — | age, sex, 10 PCs, technical covariates | — |
| PPM015992 | PGS003092 (ExPRSweb_T2D_2443_DBSLMM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.275 [1.23, 1.321] β: 0.243 (0.0184) |
AUROC: 0.563 [0.546, 0.58] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015993 | PGS003089 (ExPRSweb_T2D_2443_LASSOSUM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.524 [1.468, 1.583] β: 0.422 (0.0191) |
AUROC: 0.616 [0.6, 0.63] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015994 | PGS003091 (ExPRSweb_T2D_2443_PLINK_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.379 [1.329, 1.431] β: 0.321 (0.0189) |
AUROC: 0.591 [0.574, 0.606] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015995 | PGS003093 (ExPRSweb_T2D_2443_PRSCS_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.6 [1.539, 1.664] β: 0.47 (0.0199) |
AUROC: 0.625 [0.608, 0.639] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015996 | PGS003090 (ExPRSweb_T2D_2443_PT_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.425 [1.373, 1.479] β: 0.354 (0.0191) |
AUROC: 0.599 [0.582, 0.615] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015997 | PGS003097 (ExPRSweb_T2D_29358691-GCST005413_DBSLMM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.011 [0.976, 1.047] β: 0.011 (0.0181) |
AUROC: 0.5 [0.484, 0.517] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM015998 | PGS003112 (ExPRSweb_T2D_29358691-GCST005413_DBSLMM_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.01 [0.989, 1.031] β: 0.00976 (0.0104) |
AUROC: 0.501 [0.495, 0.507] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM015999 | PGS003094 (ExPRSweb_T2D_29358691-GCST005413_LASSOSUM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.333 [1.286, 1.382] β: 0.287 (0.0184) |
AUROC: 0.589 [0.572, 0.604] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016000 | PGS003109 (ExPRSweb_T2D_29358691-GCST005413_LASSOSUM_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.522 [1.491, 1.554] β: 0.42 (0.0106) |
AUROC: 0.616 [0.61, 0.622] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016001 | PGS003096 (ExPRSweb_T2D_29358691-GCST005413_PLINK_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.232 [1.189, 1.277] β: 0.209 (0.0181) |
AUROC: 0.56 [0.545, 0.576] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016002 | PGS003111 (ExPRSweb_T2D_29358691-GCST005413_PLINK_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.392 [1.364, 1.42] β: 0.331 (0.0103) |
AUROC: 0.59 [0.584, 0.596] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016003 | PGS003098 (ExPRSweb_T2D_29358691-GCST005413_PRSCS_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.358 [1.31, 1.408] β: 0.306 (0.0183) |
AUROC: 0.593 [0.577, 0.608] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016004 | PGS003113 (ExPRSweb_T2D_29358691-GCST005413_PRSCS_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.522 [1.491, 1.554] β: 0.42 (0.0106) |
AUROC: 0.616 [0.611, 0.622] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016005 | PGS003095 (ExPRSweb_T2D_29358691-GCST005413_PT_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.239 [1.196, 1.284] β: 0.214 (0.0181) |
AUROC: 0.562 [0.546, 0.578] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016006 | PGS003110 (ExPRSweb_T2D_29358691-GCST005413_PT_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.406 [1.378, 1.435] β: 0.341 (0.0103) |
AUROC: 0.594 [0.588, 0.6] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016007 | PGS003102 (ExPRSweb_T2D_30054458-GCST006867_DBSLMM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.639 [1.577, 1.703] β: 0.494 (0.0196) |
AUROC: 0.628 [0.611, 0.643] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016008 | PGS003117 (ExPRSweb_T2D_30054458-GCST006867_DBSLMM_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 3.061 [2.992, 3.132] β: 1.12 (0.0116) |
AUROC: 0.778 [0.774, 0.783] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016009 | PGS003099 (ExPRSweb_T2D_30054458-GCST006867_LASSOSUM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.657 [1.595, 1.722] β: 0.505 (0.0196) |
AUROC: 0.626 [0.609, 0.641] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016010 | PGS003114 (ExPRSweb_T2D_30054458-GCST006867_LASSOSUM_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 3.959 [3.866, 4.055] β: 1.38 (0.0121) |
AUROC: 0.825 [0.82, 0.829] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016011 | PGS003101 (ExPRSweb_T2D_30054458-GCST006867_PLINK_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.531 [1.474, 1.591] β: 0.426 (0.0193) |
AUROC: 0.6 [0.585, 0.616] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016012 | PGS003116 (ExPRSweb_T2D_30054458-GCST006867_PLINK_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 3.755 [3.669, 3.844] β: 1.32 (0.0119) |
AUROC: 0.816 [0.811, 0.82] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016013 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.704 [1.639, 1.772] β: 0.533 (0.0198) |
AUROC: 0.637 [0.621, 0.653] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016014 | PGS003118 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 3.193 [3.12, 3.268] β: 1.16 (0.0118) |
AUROC: 0.786 [0.782, 0.791] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016015 | PGS003100 (ExPRSweb_T2D_30054458-GCST006867_PT_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.531 [1.474, 1.591] β: 0.426 (0.0193) |
AUROC: 0.6 [0.585, 0.616] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016016 | PGS003115 (ExPRSweb_T2D_30054458-GCST006867_PT_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 3.755 [3.669, 3.844] β: 1.32 (0.0119) |
AUROC: 0.816 [0.811, 0.82] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016017 | PGS003107 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_DBSLMM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.028 [0.992, 1.065] β: 0.0276 (0.0182) |
AUROC: 0.541 [0.523, 0.557] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016018 | PGS003122 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_DBSLMM_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.009 [0.988, 1.03] β: 0.00858 (0.0105) |
AUROC: 0.547 [0.541, 0.552] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016019 | PGS003104 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_LASSOSUM_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.536 [1.479, 1.596] β: 0.429 (0.0195) |
AUROC: 0.611 [0.595, 0.626] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016020 | PGS003119 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_LASSOSUM_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.662 [1.628, 1.698] β: 0.508 (0.0107) |
AUROC: 0.639 [0.634, 0.645] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016021 | PGS003106 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PLINK_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.33 [1.283, 1.379] β: 0.285 (0.0184) |
AUROC: 0.572 [0.555, 0.588] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016022 | PGS003121 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PLINK_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.451 [1.421, 1.48] β: 0.372 (0.0104) |
AUROC: 0.603 [0.597, 0.609] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016023 | PGS003108 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PRSCS_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.563 [1.504, 1.624] β: 0.446 (0.0195) |
AUROC: 0.61 [0.594, 0.625] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016025 | PGS003105 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PT_MGI_20211120) |
PSS010014| European Ancestry| 21,356 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.33 [1.283, 1.379] β: 0.285 (0.0184) |
AUROC: 0.572 [0.555, 0.588] | — | SEX,AGE,Batch,PC1,PC2,PC3,PC4 | — |
| PPM016024 | PGS003123 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PRSCS_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.715 [1.679, 1.752] β: 0.539 (0.0107) |
AUROC: 0.648 [0.642, 0.654] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016026 | PGS003120 (ExPRSweb_T2D_METAANALYSIS-DIAGRAM_PT_UKB_20211120) |
PSS010036| European Ancestry| 203,197 individuals |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Reported Trait: Type 2 Diabetes | OR: 1.451 [1.421, 1.48] β: 0.372 (0.0104) |
AUROC: 0.603 [0.597, 0.609] | — | Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 | — |
| PPM016201 | PGS003353 (GRS_T2D) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Fasting plasma glucose | OR: 1.83 [1.59, 2.11] | — | — | — | — |
| PPM016202 | PGS003353 (GRS_T2D) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Hemoglobin A1c level | OR: 1.68 [1.46, 1.93] | — | — | — | — |
| PPM016203 | PGS003353 (GRS_T2D) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Type 2 diabetes | OR: 2.99 [2.61, 3.44] | — | — | — | — |
| PPM016204 | PGS003353 (GRS_T2D) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Fasting plasma glucose and Type 2 diabetes | OR: 3.52 [2.69, 4.61] | — | — | — | — |
| PPM017032 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: Fasting glucose | β: 0.085 [0.067, 0.103] | — | — | first five principal components (PCs) | — |
| PPM017033 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: 2h postload glucose | β: 0.207 [0.157, 0.257] | — | — | first five principal components (PCs) | — |
| PPM017034 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: AUC glucose | β: 0.155 [0.125, 0.184] | — | — | first five principal components (PCs) | — |
| PPM017035 | PGS003402 (PRS_T2D) |
PSS010101| South Asian Ancestry| 3,712 individuals |
PGP000419 | Lamri A et al. Elife (2022) |
Reported Trait: GDM (IADPSG criteria) | OR: 1.45 [1.32, 1.6] | — | — | first five principal components (PCs) | — |
| PPM014093 | PGS002573 (disease_T2D.P+T.1e-06) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013119 | PGS002354 (disease_T2D.BOLT-LMM) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0047 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013168 | PGS002354 (disease_T2D.BOLT-LMM) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0025 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013217 | PGS002354 (disease_T2D.BOLT-LMM) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0135 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013266 | PGS002354 (disease_T2D.BOLT-LMM) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0218 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013291 | PGS002379 (disease_T2D.BOLT-LMM-BBJ) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0008 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013314 | PGS002379 (disease_T2D.BOLT-LMM-BBJ) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0148 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013360 | PGS002379 (disease_T2D.BOLT-LMM-BBJ) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0091 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013407 | PGS002426 (disease_T2D.P+T.0.0001) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0001 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013505 | PGS002426 (disease_T2D.P+T.0.0001) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013554 | PGS002426 (disease_T2D.P+T.0.0001) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013603 | PGS002475 (disease_T2D.P+T.0.001) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013652 | PGS002475 (disease_T2D.P+T.0.001) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0041 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013701 | PGS002475 (disease_T2D.P+T.0.001) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013799 | PGS002524 (disease_T2D.P+T.0.01) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0002 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013848 | PGS002524 (disease_T2D.P+T.0.01) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0033 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013897 | PGS002524 (disease_T2D.P+T.0.01) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013946 | PGS002524 (disease_T2D.P+T.0.01) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013995 | PGS002573 (disease_T2D.P+T.1e-06) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014044 | PGS002573 (disease_T2D.P+T.1e-06) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014142 | PGS002573 (disease_T2D.P+T.1e-06) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014191 | PGS002622 (disease_T2D.P+T.5e-08) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014240 | PGS002622 (disease_T2D.P+T.5e-08) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0002 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014289 | PGS002622 (disease_T2D.P+T.5e-08) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014387 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0047 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See disease_T2D.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014436 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0072 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See disease_T2D.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014485 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0128 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See disease_T2D.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014534 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0251 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See disease_T2D.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014583 | PGS002720 (disease_T2D.SBayesR) |
PSS009859| African Ancestry| 6,503 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.006 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014632 | PGS002720 (disease_T2D.SBayesR) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0021 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014681 | PGS002720 (disease_T2D.SBayesR) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0129 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013337 | PGS002379 (disease_T2D.BOLT-LMM-BBJ) |
PSS009861| European Ancestry| 43,505 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0026 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013456 | PGS002426 (disease_T2D.P+T.0.0001) |
PSS009860| East Asian Ancestry| 922 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0032 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014730 | PGS002720 (disease_T2D.SBayesR) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0207 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013750 | PGS002475 (disease_T2D.P+T.0.001) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014338 | PGS002622 (disease_T2D.P+T.5e-08) |
PSS009862| South Asian Ancestry| 8,098 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (full model vs. covariates alone): 0.0001 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM017182 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS010157| Hispanic or Latin American Ancestry| 1,484 individuals |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Reported Trait: type 2 diabetes | OR: 1.9 [1.65, 2.19] | AUROC: 0.7475 | R²: 0.207 | sex, age, PCs(1-10), PRScsx_T2D_LAT_EASweights, PRScsx_T2D_LAT_LATweights | NOTE: Performance is based on a linear combination of this PGS with PRScsx_T2D_LAT_EASweights and PRScsx_T2D_LAT_LATweights (metascore=(zscoreEUR* 0.531117)+(zscoreEAS*0.5690198)+(zscoreLAT*0.1465538)). See score development details for how to apply |
| PPM017183 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS010157| Hispanic or Latin American Ancestry| 1,484 individuals |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Reported Trait: type 2 diabetes | OR: 1.9 [1.65, 2.19] | AUROC: 0.7475 | R²: 0.207 | sex, age, PCs(1-10), PRScsx_T2D_LAT_EURweights, PRScsx_T2D_LAT_LATweights | NOTE: Performance is based on a linear combination of this PGS with PRScsx_T2D_LAT_EASweights and PRScsx_T2D_LAT_LATweights (metascore=(zscoreEUR* 0.531117)+(zscoreEAS*0.5690198)+(zscoreLAT*0.1465538)). See score development details for how to apply |
| PPM018469 | PGS003729 (PS_T2D_293-DIAGRAM) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.27 [1.17, 1.38] | AUROC: 0.735 | Net reclassification improvement: 0.27 [0.149, 0.392] ∆AUC: 0.007 [0.001, 0.014] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018470 | PGS003735 (PS_T2D_276-AFR-DIAMANTE) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.13 [1.04, 1.22] | — | ∆AUC: 0.003 [0.0, 0.007] Net reclassification improvement: 0.181 [0.047, 0.316] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018471 | PGS003730 (PS_T2D_287-DIAMANTE) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.2 [1.1, 1.3] | — | Net reclassification improvement: 0.216 [0.094, 0.338] ∆AUC: 0.004 [-0.001, 0.009] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018472 | PGS003734 (PS_T2D_280-EAS-DIAMANTE) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.13 [1.04, 1.23] | — | Net reclassification improvement: 0.115 [-0.014, 0.244] ∆AUC: 0.001 [-0.002, 0.005] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018473 | PGS003733 (PS_T2D_287-EUR-DIAMANTE) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.21 [1.12, 1.32] | — | Net reclassification improvement: 0.277 [0.156, 0.397] ∆AUC: 0.005 [0.0, 0.011] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018474 | PGS003732 (PS_T2D_287-HIS-DIAMANTE) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.18 [1.09, 1.29] | — | Net reclassification improvement: 0.219 [0.097, 0.34] ∆AUC: 0.004 [-0.001, 0.008] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018475 | PGS003731 (PS_T2D_282-SAS-DIAMANTE) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.19 [1.09, 1.29] | — | Net reclassification improvement: 0.181 [0.054, 0.308] ∆AUC: 0.004 [-0.001, 0.009] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018476 | PGS003728 (PS_T2D_183-AGEN) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.28 [1.12, 1.46] | — | Net reclassification improvement: 0.331 [0.141, 0.521] ∆AUC: 0.005 [-0.003, 0.012] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018477 | PGS003729 (PS_T2D_293-DIAGRAM) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.49 [1.29, 1.72] | AUROC: 0.812 | Net reclassification improvement: 0.268 [0.072, 0.464] ∆AUC: 0.007 [-0.003, 0.017] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018478 | PGS003735 (PS_T2D_276-AFR-DIAMANTE) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.21 [1.06, 1.38] | — | Net reclassification improvement: 0.185 [-0.017, 0.388] ∆AUC: 0.005 [-0.001, 0.01] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018479 | PGS003730 (PS_T2D_287-DIAMANTE) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.34 [1.17, 1.54] | — | Net reclassification improvement: 0.314 [0.116, 0.512] ∆AUC: 0.004 [-0.001, 0.009] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018480 | PGS003734 (PS_T2D_280-EAS-DIAMANTE) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.19 [1.04, 1.36] | — | Net reclassification improvement: 0.182 [-0.019, 0.383] ∆AUC: 0.001 [-0.004, 0.007] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018481 | PGS003733 (PS_T2D_287-EUR-DIAMANTE) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.37 [1.19, 1.58] | — | Net reclassification improvement: 0.296 [0.09, 0.502] ∆AUC: 0.008 [-0.001, 0.017] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018482 | PGS003732 (PS_T2D_287-HIS-DIAMANTE) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.32 [1.15, 1.51] | — | Net reclassification improvement: 0.15 [-0.054, 0.354] ∆AUC: 0.006 [-0.001, 0.014] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018483 | PGS003731 (PS_T2D_282-SAS-DIAMANTE) |
PSS010984| Additional Diverse Ancestries| 2,229 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (youth cohort at 10 year follow-up) | HR: 1.35 [1.18, 1.56] | — | Net reclassification improvement: 0.302 [0.089, 0.515] ∆AUC: 0.002 [-0.007, 0.012] |
age, sex, parental diabetes, modified BMI z score, fasting plasma glucose | — |
| PPM018484 | PGS003728 (PS_T2D_183-AGEN) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.27 [1.15, 1.39] | — | Net reclassification improvement: 0.164 [0.025, 0.303] ∆AUC: 0.037 [0.013, 0.06] |
sex, parental diabetes, and birth weight | — |
| PPM018485 | PGS003729 (PS_T2D_293-DIAGRAM) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.48 [1.35, 1.63] | AUROC: 0.685 | Net reclassification improvement: 0.362 [0.222, 0.502] ∆AUC: 0.072 [0.045, 0.099] |
sex, parental diabetes, and birth weight | — |
| PPM018486 | PGS003735 (PS_T2D_276-AFR-DIAMANTE) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.28 [1.16, 1.41] | — | Net reclassification improvement: 0.231 [0.091, 0.376] ∆AUC: 0.042 [0.019, 0.065] |
sex, parental diabetes, and birth weight | — |
| PPM018487 | PGS003730 (PS_T2D_287-DIAMANTE) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.45 [1.32, 1.6] | — | Net reclassification improvement: 0.259 [0.115, 0.403] ∆AUC: 0.073 |
sex, parental diabetes, and birth weight | — |
| PPM018488 | PGS003734 (PS_T2D_280-EAS-DIAMANTE) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.33 [1.22, 1.46] | — | Net reclassification improvement: 0.176 [0.029, 0.323] ∆AUC: 0.052 [0.026, 0.077] |
sex, parental diabetes, and birth weight | — |
| PPM018489 | PGS003733 (PS_T2D_287-EUR-DIAMANTE) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.47 [1.33, 1.62] | — | Net reclassification improvement: 0.328 [0.183, 0.474] ∆AUC: 0.075 [0.048, 0.102] |
sex, parental diabetes, and birth weight | — |
| PPM018490 | PGS003732 (PS_T2D_287-HIS-DIAMANTE) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.4 [1.28, 1.55] | — | Net reclassification improvement: 0.277 [0.125, 0.428] ∆AUC: 0.072 [0.046, 0.099] |
sex, parental diabetes, and birth weight | — |
| PPM018491 | PGS003731 (PS_T2D_282-SAS-DIAMANTE) |
PSS010983| Additional Diverse Ancestries| 2,894 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (birth cohort at 30 year follow-up) | HR: 1.32 [1.2, 1.45] | — | Net reclassification improvement: 0.201 [0.057, 0.306] ∆AUC: 0.054 [0.031, 0.077] |
sex, parental diabetes, and birth weight | — |
| PPM018468 | PGS003728 (PS_T2D_183-AGEN) |
PSS010982| Additional Diverse Ancestries| 2,333 individuals |
PGP000469 | Wedekind LE et al. Diabetologia (2023) |
Reported Trait: Incident type 2 diabetes (adult cohort at 10 year follow-up) | HR: 1.14 [1.06, 1.24] | — | Net reclassification improvement: 0.115 [-0.014, 0.244] ∆AUC: 0.001 [-0.003, 0.005] |
age, sex, parental diabetes, BMI, fasting plasma glucose and HbA1c. | — |
| PPM018510 | PGS003751 (ModelT2D_over45) |
PSS011003| European Ancestry| 122,144 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Type 2 diabetes with age of diagnosis over 45 | — | AUROC: 0.596 | Nagelkerke R2: 0.016 | — | — |
| PPM018511 | PGS003752 (ModelT2D) |
PSS011002| European Ancestry| 125,189 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.578 | Nagelkerke R2: 0.014 | — | — |
| PPM018513 | PGS003751 (ModelT2D_over45) |
PSS011000| European Ancestry| 7,067 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Discrimination of Type 1 diabetes from Type 2 diabetes | — | AUROC: 0.527 | — | — | — |
| PPM018759 | PGS003867 (T2D_PRScs_ARB) |
PSS011097| Greater Middle Eastern Ancestry| 2,669 individuals |
PGP000501 | Shim I et al. Nature Communications (2023) |
Reported Trait: Type 2 diabetes | OR: 1.83 [1.74, 1.92] | AUROC: 0.7384 [0.7194, 0.7574] | — | age, sex, array version, and the first 10 principal components of ancestry | — |
| PPM019100 | PGS000014 (GPS_T2D) |
PSS011181| Ancestry Not Reported| 3,071 individuals |
PGP000504 | Duschek E et al. Sci Rep (2023) |Ext. |
Reported Trait: Incident type 2 diabetes | — | AUROC: 0.613 [0.565, 0.657] | — | — | — |
| PPM019098 | PGS000014 (GPS_T2D) |
PSS011181| Ancestry Not Reported| 3,071 individuals |
PGP000504 | Duschek E et al. Sci Rep (2023) |Ext. |
Reported Trait: Incident type 2 diabetes | OR: 1.67 [1.37, 2.03] | — | — | Age, Sex, BMI, Physical activity, FamRS | — |
| PPM019099 | PGS000014 (GPS_T2D) |
PSS011181| Ancestry Not Reported| 3,071 individuals |
PGP000504 | Duschek E et al. Sci Rep (2023) |Ext. |
Reported Trait: Prevelant type 2 diabetes | — | AUROC: 0.869 [0.842, 0.896] | — | — | — |
| PPM019097 | PGS000014 (GPS_T2D) |
PSS011181| Ancestry Not Reported| 3,071 individuals |
PGP000504 | Duschek E et al. Sci Rep (2023) |Ext. |
Reported Trait: Prevelant type 2 diabetes | OR: 6.21 [5.06, 7.74] | — | — | Age, Sex, BMI, Physical activity, FamRS | — |
| PPM019293 | PGS004039 (ldpred2.CV.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.51531 [1.48775049, 1.54337132] β: 0.41562 [0.39726524, 0.4339692] |
AUROC: 0.61526 [0.61016173, 0.62035426] | R²: 0.03936 [0.03588686, 0.04267541] | 0 | beta = log(or)/sd_pgs |
| PPM019294 | PGS004039 (ldpred2.CV.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.52599 [1.51226031, 1.53985401] β: 0.42265 [0.41360543, 0.43168762] |
AUROC: 0.61628 [0.6138334, 0.6187205] | R²: 0.03978 [0.03807705, 0.04144329] | 0 | beta = log(or)/sd_pgs |
| PPM019295 | PGS004039 (ldpred2.CV.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.29096 [1.25725452, 1.32556441] β: 0.25538 [0.22893039, 0.28183834] |
AUROC: 0.57087 [0.56343441, 0.57829789] | R²: 0.02046 [0.01630724, 0.02459481] | 0 | beta = log(or)/sd_pgs |
| PPM019296 | PGS004039 (ldpred2.CV.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.55991 [1.50928857, 1.61222949] β: 0.44463 [0.41163839, 0.477618] |
AUROC: 0.62359 [0.61472012, 0.63245927] | R²: 0.04444 [0.03850418, 0.0507231] | 0 | beta = log(or)/sd_pgs |
| PPM019297 | PGS004039 (ldpred2.CV.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.41025 [1.34103388, 1.48302904] β: 0.34376 [0.29344087, 0.39408665] |
AUROC: 0.59548 [0.58167722, 0.60927774] | R²: 0.03643 [0.02686064, 0.04771182] | 0 | beta = log(or)/sd_pgs |
| PPM019298 | PGS004039 (ldpred2.CV.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.6442 [1.60047798, 1.68911893] β: 0.49725 [0.47030232, 0.52420705] |
AUROC: 0.63598 [0.62882156, 0.64314397] | R²: 0.05494 [0.04954485, 0.06082436] | 0 | beta = log(or)/sd_pgs |
| PPM019299 | PGS004106 (pt_clump.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.25413 [1.23159004, 1.27707908] β: 0.22644 [0.20830605, 0.2445755] |
AUROC: 0.56403 [0.55881253, 0.56924282] | R²: 0.01187 [0.00997649, 0.01382892] | 0 | beta = log(or)/sd_pgs |
| PPM019300 | PGS004106 (pt_clump.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.2706 [1.2594811, 1.28182511] β: 0.23949 [0.23069981, 0.24828493] |
AUROC: 0.56766 [0.56515777, 0.57015874] | R²: 0.01318 [0.01221912, 0.01411644] | 0 | beta = log(or)/sd_pgs |
| PPM019301 | PGS004106 (pt_clump.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.1856 [1.15490323, 1.21712273] β: 0.17025 [0.14401656, 0.19648965] |
AUROC: 0.54709 [0.5396201, 0.55455013] | R²: 0.00921 [0.00651707, 0.01198558] | 0 | beta = log(or)/sd_pgs |
| PPM019302 | PGS004106 (pt_clump.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.30688 [1.26507981, 1.35006987] β: 0.26765 [0.23513521, 0.30015635] |
AUROC: 0.57537 [0.56607472, 0.58467319] | R²: 0.01643 [0.0128354, 0.0202509] | 0 | beta = log(or)/sd_pgs |
| PPM019303 | PGS004106 (pt_clump.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.25033 [1.19003292, 1.31369168] β: 0.22341 [0.17398097, 0.27284125] |
AUROC: 0.55908 [0.54504874, 0.57311861] | R²: 0.01574 [0.00986198, 0.02399144] | 0 | beta = log(or)/sd_pgs |
| PPM019304 | PGS004106 (pt_clump.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.32877 [1.29422201, 1.36424846] β: 0.28426 [0.25790975, 0.3106037] |
AUROC: 0.57939 [0.5719205, 0.58685014] | R²: 0.01854 [0.01531842, 0.02237953] | 0 | beta = log(or)/sd_pgs |
| PPM019305 | PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.32208 [1.29812327, 1.34647465] β: 0.2792 [0.26091958, 0.29748981] |
AUROC: 0.57929 [0.57408311, 0.58449619] | R²: 0.01777 [0.01554972, 0.02010384] | 0 | beta = log(or)/sd_pgs |
| PPM019306 | PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.34756 [1.3356256, 1.35959664] β: 0.29829 [0.2893998, 0.30718806] |
AUROC: 0.5835 [0.58101723, 0.58599044] | R²: 0.0201 [0.0188679, 0.02123087] | 0 | beta = log(or)/sd_pgs |
| PPM019307 | PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.21072 [1.17930366, 1.24298033] β: 0.19122 [0.16492415, 0.21751199] |
AUROC: 0.55374 [0.5462507, 0.56123054] | R²: 0.01157 [0.0086349, 0.01494545] | 0 | beta = log(or)/sd_pgs |
| PPM019308 | PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.36428 [1.32041418, 1.40961332] β: 0.31063 [0.27794546, 0.34331543] |
AUROC: 0.58615 [0.57696249, 0.59533435] | R²: 0.02192 [0.01765058, 0.02671499] | 0 | beta = log(or)/sd_pgs |
| PPM019309 | PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.28905 [1.2267795, 1.35447809] β: 0.2539 [0.20439244, 0.3034162] |
AUROC: 0.56815 [0.55421333, 0.58208264] | R²: 0.02033 [0.01357066, 0.03003431] | 0 | beta = log(or)/sd_pgs |
| PPM019310 | PGS004122 (pt_clump_nested.CV.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.41752 [1.38024499, 1.45579601] β: 0.34891 [0.32226101, 0.37555284] |
AUROC: 0.59713 [0.58971201, 0.60454498] | R²: 0.02739 [0.02355217, 0.03167091] | 0 | beta = log(or)/sd_pgs |
| PPM019312 | PGS003982 (dbslmm.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.50796 [1.49440047, 1.5216482] β: 0.41076 [0.4017251, 0.41979409] |
AUROC: 0.61324 [0.61079898, 0.61568516] | R²: 0.03754 [0.03585406, 0.03910114] | 0 | beta = log(or)/sd_pgs |
| PPM019313 | PGS003982 (dbslmm.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.26658 [1.23348533, 1.30057203] β: 0.23632 [0.20984376, 0.26280419] |
AUROC: 0.56588 [0.55844642, 0.57332026] | R²: 0.01747 [0.01366707, 0.02126159] | 0 | beta = log(or)/sd_pgs |
| PPM019314 | PGS003982 (dbslmm.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.53274 [1.48305093, 1.58408596] β: 0.42705 [0.39410141, 0.46000756] |
AUROC: 0.61891 [0.610046, 0.627782] | R²: 0.04102 [0.03528638, 0.04680279] | 0 | beta = log(or)/sd_pgs |
| PPM019315 | PGS003982 (dbslmm.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.40966 [1.3404092, 1.48248962] β: 0.34335 [0.29297494, 0.39372285] |
AUROC: 0.59521 [0.58145316, 0.60895737] | R²: 0.03626 [0.02742268, 0.04735748] | 0 | beta = log(or)/sd_pgs |
| PPM019316 | PGS003982 (dbslmm.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.6067 [1.56412308, 1.65044514] β: 0.47419 [0.44732533, 0.50104504] |
AUROC: 0.63025 [0.62305251, 0.63744286] | R²: 0.05021 [0.04509727, 0.0558259] | 0 | beta = log(or)/sd_pgs |
| PPM019317 | PGS004136 (sbayesr.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.48356 [1.45656875, 1.51105242] β: 0.39444 [0.3760835, 0.41280637] |
AUROC: 0.6093 [0.60418883, 0.61441369] | R²: 0.03537 [0.03199906, 0.03839572] | 0 | beta = log(or)/sd_pgs |
| PPM019319 | PGS004136 (sbayesr.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.28557 [1.25203483, 1.32001069] β: 0.2512 [0.22477009, 0.27763983] |
AUROC: 0.5697 [0.56226507, 0.57713901] | R²: 0.01982 [0.01568424, 0.02397061] | 0 | beta = log(or)/sd_pgs |
| PPM019320 | PGS004136 (sbayesr.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.54343 [1.49343881, 1.59509464] β: 0.43401 [0.40108139, 0.46693307] |
AUROC: 0.62044 [0.61153443, 0.62934548] | R²: 0.04245 [0.03633636, 0.04881292] | 0 | beta = log(or)/sd_pgs |
| PPM019321 | PGS004136 (sbayesr.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.4041 [1.33507679, 1.47668873] β: 0.3394 [0.28898881, 0.38980223] |
AUROC: 0.59558 [0.58182965, 0.60933726] | R²: 0.03537 [0.02663293, 0.04614328] | 0 | beta = log(or)/sd_pgs |
| PPM019322 | PGS004136 (sbayesr.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.60963 [1.5668847, 1.65354217] β: 0.476 [0.44908938, 0.50291976] |
AUROC: 0.63025 [0.62302729, 0.63747798] | R²: 0.0504 [0.04500444, 0.05611303] | 0 | beta = log(or)/sd_pgs |
| PPM019323 | PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.53171 [1.50382282, 1.5601111] β: 0.42638 [0.40801042, 0.44475704] |
AUROC: 0.61867 [0.61359828, 0.62375062] | R²: 0.04136 [0.03772802, 0.04482097] | 0 | beta = log(or)/sd_pgs |
| PPM019324 | PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.5534 [1.53937109, 1.56756375] β: 0.44045 [0.43137395, 0.44952266] |
AUROC: 0.62105 [0.61861295, 0.62348122] | R²: 0.04301 [0.04122648, 0.04471885] | 0 | beta = log(or)/sd_pgs |
| PPM019325 | PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.29976 [1.26573059, 1.33469955] β: 0.26218 [0.2356495, 0.28870621] |
AUROC: 0.57269 [0.5652475, 0.5801288] | R²: 0.02145 [0.01712266, 0.02558285] | 0 | beta = log(or)/sd_pgs |
| PPM019326 | PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.57552 [1.52430263, 1.62846513] β: 0.45459 [0.42153702, 0.48763793] |
AUROC: 0.62667 [0.61784608, 0.6354948] | R²: 0.04629 [0.03997767, 0.05259807] | 0 | beta = log(or)/sd_pgs |
| PPM019327 | PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.44083 [1.36975233, 1.51560089] β: 0.36522 [0.31462994, 0.41581199] |
AUROC: 0.60119 [0.58740273, 0.6149758] | R²: 0.04079 [0.03137071, 0.05259115] | 0 | beta = log(or)/sd_pgs |
| PPM019328 | PGS004152 (UKBB_EnsPGS.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.66922 [1.62479997, 1.71484963] β: 0.51236 [0.48538472, 0.5393254] |
AUROC: 0.64008 [0.63295026, 0.64720264] | R²: 0.05835 [0.05271686, 0.06428647] | 0 | beta = log(or)/sd_pgs |
| PPM019329 | PGS004024 (ldpred2.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.48498 [1.45793137, 1.51252123] β: 0.3954 [0.37701856, 0.41377795] |
AUROC: 0.60995 [0.60483983, 0.61506038] | R²: 0.03546 [0.03228635, 0.0385679] | 0 | beta = log(or)/sd_pgs |
| PPM019330 | PGS004024 (ldpred2.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.50219 [1.48869396, 1.51581347] β: 0.40693 [0.3978992, 0.41595224] |
AUROC: 0.61207 [0.60961733, 0.61451762] | R²: 0.03689 [0.03526669, 0.03854021] | 0 | beta = log(or)/sd_pgs |
| PPM019331 | PGS004024 (ldpred2.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.2876 [1.25396854, 1.32213952] β: 0.25278 [0.22631335, 0.27925127] |
AUROC: 0.57005 [0.56262472, 0.57747218] | R²: 0.02002 [0.01580636, 0.02425789] | 0 | beta = log(or)/sd_pgs |
| PPM019332 | PGS004024 (ldpred2.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.53513 [1.48527841, 1.5866465] β: 0.42861 [0.39560223, 0.46162267] |
AUROC: 0.61957 [0.61065671, 0.62847491] | R²: 0.04118 [0.03531011, 0.04724008] | 0 | beta = log(or)/sd_pgs |
| PPM019333 | PGS004024 (ldpred2.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.39993 [1.3312816, 1.47211067] β: 0.33642 [0.28614209, 0.3866972] |
AUROC: 0.59208 [0.57821586, 0.60594979] | R²: 0.03491 [0.02535025, 0.04607037] | 0 | beta = log(or)/sd_pgs |
| PPM019334 | PGS004024 (ldpred2.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.608 [1.56527667, 1.65189658] β: 0.47499 [0.4480626, 0.50192407] |
AUROC: 0.62927 [0.62203707, 0.63651076] | R²: 0.05011 [0.04486623, 0.05593798] | 0 | beta = log(or)/sd_pgs |
| PPM019335 | PGS004052 (megaprs.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.51227 [1.48473504, 1.54032011] β: 0.41361 [0.39523633, 0.43199026] |
AUROC: 0.61519 [0.61009733, 0.62027538] | R²: 0.03887 [0.03526361, 0.04197686] | 0 | beta = log(or)/sd_pgs |
| PPM019337 | PGS004052 (megaprs.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.2863 [1.25264347, 1.32086195] β: 0.25177 [0.2252561, 0.27828451] |
AUROC: 0.57001 [0.56255968, 0.57745664] | R²: 0.01979 [0.01571473, 0.02380638] | 0 | beta = log(or)/sd_pgs |
| PPM019338 | PGS004052 (megaprs.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | β: 0.43541 [0.40237992, 0.46844556] OR: 1.5456 [1.49537934, 1.59750903] |
AUROC: 0.6216 [0.61275773, 0.63044257] | R²: 0.04245 [0.0366842, 0.04862483] | 0 | beta = log(or)/sd_pgs |
| PPM019339 | PGS004052 (megaprs.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.4232 [1.35315323, 1.49688143] β: 0.35291 [0.30243759, 0.4033839] |
AUROC: 0.59803 [0.58420574, 0.61184824] | R²: 0.03821 [0.02906588, 0.04987531] | 0 | beta = log(or)/sd_pgs |
| PPM019340 | PGS004052 (megaprs.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.64766 [1.60386839, 1.69264683] β: 0.49936 [0.47241846, 0.52629348] |
AUROC: 0.63712 [0.62999838, 0.6442459] | R²: 0.05548 [0.04987829, 0.06115078] | 0 | beta = log(or)/sd_pgs |
| PPM019341 | PGS004068 (megaprs.CV.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.51406 [1.4864796, 1.5421527] β: 0.41479 [0.39641064, 0.4331793] |
AUROC: 0.61559 [0.61050645, 0.62067071] | R²: 0.03906 [0.03539714, 0.04224136] | 0 | beta = log(or)/sd_pgs |
| PPM019342 | PGS004068 (megaprs.CV.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.54026 [1.52634867, 1.55428877] β: 0.43195 [0.4228784, 0.44101806] |
AUROC: 0.61879 [0.61634938, 0.62122346] | R²: 0.04134 [0.03958426, 0.04297594] | 0 | beta = log(or)/sd_pgs |
| PPM019343 | PGS004068 (megaprs.CV.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.28668 [1.25301209, 1.32124311] β: 0.25206 [0.22555032, 0.27857304] |
AUROC: 0.57009 [0.5626455, 0.57753118] | R²: 0.01984 [0.01565192, 0.02384042] | 0 | beta = log(or)/sd_pgs |
| PPM019344 | PGS004068 (megaprs.CV.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.55065 [1.50025034, 1.60275072] β: 0.43868 [0.40563199, 0.47172135] |
AUROC: 0.62234 [0.61350571, 0.63117408] | R²: 0.04307 [0.03717444, 0.04938557] | 0 | beta = log(or)/sd_pgs |
| PPM019345 | PGS004068 (megaprs.CV.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.42683 [1.35660022, 1.50069661] β: 0.35546 [0.30498173, 0.40592941] |
AUROC: 0.59875 [0.58494945, 0.61254981] | R²: 0.03877 [0.03005182, 0.05083233] | 0 | beta = log(or)/sd_pgs |
| PPM019346 | PGS004068 (megaprs.CV.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.65089 [1.6070244, 1.69594574] β: 0.50131 [0.47438427, 0.52824054] |
AUROC: 0.63771 [0.63058745, 0.64483568] | R²: 0.05597 [0.05046745, 0.06184224] | 0 | beta = log(or)/sd_pgs |
| PPM019347 | PGS004082 (prscs.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | β: 0.40526 [0.38690803, 0.42360811] OR: 1.49969 [1.47242107, 1.52746288] |
AUROC: 0.61165 [0.60654127, 0.61676488] | R²: 0.0374 [0.03410383, 0.04077767] | 0 | beta = log(or)/sd_pgs |
| PPM019348 | PGS004082 (prscs.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.49743 [1.48396523, 1.51101149] β: 0.40375 [0.39471771, 0.41277929] |
AUROC: 0.61097 [0.60852214, 0.6134248] | R²: 0.03625 [0.03467278, 0.03781105] | 0 | beta = log(or)/sd_pgs |
| PPM019349 | PGS004082 (prscs.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.26384 [1.23082512, 1.29774721] β: 0.23416 [0.20768477, 0.26062985] |
AUROC: 0.56445 [0.55702106, 0.57188388] | R²: 0.01716 [0.01343019, 0.02100019] | 0 | beta = log(or)/sd_pgs |
| PPM019350 | PGS004082 (prscs.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.52107 [1.47183004, 1.57196502] β: 0.41942 [0.38650655, 0.45232644] |
AUROC: 0.61739 [0.60847565, 0.62630934] | R²: 0.03965 [0.03410751, 0.04592409] | 0 | beta = log(or)/sd_pgs |
| PPM019351 | PGS004082 (prscs.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.37392 [1.30679117, 1.44449653] β: 0.31767 [0.26757464, 0.36776084] |
AUROC: 0.58853 [0.57475845, 0.60231007] | R²: 0.03129 [0.02267109, 0.0409979] | 0 | beta = log(or)/sd_pgs |
| PPM019352 | PGS004082 (prscs.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.61184 [1.56906249, 1.6557754] β: 0.47737 [0.4504783, 0.50426942] |
AUROC: 0.63222 [0.62508084, 0.63936226] | R²: 0.05074 [0.04564637, 0.05604187] | 0 | beta = log(or)/sd_pgs |
| PPM019353 | PGS003998 (lassosum.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.42404 [1.39831656, 1.45023057] β: 0.3535 [0.33526905, 0.37172256] |
AUROC: 0.6001 [0.5949638, 0.60523418] | R²: 0.02877 [0.02596878, 0.03167576] | 0 | beta = log(or)/sd_pgs |
| PPM019354 | PGS003998 (lassosum.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.43926 [1.4264734, 1.45215664] β: 0.36413 [0.35520524, 0.37304979] |
AUROC: 0.60126 [0.59879824, 0.60372757] | R²: 0.03005 [0.02852958, 0.03166569] | 0 | beta = log(or)/sd_pgs |
| PPM019355 | PGS003998 (lassosum.auto.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.2647 [1.2318407, 1.29842958] β: 0.23483 [0.20850956, 0.26115552] |
AUROC: 0.56606 [0.55863241, 0.57349723] | R²: 0.01746 [0.01370114, 0.02166157] | 0 | beta = log(or)/sd_pgs |
| PPM019356 | PGS003998 (lassosum.auto.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.47667 [1.42926706, 1.52563798] β: 0.38979 [0.35716177, 0.42241267] |
AUROC: 0.60946 [0.60043401, 0.61848076] | R²: 0.03481 [0.0294737, 0.04043389] | 0 | beta = log(or)/sd_pgs |
| PPM019357 | PGS003998 (lassosum.auto.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.36032 [1.29404504, 1.42999081] β: 0.30772 [0.257773, 0.35766802] |
AUROC: 0.58489 [0.57096818, 0.59881673] | R²: 0.0295 [0.02093187, 0.03970218] | 0 | beta = log(or)/sd_pgs |
| PPM019358 | PGS003998 (lassosum.auto.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.53698 [1.49660351, 1.57844167] β: 0.42982 [0.40319821, 0.45643808] |
AUROC: 0.61777 [0.61048014, 0.62506893] | R²: 0.04189 [0.03709939, 0.0473467] | 0 | beta = log(or)/sd_pgs |
| PPM019359 | PGS004014 (lassosum.CV.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.48322 [1.45615074, 1.51080124] β: 0.39422 [0.37579648, 0.41264014] |
AUROC: 0.60927 [0.60413864, 0.61439251] | R²: 0.03509 [0.03201869, 0.03821307] | 0 | beta = log(or)/sd_pgs |
| PPM019360 | PGS004014 (lassosum.CV.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.47356 [1.46033248, 1.48689992] β: 0.38768 [0.37866414, 0.39669336] |
AUROC: 0.60683 [0.60437322, 0.60929321] | R²: 0.03346 [0.03183656, 0.03503368] | 0 | beta = log(or)/sd_pgs |
| PPM019361 | PGS004014 (lassosum.CV.GCST004773.T2D) |
PSS011249| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.25868 [1.22581085, 1.29243541] β: 0.23007 [0.20360255, 0.25652836] |
AUROC: 0.56368 [0.55624844, 0.57110807] | R²: 0.01657 [0.01281642, 0.02064047] | 0 | beta = log(or)/sd_pgs |
| PPM019362 | PGS004014 (lassosum.CV.GCST004773.T2D) |
PSS011265| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.49153 [1.44309715, 1.54158666] β: 0.3998 [0.3667916, 0.43281218] |
AUROC: 0.61121 [0.60229023, 0.62012308] | R²: 0.03578 [0.03034362, 0.04158213] | 0 | beta = log(or)/sd_pgs |
| PPM019364 | PGS004014 (lassosum.CV.GCST004773.T2D) |
PSS011278| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.57088 [1.52910276, 1.61379743] β: 0.45164 [0.42468113, 0.47859006] |
AUROC: 0.62377 [0.61654532, 0.63100089] | R²: 0.04513 [0.04017358, 0.05012104] | 0 | beta = log(or)/sd_pgs |
| PPM020115 | PGS004182 (t2d_2) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.69491 | — | year of birth, sex | — |
| PPM020116 | PGS004183 (t2d_3) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.69959 | — | year of birth, sex | — |
| PPM020117 | PGS004184 (t2d_4) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.69539 | — | year of birth, sex | — |
| PPM020118 | PGS004185 (t2d_5) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.69924 | — | year of birth, sex | — |
| PPM020217 | PGS004225 (PRS46_T2DEastAsia) |
PSS011306| East Asian Ancestry| 5,024 individuals |
PGP000526 | Liu J et al. Nutrients (2023) |
Reported Trait: Type 2 diabetes with lifestyle group | — | — | Hazard ratio (HR, poor lifestyle and high PRS vs. ideal lifestyle and low PRS): 3.93 [2.07, 7.44] | — | — |
| PPM020158 | PGS004223 (PRS139_T2D) |
PSS011299| European Ancestry| 395,809 individuals |
PGP000523 | Lin J et al. Sci Total Environ (2023) |
Reported Trait: Incident type 2 diabetes | HR: 1.5 [1.48, 1.52] | — | — | age, gender, education, Townsend deprivation index, smoking status, alcohol consumption, body mass index, total physical activity, dietary pattern, vitamin D supplement, use of sun/UV protection, PM2.5, hypertension, cardiovascular disease, antihypertensive medications use, cholesterol-lowering medications use, and average outdoor light time | — |
| PPM020159 | PGS004223 (PRS139_T2D) |
PSS011299| European Ancestry| 395,809 individuals |
PGP000523 | Lin J et al. Sci Total Environ (2023) |
Reported Trait: Incident type 2 diabetes with outdoor light time in summer | — | — | Hazard ratio (HR, outdoor light time in summer >3h/day and PRS in top tertile vs. outdoor light time in summer <2-3 h/day and PRS in bottom tertile): 2.53 [2.39, 2.69] | Hb1Ac concentrations at baseline | — |
| PPM020160 | PGS004223 (PRS139_T2D) |
PSS011299| European Ancestry| 395,809 individuals |
PGP000523 | Lin J et al. Sci Total Environ (2023) |
Reported Trait: Incident type 2 diabetes with outdoor light time in winter | — | — | Hazard ratio (HR, outdoor light time in winter >2 h/day and PRS in top tertile vs. outdoor light time in winter <1-2 h/day and PRS in bottom tertile): 2.56 [2.42, 2.71] | Hb1Ac concentrations at baseline | — |
| PPM020161 | PGS004223 (PRS139_T2D) |
PSS011299| European Ancestry| 395,809 individuals |
PGP000523 | Lin J et al. Sci Total Environ (2023) |
Reported Trait: Incident type 2 diabetes with outdoor light time on average | — | — | Hazard ratio (HR, outdoor light time on average >2.5 h/day and PRS in top tertile vs. outdoor light time on average 1.5-2.5 h/day and PRS in bottom tertile): 2.52 [2.37, 2.67] | Hb1Ac concentrations at baseline | — |
| PPM020163 | PGS000832 (T2D-GRS) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.78 [1.49, 2.13] | — | — | age, sex and BMI | Evaluated on 381 of 384 SNPs based on the availability of variants in the cohort |
| PPM020164 | PGS000857 (T2D_Obesity) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 0.87 [0.77, 0.99] | — | — | sex | — |
| PPM020167 | PGS000848 (T2D_Adiposity) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.14 [1.01, 1.28] | — | — | sex | — |
| PPM020168 | PGS000854 (T2D_BetaCell) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 0.89 [0.79, 1.0] | — | — | sex | — |
| PPM020170 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.33 [1.12, 1.58] | — | — | age, sex and BMI | — |
| PPM020171 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.11, 1.57] | — | — | age, sex and BMI | — |
| PPM020172 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.07 [0.9, 1.28] | — | — | age, sex and BMI | — |
| PPM020173 | PGS000850 (T2D_Insulin_Action) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.16 [1.03, 1.3] | — | — | sex | — |
| PPM020174 | PGS000858 (T2D_Proinsulin) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.22 [1.03, 1.44] | — | — | age, sex and BMI | — |
| PPM020175 | PGS000855 (T2D_Lipodystrophy) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.17 [1.04, 1.31] | — | — | sex | — |
| PPM020176 | PGS000849 (T2D_Impaired_Lipids) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.2 [1.0, 1.44] | — | — | age, sex and BMI | — |
| PPM020177 | PGS000856 (T2D_LiverLipids) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Type 2 diabetes | OR: 1.29 [1.09, 1.54] | — | — | age, sex and BMI | — |
| PPM020183 | PGS000848 (T2D_Adiposity) |
PSS011301| South Asian Ancestry| 1,282 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: BMI | β: 0.06772 (0.027943) | — | — | — | — |
| PPM020187 | PGS000848 (T2D_Adiposity) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.23 [1.07, 1.43] | — | — | sex | — |
| PPM020188 | PGS000854 (T2D_BetaCell) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 0.87 [0.75, 1.0] | — | — | sex | — |
| PPM020190 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.38 [1.19, 1.59] | — | — | sex | — |
| PPM020192 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.17 [1.01, 1.34] | — | — | sex | — |
| PPM020193 | PGS000855 (T2D_Lipodystrophy) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.16 [1.0, 1.34] | — | — | sex | — |
| PPM020194 | PGS000849 (T2D_Impaired_Lipids) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.2 [1.03, 1.4] | — | — | sex | — |
| PPM020195 | PGS000856 (T2D_LiverLipids) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.24 [1.07, 1.43] | — | — | sex | — |
| PPM020196 | PGS000832 (T2D-GRS) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.5 [1.27, 1.76] | — | — | sex | Evaluated on 381 of 384 SNPs based on the availability of variants in the cohort |
| PPM020199 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.25 [1.08, 1.46] | — | — | sex | — |
| PPM020200 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.24 [1.07, 1.45] | — | — | sex | — |
| PPM020201 | PGS000850 (T2D_Insulin_Action) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.17 [1.0, 1.36] | — | — | sex | — |
| PPM020202 | PGS000858 (T2D_Proinsulin) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.2 [1.03, 1.4] | — | — | sex | — |
| PPM020203 | PGS000855 (T2D_Lipodystrophy) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.18 [1.01, 1.37] | — | — | sex | — |
| PPM020204 | PGS000849 (T2D_Impaired_Lipids) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.26 [1.07, 1.49] | — | — | sex | — |
| PPM020205 | PGS000856 (T2D_LiverLipids) |
PSS011303| South Asian Ancestry| 729 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild obesity-related diabetes | OR: 1.31 [1.12, 1.53] | — | — | sex | — |
| PPM020206 | PGS000856 (T2D_LiverLipids) |
PSS011304| South Asian Ancestry| 482 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin-resistant diabetes | OR: 2.04 [1.26, 3.3] | — | — | sex | — |
| PPM020207 | PGS000832 (T2D-GRS) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 1.54 [1.27, 1.87] | — | — | sex | Evaluated on 381 of 384 SNPs based on the availability of variants in the cohort |
| PPM020209 | PGS000854 (T2D_BetaCell) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 0.81 [0.67, 0.97] | — | — | sex | — |
| PPM020210 | PGS000852 (T2D_Insulin_Secretion_1) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 1.33 [1.1, 1.61] | — | — | sex | — |
| PPM020211 | PGS000853 (T2D_Insulin_Secretion_2) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 1.32 [1.1, 1.59] | — | — | sex | — |
| PPM020212 | PGS000851 (T2D_Insulin_Action_Secretion) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 1.45 [1.19, 1.78] | — | — | sex | — |
| PPM020213 | PGS000850 (T2D_Insulin_Action) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 1.26 [1.04, 1.53] | — | — | sex | — |
| PPM020214 | PGS000858 (T2D_Proinsulin) |
PSS011305| South Asian Ancestry| 624 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Mild age-related diabetes | OR: 1.23 [1.01, 1.48] | — | — | sex | — |
| PPM020215 | PGS004225 (PRS46_T2DEastAsia) |
PSS011306| East Asian Ancestry| 5,024 individuals |
PGP000526 | Liu J et al. Nutrients (2023) |
Reported Trait: Type 2 diabetes | — | — | Hazard ratio (HR, high vs low quintile): 2.06 [1.42, 2.97] | age, gender, SBP, DBP, FBG, TC, TG, HDLC, and diabetes family history | — |
| PPM020216 | PGS004226 (PRS50_T2DEur) |
PSS011306| East Asian Ancestry| 5,024 individuals |
PGP000526 | Liu J et al. Nutrients (2023) |
Reported Trait: Type 2 diabetes | — | — | Hazard ratio (HR, high vs low quintile): 1.69 [1.17, 2.44] | age, gender, SBP, DBP, FBG, TC, TG, HDLC, and diabetes family history | — |
| PPM020114 | PGS004181 (t2d_1) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.69418 | — | year of birth, sex | — |
| PPM020184 | PGS000832 (T2D-GRS) |
PSS011302| South Asian Ancestry| 830 individuals |
PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. |
Reported Trait: Severe insulin deficiency diabetes | OR: 1.66 [1.42, 1.93] | — | — | sex | Evaluated on 381 of 384 SNPs based on the availability of variants in the cohort |
| PPM019311 | PGS003982 (dbslmm.auto.GCST004773.T2D) |
PSS011225| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | β: 0.39562 [0.37726469, 0.41397779] OR: 1.48531 [1.45829025, 1.51282353] |
AUROC: 0.61014 [0.60505035, 0.61523315] | R²: 0.03561 [0.03220308, 0.03891372] | 0 | beta = log(or)/sd_pgs |
| PPM019318 | PGS004136 (sbayesr.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.50666 [1.49312749, 1.52030687] β: 0.40989 [0.4008729, 0.4189122] |
AUROC: 0.61306 [0.61061616, 0.61550764] | R²: 0.03751 [0.03588493, 0.03912892] | 0 | beta = log(or)/sd_pgs |
| PPM019336 | PGS004052 (megaprs.auto.GCST004773.T2D) |
PSS011236| European Ancestry| 377,408 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.53613 [1.5222648, 1.55012285] β: 0.42927 [0.42019923, 0.43833419] |
AUROC: 0.61808 [0.61563838, 0.62051629] | R²: 0.04083 [0.03909121, 0.04252571] | 0 | beta = log(or)/sd_pgs |
| PPM019363 | PGS004014 (lassosum.CV.GCST004773.T2D) |
PSS011291| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Type 2 Diabetes | OR: 1.34108 [1.27567078, 1.40985112] β: 0.29348 [0.24347214, 0.34348411] |
AUROC: 0.58226 [0.56834813, 0.59616255] | R²: 0.02672 [0.01823875, 0.03700328] | 0 | beta = log(or)/sd_pgs |
| PPM020378 | PGS004310 (GenoBoost_type_2_diabetes_0) |
PSS011343| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.70295 | Covariate-adjusted pseudo-R2: 0.03816 AUPRC: 0.70295 |
age, sex, PC1-10 | — |
| PPM020379 | PGS004311 (GenoBoost_type_2_diabetes_1) |
PSS011343| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.70067 | Covariate-adjusted pseudo-R2: 0.03626 AUPRC: 0.70067 |
age, sex, PC1-10 | — |
| PPM020380 | PGS004312 (GenoBoost_type_2_diabetes_2) |
PSS011343| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.7011 | Covariate-adjusted pseudo-R2: 0.03779 AUPRC: 0.7011 |
age, sex, PC1-10 | — |
| PPM020381 | PGS004313 (GenoBoost_type_2_diabetes_3) |
PSS011343| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.70228 | Covariate-adjusted pseudo-R2: 0.03838 AUPRC: 0.70228 |
age, sex, PC1-10 | — |
| PPM020382 | PGS004314 (GenoBoost_type_2_diabetes_4) |
PSS011343| European Ancestry| 67,428 individuals |
PGP000546 | Ohta R et al. Nat Commun (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.70378 | Covariate-adjusted pseudo-R2: 0.03925 AUPRC: 0.70378 |
age, sex, PC1-10 | — |
| PPM020433 | PGS004323 (PRS91_T2D) |
PSS011360| East Asian Ancestry| 2,676 individuals |
PGP000557 | Tan Q et al. J Hazard Mater (2023) |
Reported Trait: Fasting plasma glucose | β: 0.292 [0.181, 0.404] | — | — | Age, gender, BMI, community, and the first 10 principal components of ancestry | — |
| PPM020434 | PGS004323 (PRS91_T2D) |
PSS011360| East Asian Ancestry| 2,676 individuals |
PGP000557 | Tan Q et al. J Hazard Mater (2023) |
Reported Trait: HOMA-beta | β: -0.143 [-0.212, -0.073] | — | — | Age, gender, BMI, community, and the first 10 principal components of ancestry | — |
| PPM020435 | PGS004323 (PRS91_T2D) |
PSS011360| East Asian Ancestry| 2,676 individuals |
PGP000557 | Tan Q et al. J Hazard Mater (2023) |
Reported Trait: Impaired fasting glucose | β: 1.809 [1.362, 2.402] | — | — | Age, gender, BMI, community, and the first 10 principal components of ancestry | — |
| PPM020436 | PGS004323 (PRS91_T2D) |
PSS011360| East Asian Ancestry| 2,676 individuals |
PGP000557 | Tan Q et al. J Hazard Mater (2023) |
Reported Trait: Type 2 diabetes | β: 2.263 [1.72, 2.977] | — | — | Age, gender, BMI, community, and the first 10 principal components of ancestry | — |
| PPM020614 | PGS004499 (disease.T2D.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Type 2 diabetes (T2D) | OR: 1.51252 | — | — | — | — |
| PPM020684 | PGS004569 (meta.T2D.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Type 2 diabetes (T2D) | OR: 1.63182 | — | — | — | — |
| PPM020759 | PGS004602 (PRS424_T2D) |
PSS011395| European Ancestry| 357,419 individuals |
PGP000580 | Zhuang P et al. Diabetes Care (2021) |
Reported Trait: Type 2 diabetes | HR: 1.54 [1.5, 1.58] β: 0.431 (0.014) |
— | — | Age, sex, center, BMI, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, history of hypertension, history of high cholesterol, vitamin supplement use, mineral supplement use, aspirin use, and lipid-lowering medication | — |
| PPM020760 | PGS004602 (PRS424_T2D) |
PSS011395| European Ancestry| 357,419 individuals |
PGP000580 | Zhuang P et al. Diabetes Care (2021) |
Reported Trait: HbA1c | β: 0.544 (0.007) | — | — | Age, sex, center, BMI, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, history of hypertension, history of high cholesterol, vitamin supplement use, mineral supplement use, aspirin use, and lipid-lowering medication | — |
| PPM020793 | PGS004615 (PGS_weights_TMM_All_of_1group) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.639 | liability R2 (nested model): 0.081 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020794 | PGS004615 (PGS_weights_TMM_All_of_1group) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.679 | liability R2 (nested model): 0.114 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020795 | PGS004616 (PGS_weights_TMM_HighBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.617 | liability R2 (nested model): 0.048 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020797 | PGS004617 (PGS_weights_TMM_LowBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.632 | liability R2 (nested model): 0.06 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020798 | PGS004617 (PGS_weights_TMM_LowBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.67 | liability R2 (nested model): 0.09 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020799 | PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.661 | liability R2 (nested model): 0.125 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020800 | PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.649 | liability R2 (nested model): 0.093 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020801 | PGS004618 (PGS_weights_BBJ2nd_All_of_1group) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.693 | liability R2 (nested model): 0.154 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020802 | PGS004619 (PGS_weights_BBJ2nd_HighBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.625 | liability R2 (nested model): 0.057 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020803 | PGS004619 (PGS_weights_BBJ2nd_HighBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.659 | liability R2 (nested model): 0.094 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020804 | PGS004620 (PGS_weights_BBJ2nd_LowBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.636 | liability R2 (nested model): 0.081 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020779 | PGS004602 (PRS424_T2D) |
PSS011407| Multi-ancestry (including European)| 59,325 individuals |
PGP000587 | Luo M et al. Br J Sports Med (2023) |Ext. |
Reported Trait: Incident type 2 diabetes | — | — | Hazard ratio (HR, high vs low PRS tertile): 2.43 [2.04, 2.9] | Age as the underlying timescale, gender, genotyping array, the first 10 principal components of ancestry, ethnicity, educational attainment, household income, Townsend deprivation index, employment status, assessment center, moking status, alcohol consumption, healthy diet score, hypertension, dyslipidemia, depression, total wear time, seasonality, and total volume of physical activity | — |
| PPM020889 | PGS002026 (portability-ldpred2_250.2) |
PSS011442| European Ancestry| 564 individuals |
PGP000599 | Guarischi-Sousa R et al. Circ Genom Precis Med (2023) |Ext. |
Reported Trait: Raised coronary lesion | OR: 0.96 [0.8, 1.16] | — | — | — | — |
| PPM020894 | PGS002026 (portability-ldpred2_250.2) |
PSS011441| African Ancestry| 504 individuals |
PGP000599 | Guarischi-Sousa R et al. Circ Genom Precis Med (2023) |Ext. |
Reported Trait: Raised coronary lesion | OR: 1.1 [0.9, 1.35] | — | — | — | — |
| PPM021062 | PGS004837 (t2d_PRSmix_eur) |
PSS011507| European Ancestry| 7,879 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (Full model versus model with only covariates): 0.099 [0.087, 0.112] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM021063 | PGS004838 (t2d_PRSmix_sas) |
PSS011474| South Asian Ancestry| 8,837 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (Full model versus model with only covariates): 0.061 [0.051, 0.07] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM021064 | PGS004839 (t2d_PRSmixPlus_eur) |
PSS011507| European Ancestry| 7,879 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (Full model versus model with only covariates): 0.129 [0.115, 0.143] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM021065 | PGS004840 (t2d_PRSmixPlus_sas) |
PSS011474| South Asian Ancestry| 8,837 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Type 2 diabetes | — | — | Incremental R2 (Full model versus model with only covariates): 0.065 [0.055, 0.075] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM021085 | PGS004859 (T2D_PRS_CS) |
PSS011514| African Ancestry| 7,010 individuals |
PGP000606 | Szczerbinski L et al. medRxiv (2023) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.35, 1.52] | AUROC: 0.76 [0.74, 0.77] | — | age, sex, 10 principal components | — |
| PPM021086 | PGS004859 (T2D_PRS_CS) |
PSS011516| Hispanic or Latin American Ancestry| 5,382 individuals |
PGP000606 | Szczerbinski L et al. medRxiv (2023) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 2.09 [1.92, 2.27] | AUROC: 0.84 [0.82, 0.86] | — | age, sex, 10 principal components | — |
| PPM021087 | PGS004859 (T2D_PRS_CS) |
PSS011517| East Asian Ancestry| 663 individuals |
PGP000606 | Szczerbinski L et al. medRxiv (2023) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.84 [0.79, 0.9] | — | age, sex, 10 principal components | — |
| PPM021088 | PGS004859 (T2D_PRS_CS) |
PSS011518| European Ancestry| 22,306 individuals |
PGP000606 | Szczerbinski L et al. medRxiv (2023) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 2.33 [2.23, 2.43] | AUROC: 0.77 [0.76, 0.78] | — | age, sex, 10 principal components | — |
| PPM021089 | PGS004859 (T2D_PRS_CS) |
PSS011519| South Asian Ancestry| 323 individuals |
PGP000606 | Szczerbinski L et al. medRxiv (2023) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 2.28 [1.64, 3.16] | AUROC: 0.88 [0.81, 0.95] | — | age, sex, 10 principal components | — |
| PPM021090 | PGS004859 (T2D_PRS_CS) |
PSS011515| Multi-ancestry (including European)| 35,684 individuals |
PGP000606 | Szczerbinski L et al. medRxiv (2023) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.93 [1.87, 1.99] | AUROC: 0.75 [0.74, 0.75] | — | age, sex, 10 principal components | — |
| PPM021084 | PGS004859 (T2D_PRS_CS) |
PSS011513| Multi-ancestry (including European)| 546 individuals |
PGP000605 | Deutsch AJ et al. Diabetes Care (2023) |
Reported Trait: Glucocorticoid-induced hyperglycemia | OR: 1.44 [1.02, 2.04] | AUROC: 0.68 | — | eGFR, glucocorticoid dose | — |
| PPM021133 | PGS004868 (T2DPGS) |
PSS011537| European Ancestry| 345,217 individuals |
PGP000617 | Yun JS et al. Cardiovasc Diabetol (2022) |
Reported Trait: Incident cardiovascular disease | HR: 1.06 [1.04, 1.07] | — | Hazard ratio (HR, top PRS percentile vs bottom quintile): 1.35 [1.19, 1.53] | Age, sex, genotyping array, 10 PCs | — |
| PPM021142 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011650| European Ancestry| 38,343 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.42 [1.38, 1.45] | C-index: 0.61 [0.6, 0.62] | — | PCs 1-10 | — |
| PPM021143 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011649| European Ancestry| 69,715 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.86 [1.79, 1.93] | C-index: 0.69 [0.68, 0.7] | — | PCs 1-10 | — |
| PPM021144 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011648| European Ancestry| 29,427 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.87 [1.79, 1.95] | C-index: 0.68 [0.67, 0.69] | — | PCs 1-10 | — |
| PPM021145 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011646| European Ancestry| 44,183 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.56 [1.51, 1.6] | — | — | PCs 1-10 | — |
| PPM021146 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011647| European Ancestry| 7,018 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.68 [1.55, 1.83] | C-index: 0.64 [0.62, 0.67] | — | PCs 1-10 | — |
| PPM021147 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011645| European Ancestry| 412,090 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.7 [1.69, 1.71] | C-index: 0.66 [0.66, 0.66] | — | PCs 1-10 | — |
| PPM021148 | PGS004870 (INTERVENE_MegaPRS_T2D) |
PSS011644| European Ancestry| 148,312 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T2D | HR: 1.78 [1.74, 1.82] | C-index: 0.67 [0.66, 0.67] | — | PCs 1-10 | — |
| PPM021265 | PGS004887 (T2D_gePGS) |
PSS011671| Multi-ancestry (including European)| 14,712 individuals |
PGP000619 | Mandla R et al. Genome Med (2024) |
Reported Trait: Incident type 2 diabetes cases | HR: 1.48 [1.4, 1.57] | C-index: 0.816 | — | first 10 ancestry PCs, age, sex, BMI, family history of T2D, systolic blood pressure, triglycerides, total cholesterol, and HDL combined into a clinical risk score and random glucose | — |
| PPM021336 | PGS004602 (PRS424_T2D) |
PSS011692| European Ancestry| 433,150 individuals |
PGP000634 | Chen JX et al. J Clin Endocrinol Metab (2023) |Ext. |
Reported Trait: Age at onset of type 2 diabetes ≤ 50 years | HR: 1.26 [1.13, 1.41] | — | — | Sex, ethnicity, education, Townsend deprivation index, 4 age groups, follow-up time category, HbA1c, BMI, systolic blood pressure, smoking status, physical activity, diet, use of antihypertensive drugs, use of lipid-lowering drugs, cardiovascular disease, parental history of diabetes | — |
| PPM021411 | PGS002771 (Type_2_diabetes_prscs) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.89 [1.85, 1.94] | AUROC: 0.735 [0.73, 0.74] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021413 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.86 [1.82, 1.9] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021414 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.86 [1.82, 1.9] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021415 | PGS003867 (T2D_PRScs_ARB) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.84 [1.8, 1.88] | AUROC: 0.73 [0.725, 0.735] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021416 | PGS000330 (PRS_T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.79 [1.75, 1.83] | AUROC: 0.726 [0.721, 0.73] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021417 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.74, 1.81] | AUROC: 0.725 [0.72, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021418 | PGS002026 (portability-ldpred2_250.2) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.67 [1.63, 1.71] | AUROC: 0.714 [0.709, 0.719] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021419 | PGS000729 (T2D_PGS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.65 [1.61, 1.68] | AUROC: 0.712 [0.707, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021420 | PGS000713 (T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.63 [1.6, 1.67] | AUROC: 0.712 [0.707, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021421 | PGS001818 (portability-PLR_250.2) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.62 [1.58, 1.65] | AUROC: 0.709 [0.704, 0.714] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021422 | PGS000805 (GRS582_T2Deur) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.59 [1.56, 1.63] | AUROC: 0.707 [0.702, 0.712] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021423 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.56 [1.53, 1.59] | AUROC: 0.704 [0.699, 0.709] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021424 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.52, 1.59] | AUROC: 0.704 [0.699, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021425 | PGS002243 (ldpred_t2d) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.52, 1.59] | AUROC: 0.703 [0.698, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021426 | PGS001781 (T2D_PRSCS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.54 [1.51, 1.58] | AUROC: 0.702 [0.698, 0.707] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021427 | PGS000036 (gePS_T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.53 [1.5, 1.56] | AUROC: 0.701 [0.696, 0.706] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021428 | PGS000014 (GPS_T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.51 [1.48, 1.55] | AUROC: 0.7 [0.695, 0.705] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021429 | PGS000868 (T2D_221) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.48 [1.45, 1.51] | AUROC: 0.696 [0.691, 0.701] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021432 | PGS004923 (T2D_metaGRS) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 2.3 [2.26, 2.35] | AUROC: 0.777 [0.772, 0.781] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021433 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.77, 1.84] | AUROC: 0.739 [0.734, 0.743] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021434 | PGS002243 (ldpred_t2d) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.78 [1.75, 1.82] | AUROC: 0.737 [0.733, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021435 | PGS001781 (T2D_PRSCS) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.74, 1.81] | AUROC: 0.736 [0.732, 0.741] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021436 | PGS000036 (gePS_T2D) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.73 [1.69, 1.76] | AUROC: 0.733 [0.728, 0.737] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021437 | PGS000014 (GPS_T2D) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.71 [1.67, 1.74] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021438 | PGS004923 (T2D_metaGRS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 2.07 [1.92, 2.23] | C-index: 0.774 [0.758, 0.79] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021439 | PGS002771 (Type_2_diabetes_prscs) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 2.03 [1.88, 2.18] | C-index: 0.772 [0.756, 0.788] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021441 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.98 [1.84, 2.13] | C-index: 0.77 [0.754, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021442 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.98 [1.84, 2.13] | C-index: 0.77 [0.754, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021443 | PGS003867 (T2D_PRScs_ARB) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.95 [1.81, 2.1] | C-index: 0.766 [0.75, 0.782] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021444 | PGS000330 (PRS_T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.94 [1.8, 2.09] | C-index: 0.767 [0.75, 0.783] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021445 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.89 [1.76, 2.04] | C-index: 0.759 [0.743, 0.775] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021446 | PGS002026 (portability-ldpred2_250.2) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.81 [1.68, 1.95] | C-index: 0.752 [0.735, 0.769] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021447 | PGS001818 (portability-PLR_250.2) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.75 [1.63, 1.89] | C-index: 0.75 [0.734, 0.767] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021448 | PGS000729 (T2D_PGS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.75 [1.62, 1.88] | C-index: 0.753 [0.737, 0.77] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021449 | PGS000713 (T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.74 [1.62, 1.88] | C-index: 0.748 [0.732, 0.765] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021450 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.67 [1.56, 1.8] | C-index: 0.742 [0.724, 0.759] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021451 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.65 [1.53, 1.77] | C-index: 0.742 [0.725, 0.76] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021452 | PGS002780 (GTG_T2D_SCT) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.65 [1.53, 1.77] | C-index: 0.742 [0.725, 0.759] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021453 | PGS002243 (ldpred_t2d) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.64 [1.53, 1.77] | C-index: 0.741 [0.723, 0.758] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021454 | PGS000036 (gePS_T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.63 [1.52, 1.75] | C-index: 0.742 [0.725, 0.759] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021455 | PGS001781 (T2D_PRSCS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.61 [1.5, 1.73] | C-index: 0.741 [0.723, 0.758] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021456 | PGS000868 (T2D_221) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.6 [1.48, 1.72] | C-index: 0.736 [0.719, 0.753] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021457 | PGS000805 (GRS582_T2Deur) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.59 [1.48, 1.71] | C-index: 0.736 [0.718, 0.753] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021458 | PGS000014 (GPS_T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.58 [1.47, 1.7] | C-index: 0.737 [0.719, 0.754] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021459 | PGS000864 (T2D-gPRS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.32 [1.27, 1.38] | C-index: 0.731 [0.714, 0.749] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021460 | PGS004923 (T2D_metaGRS) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.8 [1.75, 1.85] | C-index: 0.719 [0.713, 0.725] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021461 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.51 [1.47, 1.55] | C-index: 0.69 [0.684, 0.696] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021462 | PGS002243 (ldpred_t2d) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.49 [1.45, 1.52] | C-index: 0.689 [0.683, 0.695] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021463 | PGS001781 (T2D_PRSCS) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.48 [1.45, 1.52] | C-index: 0.688 [0.682, 0.695] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021464 | PGS000036 (gePS_T2D) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.46 [1.42, 1.5] | C-index: 0.687 [0.68, 0.693] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021465 | PGS000014 (GPS_T2D) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.45 [1.42, 1.49] | C-index: 0.686 [0.679, 0.692] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021466 | PGS003867 (T2D_PRScs_ARB) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.37 [1.33, 1.41] | AUROC: 0.727 [0.72, 0.733] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021467 | PGS004923 (T2D_metaGRS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.35 [1.31, 1.39] | AUROC: 0.725 [0.718, 0.731] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021468 | PGS002771 (Type_2_diabetes_prscs) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.33 [1.3, 1.37] | AUROC: 0.724 [0.717, 0.73] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021469 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | AUROC: 0.723 [0.717, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021470 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | AUROC: 0.723 [0.717, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021471 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | AUROC: 0.723 [0.717, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021473 | PGS002026 (portability-ldpred2_250.2) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.28 [1.24, 1.32] | AUROC: 0.721 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021474 | PGS000330 (PRS_T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.23, 1.31] | AUROC: 0.72 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021475 | PGS001818 (portability-PLR_250.2) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.23, 1.3] | AUROC: 0.72 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021476 | PGS002243 (ldpred_t2d) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.712, 0.725] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021477 | PGS000805 (GRS582_T2Deur) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021478 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021479 | PGS000713 (T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021480 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.22 [1.19, 1.26] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021481 | PGS000729 (T2D_PGS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.19, 1.26] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021482 | PGS000036 (gePS_T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.18, 1.25] | AUROC: 0.717 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021483 | PGS000868 (T2D_221) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.17, 1.24] | AUROC: 0.717 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021484 | PGS000014 (GPS_T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.17, 1.24] | AUROC: 0.717 [0.71, 0.723] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021485 | PGS001781 (T2D_PRSCS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.2 [1.16, 1.23] | AUROC: 0.716 [0.71, 0.723] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021486 | PGS002780 (GTG_T2D_SCT) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.18 [1.14, 1.21] | AUROC: 0.715 [0.709, 0.722] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021489 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.71, 1.84] | AUROC: 0.78 [0.773, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021490 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.71, 1.84] | AUROC: 0.78 [0.773, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021491 | PGS004923 (T2D_metaGRS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.73 [1.67, 1.79] | AUROC: 0.777 [0.77, 0.783] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021492 | PGS003867 (T2D_PRScs_ARB) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.72 [1.65, 1.78] | AUROC: 0.776 [0.769, 0.783] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021493 | PGS002771 (Type_2_diabetes_prscs) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.7 [1.64, 1.76] | AUROC: 0.775 [0.769, 0.782] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021494 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.55, 1.67] | AUROC: 0.77 [0.764, 0.777] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021495 | PGS000330 (PRS_T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.58 [1.53, 1.64] | AUROC: 0.768 [0.761, 0.775] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021496 | PGS002026 (portability-ldpred2_250.2) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.49 [1.44, 1.55] | AUROC: 0.764 [0.757, 0.771] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021497 | PGS000805 (GRS582_T2Deur) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.49 [1.44, 1.55] | AUROC: 0.764 [0.758, 0.771] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021498 | PGS001818 (portability-PLR_250.2) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.41, 1.51] | AUROC: 0.762 [0.755, 0.769] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021499 | PGS000713 (T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.41, 1.51] | AUROC: 0.762 [0.755, 0.769] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021500 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.45 [1.4, 1.51] | AUROC: 0.761 [0.754, 0.768] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021501 | PGS000729 (T2D_PGS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.45 [1.4, 1.51] | AUROC: 0.761 [0.754, 0.768] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021502 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.44 [1.39, 1.49] | AUROC: 0.761 [0.754, 0.768] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021503 | PGS002243 (ldpred_t2d) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.38, 1.48] | AUROC: 0.76 [0.753, 0.767] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021504 | PGS001781 (T2D_PRSCS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.38, 1.48] | AUROC: 0.76 [0.753, 0.767] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021505 | PGS000036 (gePS_T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.41 [1.36, 1.46] | AUROC: 0.759 [0.752, 0.766] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021506 | PGS000014 (GPS_T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.39 [1.34, 1.44] | AUROC: 0.757 [0.75, 0.764] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021507 | PGS000868 (T2D_221) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.38 [1.33, 1.43] | AUROC: 0.758 [0.751, 0.765] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021508 | PGS002780 (GTG_T2D_SCT) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.35 [1.31, 1.4] | AUROC: 0.756 [0.749, 0.763] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021509 | PGS000864 (T2D-gPRS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.02 [0.99, 1.06] | AUROC: 0.745 [0.738, 0.752] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021510 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.29, 1.77] | AUROC: 0.648 [0.607, 0.688] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021511 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.29, 1.77] | AUROC: 0.648 [0.607, 0.688] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021512 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.29, 1.77] | AUROC: 0.648 [0.607, 0.688] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021513 | PGS003867 (T2D_PRScs_ARB) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.42 [1.22, 1.66] | AUROC: 0.635 [0.594, 0.676] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021514 | PGS002771 (Type_2_diabetes_prscs) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.4 [1.2, 1.64] | AUROC: 0.634 [0.592, 0.676] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021515 | PGS004923 (T2D_metaGRS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.37 [1.17, 1.6] | AUROC: 0.627 [0.585, 0.669] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021517 | PGS001818 (portability-PLR_250.2) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.3 [1.11, 1.51] | AUROC: 0.622 [0.581, 0.664] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021518 | PGS000805 (GRS582_T2Deur) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.3 [1.11, 1.52] | AUROC: 0.613 [0.572, 0.654] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021519 | PGS000330 (PRS_T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.29 [1.11, 1.51] | AUROC: 0.619 [0.577, 0.661] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021520 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.28 [1.1, 1.5] | AUROC: 0.619 [0.578, 0.661] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021521 | PGS000036 (gePS_T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.25 [1.07, 1.46] | AUROC: 0.608 [0.566, 0.651] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021522 | PGS000729 (T2D_PGS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.25 [1.07, 1.46] | AUROC: 0.615 [0.572, 0.657] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021523 | PGS000868 (T2D_221) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.24 [1.06, 1.44] | AUROC: 0.604 [0.564, 0.645] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021524 | PGS000713 (T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.19 [1.02, 1.39] | AUROC: 0.598 [0.554, 0.641] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021525 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.15 [0.98, 1.34] | AUROC: 0.593 [0.55, 0.636] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021526 | PGS002780 (GTG_T2D_SCT) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.14 [0.98, 1.33] | AUROC: 0.598 [0.556, 0.641] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021527 | PGS001781 (T2D_PRSCS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.12 [0.96, 1.3] | AUROC: 0.593 [0.551, 0.636] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021528 | PGS002243 (ldpred_t2d) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.08 [0.93, 1.26] | AUROC: 0.592 [0.548, 0.635] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021529 | PGS000864 (T2D-gPRS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.04 [0.9, 1.21] | AUROC: 0.584 [0.54, 0.628] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021530 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.98 [0.84, 1.14] | AUROC: 0.585 [0.541, 0.629] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021531 | PGS000014 (GPS_T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.99 [0.85, 1.16] | AUROC: 0.585 [0.541, 0.629] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021532 | PGS004923 (T2D_metaGRS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.69 [1.42, 2.02] | AUROC: 0.698 [0.658, 0.737] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021533 | PGS002771 (Type_2_diabetes_prscs) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.57 [1.32, 1.87] | AUROC: 0.682 [0.642, 0.723] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021534 | PGS001818 (portability-PLR_250.2) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.54 [1.3, 1.83] | AUROC: 0.677 [0.634, 0.72] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021535 | PGS003867 (T2D_PRScs_ARB) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.52 [1.29, 1.81] | AUROC: 0.681 [0.641, 0.722] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021536 | PGS000868 (T2D_221) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.52 [1.28, 1.8] | AUROC: 0.677 [0.635, 0.72] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021538 | PGS002026 (portability-ldpred2_250.2) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.666 [0.623, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021539 | PGS002780 (GTG_T2D_SCT) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.69] | AUROC: 0.666 [0.624, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021541 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.667 [0.626, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021542 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.667 [0.626, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021543 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.38 [1.17, 1.64] | AUROC: 0.667 [0.626, 0.709] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021544 | PGS000330 (PRS_T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.32 [1.12, 1.57] | AUROC: 0.66 [0.619, 0.701] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021545 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.27 [1.08, 1.5] | AUROC: 0.655 [0.613, 0.696] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021546 | PGS000729 (T2D_PGS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.25 [1.06, 1.48] | AUROC: 0.653 [0.612, 0.694] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021547 | PGS000036 (gePS_T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.23 [1.04, 1.45] | AUROC: 0.651 [0.609, 0.693] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021548 | PGS002243 (ldpred_t2d) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.12 [0.95, 1.32] | AUROC: 0.643 [0.6, 0.685] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021549 | PGS001781 (T2D_PRSCS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.12 [0.95, 1.32] | AUROC: 0.645 [0.602, 0.687] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021550 | PGS000713 (T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.91 [0.77, 1.08] | AUROC: 0.643 [0.6, 0.686] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021551 | PGS000864 (T2D-gPRS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.09 [0.93, 1.28] | AUROC: 0.643 [0.6, 0.686] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021552 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.96 [0.81, 1.13] | AUROC: 0.641 [0.598, 0.684] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021553 | PGS000014 (GPS_T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.03 [0.87, 1.21] | AUROC: 0.639 [0.596, 0.683] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021554 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.71 [1.43, 2.06] | AUROC: 0.706 [0.665, 0.746] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021555 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.71 [1.43, 2.06] | AUROC: 0.706 [0.665, 0.746] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021556 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.71 [1.43, 2.06] | AUROC: 0.706 [0.665, 0.746] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021557 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.68 [1.4, 2.01] | AUROC: 0.705 [0.664, 0.745] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021559 | PGS003867 (T2D_PRScs_ARB) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.64 [1.37, 1.98] | AUROC: 0.701 [0.659, 0.742] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021560 | PGS002771 (Type_2_diabetes_prscs) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.62 [1.36, 1.95] | AUROC: 0.696 [0.654, 0.738] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021561 | PGS000805 (GRS582_T2Deur) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.58 [1.33, 1.88] | AUROC: 0.701 [0.659, 0.743] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021562 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.5 [1.26, 1.79] | AUROC: 0.682 [0.64, 0.725] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021564 | PGS002026 (portability-ldpred2_250.2) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.44 [1.22, 1.72] | AUROC: 0.685 [0.643, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021565 | PGS000729 (T2D_PGS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.37 [1.16, 1.63] | AUROC: 0.668 [0.625, 0.712] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021566 | PGS001781 (T2D_PRSCS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.37 [1.16, 1.63] | AUROC: 0.672 [0.629, 0.715] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021567 | PGS001818 (portability-PLR_250.2) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.36 [1.15, 1.62] | AUROC: 0.675 [0.632, 0.718] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021568 | PGS000868 (T2D_221) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.34 [1.14, 1.6] | AUROC: 0.674 [0.631, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021569 | PGS002243 (ldpred_t2d) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.32 [1.11, 1.57] | AUROC: 0.669 [0.625, 0.712] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021570 | PGS002780 (GTG_T2D_SCT) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.27 [1.07, 1.5] | AUROC: 0.668 [0.625, 0.711] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021571 | PGS000014 (GPS_T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.82 [0.69, 0.97] | AUROC: 0.662 [0.618, 0.706] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021572 | PGS000036 (gePS_T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.2 [1.01, 1.42] | AUROC: 0.657 [0.612, 0.701] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021573 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.05 [0.89, 1.24] | AUROC: 0.655 [0.611, 0.698] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021574 | PGS000713 (T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.95 [0.8, 1.12] | AUROC: 0.652 [0.608, 0.696] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021575 | PGS000864 (T2D-gPRS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.98 [0.83, 1.16] | AUROC: 0.653 [0.609, 0.697] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021576 | PGS004923 (T2D_metaGRS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.41 [1.31, 1.53] | AUROC: 0.723 [0.704, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021577 | PGS002771 (Type_2_diabetes_prscs) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.41 [1.3, 1.53] | AUROC: 0.724 [0.705, 0.743] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021579 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.3, 1.52] | AUROC: 0.723 [0.705, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021580 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.3, 1.52] | AUROC: 0.723 [0.705, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021581 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.29, 1.51] | AUROC: 0.721 [0.702, 0.74] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021582 | PGS002026 (portability-ldpred2_250.2) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.35 [1.24, 1.46] | AUROC: 0.719 [0.7, 0.737] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021583 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.22, 1.43] | AUROC: 0.717 [0.698, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021584 | PGS001818 (portability-PLR_250.2) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.22, 1.43] | AUROC: 0.716 [0.697, 0.735] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021585 | PGS002243 (ldpred_t2d) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.31 [1.21, 1.42] | AUROC: 0.716 [0.696, 0.735] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021586 | PGS000330 (PRS_T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.31 [1.21, 1.42] | AUROC: 0.716 [0.696, 0.735] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021587 | PGS000713 (T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.31 [1.21, 1.42] | AUROC: 0.714 [0.695, 0.734] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021588 | PGS001781 (T2D_PRSCS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.29 [1.2, 1.4] | AUROC: 0.714 [0.695, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021589 | PGS000014 (GPS_T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.18, 1.38] | AUROC: 0.714 [0.695, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021590 | PGS000805 (GRS582_T2Deur) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.18, 1.38] | AUROC: 0.714 [0.694, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021591 | PGS000036 (gePS_T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.25 [1.16, 1.35] | AUROC: 0.71 [0.691, 0.729] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021592 | PGS000729 (T2D_PGS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.25 [1.15, 1.35] | AUROC: 0.711 [0.692, 0.73] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021593 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.14, 1.33] | AUROC: 0.711 [0.692, 0.73] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021594 | PGS000868 (T2D_221) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.19 [1.1, 1.29] | AUROC: 0.708 [0.689, 0.728] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021595 | PGS002780 (GTG_T2D_SCT) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.17 [1.09, 1.27] | AUROC: 0.708 [0.689, 0.727] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021596 | PGS000864 (T2D-gPRS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.08 [1.0, 1.17] | AUROC: 0.705 [0.686, 0.724] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021597 | PGS000713 (T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.9 [1.48, 2.45] | AUROC: 0.754 [0.7, 0.808] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021598 | PGS004923 (T2D_metaGRS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.82 [1.42, 2.37] | AUROC: 0.734 [0.678, 0.79] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021599 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.738 [0.684, 0.791] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021641 | PGS002771 (Type_2_diabetes_prscs) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.18 [1.07, 1.31] | C-index: 0.645 [0.618, 0.672] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021601 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.738 [0.684, 0.791] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021602 | PGS001818 (portability-PLR_250.2) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.74 [1.36, 2.22] | AUROC: 0.734 [0.679, 0.788] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021603 | PGS000805 (GRS582_T2Deur) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.7 [1.35, 2.16] | AUROC: 0.734 [0.679, 0.788] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021604 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.73 [1.35, 2.21] | AUROC: 0.737 [0.68, 0.793] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021605 | PGS002026 (portability-ldpred2_250.2) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.6 [1.26, 2.03] | AUROC: 0.722 [0.664, 0.78] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021606 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.26, 2.07] | AUROC: 0.726 [0.67, 0.781] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021607 | PGS002771 (Type_2_diabetes_prscs) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.64 [1.27, 2.12] | AUROC: 0.728 [0.673, 0.783] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021608 | PGS000868 (T2D_221) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.57 [1.24, 2.0] | AUROC: 0.727 [0.672, 0.782] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021609 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.45 [1.14, 1.84] | AUROC: 0.712 [0.655, 0.769] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021610 | PGS002780 (GTG_T2D_SCT) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.44 [1.13, 1.83] | AUROC: 0.712 [0.655, 0.769] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021611 | PGS000330 (PRS_T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.12, 1.83] | AUROC: 0.714 [0.658, 0.77] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021612 | PGS000036 (gePS_T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.39 [1.1, 1.77] | AUROC: 0.722 [0.668, 0.776] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021613 | PGS000729 (T2D_PGS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.1, 1.8] | AUROC: 0.718 [0.666, 0.771] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021614 | PGS002243 (ldpred_t2d) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.36 [1.08, 1.73] | AUROC: 0.708 [0.65, 0.766] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021615 | PGS000014 (GPS_T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.28 [1.01, 1.61] | AUROC: 0.705 [0.648, 0.763] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021616 | PGS001781 (T2D_PRSCS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.22 [0.96, 1.55] | AUROC: 0.704 [0.647, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021617 | PGS000864 (T2D-gPRS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.05 [0.83, 1.32] | AUROC: 0.7 [0.643, 0.757] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021619 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.91 [1.78, 2.05] | AUROC: 0.746 [0.732, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021620 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.91 [1.78, 2.05] | AUROC: 0.746 [0.732, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021621 | PGS004923 (T2D_metaGRS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.88 [1.75, 2.01] | AUROC: 0.742 [0.727, 0.756] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021622 | PGS002771 (Type_2_diabetes_prscs) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.85 [1.73, 1.99] | AUROC: 0.742 [0.728, 0.757] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021623 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.72 [1.6, 1.84] | AUROC: 0.73 [0.715, 0.745] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021624 | PGS002026 (portability-ldpred2_250.2) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.64 [1.53, 1.75] | AUROC: 0.724 [0.709, 0.739] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021625 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.62 [1.52, 1.73] | AUROC: 0.723 [0.708, 0.738] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021626 | PGS000330 (PRS_T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.62 [1.51, 1.73] | AUROC: 0.724 [0.709, 0.738] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021627 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.51, 1.72] | AUROC: 0.721 [0.706, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021628 | PGS001818 (portability-PLR_250.2) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.51, 1.72] | AUROC: 0.723 [0.708, 0.738] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021629 | PGS000805 (GRS582_T2Deur) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.51, 1.73] | AUROC: 0.721 [0.706, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021630 | PGS000713 (T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.59 [1.49, 1.7] | AUROC: 0.721 [0.705, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021631 | PGS002243 (ldpred_t2d) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.57 [1.47, 1.67] | AUROC: 0.718 [0.703, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021632 | PGS000729 (T2D_PGS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.45, 1.66] | AUROC: 0.717 [0.703, 0.732] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021633 | PGS001781 (T2D_PRSCS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.53 [1.43, 1.64] | AUROC: 0.716 [0.701, 0.731] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021634 | PGS002780 (GTG_T2D_SCT) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.53 [1.43, 1.63] | AUROC: 0.713 [0.698, 0.729] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021635 | PGS000014 (GPS_T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.48 [1.39, 1.58] | AUROC: 0.711 [0.696, 0.726] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021636 | PGS000868 (T2D_221) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.49 [1.39, 1.59] | AUROC: 0.711 [0.696, 0.726] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021637 | PGS000036 (gePS_T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.44 [1.35, 1.54] | AUROC: 0.707 [0.692, 0.722] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021638 | PGS000864 (T2D-gPRS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.16, 1.31] | AUROC: 0.693 [0.678, 0.709] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021639 | PGS004923 (T2D_metaGRS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.22 [1.1, 1.34] | C-index: 0.649 [0.623, 0.676] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021640 | PGS000805 (GRS582_T2Deur) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.19 [1.08, 1.31] | C-index: 0.646 [0.619, 0.673] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021643 | PGS000729 (T2D_PGS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.16 [1.05, 1.28] | C-index: 0.642 [0.615, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021644 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [1.04, 1.27] | C-index: 0.645 [0.618, 0.672] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021645 | PGS001781 (T2D_PRSCS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.03, 1.25] | C-index: 0.641 [0.613, 0.668] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021647 | PGS000868 (T2D_221) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.644 [0.616, 0.671] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021649 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.616, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021650 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.616, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021651 | PGS002026 (portability-ldpred2_250.2) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.02, 1.24] | C-index: 0.643 [0.616, 0.67] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021652 | PGS002780 (GTG_T2D_SCT) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.01, 1.23] | C-index: 0.644 [0.617, 0.671] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021653 | PGS000014 (GPS_T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.01, 1.23] | C-index: 0.641 [0.614, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021654 | PGS000713 (T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.01, 1.23] | C-index: 0.644 [0.617, 0.671] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021655 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.11 [1.01, 1.23] | C-index: 0.643 [0.615, 0.67] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021656 | PGS000036 (gePS_T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.11 [1.0, 1.22] | C-index: 0.641 [0.614, 0.668] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021657 | PGS002243 (ldpred_t2d) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.1 [1.0, 1.22] | C-index: 0.641 [0.614, 0.668] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021658 | PGS001818 (portability-PLR_250.2) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.09 [0.98, 1.2] | C-index: 0.642 [0.615, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021659 | PGS000864 (T2D-gPRS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 0.94 [0.85, 1.03] | C-index: 0.639 [0.612, 0.667] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021660 | PGS000713 (T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.74 [1.25, 2.41] | C-index: 0.722 [0.646, 0.798] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021661 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.66 [1.19, 2.31] | C-index: 0.713 [0.638, 0.787] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021662 | PGS002771 (Type_2_diabetes_prscs) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.61 [1.14, 2.27] | C-index: 0.697 [0.619, 0.775] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021663 | PGS000330 (PRS_T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.58 [1.13, 2.22] | C-index: 0.695 [0.611, 0.779] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021664 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.57 [1.12, 2.21] | C-index: 0.689 [0.612, 0.765] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021665 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.57 [1.12, 2.21] | C-index: 0.689 [0.612, 0.765] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021666 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.57 [1.12, 2.21] | C-index: 0.689 [0.612, 0.765] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021667 | PGS004923 (T2D_metaGRS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.43 [1.02, 2.01] | C-index: 0.696 [0.624, 0.767] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021668 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.39 [1.01, 1.92] | C-index: 0.687 [0.612, 0.762] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021669 | PGS000729 (T2D_PGS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.4 [1.0, 1.95] | C-index: 0.686 [0.611, 0.76] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021670 | PGS000868 (T2D_221) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.37 [0.99, 1.9] | C-index: 0.684 [0.609, 0.758] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021671 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.37 [0.99, 1.89] | C-index: 0.688 [0.612, 0.764] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021672 | PGS002780 (GTG_T2D_SCT) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.31 [0.95, 1.81] | C-index: 0.683 [0.61, 0.755] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021673 | PGS000805 (GRS582_T2Deur) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.28 [0.93, 1.76] | C-index: 0.679 [0.606, 0.753] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021674 | PGS002026 (portability-ldpred2_250.2) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.28 [0.92, 1.77] | C-index: 0.686 [0.609, 0.763] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021675 | PGS001818 (portability-PLR_250.2) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.25 [0.9, 1.73] | C-index: 0.687 [0.616, 0.758] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021676 | PGS001781 (T2D_PRSCS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [0.9, 1.72] | C-index: 0.685 [0.609, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021677 | PGS000014 (GPS_T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [0.9, 1.7] | C-index: 0.684 [0.609, 0.758] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021678 | PGS000036 (gePS_T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.23 [0.89, 1.7] | C-index: 0.68 [0.603, 0.756] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021679 | PGS002243 (ldpred_t2d) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [0.83, 1.58] | C-index: 0.679 [0.606, 0.752] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM020792 | PGS004615 (PGS_weights_TMM_All_of_1group) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.657 | liability R2 (nested model): 0.097 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020796 | PGS004616 (PGS_weights_TMM_HighBMI_of_2groups) |
PSS011417| East Asian Ancestry| 26,000 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.653 | liability R2 (nested model): 0.065 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM020805 | PGS004620 (PGS_weights_BBJ2nd_LowBMI_of_2groups) |
PSS011416| East Asian Ancestry| 33,096 individuals |
PGP000593 | Ojima T et al. Nat Genet (2024) |
Reported Trait: Type 2 diabetes | — | AUROC: 0.682 | liability R2 (nested model): 0.143 | age, age2, sex, sex × age, sex × age2 and the top 20 principal components | — |
| PPM021682 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.42 [1.3, 1.55] | C-index: 0.639 [0.617, 0.662] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021683 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.42 [1.3, 1.55] | C-index: 0.639 [0.617, 0.662] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021684 | PGS002771 (Type_2_diabetes_prscs) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.35 [1.24, 1.48] | C-index: 0.63 [0.607, 0.652] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021685 | PGS004923 (T2D_metaGRS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.35 [1.24, 1.48] | C-index: 0.629 [0.606, 0.651] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021686 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.33 [1.22, 1.45] | C-index: 0.627 [0.605, 0.65] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021687 | PGS000330 (PRS_T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.28 [1.17, 1.4] | C-index: 0.622 [0.6, 0.645] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021688 | PGS000805 (GRS582_T2Deur) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.26 [1.16, 1.38] | C-index: 0.617 [0.594, 0.64] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021689 | PGS000713 (T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.26 [1.15, 1.37] | C-index: 0.619 [0.596, 0.641] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021690 | PGS000729 (T2D_PGS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.14, 1.36] | C-index: 0.615 [0.592, 0.638] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021691 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.13, 1.35] | C-index: 0.612 [0.589, 0.636] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021692 | PGS000868 (T2D_221) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.14, 1.35] | C-index: 0.613 [0.59, 0.637] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021693 | PGS001818 (portability-PLR_250.2) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.13, 1.35] | C-index: 0.616 [0.594, 0.639] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021694 | PGS002026 (portability-ldpred2_250.2) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.23 [1.13, 1.35] | C-index: 0.617 [0.595, 0.64] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021695 | PGS002243 (ldpred_t2d) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.17 [1.08, 1.28] | C-index: 0.609 [0.586, 0.632] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021696 | PGS001781 (T2D_PRSCS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.16 [1.06, 1.27] | C-index: 0.607 [0.584, 0.63] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021697 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [1.06, 1.26] | C-index: 0.606 [0.583, 0.629] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021698 | PGS000036 (gePS_T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [1.05, 1.25] | C-index: 0.606 [0.583, 0.629] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021699 | PGS000014 (GPS_T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.14 [1.05, 1.24] | C-index: 0.605 [0.582, 0.628] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021700 | PGS002780 (GTG_T2D_SCT) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.03, 1.22] | C-index: 0.603 [0.58, 0.626] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021701 | PGS000864 (T2D-gPRS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.1 [1.02, 1.2] | C-index: 0.604 [0.58, 0.627] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021410 | PGS004923 (T2D_metaGRS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.92 [1.88, 1.97] | AUROC: 0.737 [0.732, 0.742] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021412 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.86 [1.82, 1.9] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021430 | PGS002780 (GTG_T2D_SCT) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.42, 1.49] | AUROC: 0.694 [0.689, 0.699] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021431 | PGS000864 (T2D-gPRS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.34 [1.32, 1.37] | AUROC: 0.687 [0.682, 0.692] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021440 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.98 [1.84, 2.13] | C-index: 0.77 [0.754, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021472 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.28 [1.25, 1.32] | AUROC: 0.721 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021487 | PGS000864 (T2D-gPRS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.03 [1.0, 1.06] | AUROC: 0.711 [0.705, 0.718] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021726 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011762| European Ancestry| 8,417 individuals |
PGP000665 | Moreno-Grau S et al. Human Genomics (2024) |Ext. |
Reported Trait: Type 2 diabetes mellitus | OR: 1.93 [1.8, 2.07] | AUROC: 0.75 | — | — | — |
| PPM021488 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.71, 1.84] | AUROC: 0.78 [0.773, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021516 | PGS002026 (portability-ldpred2_250.2) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.32 [1.13, 1.54] | AUROC: 0.621 [0.579, 0.663] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021537 | PGS000805 (GRS582_T2Deur) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.45 [1.23, 1.72] | AUROC: 0.674 [0.633, 0.716] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021540 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.667 [0.626, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021558 | PGS004923 (T2D_metaGRS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.63 [1.37, 1.96] | AUROC: 0.697 [0.655, 0.739] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021563 | PGS000330 (PRS_T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.45 [1.22, 1.72] | AUROC: 0.674 [0.632, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021578 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.3, 1.52] | AUROC: 0.723 [0.705, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021600 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.738 [0.684, 0.791] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021618 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.91 [1.78, 2.05] | AUROC: 0.746 [0.732, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021642 | PGS000330 (PRS_T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.17 [1.06, 1.29] | C-index: 0.646 [0.619, 0.672] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021646 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.615, 0.67] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021648 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.616, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021680 | PGS000864 (T2D-gPRS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.1 [0.81, 1.5] | C-index: 0.677 [0.604, 0.75] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021681 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.42 [1.3, 1.55] | C-index: 0.639 [0.617, 0.662] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021777 | PGS005031 (Phe_250_2_prscs_METAss_amrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.726 [1.62, 1.84] | C-index: 0.79244 | — | age, sex, 20 PCs | — |
| PPM021778 | PGS005032 (Phe_250_2_prscs_METAss_eurld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.725 [1.61, 1.84] | C-index: 0.79098 | — | age, sex, 20 PCs | — |
| PPM021779 | PGS005027 (Phe_250_2_prscs_AFRss_afrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.19 [1.12, 1.26] | C-index: 0.7739 | — | age, sex, 20 PCs | — |
| PPM021780 | PGS005029 (Phe_250_2_prscs_HISss_amrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.604 [1.48, 1.74] | C-index: 0.78047 | — | age, sex, 20 PCs | — |
| PPM021782 | PGS005033 (Phe_250_2_prscsx_METAweight) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.887 [1.77, 2.02] | C-index: 0.79907 | — | age, sex, 20 PCs | — |
| PPM021783 | PGS005030 (Phe_250_2_prscs_METAss_afrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.723 [1.67, 1.78] | C-index: 0.72541 | — | age, sex, 20 PCs | — |
| PPM021784 | PGS005031 (Phe_250_2_prscs_METAss_amrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.843 [1.78, 1.91] | C-index: 0.73344 | — | age, sex, 20 PCs | — |
| PPM021785 | PGS005032 (Phe_250_2_prscs_METAss_eurld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.901 [1.84, 1.97] | C-index: 0.73686 | — | age, sex, 20 PCs | — |
| PPM021786 | PGS005027 (Phe_250_2_prscs_AFRss_afrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.238 [1.2, 1.28] | C-index: 0.6883 | — | age, sex, 20 PCs | — |
| PPM021787 | PGS005029 (Phe_250_2_prscs_HISss_amrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | C-index: 0.69379 | — | age, sex, 20 PCs | — |
| PPM021788 | PGS005028 (Phe_250_2_prscs_EURss_eurld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.939 [1.88, 2.0] | C-index: 0.74223 | — | age, sex, 20 PCs | — |
| PPM021789 | PGS005033 (Phe_250_2_prscsx_METAweight) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.905 [1.84, 1.97] | C-index: 0.74131 | — | age, sex, 20 PCs | — |
| PPM021791 | PGS005031 (Phe_250_2_prscs_METAss_amrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.555 [1.47, 1.64] | C-index: 0.72865 | — | age, sex, 20 PCs | — |
| PPM021792 | PGS005032 (Phe_250_2_prscs_METAss_eurld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.599 [1.5, 1.7] | C-index: 0.72643 | — | age, sex, 20 PCs | — |
| PPM021793 | PGS005027 (Phe_250_2_prscs_AFRss_afrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.31, 1.5] | C-index: 0.71542 | — | age, sex, 20 PCs | — |
| PPM021794 | PGS005029 (Phe_250_2_prscs_HISss_amrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.15, 1.27] | C-index: 0.71129 | — | age, sex, 20 PCs | — |
| PPM021795 | PGS005028 (Phe_250_2_prscs_EURss_eurld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.486 [1.4, 1.58] | C-index: 0.72107 | — | age, sex, 20 PCs | — |
| PPM021796 | PGS005033 (Phe_250_2_prscsx_METAweight) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.634 [1.54, 1.73] | C-index: 0.73245 | — | age, sex, 20 PCs | — |
| PPM021881 | PGS005024 (Phe_250_2_ldpred_METAss_afrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.763 [1.65, 1.88] | C-index: 0.793 | — | age, sex, 20 PCs | — |
| PPM021882 | PGS005025 (Phe_250_2_ldpred_METAss_amrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.662 [1.56, 1.77] | C-index: 0.78959 | — | age, sex, 20 PCs | — |
| PPM021883 | PGS005026 (Phe_250_2_ldpred_METAss_eurld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.728 [1.61, 1.85] | C-index: 0.78877 | — | age, sex, 20 PCs | — |
| PPM021884 | PGS005021 (Phe_250_2_ldpred_AFRss_afrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.269 [1.19, 1.35] | C-index: 0.77529 | — | age, sex, 20 PCs | — |
| PPM021885 | PGS005023 (Phe_250_2_ldpred_HISss_amrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.656 [1.52, 1.8] | C-index: 0.78141 | — | age, sex, 20 PCs | — |
| PPM021886 | PGS005022 (Phe_250_2_ldpred_EURss_eurld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.725 [1.6, 1.86] | C-index: 0.78638 | — | age, sex, 20 PCs | — |
| PPM021887 | PGS005024 (Phe_250_2_ldpred_METAss_afrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.823 [1.76, 1.88] | C-index: 0.73139 | — | age, sex, 20 PCs | — |
| PPM021888 | PGS005025 (Phe_250_2_ldpred_METAss_amrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.699 [1.65, 1.75] | C-index: 0.7247 | — | age, sex, 20 PCs | — |
| PPM021889 | PGS005026 (Phe_250_2_ldpred_METAss_eurld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.916 [1.85, 1.98] | C-index: 0.73619 | — | age, sex, 20 PCs | — |
| PPM021890 | PGS005021 (Phe_250_2_ldpred_AFRss_afrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.276 [1.24, 1.31] | C-index: 0.69101 | — | age, sex, 20 PCs | — |
| PPM021892 | PGS005022 (Phe_250_2_ldpred_EURss_eurld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.741 [1.68, 1.8] | C-index: 0.72067 | — | age, sex, 20 PCs | — |
| PPM021893 | PGS005024 (Phe_250_2_ldpred_METAss_afrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.527 [1.45, 1.61] | C-index: 0.72638 | — | age, sex, 20 PCs | — |
| PPM021894 | PGS005025 (Phe_250_2_ldpred_METAss_amrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.509 [1.43, 1.59] | C-index: 0.72698 | — | age, sex, 20 PCs | — |
| PPM021895 | PGS005026 (Phe_250_2_ldpred_METAss_eurld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.529 [1.44, 1.63] | C-index: 0.72263 | — | age, sex, 20 PCs | — |
| PPM021896 | PGS005021 (Phe_250_2_ldpred_AFRss_afrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.429 [1.35, 1.51] | C-index: 0.72017 | — | age, sex, 20 PCs | — |
| PPM021897 | PGS005023 (Phe_250_2_ldpred_HISss_amrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.22 [1.16, 1.28] | C-index: 0.71211 | — | age, sex, 20 PCs | — |
| PPM021898 | PGS005022 (Phe_250_2_ldpred_EURss_eurld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.358 [1.27, 1.46] | C-index: 0.71296 | — | age, sex, 20 PCs | — |
| PPM021776 | PGS005030 (Phe_250_2_prscs_METAss_afrld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.67 [1.57, 1.78] | C-index: 0.79159 | — | age, sex, 20 PCs | — |
| PPM021781 | PGS005028 (Phe_250_2_prscs_EURss_eurld) |
PSS011807| Hispanic or Latin American Ancestry| 8,102 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.902 [1.77, 2.04] | C-index: 0.798 | — | age, sex, 20 PCs | — |
| PPM021790 | PGS005030 (Phe_250_2_prscs_METAss_afrld) |
PSS011797| African Ancestry| 10,808 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.507 [1.43, 1.59] | C-index: 0.72607 | — | age, sex, 20 PCs | — |
| PPM021891 | PGS005023 (Phe_250_2_ldpred_HISss_amrld) |
PSS011817| European Ancestry| 30,374 individuals |
PGP000679 | Gunn S et al. HGG Adv (2024) |
Reported Trait: Type 2 diabetes | OR: 1.342 [1.3, 1.38] | C-index: 0.69576 | — | age, sex, 20 PCs | — |
| PPM022367 | PGS005147 (Type 2 diabetes (PRS-CS; EAS)) |
PSS011923| East Asian Ancestry| 47,738 individuals |
PGP000704 | Jung HU et al. Commun Biol (2025) |
Reported Trait: Type 2 diabetes | β: 2.16063 | — | — | age, sex | — |
| PPM022294 | PGS005108 (PRSdiabetes) |
PSS011905| East Asian Ancestry| 7,745 individuals |
PGP000697 | Takase M et al. J Atheroscler Thromb (2023) |
Reported Trait: Prevalent diabetes | — | — | Odds ratio (OR, high vs low PGS tertile): 3.16 [2.45, 4.12] | Age, sex, 6 PCs | — |
| PPM022302 | PGS005111 (PGS_T2D_gwas) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.45 [1.41, 1.5] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022306 | PGS005115 (PGS_T2D_beta_cell) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.27 [1.23, 1.31] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022307 | PGS005116 (PGS_T2D_lipodystrophy) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.18 [1.14, 1.22] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022308 | PGS005117 (PGS_T2D_liver_lipid) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.06 [1.03, 1.1] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022309 | PGS005118 (PGS_T2D_obesity) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.1 [1.07, 1.14] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022312 | PGS005110 (PGS_T2D_gw) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 2.42 [2.33, 2.51] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022313 | PGS005111 (PGS_T2D_gwas) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.46 [1.41, 1.51] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022317 | PGS005115 (PGS_T2D_beta_cell) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.27 [1.23, 1.31] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022318 | PGS005116 (PGS_T2D_lipodystrophy) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.18 [1.14, 1.22] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022319 | PGS005117 (PGS_T2D_liver_lipid) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.07 [1.04, 1.11] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022320 | PGS005118 (PGS_T2D_obesity) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.11 [1.07, 1.14] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022301 | PGS005110 (PGS_T2D_gw) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 2.33 [2.25, 2.41] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022310 | PGS005119 (PGS_T2D_proinsulin) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.09 [1.05, 1.12] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022321 | PGS005119 (PGS_T2D_proinsulin) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |
Reported Trait: type 2 diabetes | OR: 1.09 [1.06, 1.13] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022377 | PGS005157 (Type 2 diabetes (CT-SLEB; EAS+EUR)) |
PSS011923| East Asian Ancestry| 47,738 individuals |
PGP000704 | Jung HU et al. Commun Biol (2025) |
Reported Trait: Type 2 diabetes | β: 2.32703 | — | — | age, sex | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011692 | ICD-10 code, E11 | — | 433,150 individuals | — | European (British) |
— | UKB | — |
| PSS011441 | — | — | [ ,
82.0 % Male samples |
Mean = 27.5 years | African unspecified | — | PDAY | — |
| PSS011442 | — | — | [ ,
77.0 % Male samples |
Mean = 26.7 years | European | — | PDAY | — |
| PSS008170 | — | — | 6,312 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS011905 | Diabetes was defined as non-fasting glucose ≥ 200 mg/dL, HbA1c ≥ 6.5% (48 mmol/mol), and/or self-reported treatment for diabetes | — | 7,745 individuals, 23.7 % Male samples |
Mean = 57.3 years Sd = 13.4 years |
East Asian | — | TMM | — |
| PSS010014 | PheCode 250.2 (http://phewascatalog.org/); Binary | — | [
|
— | European | — | MGI | — |
| PSS000017 | Type 2 diabetes ascertainment was based on self-report in an interview with a trained nurse or an ICD-10 code of E11.X in hospitalization records. | — | [
|
— | European | — | UKB | UKB Phase 2 |
| PSS000754 | — | — | 87,413 individuals | — | European | — | UKB | — |
| PSS000755 | — | — | 87,413 individuals | — | European | — | UKB | — |
| PSS000756 | ICD-10 E11.0 - E11.9 | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS011513 | Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) | — | [
|
— | Not reported | — | MGBB | — |
| PSS011911 | ICD10: E11 for T2D, N18 for CKD, first occurence of I20-125 for CAD. BMI: baseline body mass index | Median = 14.8 years | 48,603 individuals, 46.0 % Male samples |
Mean = 56.8 years Sd = 8.2 years |
European, East Asian, South Asian, Hispanic or Latin American, African unspecified | — | UKB | — |
| PSS011912 | ICD10: E11 for T2D, N18 for CKD, first occurence of I20-125 for CAD, K76.0 for NAFLD. BMI: baseline body mass index | Median = 14.8 years | 45,356 individuals, 46.0 % Male samples |
Mean = 57.1 years Sd = 8.1 years |
European | — | UKB | — |
| PSS011225 | — | — | [
|
— | European | — | EB | — |
| PSS010036 | Field ID: 2443; Binary | — | [
|
— | European | — | UKB | — |
| PSS009893 | — | — | 366 individuals | — | African American or Afro-Caribbean | — | SEARCH | — |
| PSS009894 | — | — | 412 individuals | — | Hispanic or Latin American | — | SEARCH | — |
| PSS009895 | — | — | 1,168 individuals | — | European | — | SEARCH | — |
| PSS009896 | — | — | 99 individuals | — | Not reported | — | SEARCH | — |
| PSS011236 | T2D, ICD10: E11, ICD9: 250[0|1]0 (exclude E10) | — | [
|
— | European | — | FinnGen | — |
| PSS000025 | Incident cases of Type 2 Diabetes in 5.63 years follow-up | — | [ ,
55.0 % Male samples |
— | European (Estonian) |
— | EB | — |
| PSS009902 | — | — | [
|
— | European (Italian) |
— | NR | — |
| PSS011249 | — | — | [
|
— | South Asian | — | G&H | — |
| PSS011645 | — | — | [
|
— | European | — | FinnGen | — |
| PSS000441 | National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9. | — | [ ,
47.3 % Male samples |
Mean (Age At Baseline) = 48.0 years | European (Finnish) |
— | FINRISK | FINRISK surveys from 1992, 1997, 2002 and 2007 |
| PSS011923 | — | — | [
|
— | East Asian (Korean) |
— | HEXA | — |
| PSS007738 | — | — | 2,476 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS011647 | — | — | [
|
— | European | — | GS:SFHS | — |
| PSS000448 | National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9. | — | [ ,
43.7 % Male samples |
Mean (Age At Baseline) = 59.2 years Sd = 16.6 years |
European (Finnish) |
— | FinnGen | — |
| PSS011265 | — | — | [
|
— | European | — | HUNT | — |
| PSS011648 | — | — | [
|
— | European | — | GEL | — |
| PSS011649 | — | — | [
|
— | European | — | HUNT | — |
| PSS009288 | — | — | 19,931 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS011278 | — | — | [
|
— | European | — | UKB | — |
| PSS011650 | — | — | [
|
— | European | — | MGBB | — |
| PSS010055 | — | — | 22,608 individuals | — | East Asian | — | KBA, KoGES | — |
| PSS011291 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS000042 | T2D was defined by a fasting plasma glucose ≥7.0 mmol/L (≥126 mg/dL) or report of taking diabetes medications | — | [ ,
38.8 % Male samples |
— | African American or Afro-Caribbean | — | CARDIA | — |
| PSS000043 | T2D was defined by a fasting plasma glucose ≥7.0 mmol/L (≥126 mg/dL) or report of taking diabetes medications | — | [ ,
46.5 % Male samples |
— | European | — | CARDIA | — |
| PSS000044 | T2D was defined by a fasting plasma glucose ≥7.0 mmol/L (≥126 mg/dL) or report of taking diabetes medications | — | [ ,
46.6 % Male samples |
— | European | — | FOS | — |
| PSS009629 | — | — | 5,806 individuals | — | South Asian (Indian) |
— | INSPIRED | Dr. Mohan’s Diabetes Specialities Centre (INSPIRED - DMDSC) |
| PSS004312 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004313 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004314 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004315 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004316 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS011474 | — | — | 8,837 individuals | — | South Asian | — | G&H | — |
| PSS011296 | 22,667 sibling pairs | — | 45,334 individuals | — | European | — | UKB | — |
| PSS011735 | T2D cases were ascertained based on a combination of hospital diagnosis codes, prescription medication, and lab results from blood tests occurring prior to baseline assessment. Participants were considered controls if they had no history of any diabetes diagnoses, T2D medication, or abnormal glucose or HbA1c lab results. Participants with T1D or uncertain diabetes status were excluded from analysis | — | [
|
— | African unspecified | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | AllofUs | — |
| PSS011736 | T2D cases were ascertained based on a combination of hospital diagnosis codes, prescription medication, and lab results from blood tests occurring prior to baseline assessment. Participants were considered controls if they had no history of any diabetes diagnoses, T2D medication, or abnormal glucose or HbA1c lab results. Participants with T1D or uncertain diabetes status were excluded from analysis | — | [
|
— | Hispanic or Latin American | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | AllofUs | — |
| PSS011737 | T2D cases were ascertained based on a combination of hospital diagnosis codes, prescription medication, and lab results from blood tests occurring prior to baseline assessment. Participants were considered controls if they had no history of any diabetes diagnoses, T2D medication, or abnormal glucose or HbA1c lab results. Participants with T1D or uncertain diabetes status were excluded from analysis | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | AllofUs | — |
| PSS000054 | Prevalent T2D status was defined using self-reported medical history and medication | — | [
|
— | European | — | UKB | — |
| PSS011097 | — | — | 2,669 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) (Arab) |
— | NR | N total after excluding missing values = 2,553 |
| PSS011738 | T2D was defined using ICD-10 codes E10-E14, G59.0, G63.2, H28.0, H36.0, M14.2, N08.3, or O24.0-O24.3. Participants with any diabetes history were excluded from analysis. Incident diabetes events were treated as incident T2D | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | INTERVAL | — |
| PSS011299 | T2D ICD-10 code E11 | Median = 12.55 years IQR = [11.72, 13.27] years |
395,809 individuals, 45.8 % Male samples |
Mean = 56.7 years Sd = 8.0 years |
European | — | UKB | — |
| PSS011740 | Incident T2D was ascertained through a combination of linkage to national healthcare records, self-reported medical history at follow-up assessment (either diagnosis from a primary care physician or current diabetes medication usage), or with blood biomarker concentrations indicative of diabetes following the American Diabetes Association criteria (fasting glucose ≥ 7 mmol/L or HbA1c ≥ 6.5% or random blood glucose ≥11 mmol/L) | — | [
|
— | East Asian (Chinese Singaporean) |
Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | SingaporeMEC | — |
| PSS011741 | Incident T2D was ascertained through a combination of linkage to national healthcare records, self-reported medical history at follow-up assessment (either diagnosis from a primary care physician or current diabetes medication usage), or with blood biomarker concentrations indicative of diabetes following the American Diabetes Association criteria (fasting glucose ≥ 7 mmol/L or HbA1c ≥ 6.5% or random blood glucose ≥11 mmol/L) | — | [
|
— | South Asian (Indian Singaporean) |
Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | SingaporeMEC | — |
| PSS011739 | Incident T2D was ascertained through a combination of linkage to national healthcare records, self-reported medical history at follow-up assessment (either diagnosis from a primary care physician or current diabetes medication usage), or with blood biomarker concentrations indicative of diabetes following the American Diabetes Association criteria (fasting glucose ≥ 7 mmol/L or HbA1c ≥ 6.5% or random blood glucose ≥11 mmol/L) | — | [
|
— | South East Asian (Malay Singaporean) |
Ancestry label assigned based on Malay being the majority reported ethnicity within the genetic cluster | SingaporeMEC | — |
| PSS011301 | — | — | [
|
— | South Asian (Indian) |
— | WellGen | — |
| PSS011302 | — | — | [
|
— | South Asian (Indian) |
— | WellGen | — |
| PSS011303 | — | — | [
|
— | South Asian (Indian) |
— | WellGen | — |
| PSS011304 | — | — | [
|
— | South Asian (Indian) |
— | WellGen | — |
| PSS011305 | — | — | [
|
— | South Asian (Indian) |
— | WellGen | — |
| PSS011747 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011746 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011743 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | African unspecified | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011745 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | East Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011749 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | South Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011748 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | South Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011507 | — | — | 7,879 individuals | — | European | — | AllofUs | — |
| PSS008841 | — | — | 3,896 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS011513 | Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) | — | [
|
— | Asian unspecified | — | MGBB | — |
| PSS011513 | Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) | — | [
|
— | African American or Afro-Caribbean | — | MGBB | — |
| PSS011513 | Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) | — | [
|
— | European | — | MGBB | — |
| PSS011306 | — | — | 5,024 individuals, 40.0 % Male samples |
— | East Asian (Chinese) |
— | Wuxi NCDs | — |
| PSS000232 | Individuals with T2D were defined as those with fasting time >8 h and fasting glucose levels ≥126 mg/dL, fasting ≤8 h and fasting glucose ≥200 mg/dL, post–oral glucose tolerance test glucose ≥200 mg/dL, HbA1c ≥6.5% (48 mmol/mol), or on current treatment with antihyperglycemia medications. | — | [ ,
39.65 % Male samples |
— | Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, South American) |
Ancestry groups were defined based on a combination of self-identified Hispanic/Latino background and genetic similarity | HCHS, SOL | — |
| PSS011514 | — | — | [
|
— | African American or Afro-Caribbean | — | AllofUs | — |
| PSS011515 | — | — | [
|
— | African American or Afro-Caribbean | — | AllofUs | — |
| PSS011515 | — | — | [
|
— | Hispanic or Latin American | — | AllofUs | — |
| PSS011515 | — | — | [
|
— | East Asian | — | AllofUs | — |
| PSS011515 | — | — | [
|
— | European | — | AllofUs | — |
| PSS011516 | — | — | [
|
— | Hispanic or Latin American | — | AllofUs | — |
| PSS011517 | — | — | [
|
— | East Asian | — | AllofUs | — |
| PSS011518 | — | — | [
|
— | European | — | AllofUs | — |
| PSS011519 | — | — | [
|
— | South Asian | — | AllofUs | — |
| PSS011515 | — | — | [
|
— | South Asian | — | AllofUs | — |
| PSS011762 | — | — | 8,417 individuals | — | European | — | BBofA | — |
| PSS009939 | — | — | 39,444 individuals | — | European (Finnish) |
— | FinnGen | — |
| PSS000869 | CALIBER rule-based phenotyping algorithms (https://github.com/spiros/chronological-map-phenotypes#diabetes) | Median = 6.9 years | [ ,
51.0 % Male samples |
Median = 44.0 years IQR = [30.5, 54.7] years |
European | — | INTERVAL | — |
| PSS009943 | We used the disease definitions described in the supplement of Eastwood et al (2016). PMID: 27631769 | — | [ ,
45.0 % Male samples |
European | — | UKB | — | |
| PSS009669 | T2D cases were defined with T2D ICD codes, a single measurement of glucose (fasting glucose ≥126 mg/dL [7 mmol/L] or random glucose ≥ 200 mg/dL [11.1 mmol/L]) or use of any glucose-lowering medications. | — | [
|
— | African American or Afro-Caribbean (African) |
— | GenHAT | — |
| PSS009670 | T2D cases were defined with T2D ICD codes, a single measurement of glucose (fasting glucose ≥126 mg/dL [7 mmol/L] or random glucose ≥ 200 mg/dL [11.1 mmol/L]) or use of any glucose-lowering medications. | — | [
|
— | African American or Afro-Caribbean (African) |
— | HYPERGEN | — |
| PSS009671 | T2D cases were defined with T2D ICD codes, a single measurement of glucose (fasting glucose ≥126 mg/dL [7 mmol/L] or random glucose ≥ 200 mg/dL [11.1 mmol/L]) or use of any glucose-lowering medications. | — | [
|
— | African American or Afro-Caribbean (African) |
— | REGARDS | — |
| PSS009672 | Self-reported T2D | — | [
|
— | East Asian (Taiwanese) |
— | TWB | — |
| PSS009673 | Self-reported T2D | — | [
|
— | East Asian (Taiwanese) |
— | TWB | — |
| PSS009674 | Self-reported T2D | — | [
|
— | East Asian (Taiwanese) |
— | TWB | — |
| PSS009675 | T2D cases were defined with T2D ICD codes, a single measurement of glucose (fasting glucose ≥126 mg/dL [7 mmol/L] or random glucose ≥ 200 mg/dL [11.1 mmol/L]) or use of any glucose-lowering medications. | — | [
|
— | African American or Afro-Caribbean (African) |
— | WPC | — |
| PSS009676 | An EHR-based phenotyping algorithm of T2D implemented across eMERGE sites | — | [
|
— | African American or Afro-Caribbean (African) |
— | eMERGE | — |
| PSS009677 | An EHR-based phenotyping algorithm of T2D implemented across eMERGE sites | — | [
|
— | European (European) |
— | eMERGE | — |
| PSS009678 | An EHR-based phenotyping algorithm of T2D implemented across eMERGE sites | — | [
|
— | Hispanic or Latin American (Hispanic/Latino) |
— | eMERGE | — |
| PSS010101 | — | — | [ ,
0.0 % Male samples |
— | South Asian | — | BiB, START | 70% validation set from each cohort |
| PSS008392 | — | — | 1,197 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS011537 | — | Median = 8.9 years IQR = [8.3, 9.5] years |
[ ,
44.6 % Male samples |
Mean = 56.1 years Sd = 8.0 years |
European (White British) |
— | UKB | — |
| PSS011343 | — | — | [ ,
46.0 % Male samples |
— | European (White British) |
— | UKB | — |
| PSS009971 | — | — | 30,716 individuals | — | European | — | MGBB | — |
| PSS009971 | — | — | 1,807 individuals | — | African unspecified (Black) |
— | MGBB | — |
| PSS009971 | — | — | 786 individuals | — | Asian unspecified | — | MGBB | — |
| PSS009971 | — | — | 3,113 individuals | — | Other | — | MGBB | — |
| PSS011181 | — | — | 3,071 individuals, 48.8 % Male samples |
Mean = 57.4 years Sd = 12.88 years |
Not reported | — | KORA | — |
| PSS001044 | Cases are individuals with type 2 diabetes (T2D). T2D cases were defined as individuals with (1) a T2D diagnosis by a physician/medical professional and use of medication for treatment of diabetes, and/or (2)a fasting(R8h)blood glucose measurement R126 mg/dL indicated in examination records. For the BMBB cohort T2D diabetes status was defined from algorithms extracted from electronic medical record (EMR) and includes family history of T2D as an exclusion criteria. For T2D cases, BMBB defined medications using unique RxNorm codes at an ingredient level and defined laboratory tests using the logical observations identifiers names and codes (LOINC) standard (https://www.phekb.org/phenotype/type-2-diabetes-mellitus). BioMe included all patients with ICD-9-CM codes of 250.x0 or 250.x2, except for codes 250.10 and 250.12 (indicative of T2D with ketoacidosis, a condition also closely associated with T1D), patients on T2D medications and/or insulin at any time, and all patients with abnormal glucose (>200 mg/dl) or hemoglobin A1c (HbA1c; ≥6.5%) laboratory test results. For the MEC cohort, T2D cases were defined using the following criteria: (a) a self-report of diabetes on the baseline questionnaire, 2nd questionnaire or 3rd questionnaire; and (b) self-report of taking medication for T2D at the time of blood draw; and (c) no diagnosis of T1D in the absence of a T2D diagnosis from the California Office of Statewide Health Planning and Development (OSHPD) for California Residents. In addition, cases included individuals who were linked to the diabetes registries of Hawaii Medical Service Association (HMSA) or Kaiser Permanente Hawaii (KPH) health plans, or who were designated as diabetic in the Chronic Conditions Data Warehouse (CCW) of Medicare. For the WHI cohort, T2D was documented at baseline by self-report in which each woman was asked whether she had ever been told that she had “sugar diabetes” by her physician. Incident diabetes during follow-up was documented by self-report at each semi-annual contact, when participants were asked, “Since the date given on the front of this form, has a doctor prescribed any of the following pills or treatments?” Choices included “pills for diabetes” and “insulin shots for diabetes.”. For the ARIC cohort prevalent type 2 diabetes was defined at the baseline examination as fasting (≥8 h) blood glucose ≥126 mg/dL, or nonfasting glucose ≥200 mg/dL, self-report physician diagnosis of diabetes or “sugar in the blood,” or current medication use for diabetes within the last two weeks. For the CARDIA cohort, T2D was determined at last visit based on a combination of measured fasting glucose levels (≥7.0 mmol/L and ≥126 mg/dL) at examination years 0, 7, 10, 15, 20, or 25; self-report of oral hypoglycemic medications or insulin at years 0, 7, 10, 15, 20, or 25; a 2-h postload glucose ≥11.1 mmol/L (≥200 mg/dL) during a 75-g oral glucose tolerance test at years 10, 20, and 25; or an HbA1c ≥6.5% at years 20 and 25. | — | [
|
— | African American or Afro-Caribbean | — | ARIC, BioMe, CARDIA, MEC, WHI | Possible sample overlap with this dataset and the datasets used to source/develop GRS582_T2Dmulti and GRS582_T2Dafr. |
| PSS001045 | Cases are individuals with type 2 diabetes (T2D). T2D cases were defined as individuals with (1) a T2D diagnosis by a physician/medical professional and use of medication for treatment of diabetes,and/or (2)a fasting(R8h)blood glucose measurement R126 mg/dL indicated in examination records. For the BMBB cohort T2D diabetes status was defined from algorithms extracted from electronic medical record (EMR) and includes family history of T2D as an exclusion criteria. For T2D cases, BMBB defined medications using unique RxNorm codes at an ingredient level and defined laboratory tests using the logical observations identifiers names and codes (LOINC) standard (https://www.phekb.org/phenotype/type-2-diabetes-mellitus). BioMe included all patients with ICD-9-CM codes of 250.x0 or 250.x2, except for codes 250.10 and 250.12 (indicative of T2D with ketoacidosis, a condition also closely associated with T1D), patients on T2D medications and/or insulin at any time, and all patients with abnormal glucose (>200 mg/dl) or hemoglobin A1c (HbA1c; ≥6.5%) laboratory test results. For the MEC cohort, T2D cases were defined using the following criteria: (a) a self-report of diabetes on the baseline questionnaire, 2nd questionnaire or 3rd questionnaire; and (b) self-report of taking medication for T2D at the time of blood draw; and (c) no diagnosis of T1D in the absence of a T2D diagnosis from the California Office of Statewide Health Planning and Development (OSHPD) for California Residents. In addition, cases included individuals who were linked to the diabetes registries of Hawaii Medical Service Association (HMSA) or Kaiser Permanente Hawaii (KPH) health plans, or who were designated as diabetic in the Chronic Conditions Data Warehouse (CCW) of Medicare. For the WHI cohort, T2D was documented at baseline by self-report in which each woman was asked whether she had ever been told that she had “sugar diabetes” by her physician. Incident diabetes during follow-up was documented by self-report at each semi-annual contact, when participants were asked, “Since the date given on the front of this form, has a doctor prescribed any of the following pills or treatments?” Choices included “pills for diabetes” and “insulin shots for diabetes.”. | — | [
|
— | Asian unspecified | — | BioMe, MEC, WHI | Possible sample overlap with this dataset and the datasets used to source/develop GRS582_T2Dmulti and GRS582_T2Dasn. |
| PSS001046 | Cases are individuals with type 2 diabetes (T2D). T2D cases were defined as individuals with (1) a T2D diagnosis by a physician/medical professional and use of medication for treatment of diabetes,and/or (2)a fasting(R8h)blood glucose measurement R126 mg/dL indicated in examination records. For the UKB cohort, T2D cases were defined by an ICD-10 code of E11.X or a self-reported diagnosis in an interview with a trained nurse. | — | [
|
— | European | — | UKB | Possible significant sample overlap with this dataset and the datasets used to source/develop GRS582_T2Dmulti and GRS582_T2Deur |
| PSS001047 | Cases are individuals with type 2 diabetes (T2D). T2D cases were defined as individuals with (1) a T2D diagnosis by a physician/medical professional and use of medication for treatment of diabetes,and/or (2)a fasting(R8h)blood glucose measurement R126 mg/dL indicated in examination records. For the BMBB cohort T2D diabetes status was defined from algorithms extracted from electronic medical record (EMR) and includes family history of T2D as an exclusion criteria. For T2D cases, BMBB defined medications using unique RxNorm codes at an ingredient level and defined laboratory tests using the logical observations identifiers names and codes (LOINC) standard (https://www.phekb.org/phenotype/type-2-diabetes-mellitus). BioMe included all patients with ICD-9-CM codes of 250.x0 or 250.x2, except for codes 250.10 and 250.12 (indicative of T2D with ketoacidosis, a condition also closely associated with T1D), patients on T2D medications and/or insulin at any time, and all patients with abnormal glucose (>200 mg/dl) or hemoglobin A1c (HbA1c; ≥6.5%) laboratory test results. For the MEC cohort, T2D cases were defined using the following criteria: (a) a self-report of diabetes on the baseline questionnaire, 2nd questionnaire or 3rd questionnaire; and (b) self-report of taking medication for T2D at the time of blood draw; and (c) no diagnosis of T1D in the absence of a T2D diagnosis from the California Office of Statewide Health Planning and Development (OSHPD) for California Residents. In addition, cases included individuals who were linked to the diabetes registries of Hawaii Medical Service Association (HMSA) or Kaiser Permanente Hawaii (KPH) health plans, or who were designated as diabetic in the Chronic Conditions Data Warehouse (CCW) of Medicare. For the WHI cohort, T2D was documented at baseline by self-report in which each woman was asked whether she had ever been told that she had “sugar diabetes” by her physician. Incident diabetes during follow-up was documented by self-report at each semi-annual contact, when participants were asked, “Since the date given on the front of this form, has a doctor prescribed any of the following pills or treatments?” Choices included “pills for diabetes” and “insulin shots for diabetes.”. For the SOL cohort, T2D cases were defined as those with fasting time >8 h and fasting glucose levels ≥126 mg/dL, fasting ≤8 h and fasting glucose ≥200 mg/dL, post–oral glucose tolerance test glucose ≥200 mg/dL, HbA1c ≥6.5% (48 mmol/mol), or on current treatment with antihyperglycemia medications. | — | [
|
— | Hispanic or Latin American | — | BioMe, MEC, SOL, WHI | Possible sample overlap with this dataset and the datasets used to source/develop GRS582_T2Dmulti and GRS582_T2Dhis. |
| PSS001048 | Cases are individuals with type 2 diabetes (T2D). T2D cases were defined as individualswith (1) a T2D diagnosis by a physician/medical professional and use of medication for treat-mentofdiabetes,and/or (2)a fasting(R8h)blood glucose measurement R126 mg/dL indicated in examination records. For the MEC cohort, T2D cases were defined using the following criteria: (a) a self-report of diabetes on the baseline questionnaire, 2nd questionnaire or 3rd questionnaire; and (b) self-report of taking medication for T2D at the time of blood draw; and (c) no diagnosis of T1D in the absence of a T2D diagnosis from the California Office of Statewide Health Planning and Development (OSHPD) for California Residents. In addition, cases included individuals who were linked to the diabetes registries of Hawaii Medical Service Association (HMSA) or Kaiser Permanente Hawaii (KPH) health plans, or who were designated as diabetic in the Chronic Conditions Data Warehouse (CCW) of Medicare. | — | [
|
— | Oceanian (Native Hawaiian) |
— | MEC | — |
| PSS007957 | — | — | 1,808 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS011360 | — | — | 2,676 individuals, 32.47 % Male samples |
Mean = 54.0 years Sd = 11.8 years |
East Asian (Chinese) |
— | WHZH | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS011797 | — | — | [
|
— | African American or Afro-Caribbean | — | AllofUs | — |
| PSS010157 | — | — | [
|
Mean = 42.3 years | Hispanic or Latin American (Mexican) |
— | METSB | — |
| PSS011807 | — | — | [
|
— | Hispanic or Latin American | — | AllofUs | — |
| PSS010982 | — | Mean = 7.15 years | [
|
Mean = 31.04 years Sd = 10.43 years |
Native American | — | NR | — |
| PSS010983 | — | Mean = 21.28 years | [
|
— | Native American | — | NR | — |
| PSS010984 | — | Mean = 7.99 years | [
|
Mean = 12.05 years Sd = 3.73 years |
Native American | — | NR | — |
| PSS011817 | — | — | [
|
— | European | — | AllofUs | — |
| PSS009514 | — | — | [
|
— | East Asian (Japanese) |
— | BBJ | — |
| PSS009518 | — | — | [
|
— | European (Estonian) |
— | EB | — |
| PSS003606 | — | — | [
|
Mean = 56.81 years | European | — | UKB | — |
| PSS009522 | — | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS009526 | — | — | [
|
— | European | Norwegian | HUNT | — |
| PSS009530 | — | — | [
|
— | African American or Afro-Caribbean | — | MGBB | — |
| PSS011644 | — | — | [
|
— | European | — | EB | — |
| PSS009534 | — | — | [
|
— | European | — | MGBB | — |
| PSS011646 | — | — | [
|
— | European | — | G&H | — |
| PSS009062 | — | — | 4,121 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS004575 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004576 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004577 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004578 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004579 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009538 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS009542 | — | — | [
|
— | European | British | UKB | — |
| PSS011003 | — | — | [
|
— | European | — | UKB | — |
| PSS011002 | — | — | [
|
— | European | — | UKB | — |
| PSS011000 | — | — | [
|
— | European | — | UKB | — |
| PSS011395 | — | Mean = 8.1 years | 357,419 individuals | — | European (White British) |
— | UKB | — |
| PSS009546 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS001084 | Moderate Age-Related Diabetes (MARD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001085 | Moderate Obesity-related Diabetes (MOD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001086 | Severe Autoimmune Diabetes (SAID) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001087 | Severe Insulin-Deficient Diabetes (SIDD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001088 | Severe Insulin-Resistant Diabetes (SIRD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS011407 | — | Mean = 6.8 years IQR = [6.3, 7.3] years |
[ ,
44.0 % Male samples |
Mean = 61.1 years Sd = 7.8 years |
European, Not reported | White European (97.1%) | UKB | — |
| PSS011742 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | African unspecified | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011744 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | East Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS001092 | All individuals had cystic fibrosis with either 2 severe CFTR mutations and/or clinically diagnosed exocrine pancreatic insufficiency. Cases are individuals with cystic fibrosis related diabetes (CFRD).Phenotypes were obtained from extracted medical charts and CF Foundation Patient Registry through 2011. CFRD was defined by clinician diagnosis of diabetes plus insulin treatment for at least 1 year. The onset of CFRD was defined as the date at which insulin was started, if it was subsequently continued for at least 1 year. In approximately 50% of the participants, independent laboratory data (such as oral glucose tolerance test or hemoglobin A1c) were able to independently confirm the diagnosis of CFRD. Diabetes data were censored at the last clinic visit or date of solid organ transplant. | — | [ ,
47.04 % Male samples |
Mean = 20.0 years | Not reported | — | CGS, CWRU, FrGMC, JHU, UNC | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 12,508 individuals, 45.86 % Male samples |
Mean = 48.9 years | European | — | MGBB | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 1,003 individuals, 45.86 % Male samples |
Mean = 48.9 years | Hispanic or Latin American | — | MGBB | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 520 individuals, 45.86 % Male samples |
Mean = 48.9 years | African unspecified | — | MGBB | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 240 individuals, 45.86 % Male samples |
Mean = 48.9 years | East Asian | — | MGBB | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 117 individuals, 45.86 % Male samples |
Mean = 48.9 years | South Asian | — | MGBB | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 125 individuals, 45.86 % Male samples |
Mean = 48.9 years | Greater Middle Eastern (Middle Eastern, North African or Persian) | — | MGBB | — |
| PSS011671 | Inclusion: MGH encounter AND ICD-9 code for diabetes AND Problem list term for diabetes OR HbA1C >6.5 in prior 3 years Exclusion: Problem list term not associated with diabetes; Inclusion problem list terms: DM, Diabetes Mellitus, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Retinopathy, Diabetic foot care, Diabetic foot infection, Diabetes Mellitus without complication, Insulin dependent diabetes mellitus, Insulin dependent diabetes without complications, Type 1, Diabetes mellitus I, DM type I, Juvenile, DM type i, Type I DM, Diabetes Mellitus type 1, Juvenile onset diabetes mellitus, Type 1 diabetes mellitus uncontrolled, Type 1 diabetes mellitus well controlled, DM1, Adult onset, AODM, Type 2, DM type ii, Diabetes mellitus ii, DMii, Type 2 DM, Type ii DM, Diabetes mellitus type 2, noninsulin dependent diabetes mellitus, Type 2 diabetes mellitus uncontrolled, Type 2 diabetes mellitus well controlled, Diabetes adult-adult onset, NIDDM.; Inclusion ICD-9 codes: 250.21, 250.23, 250.11, 250.13, 250.61, 250.63, 250.51, 250.53, 250.31, 250.33, 250.81, 250.83, 250.71, 250.73, 250.41, 250.43, 250.91, 250.93, 250.01, 250.03, 250.20, 250.22, 250.10, 250.12, 250.60, 250.62, 250.50, 250.52, 250.30, 250.32, 250.80, 250.82, 250.70, 250.72, 250.40, 250.42, 250.90, 250.92, 250.00, 250.02; Exclusion problem list terms: negative, neg, r/o, risk, rule out, no, consider diabetes, borderline, gestational, maternal, pregnancy, glucose impai, impaired glucose, insipidus, pre diabetes, prediab, family history, PCOS, Polycystic Ovary Syndrome | Median = 13.9 years | 199 individuals, 45.86 % Male samples |
Mean = 48.9 years | Not reported | — | MGBB | — |
| PSS011416 | — | — | [ ,
65.0 % Male samples |
— | East Asian (Japanese) |
— | BBJ | — |
| PSS008616 | — | — | 6,646 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS011417 | — | — | [ ,
50.0 % Male samples |
— | East Asian (Japanese) |
— | ToMMo | — |
| PSS007684 | Type 2 diabetes was defined by a strict type 2 diabetes definition, that excluded type 1 diabetes, ICD 8/9/10 codes are listed in Supplementary Data 1. National registeries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2019, whichever came first. | Median = 13.0 years IQR = [7.5, 19.7] years |
[ ,
43.8 % Male samples |
Mean (Age At Baseline) = 53.2 years Sd = 17.4 years |
European (Finnish) |
— | FinnGen | — |
| PSS007685 | Type 2 diabetes was defined by a strict type 2 diabetes definition, that excluded type 1 diabetes, ICD 8/9/10 codes are listed in Supplementary Data 1. National registeries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2019, whichever came first. | — | [ ,
42.9 % Male samples |
Mean (Age At Baseline) = 51.8 years Sd = 17.4 years |
European (Finnish) |
— | FinnGen | — |
| PSS007686 | Type 2 diabetes was defined by a strict type 2 diabetes definition, that excluded type 1 diabetes, ICD 8/9/10 codes are listed in Supplementary Data 1. National registeries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2019, whichever came first. | — | [ ,
43.8 % Male samples |
Mean (Age At Baseline) = 53.2 years Sd = 17.4 years |
European (Finnish) |
— | FinnGen | — |
| PSS007690 | Type 2 diabetes was defined by a strict type 2 diabetes definition, that excluded type 1 diabetes, ICD 9/10 codes are listed in Supplementary Data 1. National registeries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the censoring date of hospital inpatient data (UK Biobank; English hospital inpatient records up to May 2020, Scottish up to November 2016, Welsh up to March 2016), whichever came first. | Median = 10.4 years IQR = [8.3, 11.3] years |
[ ,
46.3 % Male samples |
Mean (Age At Baseline) = 57.4 years Sd = 8.0 years |
European (British) |
UK Biobank participants with non-British ancestry were excluded based on genetically inferred ancestry. | UKB | — |
| PSS007691 | Type 2 diabetes was defined by a strict type 2 diabetes definition, that excluded type 1 diabetes, ICD 9/10 codes are listed in Supplementary Data 1. National registeries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the censoring date of hospital inpatient data (UK Biobank; English hospital inpatient records up to May 2020, Scottish up to November 2016, Welsh up to March 2016), whichever came first. | — | [ ,
45.5 % Male samples |
Mean (Age At Baseline) = 57.2 years Sd = 8.0 years |
European (British) |
UK Biobank participants with non-British ancestry were excluded based on genetically inferred ancestry. | UKB | — |
| PSS001117 | T2D cases were defined as having an ICD-10 code of E11.X or having self-reported T2D in the in- terview. Only cases in which the individuals did not have T2D during the first assessment visit period (2006–2010) but were subsequently fol- lowed up for incident T2D events were considered. | Median = 3.58 years | [ ,
47.81 % Male samples |
— | European | — | UKB | — |
| PSS007692 | Type 2 diabetes was defined by a strict type 2 diabetes definition, that excluded type 1 diabetes, ICD 9/10 codes are listed in Supplementary Data 1. National registeries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the censoring date of hospital inpatient data (UK Biobank; English hospital inpatient records up to May 2020, Scottish up to November 2016, Welsh up to March 2016), whichever came first. | — | [ ,
46.3 % Male samples |
Mean (Age At Baseline) = 57.4 years Sd = 8.0 years |
European (British) |
UK Biobank participants with non-British ancestry were excluded based on genetically inferred ancestry. | UKB | — |
| PSS009859 | — | — | 6,503 individuals | — | African unspecified | — | UKB | — |
| PSS009860 | — | — | 922 individuals | — | East Asian | — | UKB | — |
| PSS009861 | — | — | 43,505 individuals | — | European | Non-British European | UKB | — |
| PSS009862 | — | — | 8,098 individuals | — | South Asian | — | UKB | — |