Trait: cardiovascular disease

Experimental Factor Ontology (EFO) Information
Identifier EFO_0000319
Description A disease involving the cardiovascular system. [MONDO: DesignPattern]
Trait category
Cardiovascular disease
Synonyms 76 synonyms
  • ASCVD
  • CARDIOVASC DIS
  • CIRCULATORY DISEASE NOS
  • CVD
  • CVD, NOS
  • CVS disease
  • Cardiovascular Disease (CVD)
  • Cardiovascular Diseases
  • Cardiovascular Disorder
  • Cardiovascular Disorders
  • Cardiovascular disease, NOS
  • Cardiovascular disease, unspecified
  • Cardiovascular disorder, NOS
  • Cardiovascular system disease
  • Certain sequelae of myocardial infarction, not elsewhere classified
  • Circulatory system disease NOS
  • Circulatory system disease NOS (disorder)
  • DISEASES OF THE CIRCULATORY SYSTEM
  • Disease affecting entire cardiovascular system
  • Disease affecting entire cardiovascular system (disorder)
  • Disease of cardiovascular system
  • Disease of cardiovascular system (disorder)
  • Disease of cardiovascular system, NOS
  • Disease, Cardiovascular
  • Diseases, Cardiovascular
  • Disorder of cardiovascular system
  • Disorder of cardiovascular system (disorder)
  • Disorder of circulatory system
  • Disorder of circulatory system, NOS
  • Disorder of the circulatory system
  • ILL-DEFINED HRT DIS NEC
  • Ill-defined descriptions and complications of heart disease
  • OTHER SEQUELAE OF MI NEC
  • Other diseases of endocardium
  • Other diseases of endocardium (disorder)
  • Other diseases of pericardium
  • Other diseases of pericardium (disorder)
  • Other disorders of papillary muscle
  • Other forms of heart disease
  • Other forms of heart disease (disorder)
  • Other heart disease
  • Other heart disease (disorder)
  • Other heart disease NOS
  • Other heart disease NOS (disorder)
  • Other ill-defined heart disease
  • Other ill-defined heart disease (disorder)
  • Other ill-defined heart disease NOS
  • Other ill-defined heart disease NOS (disorder)
  • Other ill-defined heart diseases
  • Other pericardial disease NOS
  • Other pericardial disease NOS (disorder)
  • Other sequelae of myocardial infarction, not elsewhere classified
  • Other specified diseases of pericardium
  • Other specified pericardial disease NOS
  • Other specified pericardial disease NOS (disorder)
  • PAPILLARY MUSCLE DIS NEC
  • PERICARDIAL DISEASE NEC
  • Unspecified circulatory system disorder
  • [X]Cardiovascular disease, unspecified
  • [X]Cardiovascular disease, unspecified (disorder)
  • [X]Other forms of heart disease
  • [X]Other forms of heart disease (disorder)
  • [X]Other ill-defined heart diseases
  • [X]Other ill-defined heart diseases (disorder)
  • [X]Other specified diseases of pericardium
  • [X]Other specified diseases of pericardium (disorder)
  • cardiovascular disease
  • cardiovascular disease (CVD)
  • cardiovascular disorder
  • cardiovascular system disease
  • cardiovascular system disease or disorder
  • circulatory system disease
  • disease of cardiovascular system
  • disease of subdivision of hemolymphoid system
  • disease or disorder of cardiovascular system
  • disorder of cardiovascular system
Mapped term(s) 26 mapped terms
  • DOID:1287
  • ICD10:I00.I99
  • ICD10:I98
  • ICD10:I99
  • ICD9:390-459.99
  • ICD9:420-429.99
  • ICD9:423
  • ICD9:423.8
  • ICD9:424
  • ICD9:429
  • ICD9:429.2
  • ICD9:429.7
  • ICD9:429.8
  • ICD9:429.81
  • ICD9:429.89
  • ICD9:459.89
  • ICD9:459.9
  • MESH:D002318
  • MONDO:0004995
  • MeSH:D002318
  • NCIT:C2931
  • NCIt:C2931
  • SCTID:49601007
  • SNOMEDCT:105980002
  • SNOMEDCT:49601007
  • UMLS:C0007222
Child trait(s) 11 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "cardiovascular disease" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000010
(GRS27)
PGP000003 |
Mega JL et al. Lancet (2015)
Coronary heart disease coronary artery disease 27
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000010/ScoringFiles/PGS000010.txt.gz
PGS000011
(GRS50)
PGP000004 |
Tada H et al. Eur Heart J (2015)
Coronary artery disease coronary artery disease 50
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000012
(GRS49K)
PGP000005 |
Abraham G et al. Eur Heart J (2016)
Coronary artery disease coronary artery disease 49,310
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz
PGS000013
(GPS_CAD)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Coronary artery disease coronary artery disease 6,630,150
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses
PGS000016
(GPS_AF)
PGP000006 |
Khera AV et al. Nat Genet (2018)
Atrial fibrillation atrial fibrillation 6,730,541
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000016/ScoringFiles/PGS000016.txt.gz - Check Terms/Licenses
PGS000018
(metaGRS_CAD)
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
Coronary artery disease coronary artery disease 1,745,179
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000019
(GRS_CAD)
PGP000009 |
Paquette M et al. J Clin Lipidol (2017)
Coronary artery disease coronary artery disease 192
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000019/ScoringFiles/PGS000019.txt.gz
PGS000035
(PRS_AF)
PGP000022 |
Weng LC et al. Circulation (2017)
Atrial fibrillation atrial fibrillation 1,168
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000035/ScoringFiles/PGS000035.txt.gz
PGS000038
(PRS90)
PGP000026 |
Rutten-Jacobs LC et al. BMJ (2018)
Stroke stroke 90
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000038/ScoringFiles/PGS000038.txt.gz
PGS000039
(metaGRS_ischaemicstroke)
PGP000027 |
Abraham G et al. Nat Commun (2019)
Ischaemic stroke stroke,
Ischemic stroke
3,225,583
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000039/ScoringFiles/PGS000039.txt.gz
PGS000043
(PRS_VTE)
PGP000030 |
Klarin D et al. Nat Genet (2019)
Venous thromboembolism venous thromboembolism 297
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000043/ScoringFiles/PGS000043.txt.gz
PGS000057
(CHD57)
PGP000042 |
Natarajan P et al. Circulation (2017)
Coronary heart disease coronary artery disease 57
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000057/ScoringFiles/PGS000057.txt.gz
PGS000058
(CAD_GRS_204)
PGP000043 |
Morieri ML et al. Diabetes Care (2018)
Coronary artery disease coronary artery disease 204
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000058/ScoringFiles/PGS000058.txt.gz
PGS000059
(CHD46)
PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
Coronary heart disease coronary artery disease 46
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000059/ScoringFiles/PGS000059.txt.gz
PGS000116
(CAD_EJ2020)
PGP000054 |
Elliott J et al. JAMA (2020)
Coronary Artery Disease coronary artery disease 40,079
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000116/ScoringFiles/PGS000116.txt.gz - Check Terms/Licenses
PGS000117
(CVD_EJ2020)
PGP000054 |
Elliott J et al. JAMA (2020)
Cardiovascular Disease cardiovascular disease 297,862
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000117/ScoringFiles/PGS000117.txt.gz - Check Terms/Licenses
PGS000200
(GRS28)
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Coronary heart disease coronary artery disease 28
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz
PGS000296
(GPS_CAD_SA)
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
Coronary artery disease coronary artery disease 6,630,150
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000296/ScoringFiles/PGS000296.txt.gz - Check Terms/Licenses
PGS000329
(PRS_CHD)
PGP000100 |
Mars N et al. Nat Med (2020)
Coronary heart disease coronary artery disease 6,423,165
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000329/ScoringFiles/PGS000329.txt.gz
PGS000331
(PRS_AF)
PGP000100 |
Mars N et al. Nat Med (2020)
Atrial fibrillation atrial fibrillation 6,183,494
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000331/ScoringFiles/PGS000331.txt.gz
PGS000337
(MetaPRS_CAD)
PGP000104 |
Koyama S et al. Nat Genet (2020)
Coronary artery disease coronary artery disease 75,028
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000337/ScoringFiles/PGS000337.txt.gz - Check Terms/Licenses
PGS000338
(GRS97_AF)
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Atrial fibrillation atrial fibrillation 97
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000338/ScoringFiles/PGS000338.txt.gz
PGS000341
(GRS33_SSc)
PGP000110 |
Bossini-Castillo L et al. Ann Rheum Dis (2020)
Systemic sclerosis systemic scleroderma 33
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000341/ScoringFiles/PGS000341.txt.gz
PGS000349
(PRS70_CAD)
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Coronary artery disease coronary artery disease 70
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000349/ScoringFiles/PGS000349.txt.gz
PGS000665
(GRS_32)
PGP000125 |
Marston NA et al. Circulation (2020)
Ischemic stroke Ischemic stroke,
stroke
32
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000665/ScoringFiles/PGS000665.txt.gz
PGS000706
(HC215)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Hypertension hypertension 186,726
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000706/ScoringFiles/PGS000706.txt.gz - Check Terms/Licenses
PGS000709
(HC299)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Heart failure heart failure 183,287
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000709/ScoringFiles/PGS000709.txt.gz - Check Terms/Licenses
PGS000710
(HC326)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Myocardial infarction myocardial infarction 183,566
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000710/ScoringFiles/PGS000710.txt.gz - Check Terms/Licenses
PGS000727
(AF_PGS)
PGP000137 |
Ritchie SC et al. bioRxiv (2019)
|Pre
Atrial fibrillation atrial fibrillation 2,210,336
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000727/ScoringFiles/PGS000727.txt.gz
PGS000737
(PRS_BrS)
PGP000144 |
Tadros R et al. Eur Heart J (2019)
Brugada syndrome Brugada syndrome 3
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000737/ScoringFiles/PGS000737.txt.gz
PGS000739
(HCM_GRS)
PGP000146 |
Harper AR et al. Nat Genet (2021)
Hypertrophic cardiomyopathy hypertrophic cardiomyopathy 27
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000739/ScoringFiles/PGS000739.txt.gz
PGS000746
(PRS_UKB)
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Coronary artery disease coronary artery disease 1,940
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000746/ScoringFiles/PGS000746.txt.gz
PGS000747
(PRS_EB)
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Coronary artery disease coronary artery disease 375,822
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000747/ScoringFiles/PGS000747.txt.gz
PGS000748
(PRS_DE)
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Coronary artery disease coronary artery disease 3,423,987
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000748/ScoringFiles/PGS000748.txt.gz
PGS000749
(PRS_COMBINED)
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Coronary artery disease coronary artery disease 1,056,021
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000749/ScoringFiles/PGS000749.txt.gz
PGS000753
(PRS29_AAA)
PGP000159 |
Klarin D et al. Circulation (2020)
Abdominal aortic aneurysm Abdominal Aortic Aneurysm 29
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000753/ScoringFiles/PGS000753.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000014 PGS000010
(GRS27)
PSS000008|
European Ancestry|
42,998 individuals
PGP000003 |
Mega JL et al. Lancet (2015)
Reported Trait: Coronary heart disease HR: 1.21 [1.17, 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PGS000010
(GRS27)
PSS000009|
European Ancestry|
4,877 individuals
PGP000003 |
Mega JL et al. Lancet (2015)
Reported Trait: Coronary heart disease HR: 1.14 [1.02, 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000018 PGS000012
(GRS49K)
PSS000012|
European Ancestry|
12,676 individuals
PGP000005 |
Abraham G et al. Eur Heart J (2016)
Reported Trait: Incident coronary artery disease HR: 1.74 [1.61, 1.86]
OR: 1.74 [1.61, 1.89]
sex, sub-cohort, location (east/west), 5 genetic PCs Used only the 42,364 SNPs that were available in FINRISK
PPM000020 PGS000012
(GRS49K)
PSS000011|
European Ancestry|
3,406 individuals
PGP000005 |
Abraham G et al. Eur Heart J (2016)
Reported Trait: Incident coronary artery disease HR: 1.28 [1.18, 1.38]
OR: 1.28 [1.17, 1.41]
sex, sub-cohort, 5 genetic PCs Used only the 46,773 SNPs that were available in FHS
PPM001620 PGS000013
(GPS_CAD)
PSS000837|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.7 [0.677, 0.721] Δ C-index (PRS+covariates vs. covariates alone): -0.001 [-0.009, 0.006] Pooled cohort risk percentile, age, sex, PCs (1-5)
PPM001639 PGS000043
(PRS_VTE)
PSS000850|
European Ancestry|
715 individuals
PGP000133 |
Naito T et al. Gastroenterology (2020)
|Ext.
Reported Trait: Thromboembolic disease event in individuals with inflammatory bowel disease Odds Ratio (OR, top 5% vs. remaining 95%): 2.7 [1.03, 7.09] Age at last visit, PCs(1-2) Included 265/297 variants from the original score
PPM000027 PGS000018
(metaGRS_CAD)
PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
Reported Trait: Incident coronary artery disease HR: 1.706 [1.682, 1.73] AUROC: 0.79
C-index: 0.623 [0.615, 0.631]
AUPRC: 0.161 sex, genetic PCs (1-10), genotyping array age-as-time-scale Cox regression
PPM000028 PGS000012
(GRS49K)
PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.524 [1.498, 1.551] sex, genetic PCs (1-10), genotyping array Used GRS46K (excludes A/T and C/G SNPs, with performance similar to GRS49K)
PPM000038 PGS000019
(GRS_CAD)
PSS000023|
European Ancestry|
725 individuals
PGP000009 |
Paquette M et al. J Clin Lipidol (2017)
Reported Trait: Coronary artery disease in familial hypercholesterolemia patients OR: 1.66 [1.06, 2.62] age, gender, prior statin use, smoking, diabetes, hypertension, BMI, LDL-C, HDL-C, TGs, Lp(a), and type of LDLR mutation Performance metrics are from Model 2 (adjusted for cardiovascular risk factors)
PPM000039 PGS000019
(GRS_CAD)
PSS000024|
European Ancestry|
725 individuals
PGP000009 |
Paquette M et al. J Clin Lipidol (2017)
Reported Trait: Coronary artery disease in familial hypercholesterolemia patients OR: 1.8 [1.14, 2.85] age, gender, prior statin use, smoking, diabetes, hypertension, BMI, LDL-C, HDL-C, TGs, Lp(a), and type of LDLR mutation Performance metrics are from Model 2 (adjusted for cardiovascular risk factors)
PPM000016 PGS000011
(GRS50)
PSS000010|
European Ancestry|
23,595 individuals
PGP000004 |
Tada H et al. Eur Heart J (2015)
Reported Trait: Incident coronary heart disease HR: 1.23 [1.18, 1.28] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000079 PGS000035
(PRS_AF)
PSS000053|
Multi-ancestry (including European)|
4,606 individuals
PGP000022 |
Weng LC et al. Circulation (2017)
Reported Trait: Incident atrial fibrillation HR: 1.14 [1.11, 1.16] Clinical risk (CHARGE-AF Score: height, weight, systolic and diastolic blood pressure, current smoking status, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure), age, sex, genotyping array, 1 PC of ancestry Unadjusted for Competing Risk of Death
PPM000090 PGS000038
(PRS90)
PSS000057|
European Ancestry|
306,473 individuals
PGP000026 |
Rutten-Jacobs LC et al. BMJ (2018)
Reported Trait: Incident stroke HR (High [top 33%] vs. Low [bottom 33%] of genetic risk): 1.35 [1.21, 1.5] age, sex, 10 PCs of genetic ancestry, genotyping batch The best performing PRS (e.g. C+T thresholds) were selected based on this sample set, as well as being used for the evaluation.
PPM000091 PGS000039
(metaGRS_ischaemicstroke)
PSS000058|
European Ancestry|
395,393 individuals
PGP000027 |
Abraham G et al. Nat Commun (2019)
Reported Trait: Ischaemic stroke before age 75 HR: 1.26 [1.22, 1.31] C-index: 0.585 [0.574, 0.595] Sex, genotyping chip, 10 PCs
PPM000092 PGS000038
(PRS90)
PSS000058|
European Ancestry|
395,393 individuals
PGP000027 |
Abraham G et al. Nat Commun (2019)
|Ext.
Reported Trait: Ischaemic stroke before age 75 HR: 1.13 [1.1, 1.17] Sex, genotyping chip, 10 PCs
PPM000102 PGS000043
(PRS_VTE)
PSS000066|
European Ancestry|
55,965 individuals
PGP000030 |
Klarin D et al. Nat Genet (2019)
Reported Trait: Venous thromboembolism OR (top 5% of individuals with the highest PRS_VTE relative to the rest of the population): 2.89 [2.52, 3.3] age, sex, 5 PCs of ancestry
PPM001011 PGS000013
(GPS_CAD)
PSS000515|
African Ancestry|
6,979 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.58 PCs (1-10) of ancestry
PPM001010 PGS000013
(GPS_CAD)
PSS000517|
Hispanic or Latin American Ancestry|
7,048 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.63 PCs (1-10) of ancestry
PPM001009 PGS000013
(GPS_CAD)
PSS000516|
European Ancestry|
10,344 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.53 PCs (1-10) of ancestry
PPM001008 PGS000013
(GPS_CAD)
PSS000515|
African Ancestry|
6,979 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.29 [1.23, 1.34] age, sex, PCs (1-10) of ancestry
PPM001007 PGS000013
(GPS_CAD)
PSS000517|
Hispanic or Latin American Ancestry|
7,048 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.5 [1.44, 1.57] age, sex, PCs (1-10) of ancestry
PPM001006 PGS000013
(GPS_CAD)
PSS000516|
European Ancestry|
10,344 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.52 [1.46, 1.58] age, sex, PCs (1-10) of ancestry
PPM001005 PGS000013
(GPS_CAD)
PSS000514|
Multi-ancestry (including European)|
24,371 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.61 PCs (1-10) of ancestry
PPM001004 PGS000013
(GPS_CAD)
PSS000519|
Multi-ancestry (including European)|
9,070 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.6 PCs (1-10) of ancestry
PPM001003 PGS000013
(GPS_CAD)
PSS000518|
Multi-ancestry (including European)|
13,667 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease AUROC: 0.59 PCs (1-10) of ancestry
PPM001002 PGS000013
(GPS_CAD)
PSS000514|
Multi-ancestry (including European)|
24,371 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.35, 1.48] age, sex, PCs (1-10) of ancestry
PPM001001 PGS000013
(GPS_CAD)
PSS000519|
Multi-ancestry (including European)|
9,070 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.45 [1.38, 1.52] age, sex, PCs (1-10) of ancestry, genotyping array
PPM001000 PGS000013
(GPS_CAD)
PSS000518|
Multi-ancestry (including European)|
13,667 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.41 [1.34, 1.47] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000583 PGS000200
(GRS28)
PSS000330|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident cardiovascular disease HR: 1.18 [1.12, 1.24] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000150 PGS000059
(CHD46)
PSS000094|
European Ancestry|
1,320 individuals
PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 0.76 [0.41, 1.39]
p-value (association between risk and incidence): 0.31
NR
PPM000999 PGS000013
(GPS_CAD)
PSS000520|
Multi-ancestry (including European)|
47,108 individuals
PGP000116 |
Aragam KG et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Prevalent Coronary Artery Disease OR: 1.42 [1.38, 1.46] age, sex, PCs (1-10) of ancestry, genotyping array
PPM000589 PGS000011
(GRS50)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] C-index: 0.698 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000588 PGS000200
(GRS28)
PSS000328|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident acute coronary syndrome C-index: 0.859 ΔC-index (over covariate only model): 0.004 [0.003, 0.005] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000587 PGS000200
(GRS28)
PSS000329|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident coronary heart disease C-index: 0.856 ΔC-index (over covariate only model): 0.005 [0.004, 0.006] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000586 PGS000200
(GRS28)
PSS000330|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident cardiovascular disease C-index: 0.84 ΔC-index (over covariate only model): 0.003 [0.002, 0.004] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000585 PGS000200
(GRS28)
PSS000328|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident acute coronary syndrome HR: 1.27 [1.18, 1.37] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000597 PGS000018
(metaGRS_CAD)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.53 [1.23, 1.9] C-index: 0.683 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000596 PGS000013
(GPS_CAD)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.16 [0.96, 1.41] C-index: 0.659 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000595 PGS000011
(GRS50)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.13 [0.93, 1.36] C-index: 0.654 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000594 PGS000018
(metaGRS_CAD)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.27 [1.13, 1.43] C-index: 0.663 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000593 PGS000013
(GPS_CAD)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.19 [1.07, 1.33] C-index: 0.656 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000592 PGS000011
(GRS50)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.05 [0.94, 1.17] C-index: 0.649 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000591 PGS000018
(metaGRS_CAD)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.53 [1.46, 1.6] C-index: 0.719 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000619 PGS000013
(GPS_CAD)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.17 [1.04, 1.31] C-index: 0.712 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000618 PGS000011
(GRS50)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.05 [0.94, 1.18] C-index: 0.704 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000617 PGS000200
(GRS28)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.11 [0.99, 1.25] C-index: 0.706 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000616 PGS000018
(metaGRS_CAD)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.49 [1.43, 1.56] C-index: 0.75 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000615 PGS000013
(GPS_CAD)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.47 [1.41, 1.54] C-index: 0.75 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000614 PGS000011
(GRS50)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] C-index: 0.736 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000613 PGS000200
(GRS28)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.17 [1.12, 1.22] C-index: 0.735 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000620 PGS000018
(metaGRS_CAD)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.25 [1.12, 1.41] C-index: 0.723 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000624 PGS000018
(metaGRS_CAD)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.5 [1.21, 1.87] C-index: 0.725 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000623 PGS000013
(GPS_CAD)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.39] C-index: 0.708 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000622 PGS000011
(GRS50)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.12 [0.93, 1.36] C-index: 0.708 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000621 PGS000200
(GRS28)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.13 [0.93, 1.37] C-index: 0.709 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM001666 PGS000018
(metaGRS_CAD)
PSS000868|
European Ancestry|
3,087 individuals
PGP000137 |
Ritchie SC et al. bioRxiv (2019)
|Ext.|Pre
Reported Trait: Incident myocardial infarction HR: 2.89 [1.66, 5.04] age, sex, 10 genetic PCs
PPM001668 PGS000727
(AF_PGS)
PSS000867|
European Ancestry|
3,087 individuals
PGP000137 |
Ritchie SC et al. bioRxiv (2019)
|Pre
Reported Trait: Incident atrial fibrillation HR: 1.72 [1.2, 2.47] age, sex, 10 genetic PCs
PPM000590 PGS000013
(GPS_CAD)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.5 [1.43, 1.56] C-index: 0.719 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000584 PGS000200
(GRS28)
PSS000329|
European Ancestry|
24,124 individuals
PGP000082 |
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Reported Trait: Incident coronary heart disease HR: 1.27 [1.2, 1.35] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000385 PGS000016
(GPS_AF)
PSS000217|
European Ancestry|
10,303 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Atrial Fibrillation (personal history) OR: 1.277 [1.12, 1.46] AUROC: 0.78 age, sex
PPM000496 PGS000011
(GRS50)
PSS000285|
European Ancestry|
22,389 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.
Reported Trait: Incident coronary artery disease Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.98 [1.76, 2.23] age, sex, self reported education level
PPM000495 PGS000011
(GRS50)
PSS000286|
European Ancestry|
21,222 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.
Reported Trait: Incident coronary artery disease Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.94 [1.58, 2.39] age, self reported education level, treatment (vitamin E vs aspirin), 5 genetic principal components
PPM000494 PGS000011
(GRS50)
PSS000283|
European Ancestry|
7,814 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.
Reported Trait: Incident coronary artery disease Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.75 [1.46, 2.1] age, sex, self reported education level, 5 genetic principal components
PPM001839 PGS000747
(PRS_EB)
PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6043 [0.6004, 0.6082] Area under the Precision-Recall curve (AUPRC): 0.0712 [0.0703, 0.076]
PPM001841 PGS000748
(PRS_DE)
PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6156 [0.5963, 0.6349] Area under the Precision-Recall curve (AUPRC): 0.0506 [0.0504, 0.0508]
PPM001842 PGS000748
(PRS_DE)
PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.5989 [0.595, 0.6028] Area under the Precision-Recall curve (AUPRC): 0.0696 [0.0694, 0.0698]
PPM001843 PGS000749
(PRS_COMBINED)
PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6112 [0.5919, 0.6305] Area under the Precision-Recall curve (AUPRC): 0.048 [0.0473, 0.0487]
PPM001845 PGS000018
(metaGRS_CAD)
PSS000929|
European Ancestry|
5,581 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.5015 [0.483, 0.514] Area under the Precision-Recall curve (AUPRC): 0.5205 [0.5201, 0.521]
PPM001846 PGS000018
(metaGRS_CAD)
PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.6597 [0.6405, 0.6789] Area under the Precision-Recall curve (AUPRC): 0.0673 [0.0668, 0.0679]
PPM000017 PGS000010
(GRS27)
PSS000010|
European Ancestry|
23,595 individuals
PGP000004 |
Tada H et al. Eur Heart J (2015)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.2 [1.15, 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000022 PGS000013
(GPS_CAD)
PSS000015|
European Ancestry|
288,978 individuals
PGP000006 |
Khera AV et al. Nat Genet (2018)
Reported Trait: Coronary artery disease AUROC: 0.81 [0.81, 0.81] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.04 age; sex; Ancestry PC 1-4; genotyping chip
PPM000025 PGS000016
(GPS_AF)
PSS000013|
European Ancestry|
288,978 individuals
PGP000006 |
Khera AV et al. Nat Genet (2018)
Reported Trait: Atrial fibrillation AUROC: 0.77 [0.76, 0.77] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.029 age; sex; Ancestry PC 1-4; genotyping chip
PPM000029 PGS000011
(GRS50)
PSS000018|
Multi-ancestry (including European)|
482,629 individuals
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.263 [1.247, 1.28] sex, genetic PCs (1-10), genotyping array
PPM000030 PGS000013
(GPS_CAD)
PSS000021|
European Ancestry|
1,964 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.64 [1.48, 1.81] AUROC: 0.72 [0.7, 0.74] age, sex, first four genetic PCs
PPM000031 PGS000013
(GPS_CAD)
PSS000022|
European Ancestry|
3,309 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.55 [1.38, 1.73] AUROC: 0.89 [0.88, 0.91] age, sex, first four genetic PCs
PPM000032 PGS000013
(GPS_CAD)
PSS000019|
European Ancestry|
5,762 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.69 [1.44, 1.99] AUROC: 0.84 [0.81, 0.87] age, sex, first four genetic PCs, cohort recruitment centre
PPM000033 PGS000013
(GPS_CAD)
PSS000020|
European Ancestry|
3,195 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Reccurent coronary artery disease events OR: 1.13 [1.06, 1.22] age, sex, first four genetic PCs
PPM000034 PGS000018
(metaGRS_CAD)
PSS000021|
European Ancestry|
1,964 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.74 [1.57, 1.93] AUROC: 0.72 [0.7, 0.75] age, sex, first four genetic PCs
PPM000035 PGS000018
(metaGRS_CAD)
PSS000022|
European Ancestry|
3,309 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.6 [1.43, 1.8] AUROC: 0.89 [0.88, 0.91] age, sex, first four genetic PCs
PPM000036 PGS000018
(metaGRS_CAD)
PSS000019|
European Ancestry|
5,762 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.75 [1.49, 2.05] AUROC: 0.84 [0.81, 0.87] age, sex, first four genetic PCs, cohort recruitment centre
PPM000037 PGS000018
(metaGRS_CAD)
PSS000020|
European Ancestry|
3,195 individuals
PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.
Reported Trait: Reccurent coronary artery disease events OR: 1.17 [1.08, 1.26] age, sex, first four genetic PCs
PPM000103 PGS000043
(PRS_VTE)
PSS000067|
European Ancestry|
10,975 individuals
PGP000030 |
Klarin D et al. Nat Genet (2019)
Reported Trait: Venous thromboembolism HR (top 5% of individuals with the highest PRS_VTE relative to the rest of the population): 2.51 [1.97, 3.19] age, 10 PCs of ancestry, hormone therapy intervention status
PPM000144 PGS000057
(CHD57)
PSS000091|
Ancestry Not Reported|
2,440 individuals
PGP000042 |
Natarajan P et al. Circulation (2017)
Reported Trait: Coronary heart disease (incident) HR (highest vs. lowest quintile of PGS): 1.66 [1.21, 2.29] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000145 PGS000057
(CHD57)
PSS000090|
Ancestry Not Reported|
1,154 individuals
PGP000042 |
Natarajan P et al. Circulation (2017)
Reported Trait: Coronary artery calcification OR: 1.32 [1.04, 1.68] OR (highest vs. lowest quintile of PGS): 2.51 [1.08, 5.85] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000146 PGS000057
(CHD57)
PSS000089|
Ancestry Not Reported|
4,392 individuals
PGP000042 |
Natarajan P et al. Circulation (2017)
Reported Trait: Carotid artery plaque burden β: 1.097 [1.022, 1.178] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000147 PGS000058
(CAD_GRS_204)
PSS000092|
European Ancestry|
5,360 individuals
PGP000043 |
Morieri ML et al. Diabetes Care (2018)
Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.27 [1.18, 1.37] age, sex, ACCORD study covariates (randomized treament assignement, clinical network, genotyping platform, PCs of genetic ancestry)
PPM000148 PGS000058
(CAD_GRS_204)
PSS000093|
European Ancestry|
1,931 individuals
PGP000043 |
Morieri ML et al. Diabetes Care (2018)
Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.35 [1.16, 1.58] age, sex, ORIGIN study covariates (randomized treament assignement, PCs of genetic ancestry)
PPM000149 PGS000059
(CHD46)
PSS000095|
European Ancestry|
1,206 individuals
PGP000044 |
Hajek C et al. Circ Genom Precis Med (2018)
Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 1.92 [1.19, 3.11]
p-value (association between risk and incidence): 0.029
NR
PPM000898 PGS000331
(PRS_AF)
PSS000439|
European Ancestry|
10,561 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Incident atrial fibrillation C-index: 0.734 CHARGE-AF calculator (age, height, weight, SBP, DBP, smoking status, blood-pressure-lowering medication, diabetes, heart failure and history of myocardial infarction), FINRISK cohort, genotyping array/batch, 10 ancestry PCs 5-year risk
PPM000896 PGS000329
(PRS_CHD)
PSS000440|
European Ancestry|
20,165 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Incident coronary heart disease C-index: 0.82 ASCVD risk calculator(age, sex, total cholesterol, HDL, SBP, blood-pressure-lowering medication, diabetes and smoking status), FINRISK cohort, genotyping array/batch, 10 ancestry PCs 10-year risk
PPM000893 PGS000331
(PRS_AF)
PSS000439|
European Ancestry|
10,561 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Incident atrial fibrillation HR: 1.62 [1.54, 1.7] C-index: 0.751 age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs 5-year risk
PPM000891 PGS000329
(PRS_CHD)
PSS000440|
European Ancestry|
20,165 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Incident coronary heart disease HR: 1.25 [1.18, 1.32] C-index: 0.832 age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs 10-year risk
PPM000909 PGS000337
(MetaPRS_CAD)
PSS000456|
East Asian Ancestry|
49,230 individuals
PGP000104 |
Koyama S et al. Nat Genet (2020)
Reported Trait: Mortality (diseases of the circulatory system) HR: 1.10351 [1.057, 1.152] Sex, age, age^2, PCs (1-10), disease status
PPM000908 PGS000337
(MetaPRS_CAD)
PSS000454|
East Asian Ancestry|
49,230 individuals
PGP000104 |
Koyama S et al. Nat Genet (2020)
Reported Trait: All-cause Mortality HR: 1.03159 [1.011, 1.052] Sex, age, age^2, PCs (1-10), disease status
PPM000383 PGS000013
(GPS_CAD)
PSS000219|
European Ancestry|
11,010 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Coronary artery disease (personal history) OR: 1.589 [1.32, 1.92] AUROC: 0.86 age, sex
PPM000402 PGS000013
(GPS_CAD)
PSS000227|
Additional Asian Ancestries|
544 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.16 [1.35, 1.59] Odds Ratio (OR; top 5% vs. rest): 3.33 [0.82, 13.51] 4 genetic PCs
PPM000401 PGS000013
(GPS_CAD)
PSS000229|
Hispanic or Latin American Ancestry|
919 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.56 [1.29, 1.88] Odds Ratio (OR; top 5% vs. rest): 3.38 [2.03, 5.64] 4 genetic PCs
PPM000400 PGS000013
(GPS_CAD)
PSS000228|
African Ancestry|
1,298 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.46 [1.28, 1.66] Odds Ratio (OR; top 5% vs. rest): 2.02 [1.29, 3.16] 4 genetic PCs
PPM000399 PGS000013
(GPS_CAD)
PSS000230|
European Ancestry|
3,081 individuals
PGP000060 |
Khera AV et al. Circulation (2019)
|Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.06 [1.89, 2.25] Odds Ratio (OR; top 5% vs. rest): 5.09 [3.82, 6.78] 4 genetic PCs
PPM000518 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Plaque vulnerability score β: 0.07 [0.003, 0.137] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000517 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Microvessels β: 0.037 [-0.006, 0.08] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000516 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Number of smoooth muscle cells β: -0.004 [-0.038, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000515 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Number of macrophages β: 0.01 [-0.015, 0.036] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000514 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy macrophages OR: 1.103 [0.983, 1.237] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000513 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy smooth muscle cells OR: 1.004 [0.88, 1.145] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000512 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Presence of IPH OR: 1.126 [0.999, 1.27] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000511 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Presence of lipid core >10% OR: 1.171 [1.026, 1.337] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000510 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy collagen OR: 1.064 [0.919, 1.231] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000509 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy calficiations OR: 0.94 [0.826, 1.07] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000508 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Plaque vulnerability score OR: 0.198 [0.003, 0.364] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000507 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Microvessels Beta (top 20% vs. rest): 0.072 [-0.037, 0.182] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000506 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Number of smoooth muscle cells Beta (top 20% vs. rest): -0.056 [-0.143, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000505 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Number of macrophages Beta (top 20% vs. rest): 0.55 [-0.012, 0.121] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000504 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy macrophages Odds Ratio (OR; top 20% vs. rest): 1.49 [1.118, 1.986] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000503 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy smooth muscle cells Odds Ratio (OR; top 20% vs. rest): 0.908 [0.652, 1.265] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000502 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Presence of IPH Odds Ratio (OR; top 20% vs. rest): 1.112 [0.821, 1.506] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000501 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Presence of lipid core >10% Odds Ratio (OR; top 20% vs. rest): 1.591 [1.105, 2.291] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000500 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy collagen Odds Ratio (OR; top 20% vs. rest): 1.091 [0.755, 1.577] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000499 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Moderate/heavy calficiations Odds Ratio (OR; top 20% vs. rest): 1.001 [0.754, 1.33] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000498 PGS000018
(metaGRS_CAD)
PSS000287|
European Ancestry|
1,319 individuals
PGP000077 |
Timmerman N et al. medRxiv (2019)
|Ext.|Pre
Reported Trait: Secondary cardiovascular events HR: 1.15 [1.02, 1.29] Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs
PPM000019 PGS000010
(GRS27)
PSS000012|
European Ancestry|
12,676 individuals
PGP000005 |
Abraham G et al. Eur Heart J (2016)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.21 [1.12, 1.3]
PPM000021 PGS000010
(GRS27)
PSS000011|
European Ancestry|
3,406 individuals
PGP000005 |
Abraham G et al. Eur Heart J (2016)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.2 [1.07, 1.26]
PPM000389 PGS000016
(GPS_AF)
PSS000217|
European Ancestry|
10,303 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Atrial Fibrillation (personal history) AUROC: 0.57
PPM000387 PGS000013
(GPS_CAD)
PSS000219|
European Ancestry|
11,010 individuals
PGP000057 |
Homburger JR et al. Genome Med (2019)
|Ext.
Reported Trait: Coronary artery disease (personal history) AUROC: 0.6
PPM000497 PGS000011
(GRS50)
PSS000284|
European Ancestry|
4,260 individuals
PGP000076 |
Khera AV et al. N Engl J Med (2016)
|Ext.
Reported Trait: Coronary artery calcification Agatston score (mean, top 20% of GRS): 46.0 [9.0, 54.0]
Agatston score (mean, btttom 25% of GRS): 21.0 [18.0, 25.0]
PPM000916 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation OR: 2.13 [1.86, 2.44] age, sex, PCs (1-10) of ancestry
PPM000913 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation OR: 2.12 [1.84, 2.45] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000911 PGS000337
(MetaPRS_CAD)
PSS000457|
East Asian Ancestry|
49,230 individuals
PGP000104 |
Koyama S et al. Nat Genet (2020)
Reported Trait: Mortality (ischemic heart disease) HR: 1.2158 [1.109, 1.333] Sex, age, age^2, PCs (1-10), disease status
PPM000917 PGS000338
(GRS97_AF)
PSS000461|
European Ancestry|
2,262 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.12 [1.77, 2.54] age, sex, PCs (1-10) of ancestry
PPM000915 PGS000338
(GRS97_AF)
PSS000460|
European Ancestry|
530 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 2.02 [1.37, 2.99] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000914 PGS000338
(GRS97_AF)
PSS000461|
European Ancestry|
2,262 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.08 [1.72, 2.5] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000920 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation AUROC: 0.721 [0.704, 737.0] PCs (1-10) of ancestry, CHARGE-AF risk factors (age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, myocardial infarction, diabetes)
PPM000919 PGS000338
(GRS97_AF)
PSS000462|
European Ancestry|
3,759 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation AUROC: 0.606 [0.588, 0.624] PCs (1-10) of ancestry
PPM000912 PGS000337
(MetaPRS_CAD)
PSS000455|
East Asian Ancestry|
49,230 individuals
PGP000104 |
Koyama S et al. Nat Genet (2020)
Reported Trait: Mortality (congestive heart failure) HR: 1.15604 [1.042, 1.2283] Sex, age, age^2, PCs (1-10), disease status
PPM000910 PGS000337
(MetaPRS_CAD)
PSS000458|
East Asian Ancestry|
49,230 individuals
PGP000104 |
Koyama S et al. Nat Genet (2020)
Reported Trait: Mortality (diseases of the respiratory system) HR: 1.07133 [1.012, 1.134] Sex, age, age^2, PCs (1-10), disease status
PPM000907 PGS000337
(MetaPRS_CAD)
PSS000459|
East Asian Ancestry|
10,999 individuals
PGP000104 |
Koyama S et al. Nat Genet (2020)
Reported Trait: Coronary artery disease OR: 1.84 [1.744, 1.943] AUROC: 0.674 [0.661, 0.687] : 0.087 [0.074, 0.101]
PPM000918 PGS000338
(GRS97_AF)
PSS000460|
European Ancestry|
530 individuals
PGP000105 |
Kloosterman M et al. Eur J Heart Fail (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 1.82 [1.28, 2.59] age, sex, PCs (1-10) of ancestry
PPM000933 PGS000013
(GPS_CAD)
PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.768 [0.76, 0.776] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000932 PGS000013
(GPS_CAD)
PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.756 [0.75, 0.762] age, sex, PCs (1-10)
PPM000929 PGS000013
(GPS_CAD)
PSS000468|
Multi-ancestry (including European)|
5,685 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.802 [0.763, 0.8841] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000928 PGS000013
(GPS_CAD)
PSS000468|
Multi-ancestry (including European)|
5,685 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease C-index: 0.759 [0.724, 0.794] age, sex, PCs (1-10)
PPM000927 PGS000013
(GPS_CAD)
PSS000468|
Multi-ancestry (including European)|
5,685 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.45 [1.34, 1.56] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM000930 PGS000013
(GPS_CAD)
PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.53 [1.49, 1.56] age, sex
PPM000926 PGS000013
(GPS_CAD)
PSS000467|
Multi-ancestry (including European)|
28,556 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.45 [1.4, 1.49] age, sex
PPM000931 PGS000013
(GPS_CAD)
PSS000469|
Multi-ancestry (including European)|
325,003 individuals
PGP000108 |
Hindy G et al. Arterioscler Thromb Vasc Biol (2020)
|Ext.
Reported Trait: Incident coronary artery disease HR: 1.46 [1.42, 1.49] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM000970 PGS000341
(GRS33_SSc)
PSS000489|
European Ancestry|
339 individuals
PGP000110 |
Bossini-Castillo L et al. Ann Rheum Dis (2020)
Reported Trait: Systemic sclerosis AUROC: 0.787 [0.73, 0.84] Systemic sclerosis status, age and immune cell counts of: memory B cells, resting NK cells, M0 macrophages and activated dendritic cells *Some overlap with score development and testing samples
PPM000969 PGS000341
(GRS33_SSc)
PSS000489|
European Ancestry|
339 individuals
PGP000110 |
Bossini-Castillo L et al. Ann Rheum Dis (2020)
Reported Trait: Systemic sclerosis AUROC: 0.722 Systemic sclerosis status and immune cell counts of: memory B cells, resting NK cells, M0 macrophages and activated dendritic cells *Some overlap with score development and testing samples
PPM000968 PGS000341
(GRS33_SSc)
PSS000489|
European Ancestry|
339 individuals
PGP000110 |
Bossini-Castillo L et al. Ann Rheum Dis (2020)
Reported Trait: Systemic sclerosis AUROC: 0.644 *Some overlap with score development and testing samples
PPM000996 PGS000349
(PRS70_CAD)
PSS000508|
European Ancestry|
3,748 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Coronary artery calcification OR: 1.19 [1.1, 1.29] age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes).
PPM000995 PGS000349
(PRS70_CAD)
PSS000505|
European Ancestry|
4,041 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Coronary artery calcification OR: 1.18 [1.1, 1.27] age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes).
PPM000993 PGS000349
(PRS70_CAD)
PSS000509|
European Ancestry|
2,560 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Incident Coronary Heart Disease in indiviuals with coronary artery calcification > 0 HR: 1.21 [1.08, 1.36] age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes).
PPM000992 PGS000349
(PRS70_CAD)
PSS000510|
European Ancestry|
1,765 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Incident Coronary Heart Disease in males HR: 1.23 [1.07, 1.41] age, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes) and coronary artery calcification.
PPM000991 PGS000349
(PRS70_CAD)
PSS000506|
European Ancestry|
1,919 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Incident Coronary Heart Disease in males HR: 1.25 [1.1, 1.42] age
PPM000990 PGS000349
(PRS70_CAD)
PSS000507|
European Ancestry|
3,748 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Incident Coronary Heart Disease HR: 1.18 [1.06, 1.31] age, sex, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes) and coronary artery calcification.
PPM000989 PGS000349
(PRS70_CAD)
PSS000504|
European Ancestry|
4,041 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Incident Coronary Heart Disease HR: 1.18 [1.06, 1.31] age, sex
PPM000994 PGS000349
(PRS70_CAD)
PSS000511|
European Ancestry|
1,426 individuals
PGP000114 |
Pechlivanis S et al. BMC Med Genet (2020)
Reported Trait: Incident Coronary Heart Disease in males with coronary artery calcification > 0 HR: 1.26 [1.09, 1.46] age, cardiovascular risk factors (systolic blood pressure, antihypertensive medication, smoking, LDL-cholestrol, HDL-cholesterol, lipid lowering medication, BMI and diabetes).
PPM000825 PGS000117
(CVD_EJ2020)
PSS000388|
Multi-ancestry (including European)|
204,675 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (under age 55) C-index: 0.66 [0.65, 0.66] age,sex
PPM000826 PGS000117
(CVD_EJ2020)
PSS000388|
Multi-ancestry (including European)|
204,675 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (under age 55) C-index: 0.7 [0.7, 0.71] pooled cohort equations
PPM000828 PGS000117
(CVD_EJ2020)
PSS000384|
Multi-ancestry (including European)|
147,985 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (over age 55) C-index: 0.7 [0.69, 0.71] age,sex
PPM000829 PGS000117
(CVD_EJ2020)
PSS000384|
Multi-ancestry (including European)|
147,985 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (over age 55) C-index: 0.77 [0.76, 0.78] pooled cohort equations
PPM000831 PGS000117
(CVD_EJ2020)
PSS000392|
Multi-ancestry (including European)|
147,363 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in males) C-index: 0.67 [0.66, 0.67] age,sex
PPM000832 PGS000117
(CVD_EJ2020)
PSS000392|
Multi-ancestry (including European)|
147,363 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in males) C-index: 0.71 [0.71, 0.72] pooled cohort equations
PPM000834 PGS000117
(CVD_EJ2020)
PSS000396|
Multi-ancestry (including European)|
205,297 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in females) C-index: 0.69 [0.68, 0.7] age,sex
PPM000835 PGS000117
(CVD_EJ2020)
PSS000396|
Multi-ancestry (including European)|
205,297 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in females) C-index: 0.74 [0.73, 0.75] pooled cohort equations
PPM001373 PGS000665
(GRS_32)
PSS000602|
European Ancestry|
51,288 individuals
PGP000125 |
Marston NA et al. Circulation (2020)
Reported Trait: Incident ischemic stroke Hazard Ratio (HR, top vs. bottom tertile): 1.24 [1.05, 1.45]
Hazard Ratio (HR, intermediate vs. bottom tertile): 1.15 [0.98, 1.36]
age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation
PPM001374 PGS000665
(GRS_32)
PSS000602|
European Ancestry|
51,288 individuals
PGP000125 |
Marston NA et al. Circulation (2020)
Reported Trait: Incident ischemic stroke C-index: 0.65 [0.63, 0.66] Clinical variables from the Revised Framingham Stroke Risk score, geographic region
PPM001375 PGS000665
(GRS_32)
PSS000601|
European Ancestry|
11,187 individuals
PGP000125 |
Marston NA et al. Circulation (2020)
Reported Trait: Incident ischemic stroke in individuals with atrial fibrillation Hazard Ratio (HR, top vs. bottom tertile): 1.29 [1.01, 1.64] age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation, components of CHA2DS2-VASc score
PPM000823 PGS000117
(CVD_EJ2020)
PSS000400|
Multi-ancestry (including European)|
352,660 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease C-index: 0.75 [0.75, 0.76] pooled cohort equations
PPM000605 PGS000013
(GPS_CAD)
PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.42 [1.25, 1.61] AUROC: 0.776 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000604 PGS000011
(GRS50)
PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.2 [1.06, 1.35] AUROC: 0.769 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000603 PGS000018
(metaGRS_CAD)
PSS000331|
African Ancestry|
7,597 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.4 [1.3, 1.52] AUROC: 0.775 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000602 PGS000013
(GPS_CAD)
PSS000331|
African Ancestry|
7,597 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.3 [1.21, 1.41] AUROC: 0.771 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000601 PGS000011
(GRS50)
PSS000331|
African Ancestry|
7,597 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.05 [0.98, 1.14] AUROC: 0.763 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000600 PGS000018
(metaGRS_CAD)
PSS000333|
European Ancestry|
45,645 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.73 [1.68, 1.78] AUROC: 0.772 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000599 PGS000013
(GPS_CAD)
PSS000333|
European Ancestry|
45,645 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.66 [1.62, 1.71] AUROC: 0.77 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000598 PGS000011
(GRS50)
PSS000333|
European Ancestry|
45,645 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.28 [1.25, 1.32] AUROC: 0.75 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000612 PGS000200
(GRS28)
PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.27 [1.12, 1.42] AUROC: 0.771 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000611 PGS000200
(GRS28)
PSS000331|
African Ancestry|
7,597 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.07 [0.99, 1.16] AUROC: 0.763 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000610 PGS000200
(GRS28)
PSS000333|
European Ancestry|
45,645 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.24 [1.21, 1.28] AUROC: 0.748 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000609 PGS000200
(GRS28)
PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.14 [0.94, 1.37] C-index: 0.655 sex, eMERGE site, first five ancestry-specific principal components
PPM000608 PGS000200
(GRS28)
PSS000332|
African Ancestry|
7,070 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.11 [0.99, 1.24] C-index: 0.652 sex, eMERGE site, first five ancestry-specific principal components
PPM000607 PGS000200
(GRS28)
PSS000334|
European Ancestry|
39,758 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Incident coronary heart disease HR: 1.18 [1.13, 1.23] C-index: 0.697 sex, eMERGE site, first five ancestry-specific principal components
PPM001746 PGS000013
(GPS_CAD)
PSS000898|
African Ancestry|
16,755 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.25 [1.12, 1.4] PCs(1-4)
PPM001747 PGS000013
(GPS_CAD)
PSS000902|
South Asian Ancestry|
8,102 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.47 [1.36, 1.59] PCs(1-4)
PPM000606 PGS000018
(metaGRS_CAD)
PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.93 [1.67, 2.22] AUROC: 0.794 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000836 PGS000116
(CAD_EJ2020)
PSS000401|
Multi-ancestry (including European)|
350,730 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease C-index: 0.74 [0.73, 0.75] QRISK3
PPM000837 PGS000116
(CAD_EJ2020)
PSS000389|
Multi-ancestry (including European)|
203,620 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.75 [0.74, 0.76] QRISK3
PPM000838 PGS000116
(CAD_EJ2020)
PSS000385|
Multi-ancestry (including European)|
147,110 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.83 [0.81, 0.84] QRISK3
PPM000839 PGS000116
(CAD_EJ2020)
PSS000393|
Multi-ancestry (including European)|
146,573 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.73 [0.72, 0.74] QRISK3
PPM000840 PGS000116
(CAD_EJ2020)
PSS000397|
Multi-ancestry (including European)|
204,157 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.78 [0.76, 0.79] QRISK3
PPM000841 PGS000117
(CVD_EJ2020)
PSS000402|
Multi-ancestry (including European)|
350,730 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease C-index: 0.75 [0.75, 0.76] QRISK3
PPM000842 PGS000117
(CVD_EJ2020)
PSS000390|
Multi-ancestry (including European)|
203,620 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (over age 55) C-index: 0.7 [0.7, 0.71] QRISK3
PPM000843 PGS000117
(CVD_EJ2020)
PSS000386|
Multi-ancestry (including European)|
147,110 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (under age 55) C-index: 0.77 [0.76, 0.78] QRISK3
PPM000844 PGS000117
(CVD_EJ2020)
PSS000394|
Multi-ancestry (including European)|
146,573 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in males) C-index: 0.71 [0.71, 0.72] QRISK3
PPM000845 PGS000117
(CVD_EJ2020)
PSS000398|
Multi-ancestry (including European)|
204,157 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in females) C-index: 0.74 [0.73, 0.75] QRISK3
PPM000743 PGS000296
(GPS_CAD_SA)
PSS000365|
South Asian Ancestry|
491 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
Reported Trait: Myocardial infarction (first-ever) OR: 1.6 [1.32, 1.94] AUROC: 0.6632 age, sex, top 5 genetic PCs
PPM000745 PGS000296
(GPS_CAD_SA)
PSS000366|
South Asian Ancestry|
2,963 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
Reported Trait: Coronary artery disease OR: 1.66 [1.53, 1.81] AUROC: 0.712 age, sex, top 5 genetic PCs
PPM001749 PGS000013
(GPS_CAD)
PSS000901|
Hispanic or Latin American Ancestry|
9,085 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.52 [1.43, 1.62] PCs(1-4)
PPM001757 PGS000737
(PRS_BrS)
PSS000905|
European Ancestry|
1,185 individuals
PGP000144 |
Tadros R et al. Eur Heart J (2019)
Reported Trait: Ajmaline-induced Type I Brugada syndrome electrocardiogram OR: 1.174 [1.138, 1.21]
PPM001758 PGS000737
(PRS_BrS)
PSS000905|
European Ancestry|
1,185 individuals
PGP000144 |
Tadros R et al. Eur Heart J (2019)
Reported Trait: Ajmaline-induced Type I Brugada syndrome electrocardiogram C-index: 0.68 [0.65, 0.71] correlation coefficient (r): -0.14
PPM001765 PGS000739
(HCM_GRS)
PSS000909|
Multi-ancestry (including European)|
41,597 individuals
PGP000146 |
Harper AR et al. Nat Genet (2021)
Reported Trait: Hypertrophic cardiomyopathy OR: 1.73 [1.63, 1.83] Age, gender, PCs(1-10)
PPM000746 PGS000296
(GPS_CAD_SA)
PSS000366|
South Asian Ancestry|
2,963 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
Reported Trait: Coronary artery disease OR: 1.58 [1.42, 1.75] age, sex, top 5 genetic PCs, diabetes, hypertension, hypercholesterolemia, smoking, body mass index
PPM000747 PGS000013
(GPS_CAD)
PSS000367|
South Asian Ancestry|
7,244 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.5302 AUROC: 0.8021 age, sex, top 5 genetic PCs
PPM000748 PGS000013
(GPS_CAD)
PSS000365|
South Asian Ancestry|
491 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Myocardial infarction (first-ever) OR: 1.4605 AUROC: 0.6482 age, sex, top 5 genetic PCs
PPM000749 PGS000013
(GPS_CAD)
PSS000366|
South Asian Ancestry|
2,963 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.5793 AUROC: 0.7066 age, sex, top 5 genetic PCs
PPM000888 PGS000331
(PRS_AF)
PSS000442|
European Ancestry|
135,300 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Atrial fibrillation (incident and prevalent cases) HR: 1.62 [1.59, 1.65] genotyping array/batch, 10 ancestry PCs, stratified by sex
PPM000886 PGS000329
(PRS_CHD)
PSS000445|
European Ancestry|
135,300 individuals
PGP000100 |
Mars N et al. Nat Med (2020)
Reported Trait: Coronary heart disease (incident and prevalent cases) HR: 1.31 [1.29, 1.33] genotyping array/batch, 10 ancestry PCs, stratified by sex
PPM000807 PGS000116
(CAD_EJ2020)
PSS000399|
Multi-ancestry (including European)|
352,660 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease C-index: 0.76 [0.75, 0.76] age,sex
PPM000808 PGS000116
(CAD_EJ2020)
PSS000399|
Multi-ancestry (including European)|
352,660 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease C-index: 0.78 [0.77, 0.79] pooled cohort equations
PPM000810 PGS000116
(CAD_EJ2020)
PSS000387|
Multi-ancestry (including European)|
204,675 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.71 [0.7, 0.72] age,sex
PPM000811 PGS000116
(CAD_EJ2020)
PSS000387|
Multi-ancestry (including European)|
204,675 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.74 [0.73, 0.74] pooled cohort equations
PPM000813 PGS000116
(CAD_EJ2020)
PSS000383|
Multi-ancestry (including European)|
147,985 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.76 [0.75, 0.78] age,sex
PPM000814 PGS000116
(CAD_EJ2020)
PSS000383|
Multi-ancestry (including European)|
147,985 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.8 [0.79, 0.82] pooled cohort equations
PPM001767 PGS000739
(HCM_GRS)
PSS000910|
Multi-ancestry (including European)|
20,501 individuals
PGP000146 |
Harper AR et al. Nat Genet (2021)
Reported Trait: Hypertrophic cardiomyopathy carrying a pathogenic sarcomere mutation OR: 1.54 [1.39, 1.69] Age, gender, PCs(1-10)
PPM000816 PGS000116
(CAD_EJ2020)
PSS000391|
Multi-ancestry (including European)|
147,363 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.68 [0.67, 0.69] age,sex
PPM000817 PGS000116
(CAD_EJ2020)
PSS000391|
Multi-ancestry (including European)|
147,363 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.71 [0.7, 0.72] pooled cohort equations
PPM000819 PGS000116
(CAD_EJ2020)
PSS000395|
Multi-ancestry (including European)|
205,297 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.71 [0.7, 0.73] age,sex
PPM000820 PGS000116
(CAD_EJ2020)
PSS000395|
Multi-ancestry (including European)|
205,297 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.76 [0.74, 0.77] pooled cohort equations
PPM000822 PGS000117
(CVD_EJ2020)
PSS000400|
Multi-ancestry (including European)|
352,660 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease C-index: 0.71 [0.71, 0.72] age,sex
PPM000744 PGS000296
(GPS_CAD_SA)
PSS000365|
South Asian Ancestry|
491 individuals
PGP000090 |
Wang M et al. J Am Coll Cardiol (2020)
Reported Trait: Myocardial infarction (first-ever) OR: 1.51 [1.22, 1.88] age, sex, top 5 genetic PCs, diabetes, hypertension, hypercholesterolemia, family history of heart disease, current smoking, family history of myocardial infarction
PPM000824 PGS000117
(CVD_EJ2020)
PSS000388|
Multi-ancestry (including European)|
204,675 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (under age 55) C-index: 0.56 [0.55, 0.56]
PPM000827 PGS000117
(CVD_EJ2020)
PSS000384|
Multi-ancestry (including European)|
147,985 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (over age 55) C-index: 0.59 [0.58, 0.61]
PPM000830 PGS000117
(CVD_EJ2020)
PSS000392|
Multi-ancestry (including European)|
147,363 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in males) C-index: 0.57 [0.56, 0.57]
PPM000833 PGS000117
(CVD_EJ2020)
PSS000396|
Multi-ancestry (including European)|
205,297 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease (in females) C-index: 0.56 [0.55, 0.57]
PPM000806 PGS000116
(CAD_EJ2020)
PSS000399|
Multi-ancestry (including European)|
352,660 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease HR: 1.32 [1.3, 1.34] C-index: 0.61 [0.6, 0.62]
PPM000809 PGS000116
(CAD_EJ2020)
PSS000387|
Multi-ancestry (including European)|
204,675 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.6 [0.59, 0.61]
PPM000812 PGS000116
(CAD_EJ2020)
PSS000383|
Multi-ancestry (including European)|
147,985 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.64 [0.63, 0.66]
PPM000815 PGS000116
(CAD_EJ2020)
PSS000391|
Multi-ancestry (including European)|
147,363 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.61 [0.6, 0.62]
PPM000818 PGS000116
(CAD_EJ2020)
PSS000395|
Multi-ancestry (including European)|
205,297 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.61 [0.6, 0.63]
PPM000821 PGS000117
(CVD_EJ2020)
PSS000400|
Multi-ancestry (including European)|
352,660 individuals
PGP000054 |
Elliott J et al. JAMA (2020)
Reported Trait: Incident cardiovascular disease C-index: 0.56 [0.56, 0.57]
PPM001598 PGS000706
(HC215)
PSS000822|
European Ancestry|
87,413 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Hypertension AUROC: 0.623 Age, sex, PCs(1-10)
PPM001601 PGS000709
(HC299)
PSS000820|
European Ancestry|
87,413 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Heart failure AUROC: 0.53217 Age, sex, PCs(1-10)
PPM001602 PGS000710
(HC326)
PSS000826|
European Ancestry|
87,413 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Myocardial infarction AUROC: 0.59348 Age, sex, PCs(1-10)
PPM001606 PGS000710
(HC326)
PSS000827|
European Ancestry|
135,300 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Myocardial infarction HR: 1.19 [1.17, 1.22] C-index: 0.707 Age as time scale, sex, batch, PCs(1-10)
PPM001614 PGS000709
(HC299)
PSS000821|
European Ancestry|
135,300 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Heart failure HR: 1.08 [1.06, 1.1] C-index: 0.635 Age as time scale, sex, batch, PCs(1-10)
PPM001617 PGS000013
(GPS_CAD)
PSS000839|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Prevalent and incident coronary heart disease OR: 1.89 [1.75, 2.03] Age, sex, PCs (1-5)
PPM001618 PGS000013
(GPS_CAD)
PSS000837|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.24 [1.15, 1.34] C-index: 0.669 [0.644, 0.691] Age, sex, PCs (1-5)
PPM001619 PGS000013
(GPS_CAD)
PSS000838|
European Ancestry|
2,390 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) HR: 1.38 [1.21, 1.58] C-index: 0.672 [0.627, 0.705] Age, sex, PCs (1-5)
PPM001621 PGS000013
(GPS_CAD)
PSS000838|
European Ancestry|
2,390 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.681 [0.637, 0.715] Δ C-index (PRS+covariates vs. covariates alone): 0.021 [-0.0004, 0.043] Pooled cohort risk percentile, age, sex, PCs (1-5)
PPM001622 PGS000013
(GPS_CAD)
PSS000837|
European Ancestry|
4,847 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.549 [0.521, 0.571] PCs (1-5)
PPM001623 PGS000013
(GPS_CAD)
PSS000838|
European Ancestry|
2,390 individuals
PGP000129 |
Mosley JD et al. JAMA (2020)
|Ext.
Reported Trait: Incident coronary heart disease (10-year risk) C-index: 0.587 [0.532, 0.623] PCs (1-5)
PPM001640 PGS000043
(PRS_VTE)
PSS000850|
European Ancestry|
715 individuals
PGP000133 |
Naito T et al. Gastroenterology (2020)
|Ext.
Reported Trait: Thromboembolic disease event in individuals with inflammatory bowel disease Odds Ratio (OR, top 5% vs. remaining 95%): 3.13 [1.37, 7.18] Disease duration, age at disease onset, PCs(1-2) Included 265/297 variants from the original score
PPM001641 PGS000043
(PRS_VTE)
PSS000850|
European Ancestry|
715 individuals
PGP000133 |
Naito T et al. Gastroenterology (2020)
|Ext.
Reported Trait: Thromboembolic disease event in in individuals of inflammatory bowel disease that are carriers of at least 1 thrombophillia pathogenic variant Odds Ratio (OR, top 5% vs. remaining 95%): 8.56 [1.76, 41.57] Age at last visit, PCs(1-2) Included 265/297 variants from the original score
PPM001745 PGS000013
(GPS_CAD)
PSS000900|
European Ancestry|
474,498 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.6 [1.44, 1.78] PCs(1-4)
PPM001748 PGS000013
(GPS_CAD)
PSS000899|
East Asian Ancestry|
3,988 individuals
PGP000143 |
Fahed AC et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease OR: 1.66 [1.47, 1.86] PCs(1-4)
PPM001766 PGS000739
(HCM_GRS)
PSS000908|
Multi-ancestry (including European)|
21,095 individuals
PGP000146 |
Harper AR et al. Nat Genet (2021)
Reported Trait: Hypertrophic cardiomyopathy in individuals who do not carry a pathogenic sarcomere mutation OR: 1.8 [1.67, 1.93] Age, gender, PCs(1-10)
PPM001848 PGS000013
(GPS_CAD)
PSS000929|
European Ancestry|
5,581 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.6699 [0.6557, 0.684]
PPM001849 PGS000013
(GPS_CAD)
PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.5617 [0.5402, 0.5833]
PPM001850 PGS000013
(GPS_CAD)
PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.6374 [0.6335, 0.6412] May be an overlap between score development and testing samples
PPM001836 PGS000746
(PRS_UKB)
PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6133 [0.6094, 0.6172] Area under the Precision-Recall curve (AUPRC): 0.0752 [0.0745, 0.076]
PPM001837 PGS000747
(PRS_EB)
PSS000929|
European Ancestry|
5,581 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.5407 [0.5253, 0.5561] Area under the Precision-Recall curve (AUPRC): 0.498 [0.4962, 0.4998]
PPM001838 PGS000747
(PRS_EB)
PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6565 [0.6369, 0.676] Area under the Precision-Recall curve (AUPRC): 0.0765 [0.0755, 0.0774]
PPM001840 PGS000748
(PRS_DE)
PSS000929|
European Ancestry|
5,581 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6752 [0.6612, 0.6891] Area under the Precision-Recall curve (AUPRC): 0.6891 [0.6887, 0.6895]
PPM001844 PGS000749
(PRS_COMBINED)
PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.5988 [0.5949, 0.6027] Area under the Precision-Recall curve (AUPRC): 0.0697 [0.0688, 0.0705]
PPM001834 PGS000746
(PRS_UKB)
PSS000929|
European Ancestry|
5,581 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.5143 [0.4992, 0.5294] Area under the Precision-Recall curve (AUPRC): 0.5607 [0.5593, 0.5621]
PPM001835 PGS000746
(PRS_UKB)
PSS000930|
European Ancestry|
27,048 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
Reported Trait: Coronary artery disease AUROC: 0.6049 [0.5857, 0.6241] Area under the Precision-Recall curve (AUPRC): 0.046 [0.0454, 0.0466]
PPM001847 PGS000018
(metaGRS_CAD)
PSS000931|
European Ancestry|
431,814 individuals
PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.
Reported Trait: Coronary artery disease AUROC: 0.6377 [0.6339, 0.6416] Area under the Precision-Recall curve (AUPRC): 0.0832 [0.083, 0.0835] May be an overlap between score development and testing sample
PPM001912 PGS000753
(PRS29_AAA)
PSS000958|
European Ancestry|
46,564 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 1.37 [1.3, 1.44] Age, sex, PCs (1-5)
PPM001913 PGS000753
(PRS29_AAA)
PSS000956|
African Ancestry|
47,098 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 1.15 [1.07, 1.24] Age, sex, PCs (1-5)
PPM001915 PGS000753
(PRS29_AAA)
PSS000959|
European Ancestry|
10,231 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 1.31 [1.18, 1.46] Age, sex, PCs (1-5)
PPM001917 PGS000753
(PRS29_AAA)
PSS000956|
African Ancestry|
47,098 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 1.13 [1.04, 1.22] Age, sex, PCs (1-5), smoking, hypertension, low-density lipoprotein cholesterol with statin adjustment, high-density lipoprotein cholesterol, triglycerides, coronary artery disease as a marker of atherosclerosis burden.
PPM001918 PGS000753
(PRS29_AAA)
PSS000957|
European Ancestry|
9,525 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 1.58 [1.25, 1.98] Age, sex, PCs (1-5), smoking, hypertension, low-density lipoprotein cholesterol with statin adjustment, high-density lipoprotein cholesterol, triglycerides, coronary artery disease as a marker of atherosclerosis burden.
PPM001914 PGS000753
(PRS29_AAA)
PSS000957|
European Ancestry|
9,525 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 2.46 [1.46, 4.14] Age, sex, PCs (1-5)
PPM001916 PGS000753
(PRS29_AAA)
PSS000958|
European Ancestry|
46,564 individuals
PGP000159 |
Klarin D et al. Circulation (2020)
Reported Trait: Prevalent abdominal aortic aneurysm OR: 1.34 [1.27, 1.41] Age, sex, PCs (1-5), smoking, hypertension, low-density lipoprotein cholesterol with statin adjustment, high-density lipoprotein cholesterol, triglycerides, coronary artery disease as a marker of atherosclerosis burden.
PPM001939 PGS000043
(PRS_VTE)
PSS000973|
European Ancestry|
29,663 individuals
PGP000166 |
Marston NA et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Venous Thromboembolism HR: 1.47 [1.29, 1.68] Hazard Ratio (HR, top tertile vs bottom tertile): 2.7 [1.8, 4.06] Age, sex, PCs(1-5), obesity(BMI≥30), active smoking, history of heart failure, diabetes status. 273 of original 297 SNPs from Klarin et al (PGS000043) used that reached minimum imputation of 0.58.
PPM001940 PGS000043
(PRS_VTE)
PSS000973|
European Ancestry|
29,663 individuals
PGP000166 |
Marston NA et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Venous Thromboembolism Hazard Ratio (HR, middle tertile vs bottom 3.33%): 1.88 [1.23, 2.89] Age, sex, PCs(1-5), obesity(BMI≥30), active smoking, history of heart failure, diabetes status. 273 of original 297 SNPs from Klarin et al (PGS000043) used that reached minimum imputation of 0.58.
PPM001941 PGS000043
(PRS_VTE)
PSS000973|
European Ancestry|
29,663 individuals
PGP000166 |
Marston NA et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Venous Thromboembolism C-index: 0.67 [0.63, 0.71] 273 of original 297 SNPs from Klarin et al (PGS000043) used that reached minimum imputation of 0.58.
PPM001942 PGS000043
(PRS_VTE)
PSS000973|
European Ancestry|
29,663 individuals
PGP000166 |
Marston NA et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Venous Thromboembolism C-index: 0.67 [0.63, 0.71] Age, obesity(BMI≥30), active smoking, history of heart failure, diabetes status. 273 of original 297 SNPs from Klarin et al (PGS000043) used that reached minimum imputation of 0.58.
PPM001943 PGS000043
(PRS_VTE)
PSS000973|
European Ancestry|
29,663 individuals
PGP000166 |
Marston NA et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Venous Thromboembolism in individuals without monogenic mutations HR: 1.53 [1.3, 1.82] Hazard Ratio (HR, top tertile vs. bottom tertile): 2.88 [1.85, 4.49] Age, sex, PCs(1-5), obesity(BMI≥30), active smoking, history of heart failure, diabetes status. 273 of original 297 SNPs from Klarin et al (PGS000043) used that reached minimum imputation of 0.58.
PPM001944 PGS000043
(PRS_VTE)
PSS000973|
European Ancestry|
29,663 individuals
PGP000166 |
Marston NA et al. Circ Genom Precis Med (2021)
|Ext.
Reported Trait: Venous Thromboembolism in individuals without monogenic mutations Hazard Ratio (HR, middle tertile vs. bottom tertile): 2.11 [1.34, 3.33] Age, sex, PCs(1-5), obesity(BMI≥30), active smoking, history of heart failure, diabetes status. 273 of original 297 SNPs from Klarin et al (PGS000043) used that reached minimum imputation of 0.58.

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000908 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 1,083 cases
  • , 16,072 controls
]
European GeL, RBH-CRB
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals,
38.7 % Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 108 cases
  • , 8,641 controls
]
,
67.8 % Male samples
European JUPITER Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 149 cases
  • , 6,829 controls
]
,
79.7 % Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 320 cases
  • , 2,558 controls
]
,
86.1 % Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 229 cases
  • , 1,770 controls
]
,
77.5 % Male samples
European PROVEIT Secondary prevention cohorts
PSS000908 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 53 cases
  • , 1,510 controls
]
South Asian GeL, RBH-CRB
PSS000908 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 26 cases
  • , 1,623 controls
]
Not reported GeL, RBH-CRB
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease.
[
  • 2,213 cases
  • , 21,382 controls
]
,
38.03 % Male samples
European
(Swedish)
MDC Prospective study
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24)
[
  • 587 cases
  • , 2,819 controls
]
,
45.0 % Male samples
European FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures.
[
  • 757 cases
  • , 11,919 controls
]
,
46.0 % Male samples
European
(Finnish)
FINRISK FR92, FR97, FR02
PSS000489 The diagnosttic criteria for each disease was based on gold-standard clinical guidelines. 339 individuals European
(Spanish)
PRECISESADS
PSS000013 Atrial fibrillation ascertainment was based on self-report of atrial fibrillation, atrial flutter, or cardioversion in an interview with a trained nurse, an ICD-9 code of 427.3 or ICD-10 code of I48.X in hospitalization records, or a history of a percutaneous ablation or cardioversion based on the OPCS-4 coded procedure (K57.1, K62.1, K62.2, K62.3, or K 62.4), as performed previously
[
  • 4,576 cases
  • , 284,402 controls
]
European UKB UKB Phase 2
PSS000015 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 8,676 cases
  • , 280,302 controls
]
European UKB UKB Phase 2
PSS000018 CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75.
[
  • 22,242 cases
  • , 460,387 controls
]
,
45.6 % Male samples
European, NR ~95% European ancestry samples, <5% non-European ancestry UKB
PSS000019 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 173 cases
  • , 5,589 controls
]
,
41.29 % Male samples
European
(French Canadian)
CARTaGENE
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 446 cases
  • , 416 controls
]
European
(French Canadian)
MHI Phase 1
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 937 cases
  • , 1,396 controls
]
European
(French Canadian)
MHI Phase 2
PSS000021 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 974 cases
  • , 976 controls
]
,
72.7 % Male samples
European
(French Canadian)
MHI Phase 1
PSS000022 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 2,492 cases
  • , 817 controls
]
,
72.38 % Male samples
European
(French Canadian)
MHI Phase 2
PSS000910 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 569 cases
  • , 16,120 controls
]
European GeL, RBH-CRB
PSS000023 CAD case endpoints were defined as: angina, myocardial infarction, coronary angioplasty, and coronary bypass surgery. Participants are described as Caucasian with diagnosed Familial hypercholesterolemia(FH; Dutch Lipid Criteria score >= 3 [possible, probable, or definite FH]) and carriers of classical French Canadian mutations in the LDLR gene including del .15 kb of the promoter and exon 1, del .5 kb of exons 2 and 3, W66G (exon 3), E207K (exon 4), Y468X (exon 10), and C646Y (exon 14).
[
  • 206 cases
  • , 519 controls
]
,
42.8 % Male samples
European CNMA Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) of Institut de recherches cliniques de Montréal
PSS000024 Cerebrovascular disease (CVD) case endpoints were defined as: transient ischemic attack, stroke, and carotid endarterectomy. Participants are described as Caucasian with diagnosed Familial hypercholesterolemia(FH; Dutch Lipid Criteria score >= 3 [possible, probable, or definite FH]) and carriers of classical French Canadian mutations in the LDLR gene including del .15 kb of the promoter and exon 1, del .5 kb of exons 2 and 3, W66G (exon 3), E207K (exon 4), Y468X (exon 10), and C646Y (exon 14).
[
  • 231 cases
  • , 494 controls
]
,
42.8 % Male samples
European CNMA Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) of Institut de recherches cliniques de Montréal
PSS000439 National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9.
[
  • 229 cases
  • , 10,332 controls
]
,
47.3 % Male samples
Mean (Age At Baseline) = 48.0 years European
(Finnish)
FINRISK FINRISK surveys from 1992, 1997, 2002 and 2007
PSS000440 Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complications following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first.
[
  • 1,209 cases
  • , 18,956 controls
]
,
47.3 % Male samples
Mean (Age At Baseline) = 48.0 years European
(Finnish)
FINRISK FINRISK surveys from 1992, 1997, 2002 and 2007
PSS000442 National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9.
[
  • 12,809 cases
  • , 122,491 controls
]
,
43.7 % Male samples
Mean (Age At Baseline) = 59.2 years
Sd = 16.6 years
European
(Finnish)
FinnGen
PSS000445 Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complications following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first.
[
  • 20,179 cases
  • , 115,121 controls
]
,
43.7 % Male samples
Mean (Age At Baseline) = 59.2 years
Sd = 16.6 years
European
(Finnish)
FinnGen
PSS000820 87,413 individuals European UKB
PSS000454 Cause of death under ICD-10 code Median = 7.7 years
[
  • 9,816 cases
  • , 39,414 controls
]
East Asian
(Japanese)
BBJ
PSS000455 Cause of death under ICD-10.CHF code Median = 7.7 years
[
  • 362 cases
  • , 48,868 controls
]
East Asian
(Japanese)
BBJ
PSS000456 Cause of death under ICD-10.I codes Median = 7.7 years
[
  • 2,122 cases
  • , 47,108 controls
]
East Asian
(Japanese)
BBJ
PSS000457 Cause of death under ICD-10.IHD code Median = 7.7 years
[
  • 464 cases
  • , 48,766 controls
]
East Asian
(Japanese)
BBJ
PSS000458 Cause of death under ICD-10.J codes Median = 7.7 years
[
  • 1,193 cases
  • , 48,037 controls
]
East Asian
(Japanese)
BBJ
PSS000459 CAD was defined as a composite of stable angina, unstable angina and myocardial infarction. The disease definitions are dependent on the physician's diagnosis based on general medical practices following relevant guidelines and according to the clinical symptoms and diagnotic tests.
[
  • 1,827 cases
  • , 9,172 controls
]
,
84.0 % Male samples
East Asian
(Japanese)
BBJ
PSS000822 87,413 individuals European UKB
PSS000826 87,413 individuals European UKB
PSS000827 ICD-10 I21|I22
[
  • 7,913 cases
  • , 127,387 controls
]
European
(Finnish)
FinnGen
PSS000821 ICD-10 I50, I11.0, I13.0
[
  • 13,965 cases
  • , 121,335 controls
]
European
(Finnish)
FinnGen
PSS000460 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. HFpEF defined as LVEF >/= 50%
[
  • 307 cases
  • , 223 controls
]
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000461 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.HFrEF defined as LVEF <40%
[
  • 1,125 cases
  • , 1,137 controls
]
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000462 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.
[
  • 1,976 cases
  • , 1,783 controls
]
,
70.0 % Male samples
Mean = 72.8 years
Sd = 11.5 years
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000837 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Median = 15.5 years
[
  • 696 cases
  • , 4,151 controls
]
,
43.6 % Male samples
Mean = 62.9 years European ARIC
PSS000838 Incident CHD cases were defined as MI, resuscitated cardiac arrest, definite or probable angina if followed by a revascularization, and CHD dead occuring by visit 5. Median = 14.2 years
[
  • 227 cases
  • , 2,163 controls
]
,
47.8 % Male samples
Mean = 61.8 years European MESA
PSS000839 Incident CHD cases were defined as having incident myocardial infarction (MI), fatal coronary event, or silent infarction or having undergone a revasclarization procedure. Prevalent CHD cases were participants with a reported history of MI, heart or arterial surgery, coronary artery bypass graft surgery, or angioplasty; or evidence of having had an MI based on electrocardiogram taken at their visit 1 examination.
[
  • 1,005 cases
  • , 3,842 controls
]
,
43.6 % Male samples
Mean = 62.9 years European ARIC
PSS000467 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. Median = 21.3 years
Iqr = [16.1, 23.1] years
[
  • 4,122 cases
  • , 24,434 controls
]
,
38.7 % Male samples
Mean = 57.9 years European, NR European=28286, NR=270 MDC
PSS000468 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. All individuals included had measured cholesterol concentrations. Median = 23.2 years
Iqr = [17.6, 24.2] years
[
  • 815 cases
  • , 4,870 controls
]
,
41.16 % Male samples
European, NR European=5640, NR=45 MDC-CC Cardiovascular Cohort
PSS000469 Individuals were free of CAD at time of enrollment. CAD was defined based on hospitalisation with or death due to ICD-10 codes for acute or subsequent myocaridal infarction (I21, I22, I23, I24.1, and I25.2); or hospitalisation with ICD-9 codes for myocaridal. infarction (410, 411, and 412); or hospitalisation with OPCS-4 (Office of Population Censuses and Surveys) codes. for coronary artery bypass grafting (K40, K41, and K45) or coronary angioplasty with or without stenting (K49, K50.2, and K75). Median = 8.1 years
Iqr = [7.4, 8.8] years
[
  • 7,708 cases
  • , 317,295 controls
]
,
44.2 % Male samples
Mean = 56.8 years European, African unspecified, South Asian, East Asian, NR European=304270, African unspecified=5760, South Asian=6832, East Asian (Chinese)=1117, NR=7024 UKB
PSS000053 Participants were classified as having AF if an arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records during a median 9.4 years of follow-up.
[
  • 580 cases
  • , 4,026 controls
]
,
45.9 % Male samples
European, NR FHS is principally composed of individuals of European ancestry FHS Samples were obtained from the following FHS cohorts: Original, Offspring, and Third Generation. Participants were eligible for inclusion if they were AF free at an average age of 55.
PSS000850 All individuals had inflammatory bowel disease, defined on the basis of clinical symptoms as well as standard endoscopic, radiographic and histologic findings. Cases are individuals with a thromboembolic disease (TED) event. Disease activity at the time of TED for Chron's disease was measured by the Harvey-Bradshaw Index and colonoscopy report at the time of clotting event (when available). Patients were considered to have active disease if they had Harvey-Bradshaw Index scores !5 and/or endoscopy showed active disease, Disease activity at the time of TED for Ulcerative Colitis was evaluated by the full Mayo score. A full Mayo score >2 was considered as active disease.
[
  • 63 cases
  • , 652 controls
]
,
53.3 % Male samples
European CSMC
PSS000057 Incident stroke in was defined based on the UK Biobank (UKB) algorithm, based on medical history and linkage to data on hospital admissions and mortality. The authors also subtyped ischaemic stroke, intracerebral haemorrhage, or subarachnoid haemorrhage. UKB Participants with genetic data were excluded from the analysis based on the following criteria: failing genetic quality control (missingness > 5%, sex mismatch, excessive heterozygosity), having a history of stroke or myocardial infarction (MI), self-report of stroke or MI, missing lifestyle information. Median = 7.1 years
[
  • 2,077 cases
  • , 304,396 controls
]
,
44.59 % Male samples
Mean = 56.7 years
Sd = 7.9 years
European Unrelated White British subset of UKB participants UKB
PSS000217 Phenotypic information was self-reported by the individual through an online, interactive health history tool
[
  • 239 cases
  • , 10,064 controls
]
,
17.1 % Male samples
European CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS000219 Phenotypic information was self-reported by the individual through an online, interactive health history tool
[
  • 126 cases
  • , 10,884 controls
]
,
17.1 % Male samples
European CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS000227
[
  • 40 cases
  • , 504 controls
]
Asian unspecified MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000228
[
  • 336 cases
  • , 962 controls
]
African American or Afro-Caribbean MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000229
[
  • 168 cases
  • , 751 controls
]
Hispanic or Latin American MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000230
[
  • 1,537 cases
  • , 1,544 controls
]
European MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 19.0 years
[
  • 235 cases
  • , 4,869 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 14.0 years
[
  • 229 cases
  • , 6,338 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 9.0 years
[
  • 148 cases
  • , 7,182 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 8.0 years
[
  • 119 cases
  • , 5,004 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000058 Prevalent and incident Ischaemic stroke; defined in http://biobank.ndph.ox.ac.uk/showcase/docs/alg_outcome_stroke.pdf Mean = 6.3 years
Sd = 1.9 years
[
  • 3,075 cases
  • , 392,318 controls
]
,
45.7 % Male samples
Mean = 54.3 years European UKB Validation set
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 19.0 years
[
  • 343 cases
  • , 4,761 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 14.0 years
[
  • 344 cases
  • , 6,223 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 9.0 years
[
  • 209 cases
  • , 7,121 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 19.0 years
[
  • 501 cases
  • , 4,603 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 14.0 years
[
  • 499 cases
  • , 6,068 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 9.0 years
[
  • 291 cases
  • , 7,039 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 8.0 years
[
  • 261 cases
  • , 4,862 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 8.0 years
[
  • 197 cases
  • , 4,926 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioVu
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioVu
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Mount Sinai
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000066 VTE was defined in the MVP cohort using the following diagnosis codes for: - Deep Venous Thrombosis ICD-10 codes: {I80.1, I80.2, I82.22, I82.4, I82.5} and ICD-9 codes: {451.11, 451.19, 453.2, 453.4} - Pulmonary Embolism ICD-10 codes: {I26.0, I26.9} and ICD-9 code {415.1}
[
  • 2,100 cases
  • , 53,865 controls
]
European MVP MVP Cohort = 3.0
PSS000868 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I21-I23, I24.1, I25.2 Median = 6.9 years
[
  • 15 cases
  • , 3,072 controls
]
,
51.0 % Male samples
Median = 44.0 years
Iqr = [30.5, 54.7] years
European INTERVAL
PSS000867 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I48 Median = 6.9 years
[
  • 33 cases
  • , 3,054 controls
]
,
51.0 % Male samples
Median = 44.0 years
Iqr = [30.5, 54.7] years
European INTERVAL
PSS000067
[
  • 690 cases
  • , 10,285 controls
]
,
0.0 % Male samples
Mean = 65.0 years European WHI, WHI-GARNET, WHI-HT, WHI-LLS, WHI-MS
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioVu
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000898 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,370 cases
  • , 15,385 controls
]
African unspecified BMBB, MESA, PHB, UKB, VIRGO
PSS000899 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 435 cases
  • , 3,553 controls
]
East Asian TaiChi, UKB
PSS000900 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 26,462 cases
  • , 448,036 controls
]
European BMBB, MESA, PHB, UKB, VIRGO
PSS000901 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,224 cases
  • , 7,861 controls
]
Hispanic or Latin American BMBB, MESA, PHB, VIRGO
PSS000902 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 874 cases
  • , 7,228 controls
]
South Asian BRAVE, UKB
PSS000504 Participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Median = 11.6 years
Sd = 3.7 years
[
  • 343 cases
  • , 3,698 controls
]
,
47.5 % Male samples
Mean = 58.9 years
Sd = 7.6 years
European HNR
PSS000505
[
  • 2,734 cases
  • , 1,307 controls
]
European HNR
PSS000506 Male participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death.
[
  • 219 cases
  • , 1,700 controls
]
,
100.0 % Male samples
European HNR
PSS000507 Participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater.
[
  • 321 cases
  • , 3,427 controls
]
European HNR
PSS000508
[
  • 2,536 cases
  • , 1,212 controls
]
European HNR
PSS000509 Participants with no prior Coronary Heart Disease (CHD) at the time of enrollment with coronary artery calcification>0 were included. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater.
[
  • 278 cases
  • , 2,282 controls
]
European HNR
PSS000510 Male participants with no prior Coronary Heart Disease (CHD) at the time of enrollment were included within the present study. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater.
[
  • 202 cases
  • , 1,563 controls
]
,
100.0 % Male samples
European HNR
PSS000511 Male participants with no prior Coronary Heart Disease (CHD) at the time of enrollment with coronary artery calcification>0 were included. Incidental CHD was the primary end-points of the study. CHD was defined as fatal and non-fatal myocardial infarction, stroke and coronary death. Cardiovascular risk factor data required included smoking status, current use of medication, body mass index, levels of serum triglycerides, low densitity lipoprotein-cholesterol and high densitity lipoprotein-cholesterol and diabetes defined as either of 4 criteria (1) participants reported a history of clinically diagnosed diabetes, (2) participants took glucose-lowering medications, (3) participants had fasting glucose levels of greater than 125mg/dL or (4) participants had non-fasting glucose levels of 200mg/dL or greater.
[
  • 186 cases
  • , 1,240 controls
]
,
100.0 % Male samples
European HNR
PSS000905 Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.15 1,185 individuals European Amsterdam
PSS000908 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 17 cases
  • , 545 controls
]
African unspecified GeL, RBH-CRB
PSS000908 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 1 cases
  • , 39 controls
]
Other admixed ancestry Ad Mixed American GeL, RBH-CRB
PSS000908 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 0 cases
  • , 126 controls
]
East Asian GeL, RBH-CRB
PSS000909 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 17 cases
  • , 1,098 controls
]
African unspecified GeL, RBH-CRB
PSS000909 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 1 cases
  • , 88 controls
]
Other admixed ancestry Ad Mixed American GeL, RBH-CRB
PSS000909 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 2 cases
  • , 265 controls
]
East Asian GeL, RBH-CRB
PSS000909 Cases were individuals with hypertrophic cardiomyopathy. In the individuals recruited from the Netherlands, this was identified using current diagnostic criteria(eft ventricular wall thickness ≥15mm or ≥13mm in presence of family history)
[
  • 1,653 cases
  • , 32,170 controls
]
European GeL, RBH-CRB
PSS000089 Total carotid plaque burden (mm2) 4,392 individuals Range = [55.0, 80.0] years NR BioImage
PSS000090 Total coronary arterial clacification (CAC) was coded as a a dichotomous outcome variable (CAC>0 versus CAC=0), and quantified by the Agatston method Mean = 15.0 years 1,154 individuals Range = [32.0, 47.0] years NR CARDIA
PSS000091 Nonfatal myocardial infarction or death from CHD Mean = 13.5 years
Sd = 2.8 years
2,440 individuals,
100.0 % Male samples
Mean = 55.1 years
Sd = 5.5 years
NR Participants were all men hypercholesterolemia but without a history of myocardial infarction, allocated to the placebo group
PSS000909 Cases were individuals with hypertrophic Cardiomyopathy.
[
  • 62 cases
  • , 2,974 controls
]
South Asian GeL, RBH-CRB
PSS000909 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 34 cases
  • , 3,233 controls
]
Not reported GeL, RBH-CRB
PSS000910 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 0 cases
  • , 559 controls
]
African unspecified GeL, RBH-CRB
PSS000910 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 0 cases
  • , 38 controls
]
Other admixed ancestry Ad Mixed American GeL, RBH-CRB
PSS000910 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 2 cases
  • , 132 controls
]
East Asian GeL, RBH-CRB
PSS000514 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 2,824 cases
  • , 21,547 controls
]
,
42.7 % Male samples
Mean = 57.0 years European, Hispanic or Latin American, African unspecified African unspecified=6979, European=10344, Hispanic or Latin American=7048 Mount Sinai
PSS000515 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 6,979 individuals African unspecified Mount Sinai
PSS000516 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 10,344 individuals European Mount Sinai
PSS000517 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x) 7,048 individuals Hispanic or Latin American Mount Sinai
PSS000518 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 3,538 cases
  • , 10,129 controls
]
,
45.0 % Male samples
Mean = 60.0 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=867, East Asian=167, European=11725, Hispanic or Latin American=799, South Asian=109 PHB
PSS000519 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 4,658 cases
  • , 4,412 controls
]
,
59.0 % Male samples
Mean = 68.0 years European, African unspecified African unspecified=1927, European=7143 PMB
PSS000520 ICD-9 diagnosis code for acute myocardial infarction, other acute/subacute forms of ischemic heart disease, old myocardial infarction, other forms of chronic ischemic heart disease, certain unspecified sequelae of myocardial infarction, coronary bypass, or coronary revascularization (36.1, 36.2, 410, 411, 412, 414, 429.7); ICD-10 diagnosis code for acute myocardial infarction, subsequent myocardial infarction, complications following myocardial infarction, other acute ischemic heart disease, or chronic ischemic heart disease (I21, I22, I23, I24, I25); CPT procedure code for coronary artery bypass, percutaneous transluminal angioplasty/revascularization/thrombectomy, or coronary thrombolysis (3351x, 3353x, 9292x, 9293x, 9294x, 9297x)
[
  • 11,020 cases
  • , 36,088 controls
]
,
46.52 % Male samples
Mean = 59.6 years European, African unspecified, Hispanic or Latin American, East Asian, South Asian African unspecified=9773, East Asian=167, European=29212, Hispanic or Latin America=7847, South Asian=109 Mount Sinai, PHB, PMB
PSS000910 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 9 cases
  • , 1,441 controls
]
South Asian GeL, RBH-CRB
PSS000910 Cases were individuals with hypertrophic cardiomyopathy.
[
  • 8 cases
  • , 1,623 controls
]
Not reported GeL, RBH-CRB
PSS000092 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina Median = 4.7 years
[
  • 675 cases
  • , 4,685 controls
]
,
64.8 % Male samples
Mean = 62.8 years European Self reported white ACCORD Type 2 Diabetes patients
PSS000093 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina Median = 6.2 years
[
  • 163 cases
  • , 1,768 controls
]
European Self reported white ORIGIN Participants are from the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial and were enrolled based on having some combination of impaired fasting glucose, impaired glucose tolerance or type 2 diabetes, and high cardiovascular risk
PSS000094 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death
[
  • 86 cases
  • , 1,234 controls
]
Mean = 62.6 years European Analysis restricted to "White participants" MESA
PSS000095 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death
[
  • 144 cases
  • , 1,062 controls
]
Mean = 62.7 years European Analysis restricted to "White participants" MESA
PSS000601 All patients with atrial fibrillation and CHADS2 score of 2 or higher who were treated with anticoagulation. The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. Median = 2.8 years
[
  • 395 cases
  • , 10,792 controls
]
,
60.78 % Male samples
Mean = 70.8 years
Sd = 9.1 years
European ENGAGE AF-TIMI 48
PSS000602 The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. Median = 2.5 years
[
  • 960 cases
  • , 50,328 controls
]
,
71.7 % Male samples
Mean = 65.9 years
Sd = 9.2 years
European ENGAGE AF-TIMI 48, FOURIER, PEGASUS-TIMI 54, SAVOR-TIMI 53, SOLID-TIMI 52
PSS000929 For GERMIFSI and GERMIFSII, CAD was defined as Myocardinal infarction before the age of 60 and 1 or more 1st- degree relative with CAD. In GERMIFSIII CAD was defined as myocardial infarction between the ages of 26 and 74. In GERMIFSIV, cases were based on a CAD diagnosis before age 65 in men or age 70 in women. In Luric, cases were ascertained as >50% angiographic confirmation of vascular obstruction in 1 or more coronary vessel
[
  • 2,919 cases
  • , 2,662 controls
]
European 6 cohorts
  • GERMIFSI
  • ,GERMIFSII
  • ,GERMIFSIII
  • ,GERMIFSIV
  • ,GERMIFSV
  • ,LURIC
PSS000930 CAD ascertainment was based on myocardial infarction diagnosis or death cause using ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2
[
  • 840 cases
  • , 26,208 controls
]
European EB
PSS000931 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on ICD-9 codes 410.X, 411.X, 412.X, or 429.79, or ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2. Coronary revascularization was assessed based on OPCS-4 coded procedure for coronary artery bypass grafting (K40.1-40-4, K41.1-41.4, or K45.1-45.5), or coronary angioplasty with or without stenting (K49.1-49.2, K49.0-49.9, K50.2, K75.1-75.4, or K75.8-75.9)
[
  • 21,025 cases
  • , 410,789 controls
]
European UKB
PSS000365 Case-control study of first-onset acute myocardial infarction
[
  • 247 cases
]
,
90.7 % Male samples
Mean = 34.0 years
Iqr = [30.0, 35.0] years
South Asian BRAVE
PSS000365 Case-control study of first-onset acute myocardial infarction 244 individuals,
90.2 % Male samples
Mean = 33.0 years
Iqr = [30.0, 35.0] years
South Asian BRAVE
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease.
[
  • 1,800 cases
]
,
90.2 % Male samples
Mean = 54.0 years
Iqr = [46.0, 60.0] years
South Asian MedGenome
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease. 1,163 individuals,
76.4 % Male samples
Mean = 55.0 years
Iqr = [49.0, 62.0] years
South Asian MedGenome
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 398 cases
]
,
86.7 % Male samples
Mean = 60.6 years
Iqr = [54.4, 66.1] years
South Asian UKB
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). 6,846 individuals,
52.1 % Male samples
Mean = 52.8 years
Iqr = [46.3, 60.2] years
South Asian UKB
PSS000973 Cases show venous thromboembolism events, 95 of which were deep vein thrombosis and 79 were pulmonary embolism. 27,189 individuals did not carry a Venous Thromboembolism monogenic mutation. Median = 2.4 years
[
  • 174 cases
  • , 29,489 controls
]
,
74.59 % Male samples
Mean = 64.23 years European
PSS000956 Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4. Controls were defined as possessing no occurrences of the aforementioned ICD codes, as well as no occurrences of the ICD-9 codes 440 through 448 or ICD-10 codes I71 through I75, I77 through I79, or K55.
[
  • 718 cases
  • , 46,380 controls
]
,
86.0 % Male samples
Mean = 56.3 years
Sd = 11.8 years
African unspecified MVP
PSS000957 Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4.
[
  • 194 cases
  • , 9,331 controls
]
,
48.1 % Male samples
Mean = 58.3 years
Sd = 19.5 years
European IMP
PSS000958 Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4. Controls were defined as possessing no occurrences of the aforementioned ICD codes, as well as no occurrences of the ICD-9 codes 440 through 448 or ICD-10 codes I71 through I75, I77 through I79, or K55.
[
  • 1,656 cases
  • , 44,908 controls
]
,
92.1 % Male samples
Mean = 63.8 years
Sd = 13.7 years
European MVP Sample is independent to the MVP sample used to identify SNPs and determine their weights
PSS000959 Abdominal aortic aneurysm cases were defined as the presence of 2 instances of any of the following International Classification of Diseases (ICD)–9 or ICD-10 codes in a participant’s EHR: 441.3, 441.4, I71.3, or I71.4.
[
  • 388 cases
  • , 9,843 controls
]
,
65.4 % Male samples
Mean = 71.0 years
Sd = 13.7 years
European PMB
PSS000383 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,350 cases
  • , 146,635 controls
]
Range = [40.0, 55.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000384 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 10,899 cases
  • , 137,086 controls
]
Range = [40.0, 55.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000385 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,339 cases
  • , 145,771 controls
]
Range = [40.0, 55.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000386 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 2,826 cases
  • , 144,284 controls
]
Range = [40.0, 55.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000387 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,922 cases
  • , 199,753 controls
]
Range = [55.0, 69.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000388 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 2,854 cases
  • , 201,821 controls
]
Range = [55.0, 69.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000389 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,900 cases
  • , 198,720 controls
]
Range = [55.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000390 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 10,824 cases
  • , 192,796 controls
]
Range = [55.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000391 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,493 cases
  • , 142,870 controls
]
,
100.0 % Male samples
Mean = 55.79 years
Sd = 8.35 years
European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000392 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 8,595 cases
  • , 138,768 controls
]
,
100.0 % Male samples
Mean = 55.79 years
Sd = 8.35 years
European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000393 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,471 cases
  • , 142,102 controls
]
,
100.0 % Male samples
Mean = 55.8 years
Sd = 8.3 years
European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000394 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 8,536 cases
  • , 138,037 controls
]
,
100.0 % Male samples
Mean = 55.8 years
Sd = 8.3 years
European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000395 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,779 cases
  • , 203,518 controls
]
,
0.0 % Male samples
Mean = 56.0 years
Sd = 8.01 years
European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000396 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 5,158 cases
  • , 200,139 controls
]
,
0.0 % Male samples
Mean = 56.0 years
Sd = 8.01 years
European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000397 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,768 cases
  • , 202,389 controls
]
,
0.0 % Male samples
Mean = 56.0 years
Sd = 8.0 years
European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000398 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 5,114 cases
  • , 199,043 controls
]
,
0.0 % Male samples
Mean = 56.0 years
Sd = 8.0 years
European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000399 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,272 cases
  • , 346,388 controls
]
,
41.8 % Male samples
Mean = 55.9 years
Range = [40.0, 69.0] years
European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000400 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 13,753 cases
  • , 338,907 controls
]
,
41.8 % Male samples
Mean = 55.9 years
Range = [40.0, 69.0] years
European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000401 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,239 cases
  • , 344,491 controls
]
,
41.0 % Male samples
Range = [40.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000402 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 13,650 cases
  • , 337,080 controls
]
,
41.0 % Male samples
Range = [40.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000283 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 18.8 years
[
  • 1,230 cases
  • , 6,584 controls
]
,
45.0 % Male samples
Mean = 54.0 years
Sd = 5.7 years
European ARIC
PSS000284 Cross-sectional analysis of baseline scores for coronary artery calcification (Agatston score) 4,260 individuals,
44.0 % Male samples
Mean = 69.1 years
Sd = 6.0 years
European BioImage
PSS000285 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 19.4 years
[
  • 2,902 cases
  • , 19,487 controls
]
,
38.0 % Male samples
Mean = 58.0 years
Sd = 7.7 years
European MDC-CC
PSS000286 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 20.5 years
[
  • 971 cases
  • , 20,251 controls
]
,
0.0 % Male samples
Mean = 54.2 years
Sd = 7.1 years
European WGHS
PSS000287 (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics Mean = 3.0 years 1,319 individuals,
69.3 % Male samples
Mean = 68.8 years
Sd = 9.3 years
European
(Dutch)
AEGS1